T Mauad

Summary

Country: Brazil

Publications

  1. pmc Clinico-pathological discrepancies in a general university hospital in São Paulo, Brazil
    Fabiana Kotovicz
    Laboratory of Air Pollution, Department of Pathology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 63:581-8. 2008
  2. pmc Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study
    Thérèse S Lapperre
    Dept of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Respir Res 8:85. 2007
  3. pmc Small airway remodeling in acute respiratory distress syndrome: a study in autopsy lung tissue
    Maina M B Morales
    Department of Pathology, Experimental Air Pollution Laboratory LIM05, Sao Paulo University Medical School, Av Dr, Arnaldo 455, Sao Paulo 01246 903, Brazil
    Crit Care 15:R4. 2011
  4. ncbi Elastosis and fragmentation of fibers of the elastic system in fatal asthma
    T Mauad
    Department of Pathology, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil
    Am J Respir Crit Care Med 160:968-75. 1999
  5. ncbi Pathologic similarities and differences between asthma and chronic obstructive pulmonary disease
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
    Curr Opin Pulm Med 14:31-8. 2008
  6. pmc Chronic exposure to ambient levels of urban particles affects mouse lung development
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Am J Respir Crit Care Med 178:721-8. 2008
  7. ncbi Characterization of autopsy-proven fatal asthma patients in São Paulo, Brazil
    Thais Mauad
    Faculdade de Medicina da Universidade de Sao Paulo, Patologia, Sao Paulo, Brazil
    Rev Panam Salud Publica 23:418-23. 2008
  8. ncbi Lymphocytic inflammation in childhood bronchiolitis obliterans
    Thais Mauad
    Department of Pathology, School of Medicine, Sao Paulo University, Sao Paulo, Brazil
    Pediatr Pulmonol 38:233-9. 2004
  9. ncbi Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Avenida Dr Arnaldo, 455 CEP 01246 903, Sao Paulo, SP, Brazil
    Am J Respir Crit Care Med 170:857-62. 2004
  10. doi Lung pathology in fatal novel human influenza A (H1N1) infection
    Thais Mauad
    Department of Pathology, Sao Paulo University, Brazil
    Am J Respir Crit Care Med 181:72-9. 2010

Collaborators

Detail Information

Publications47

  1. pmc Clinico-pathological discrepancies in a general university hospital in São Paulo, Brazil
    Fabiana Kotovicz
    Laboratory of Air Pollution, Department of Pathology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 63:581-8. 2008
    ..The autopsy rate has continuously diminished over the past few decades, reducing the quality of medical care and the accuracy of statistical health data...
  2. pmc Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study
    Thérèse S Lapperre
    Dept of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Respir Res 8:85. 2007
    ..We determined epithelial proliferation and composition in bronchial biopsies from current and ex-smokers with COPD, and its relation to duration of smoking cessation...
  3. pmc Small airway remodeling in acute respiratory distress syndrome: a study in autopsy lung tissue
    Maina M B Morales
    Department of Pathology, Experimental Air Pollution Laboratory LIM05, Sao Paulo University Medical School, Av Dr, Arnaldo 455, Sao Paulo 01246 903, Brazil
    Crit Care 15:R4. 2011
    ..To date, however, no study has focused on the morphological airway changes in lungs from human subjects with ARDS. The aim of this study is to evaluate structural and inflammatory changes in distal airways in ARDS patients...
  4. ncbi Elastosis and fragmentation of fibers of the elastic system in fatal asthma
    T Mauad
    Department of Pathology, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil
    Am J Respir Crit Care Med 160:968-75. 1999
    ..We also suggest that disrupture of fiber attachments at the basement membrane in the superficial layer could impair the mechanism of airway recoil in asthmatic patients...
  5. ncbi Pathologic similarities and differences between asthma and chronic obstructive pulmonary disease
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
    Curr Opin Pulm Med 14:31-8. 2008
    ..At pathological level, inflammatory and structural similarities also occur and may be related to the phenotypic overlaps...
  6. pmc Chronic exposure to ambient levels of urban particles affects mouse lung development
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Am J Respir Crit Care Med 178:721-8. 2008
    ..Chronic exposure to air pollution has been associated with adverse effects on children's lung growth...
  7. ncbi Characterization of autopsy-proven fatal asthma patients in São Paulo, Brazil
    Thais Mauad
    Faculdade de Medicina da Universidade de Sao Paulo, Patologia, Sao Paulo, Brazil
    Rev Panam Salud Publica 23:418-23. 2008
    ..3%) deaths took place outside a hospital. We conclude that this population shares characteristics of severe or poorly controlled asthma, low educational and socioeconomic levels, and lack of medical care and of inhaled steroid use...
  8. ncbi Lymphocytic inflammation in childhood bronchiolitis obliterans
    Thais Mauad
    Department of Pathology, School of Medicine, Sao Paulo University, Sao Paulo, Brazil
    Pediatr Pulmonol 38:233-9. 2004
    ..Further studies are needed to address the role of different cell types in the development of CBO...
  9. ncbi Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Avenida Dr Arnaldo, 455 CEP 01246 903, Sao Paulo, SP, Brazil
    Am J Respir Crit Care Med 170:857-62. 2004
    ..22-1.74] microm; p = 0.003), but not in the distal alveoli. We propose that structural alterations at the peribronchiolar level might contribute to the pathogenesis of some functional abnormalities observed in patients with severe asthma...
  10. doi Lung pathology in fatal novel human influenza A (H1N1) infection
    Thais Mauad
    Department of Pathology, Sao Paulo University, Brazil
    Am J Respir Crit Care Med 181:72-9. 2010
    ..There are no reports of the systemic human pathology of the novel swine H1N1 influenza (S-OIV) infection...
  11. doi Exercise inhibits allergic lung inflammation
    A C D Silva
    Physical Therapy, University of Sao Paulo, Sao Paulo, Brazil
    Int J Sports Med 33:402-9. 2012
    ..05). The effects of AC before and during the sensitization process inhibit allergic airway inflammation and reduce the production of Th2 cytokines and allergen-specific IgE and IgG1...
  12. ncbi A comparative study of extracellular matrix remodeling in two murine models of emphysema
    F D T Q S Lopes
    Department of Medicine, School of Medicine, University of Sao Paulo, Brazil
    Histol Histopathol 28:269-76. 2013
    ..In both models, there was an increase in collagen type III, which was higher in the CS-exposed mice. We concluded that ECM remodeling is different in the two most used experimental models of emphysema...
  13. doi Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke
    A C Toledo
    Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Arnaldo 455, sala 1210, 01256 903, Sao Paulo, Brazil
    Eur Respir J 39:254-64. 2012
    ..Our results suggest that regular aerobic physical training of moderate intensity attenuates the development of pulmonary disease induced by cigarette smoke exposure...
  14. doi Pulmonary periarterial inflammation in fatal asthma
    C Shiang
    Department of Pathology, School of Medicine, Sao Paulo University, Sao Paulo, SP, Brazil
    Clin Exp Allergy 39:1499-507. 2009
    ..The objective of this study was to describe the inflammatory cell phenotype of pulmonary artery adventitial inflammation in lung tissue from patients who died of asthma...
  15. pmc Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma
    D S Ferreira
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
    Clin Exp Allergy 42:1459-71. 2012
    ..Toll-like receptors (TLRs) and thymic stromal lymphopoietin (TSLP) are thought to be involved in airway inflammation, but their expression in asthmatics' both large and small airways has not been investigated...
  16. doi Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in mice
    K Yoshizaki
    Laboratory of Experimental Atmospheric Pollution LPAE, University of Sao Paulo, Avenida Dr Arnaldo 455, Sao Paulo, Brazil
    Inhal Toxicol 22:610-7. 2010
    ..Cytokines concentrations in the BAL were detectable, with no differences among the groups. Our data suggest that a low-dose of DEP over 60 days induces respiratory tract inflammation...
  17. doi Extracellular matrix components and regulators in the airway smooth muscle in asthma
    B B Araujo
    Dept of Pathology, Sao Paulo University Medical School, Avenida Dr Arnaldo, 455, 01246 903, Sao Paulo SP, Brazil
    Eur Respir J 32:61-9. 2008
    ....
  18. ncbi Inflammatory cell mapping of the respiratory tract in fatal asthma
    S de Magalhães Simões
    Division of Clinical Immunology and Allergy, Department of Pathology, University of Sau Paulo, Sau Paulo, Brazil
    Clin Exp Allergy 35:602-11. 2005
    ..Although it is now accepted that lung inflammation is not restricted to the intrapulmonary airways in asthma, little is known about cell distribution in the other lung compartments and their relation to the intrapulmonary airways...
  19. doi Aerobic training reverses airway inflammation and remodelling in an asthma murine model
    R A Silva
    Dept of Physical Therapy LIM 34, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Eur Respir J 35:994-1002. 2010
    ..AT reversed airway inflammation and remodelling and T-helper cell 2 response, and improved respiratory mechanics. These results seem to occur due to an increase in the expression of IL-10 and IL-1ra and a decrease of NF-kappaB...
  20. pmc Severe novel influenza A (H1N1) infection in cancer patients
    L A Hajjar
    Department of Anesthesia, Universidade de Sao Paulo, Brazil
    Ann Oncol 21:2333-41. 2010
    ..We describe eight cases of H1N1 infection in cancer patients admitted to the intensive care unit of a referral cancer center...
  21. pmc Histological examination has a major impact on macroscopic necropsy diagnoses
    F D C Bernardi
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo SP 01246 903, Brazil
    J Clin Pathol 58:1261-4. 2005
    ..Necropsy is the gold standard for clinicopathological discrepancy studies and epidemiological surveys. Inadequate sampling or lack of tissue may hamper the final interpretation and quality of the necropsy...
  22. doi Expression of secretory leukocyte proteinase inhibitor in the submandibular glands of AIDS patients
    L A Rocha
    Department of Oral Pathology, Faculty of Odontology of Piracicaba University of Campinas, Piracicaba, SP, Brazil
    Oral Dis 14:82-8. 2008
    ..This protease inhibitor is also expressed in submandibular glands (SMG), but there are few data on its expression in AIDS patients with infectious conditions...
  23. pmc Pulmonary amoebiasis presenting as superior vena cava syndrome
    A Lichtenstein
    Department of Medicine, Sao Paulo University Medical School, Brazil
    Thorax 60:350-2. 2005
    ..To our knowledge this is the first description of pulmonary amoebiasis presenting as superior vena cava syndrome...
  24. ncbi Structural alterations in adult rat carotid bodies exposed to hyperbaric oxygenation
    M S Leite
    Experimental Air Pollution Laboratory, Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Undersea Hyperb Med 37:419-32. 2010
    ..We hypothesized that rats will present CB structural alterations when exposed to different lower hyperbaric oxygen doses enough to alter their chemosensory response to hypoxia...
  25. pmc Pneumoconiosis after sericite inhalation
    E Algranti
    Division of Medicine, FUNDACENTRO, Sao Paulo, Brazil
    Occup Environ Med 62:e2. 2005
    ..Between 1997 and 1999 three sericite plant workers in Parana, Brazil, were diagnosed with pneumoconiosis...
  26. ncbi Lung parenchyma remodeling in a murine model of chronic allergic inflammation
    Debora G Xisto
    Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho C C S, Laboratório de Investigação Pulmonar, Ilha do Fundao, 21949 900 Rio de Janeiro RJ, Brazil
    Am J Respir Crit Care Med 171:829-37. 2005
    ..In conclusion, prolonged allergen exposure induced remodeling not only of the airway wall but also of the lung parenchyma, leading to in vivo and in vitro mechanical changes...
  27. ncbi Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of rats
    Pedro Caruso
    Alameda Anapurus 631, ZIP 04087 001, Sao Paulo SP, Brasil
    Intensive Care Med 29:1808-11. 2003
    ....
  28. ncbi Effects of residual oil fly ash (ROFA) in mice with chronic allergic pulmonary inflammation
    Fernanda M Arantes-Costa
    Department of Medicine, School of Medicine, University of Sao Paulo, Brazil
    Toxicol Pathol 36:680-6. 2008
    ..043) and a decrease in the number of ciliated cells in the airway epithelium (p = .017). PM exposure results in pulmonary effects that are more intense in mice with chronic allergic pulmonary inflammation...
  29. pmc Differential distribution of inflammatory cells in large and small airways in smokers
    Salvatore Battaglia
    Department of Pulmonology, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    J Clin Pathol 60:907-11. 2007
    ..Hypothesis: The content of cells infiltrating the airway wall differs between LA and SA...
  30. ncbi Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma
    Laura Fregonese
    Department of Pulmonology, Leiden University Medical Centre, Albinusdreef 2, 2233 ZA Leiden, The Netherlands
    J Allergy Clin Immunol 115:1148-54. 2005
    ..Recent studies suggest the involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma...
  31. ncbi Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease
    Annelies M Slats
    Leiden University Medical Center, Department of Pulmonology C2 P 62, P O Box 9600, 2300 RC Leiden, and Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 176:121-8. 2007
    ..Airway inflammation has been suggested to alter airway mechanics during deep inspiration...
  32. doi Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma
    Annelies M Slats
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 121:1196-202. 2008
    ..However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly...
  33. doi Airway basement membrane perimeter distensibility and airway smooth muscle area in asthma
    Alan L James
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Perth, Western Australia, Australia
    J Appl Physiol (1985) 104:1703-8. 2008
    ..We conclude that the effects of inflation on the relationship between Pbm and ASM are small and do not account for the differences observed in ASM between cases of asthma and nonasthmatic controls...
  34. ncbi Pathology and pathophysiology of pulmonary manifestations in leptospirosis
    Marisa Dolhnikoff
    Department of Pathology, School of Medicine, University of Sao Paulo, SP, Brazil
    Braz J Infect Dis 11:142-8. 2007
    ..In this review we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, with special focus on recent data concerning the pathophysiological mechanisms underlying lung injury...
  35. ncbi Nitric acid-induced bronchiolitis in rats mimics childhood Bronchiolitis obliterans
    Claudia L B Costa
    Department of Pediatrics, School of Medicine, Sao Paulo University, Avenida Dr Arnaldo 455, 1st Floor, Sao Paulo, SP 01246 903, Brazil
    Respiration 72:642-9. 2005
    ..Animal models could help to better understand the sequence of events culminating in bronchiolar obliteration and serve as basis for experimental therapeutic research...
  36. ncbi Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge
    A Janneke Ravensberg
    Department of Pulmonology, Lung Function Laboratory C2 P 62, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Allergy Clin Immunol 115:779-85. 2005
    ..Eotaxin-2 and eotaxin-3 might play a role in the subsequent persistence of allergen-induced bronchial eosinophilia...
  37. ncbi Histology of childhood bronchiolitis obliterans
    Thais Mauad
    Department of Pathology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Pediatr Pulmonol 33:466-74. 2002
    ..Secondary signs of airway obstruction are invariably present. Mild histological changes may predominate and should be carefully evaluated by the pathologist...
  38. ncbi Airway proteoglycans are differentially altered in fatal asthma
    Marcus de Medeiros Matsushita
    Department of Pathology, School of Medicine, University of Sao Paulo, Brazil
    J Pathol 207:102-10. 2005
    ..028). The results show that PGs are differentially expressed in the airways of fatal asthma and may contribute to airway remodelling. These data reinforce the importance of the small airways in airway remodelling in asthma...
  39. ncbi Asthma therapy and airway remodeling
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
    J Allergy Clin Immunol 120:997-1009; quiz 1010-1. 2007
    ..Progress in this area requires the explicit linking of modern structure-function analysis with innovative biopharmaceutical approaches...
  40. ncbi Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice
    Rodolfo P Vieira
    Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Am J Respir Crit Care Med 176:871-7. 2007
    ..Aerobic conditioning improves exercise capacity and decreases symptoms in patients with asthma. However, its benefits in the context of allergic airway inflammation are poorly understood...
  41. ncbi Bronchial CD8 cell infiltrate and lung function decline in asthma
    Elizabeth L J Van Rensen
    Department of Pulmonology, C3 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 172:837-41. 2005
    ..Patients with asthma have an accelerated decline in lung function, which can lead to irreversible airway obstruction. It is generally assumed that this is related to specific aspects of airway inflammation and/or remodeling...
  42. ncbi Fatal outcome in bronchus-associated lymphoid tissue lymphoma
    Romulo Loss Mattedi
    Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    J Bras Pneumol 33:487-91. 2007
    ....
  43. ncbi Simultaneous viral infection and childhood bronchiolitis obliterans
    Mário Hirschheimer
    Menino Jesus São Paulo City Children s Hospital, Sao Paulo, Brazil
    Braz J Infect Dis 6:146-8. 2002
    ..We report a 13-month-old child with bronchiolitis obliterans following co-infection by RSV and adenovirus, and suggest that complicated evolution of an acute bronchiolitis case can indicate an association of pathogens...
  44. ncbi Buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with nicotine
    Raul J Mauad
    Department of Experimental Surgery, School of Medicine, Sao Paulo University, Av Dr Arnaldo 455, 01246 903 Sao Paulo, SP, Brazil
    J Plast Reconstr Aesthet Surg 59:387-92. 2006
    ..In this study, we have compared the isolated and associated actions of the vasoactive drugs buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with subcutaneous doses of nicotine...
  45. ncbi Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress
    Gerry T M Wagenaar
    Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Netherlands
    Free Radic Biol Med 36:782-801. 2004
    ..These findings are not only of fundamental importance in the understanding of the pathophysiology of BPD, but also essential for the development of new therapeutic strategies...
  46. ncbi Missed diagnosis in hematological patients-an autopsy study
    Ana Carolina Galtarossa Xavier
    Department of Pathology, Sao Paulo University Medical School, University of Colorado Health and Science Center, Campus Box 8117, PO Box 6511, Aurora, CO 80045, USA
    Virchows Arch 446:225-31. 2005
    ..We concluded that critical diagnoses are often missed in highly complex hematological patients especially in the absence of admission to specialized hematology units...
  47. ncbi Leptospiral pneumonias
    Marisa Dolhnikoff
    Department of Pathology, University of Sao Paulo, Brazil
    Curr Opin Pulm Med 13:230-5. 2007
    ..In this review, we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, and recent data on the pathophysiology of lung damage and therapeutic implications...