Rosemari Otton

Summary

Country: Brazil

Publications

  1. ncbi request reprint Diabetes causes marked changes in lymphocyte metabolism
    R Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900 Butantan, Sao Paulo, Brazil
    J Endocrinol 174:55-61. 2002
  2. ncbi request reprint Low proliferation capacity of lymphocytes from alloxan-diabetic rats: involvement of high glucose and tyrosine phosphorylation of Shc and IRS-1
    Rosemari Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butantan, Brazil
    Life Sci 71:2759-71. 2002
  3. ncbi request reprint Diabetes induces apoptosis in lymphocytes
    R Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butantan, Sao Paulo, SP, Brazil
    J Endocrinol 182:145-56. 2004
  4. doi request reprint Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function
    Rosemari Otton
    Postgraduate Program, Health Sciences, CBS, Cruzeiro do Sul University, Sao Paulo, SP, Brazil
    Eur J Nutr 51:707-18. 2012
  5. doi request reprint Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils
    Marcelo Paes Barros
    Human Movement Sciences, Institute of Physical Activity and Sport Sciences ICAFE, Universidade Cruzeiro do Sul, Sao Paulo, SP, Brazil
    Chem Biol Interact 197:58-67. 2012
  6. doi request reprint Astaxanthin addition improves human neutrophils function: in vitro study
    Rita C Macedo
    Postgraduate Program, Health Science, CBS, Cruzeiro do Sul University, Avenida Regente Feijó, 1295 Tatuapé, Sao Paulo, SP CEP 03342 000, Brazil
    Eur J Nutr 49:447-57. 2010
  7. doi request reprint Glycolaldehyde impairs neutrophil biochemical parameters by an oxidative and calcium-dependent mechanism--protective role of antioxidants astaxanthin and vitamin C
    Beatriz Alves Guerra
    Postgraduate Program, Health Sciences, CBS, Universidade Cruzeiro do Sul, 03342000 Sao Paulo, SP, Brazil
    Diabetes Res Clin Pract 98:108-18. 2012
  8. doi request reprint ROS production in neutrophils from alloxan-induced diabetic rats treated in vivo with astaxanthin
    Douglas Popp Marin
    Postgraduate Program, Human Movement Sciences Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Sao Paulo, SP, Brazil, 01506 000
    Int Immunopharmacol 11:103-9. 2011
  9. doi request reprint Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats
    Rosemari Otton
    Postgraduate Program, Human Movement Sciences, Institute of Physical Activity and Sport Sciences, Universidade Cruzeiro do Sul, ZIP 01506000, Sao Paulo, SP, Brazil Postgraduate Program, Health Sciences, CBS, Universidade Cruzeiro do Sul, ZIP 08060070, Sao Paulo, SP, Brazil
    Chem Biol Interact 186:306-15. 2010
  10. doi request reprint Testosterone suppresses oxidative stress in human neutrophils
    Douglas Popp Marin
    Postgraduate Program Human Movement Sciences Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Sao Paulo, SP 01506 000, Brazil
    Cell Biochem Funct 28:394-402. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Diabetes causes marked changes in lymphocyte metabolism
    R Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900 Butantan, Sao Paulo, Brazil
    J Endocrinol 174:55-61. 2002
    ..Alloxan-induced diabetes did change lymphocyte metabolism and this may be an important mechanism leading to impairment of lymphocyte function...
  2. ncbi request reprint Low proliferation capacity of lymphocytes from alloxan-diabetic rats: involvement of high glucose and tyrosine phosphorylation of Shc and IRS-1
    Rosemari Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butantan, Brazil
    Life Sci 71:2759-71. 2002
    ..Also, high glycemia in addition to the lack of insulin participates in the reduced proliferation capacity of lymphocytes from diabetic rats...
  3. ncbi request reprint Diabetes induces apoptosis in lymphocytes
    R Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butantan, Sao Paulo, SP, Brazil
    J Endocrinol 182:145-56. 2004
    ..The involvement of low insulinaemia for the occurrence of apoptosis in lymphocytes was also examined. Insulin treatment markedly reduced the proportion of lymphocytes with fragmented DNA in alloxan-induced diabetic rats...
  4. doi request reprint Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function
    Rosemari Otton
    Postgraduate Program, Health Sciences, CBS, Cruzeiro do Sul University, Sao Paulo, SP, Brazil
    Eur J Nutr 51:707-18. 2012
    ....
  5. doi request reprint Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils
    Marcelo Paes Barros
    Human Movement Sciences, Institute of Physical Activity and Sport Sciences ICAFE, Universidade Cruzeiro do Sul, Sao Paulo, SP, Brazil
    Chem Biol Interact 197:58-67. 2012
    ..g. salmon, which is a natural source of both astaxanthin and fish oil) is beneficial to human health, in particular by improving immune response and lowering the risk of vascular and infectious diseases...
  6. doi request reprint Astaxanthin addition improves human neutrophils function: in vitro study
    Rita C Macedo
    Postgraduate Program, Health Science, CBS, Cruzeiro do Sul University, Avenida Regente Feijó, 1295 Tatuapé, Sao Paulo, SP CEP 03342 000, Brazil
    Eur J Nutr 49:447-57. 2010
    ..The aim of the present study was to evaluate the in vitro effect of carotenoid astaxanthin (ASTA) on the phagocytic and microbicidal capacities, cytokine release, and reactive oxygen species production in human neutrophils...
  7. doi request reprint Glycolaldehyde impairs neutrophil biochemical parameters by an oxidative and calcium-dependent mechanism--protective role of antioxidants astaxanthin and vitamin C
    Beatriz Alves Guerra
    Postgraduate Program, Health Sciences, CBS, Universidade Cruzeiro do Sul, 03342000 Sao Paulo, SP, Brazil
    Diabetes Res Clin Pract 98:108-18. 2012
    ..The present study examined the effects of glycolaldehyde (GC) on biochemical parameters of human neutrophils and whether the antioxidant astaxanthin associated with vitamin C can modulate these parameters...
  8. doi request reprint ROS production in neutrophils from alloxan-induced diabetic rats treated in vivo with astaxanthin
    Douglas Popp Marin
    Postgraduate Program, Human Movement Sciences Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Sao Paulo, SP, Brazil, 01506 000
    Int Immunopharmacol 11:103-9. 2011
    ..The present study investigated the effect of daily ASTA intake on oxidative stress and the functional properties of neutrophils from alloxan-induced diabetic rats...
  9. doi request reprint Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats
    Rosemari Otton
    Postgraduate Program, Human Movement Sciences, Institute of Physical Activity and Sport Sciences, Universidade Cruzeiro do Sul, ZIP 01506000, Sao Paulo, SP, Brazil Postgraduate Program, Health Sciences, CBS, Universidade Cruzeiro do Sul, ZIP 08060070, Sao Paulo, SP, Brazil
    Chem Biol Interact 186:306-15. 2010
    ..However, questions are still open regarding the proper ASTA supplementation dose needed to balance efficient antioxidant protection and essential NO/H(2)O(2)-mediated proliferative capacities of diabetic lymphocytes...
  10. doi request reprint Testosterone suppresses oxidative stress in human neutrophils
    Douglas Popp Marin
    Postgraduate Program Human Movement Sciences Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Sao Paulo, SP 01506 000, Brazil
    Cell Biochem Funct 28:394-402. 2010
    ..Therefore, the plasma levels of testosterone are important regulators of neutrophil function and so of the inflammatory response...
  11. doi request reprint Astaxanthin restores the enzymatic antioxidant profile in salivary gland of alloxan-induced diabetic rats
    Mariana Ferreira Leite
    Universidade Cruzeiro do Sul, CEP, Sao Paulo, Brazil
    Arch Oral Biol 55:479-85. 2010
    ..The hypothesis of the study was whether the supplementation of diabetic rats with astaxanthin might antagonize, or at least prevent, the defect in their antioxidative status...
  12. doi request reprint Impact of the carotenoid astaxanthin on phagocytic capacity and ROS/RNS production of human neutrophils treated with free fatty acids and high glucose
    Beatriz Alves Guerra
    Postgraduate Program Health Sciences CBS, Cruzeiro do Sul University, Sao Paulo, SP, 03342000, Brazil
    Int Immunopharmacol 11:2220-6. 2011
    ....
  13. ncbi request reprint Induction of apoptosis in rat lymphocytes by starvation
    Juliana Pires
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, Butantan 05508 900, Sao Paulo, SP, Brazil
    Clin Sci (Lond) 112:59-67. 2007
    ..These findings support the hypothesis that conditions that raise plasma fatty acids levels (e.g. diabetes and starvation) may impair immune function by causing lymphocyte death...
  14. doi request reprint Oxidative stress and antioxidant status response of handball athletes: implications for sport training monitoring
    Douglas Popp Marin
    Metodista University of São Paulo, Sao Bernardo do Campo, Sao Paulo, Brazil
    Int Immunopharmacol 17:462-70. 2013
    ..In addition, these biochemical measurements can be applied in the physiological follow-up of athletes. ..
  15. doi request reprint Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: putative anxiolytic effects?
    Rita Mattei
    Department of Psychobiology, Universidade Federal de Sao Paulo UNIFESP, ZIP 04023062, Sao Paulo, SP, Brazil
    Pharmacol Biochem Behav 99:349-55. 2011
    ..Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations...
  16. ncbi request reprint Modulation of lymphocyte proliferation by macrophages and macrophages loaded with arachidonic acid
    Carmem Maldonado Peres
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Cell Biochem Funct 23:373-81. 2005
    ..These findings support the proposition that AA can directly modulate lymphocyte proliferation and the interaction between macrophages and lymphocytes...
  17. pmc Cytokines and oxidative stress status following a handball game in elite male players
    Douglas Popp Marin
    Postgraduate Program Health Sciences, Cruzeiro do Sul University, Sao Paulo, SP, Brazil
    Oxid Med Cell Longev 2011:804873. 2011
    ..However, the oxidative stress responses following a handball game remain unknown. We investigated the responses of plasma and erythrocyte antioxidant system and oxidative stress biomarkers following a single handball game...
  18. doi request reprint Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes
    Anaysa P Bolin
    Cellular Physiology Laboratory, Postgraduate Program Health Science, CBS, Cruzeiro do Sul University, Tatuape, Sao Paulo, Brazil
    Cell Biol Toxicol 26:457-67. 2010
    ..Further studies are necessary to establish the ASTA-dose compensation point between minimizing oxidative damages and allowing efficient redox-mediated immune functions, such as proliferation, adhesion, and oxidative burst...
  19. ncbi request reprint Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function
    Renata Gorjao
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butanta, Sao Paulo, SP, Brazil
    Clin Nutr 25:923-38. 2006
    ..The effect of a docosahexaenoic acid (DHA)-rich fish oil (FO) supplementation on human leukocyte function was investigated...
  20. ncbi request reprint Toxicity of a mixture of fatty acids on human blood lymphocytes and leukaemia cell lines
    Rosemari Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900 Butantan, Sao Paulo, SP, Brazil
    Toxicol In Vitro 19:749-55. 2005
    ..Evidence is presented herein that mitochondria from leukaemic cells are more susceptible to the toxicity of the fatty acids than mitochondria from human circulating lymphocytes...
  21. ncbi request reprint Non-esterified fatty acids and human lymphocyte death: a mechanism that involves calcium release and oxidative stress
    Rosemari Otton
    Biological Sciences and Health Center CCBS, Cruzeiro do Sul University, Regente Feijó Avenue, 1295, Analia Franco, 03342 000 São Paulo, Brazil
    J Endocrinol 195:133-43. 2007
    ....
  22. doi request reprint Crotoxin alters lymphocyte distribution in rats: Involvement of adhesion molecules and lipoxygenase-derived mediators
    Vanessa O Zambelli
    Laboratory of Pathophysiology, Butantan Institute, Av Vital Brazil 1500, Sao Paulo SP, Brazil
    Toxicon 51:1357-67. 2008
    ....