Letícia S Koester


Affiliation: Porto Alegre
Country: Brazil


  1. de Matos S, Teixeira H, de Lima Á, Veiga Junior V, Koester L. Essential Oils and Isolated Terpenes in Nanosystems Designed for Topical Administration: A Review. Biomolecules. 2019;9: pubmed publisher
  2. Colombo M, de Lima Melchiades G, Michels L, Figueiró F, Bassani V, Teixeira H, et al. Solid Dispersion of Kaempferol: Formulation Development, Characterization, and Oral Bioavailability Assessment. AAPS PharmSciTech. 2019;20:106 pubmed publisher
    ..05). In conclusion, SD with Poloxamer 407 is a feasible pharmacotechnical strategy to ameliorate the dissolution and bioavailability of KPF. ..
  3. de Matos S, Lucca L, Koester L. Essential oils in nanostructured systems: Challenges in preparation and analytical methods. Talanta. 2019;195:204-214 pubmed publisher
    ..Analytical methods used to assess essential oil encapsulation efficiency were discussed regarding their suitability. ..
  4. Colombo M, Figueiró F, de Fraga Dias A, Teixeira H, Battastini A, Koester L. Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro. Int J Pharm. 2018;543:214-223 pubmed publisher
    ..The mucoadhesive nanoemulsion developed for intranasal administration may be a promising system for delivery to the brain, and KPF-MNE is a candidate for further antiglioma trials. ..
  5. Kreutz T, Lucca L, Loureiro Paes O, Teixeira H, Veiga V, Limberger R, et al. Optimization, validation and application of headspace solid-phase microextraction gas chromatography for the determination of 1-nitro-2-phenylethane and methyleugenol from Aniba canelilla (H.B.K.) Mez essential oil in skin permeation samples. J Chromatogr A. 2018;1564:163-175 pubmed publisher
  6. Lucca L, de Matos S, Borille B, de O Dias D, Teixeira H, Veiga V, et al. Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method. J Pharm Biomed Anal. 2015;104:144-8 pubmed publisher
  7. Kelmann R, Colombo M, Nunes R, Simões C, Koester L. Nanoemulsion-Loaded Hydrogels for Topical Administration of Pentyl Gallate. AAPS PharmSciTech. 2018;19:2672-2678 pubmed publisher
    ..Both vehicles neither enhanced PG penetration nor delayed its release from the nanoemulsion. Formulations remained physically stable at 8°C during 3 months of storage. ..
  8. Kelmann R, Colombo M, de Araújo Lopes S, Nunes R, Pistore M, Dall Agnol D, et al. Pentyl Gallate Nanoemulsions as Potential Topical Treatment of Herpes Labialis. J Pharm Sci. 2016;105:2194-203 pubmed publisher
    ..This formulation as well as PG were considered safe for topical use. Nanoemulsions seem to be a safe and effective approach for topically delivering PG in the treatment of human herpes labialis infection. ..
  9. Giongo J, Vaucher R, Da Silva A, Oliveira C, de Mattos C, Baldissera M, et al. Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes. Microb Pathog. 2017;103:13-18 pubmed publisher
    ..canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi. ..

More Information


  1. Colombo M, Melchiades G, Figueiró F, Battastini A, Teixeira H, Koester L. Validation of an HPLC-UV method for analysis of Kaempferol-loaded nanoemulsion and its application to in vitro and in vivo tests. J Pharm Biomed Anal. 2017;145:831-837 pubmed publisher
    ..Furthermore, the method is applicable in bioavailability studies and the developed formulation (KPF-NE) is suitable for preclinical trials in different brain disorders. ..
  2. Lucca L, de Matos S, Kreutz T, Teixeira H, Veiga V, de Araújo B, et al. Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne). AAPS PharmSciTech. 2018;19:522-530 pubmed publisher