Traldi P, Castilho G, Sartori C, Machado Lima A, Nakandakare E, CorrÃªa Giannella M, et al
. Glycated human serum albumin isolated from poorly controlled diabetic patients impairs cholesterol efflux from macrophages: an investigation by mass spectrometry. Eur J Mass Spectrom (Chichester). 2015;21:233-44 pubmed publisher
..We provide evidence that the level of glycation that occurs in albumin in vivo damages the ER function related to the impairment in macrophage reverse cholesterol transport and so contributes to atherosclerosis in diabetes. ..
Pinto P, Rocco D, Okuda L, Machado Lima A, Castilho G, da Silva K, et al
. Aerobic exercise training enhances the in vivo cholesterol trafficking from macrophages to the liver independently of changes in the expression of genes involved in lipid flux in macrophages and aorta. Lipids Health Dis. 2015;14:109 pubmed publisher
..Aerobic exercise in vivo accelerates the traffic of cholesterol from macrophages to the liver contributing to prevention and regression of atherosclerosis, independently of changes in macrophage and aorta gene expression. ..
Gomes D, Velosa A, Okuda L, Fusco F, da Silva K, Pinto P, et al
. Glycated albumin induces lipid infiltration in mice aorta independently of DM and RAS local modulation by inducing lipid peroxidation and inflammation. J Diabetes Complications. 2016;30:1614-1621 pubmed publisher
..AGE-albumin evokes a pre-stage of atherogenesis in dyslipidemic mice independently of the presence of diabetes mellitus or modulation in the RAS in part by the induction of lipid peroxidation and inflammation. ..
Afonso M, Lavrador M, Koike M, Cintra D, Ferreira F, Nunes V, et al
. Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. J Nutr Biochem. 2016;32:91-100 pubmed publisher
..Interesterified fats containing palmitic acid induce atherosclerosis development by promoting cholesterol accumulation in LDL particles and macrophagic cells, activating the inflammatory process in LDLr-KO mice. ..
Machado J, Iborra R, Fusco F, Castilho G, Pinto R, Machado Lima A, et al
. N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1. Atherosclerosis. 2014;237:343-52 pubmed publisher
..NAC may contribute to attenuate the deleterious effects of CKD-albumin on lipid accumulation in macrophages helping to prevent atherogenesis in CKD. ..
Monteiro M, Thieme K, Santos Bezerra D, Queiroz M, Woronik V, Passarelli M, et al
. Beta-2-microglobulin (B2M) expression in the urinary sediment correlates with clinical markers of kidney disease in patients with type 1 diabetes. Metabolism. 2016;65:816-24 pubmed publisher
..Given the proinflammatory nature of B2M, we suggest that this protein contributes to diabetic (and possibly, to non-diabetic) tubulopathy. ..
Iborra R, Machado Lima A, Okuda L, Pinto P, Nakandakare E, Machado U, et al
. AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages. J Diabetes Complications. 2018;32:1-10 pubmed publisher
..This may increase lipid accumulation in macrophages by diminishing cholesterol efflux via RAGE signaling contributing to atherosclerosis in diabetes mellitus. ..