Geraldo Lorenzi Filho

Summary

Country: Brazil

Publications

  1. ncbi Cheyne-Stokes respiration in patients with congestive heart failure: causes and consequences
    Geraldo Lorenzi-Filho
    Heart Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 60:333-44. 2005
  2. ncbi [Cardiovascular consequences of obstructive sleep apnea syndrome]
    Geraldo Lorenzi Filho
    Disciplina de Pneumologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    J Bras Pneumol 36:38-42. 2010
  3. ncbi Obstructive sleep apnea: an emerging risk factor for atherosclerosis
    Luciano F Drager
    Hypertension Unit, Sleep Laboratory, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Chest 140:534-42. 2011
  4. ncbi Obstructive sleep apnea is highly prevalent and correlates with impaired glycemic control in consecutive patients with the metabolic syndrome
    Luciano F Drager
    Hypertension Unit, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Cardiometab Syndr 4:89-95. 2009
  5. ncbi Early signs of atherosclerosis in obstructive sleep apnea
    Luciano F Drager
    Hypertension Unit and Sleep Laboratory, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, CEP 05403 900 São Paulo, Brazil
    Am J Respir Crit Care Med 172:613-8. 2005
  6. ncbi Additive effects of obstructive sleep apnea and hypertension on early markers of carotid atherosclerosis
    Luciano F Drager
    Hypertension Unit, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Hypertension 53:64-9. 2009
  7. ncbi Periodic breathing during incremental exercise predicts mortality in patients with chronic heart failure evaluated for cardiac transplantation
    Joao J Leite
    Division of Respiratory Disease Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Am Coll Cardiol 41:2175-81. 2003
  8. ncbi Sleep-related changes in hemodynamic and autonomic regulation in human hypertension
    Luciano F Drager
    Hypertension Unit Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, Zip Code 05403 904, Sao Paulo, Brazil
    J Hypertens 27:1655-63. 2009
  9. ncbi Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males
    Renata G Koyama
    Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Sleep Med 10:1107-11. 2009
  10. ncbi The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome
    Luciano F Drager
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, CEP 05403 904, Sao Paulo, Brazil
    Atherosclerosis 208:490-5. 2010

Collaborators

  • L F Drager
  • Denis Martinez
  • J Alberto Neder
  • Marcelo Park
  • Dalva Poyares
  • Edmundo Arteaga
  • Charles Mady
  • Alexandre C Pereira
  • Carolina C Gonzaga
  • Lucia Castro Lemos
  • F Bacal
  • V Y Polotsky
  • Claudia Roberta de Castro Moreno
  • P L daLuz
  • Jose M Aldrighi
  • Mario Pedrazzoli
  • Virend Somers
  • H R Middlekauff
  • Christiano Pereira Silva
  • Richard S T Leung
  • T D Bradley
  • Geraldo Lorenzi-Filho
  • Rodrigo P Pedrosa
  • Pedro R Genta
  • Luciana R de Oliveira
  • Aline C S Amaro
  • Ivani C Trombetta
  • Eduardo M Krieger
  • Carlos E Negrao
  • Rosilene Motta Elias
  • Linda M Ueno
  • Cristiana Marques de Araujo
  • Renata G Koyama
  • Kátia C Guimarães
  • Mauro Miguel Daniel
  • Paulo H N Saldiva
  • Adelaide C Figueiredo
  • Dolores Helena Rodriguez Ferreira Rivero
  • Carmen Lúcia Souza
  • Claudia S Albertini-Yagi
  • Joao J Leite
  • Luiz A Bortolotto
  • Márcio G Sousa
  • Celso Amodeo
  • Lílian K G de Paula
  • Maíta G Bechara
  • Raffael F Fraga
  • Maria Janieire N N Alves
  • Edgar Toschi-Dias
  • Murillo O Antunes
  • Afonso Y Matsumoto
  • Maria Urbana P B Rondon
  • Cristiane Maki-Nunes
  • Antonio C P Barretto
  • Wilson Mathias
  • Maria U P B Rondon
  • Cesar Jose Grupi
  • Marco Tulio de Mello
  • Protasio Lemos da Luz
  • Bianca F Marcondes
  • Maria Cecilia Solimene
  • Manuel Carlos Martins Castro
  • Sergio Tufik
  • João Egidio Romão
  • Pedro Rodrigues Genta
  • Jose Eduardo Krieger
  • Eduardo Lyra de Queiroz
  • Ana C T Rodrigues
  • Hugo Abensur
  • Rosa M R P S Castro
  • Fátima D Cintra
  • Ana M F W Braga
  • Claudia Da Costa Leite
  • Maria Cecilia Lorenzi
  • Claudia S Albertini Yagi
  • John J Godleski
  • Sandra Regina Castro Soares
  • Joaquim E Vieira
  • Mitiko Saiki
  • Leila Antonangelo
  • Daniel Inoue
  • Elnara M Negri
  • Paulo Hilario Nascimento Saldiva
  • Marisa Dolhnikoff
  • Regiani C Oliveira
  • Alfredo J Mansur
  • Edimar A Bocchi
  • Paulo R Chizola
  • Mario Terra-Filho
  • Humberto F G de Freitas

Detail Information

Publications38

  1. ncbi Cheyne-Stokes respiration in patients with congestive heart failure: causes and consequences
    Geraldo Lorenzi-Filho
    Heart Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 60:333-44. 2005
    ..Cheyne-Stokes respiration is an independent marker of poor prognosis and may participate in a vicious cycle, further stressing the failing heart...
  2. ncbi [Cardiovascular consequences of obstructive sleep apnea syndrome]
    Geraldo Lorenzi Filho
    Disciplina de Pneumologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    J Bras Pneumol 36:38-42. 2010
    ....
  3. ncbi Obstructive sleep apnea: an emerging risk factor for atherosclerosis
    Luciano F Drager
    Hypertension Unit, Sleep Laboratory, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Chest 140:534-42. 2011
    ..This review provides an update on the role of OSA in atherogenesis and highlights future perspectives in this important research area...
  4. ncbi Obstructive sleep apnea is highly prevalent and correlates with impaired glycemic control in consecutive patients with the metabolic syndrome
    Luciano F Drager
    Hypertension Unit, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Cardiometab Syndr 4:89-95. 2009
    ..001) and apnea-hypopnea index (P=.03). The prevalence of OSA is in the same range as all the individual components of MS and is independently associated with impaired glycemic control...
  5. ncbi Early signs of atherosclerosis in obstructive sleep apnea
    Luciano F Drager
    Hypertension Unit and Sleep Laboratory, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, CEP 05403 900 São Paulo, Brazil
    Am J Respir Crit Care Med 172:613-8. 2005
    ..Recent studies have shown that OSA is associated with multiple markers of endothelial damage. We hypothesized that OSA affects functional and structural properties of large arteries, contributing to atherosclerosis progression...
  6. ncbi Additive effects of obstructive sleep apnea and hypertension on early markers of carotid atherosclerosis
    Luciano F Drager
    Hypertension Unit, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Hypertension 53:64-9. 2009
    ....
  7. ncbi Periodic breathing during incremental exercise predicts mortality in patients with chronic heart failure evaluated for cardiac transplantation
    Joao J Leite
    Division of Respiratory Disease Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Am Coll Cardiol 41:2175-81. 2003
    ..We hypothesized that exercise-related periodic breathing (EPB) would be associated with poor prognosis in advanced chronic heart failure (CHF)...
  8. ncbi Sleep-related changes in hemodynamic and autonomic regulation in human hypertension
    Luciano F Drager
    Hypertension Unit Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, Zip Code 05403 904, Sao Paulo, Brazil
    J Hypertens 27:1655-63. 2009
    ..The present study investigates the hemodynamic and autonomic regulation during sleep-awake transitions and across different sleep cycles in patients with essential hypertension...
  9. ncbi Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males
    Renata G Koyama
    Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Sleep Med 10:1107-11. 2009
    ..However, ACE is a pleiotropic gene that has several influences, including skeletal muscle and control of ventilation. We therefore tested the hypothesis that ACE polymorphism influences OSA severity...
  10. ncbi The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome
    Luciano F Drager
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, CEP 05403 904, Sao Paulo, Brazil
    Atherosclerosis 208:490-5. 2010
    ..The main objective of this study is to determine the impact of OSA on markers of atherosclerosis in patients with MS...
  11. ncbi Obstructive sleep apnea, masked hypertension, and arterial stiffness in men
    Luciano F Drager
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Am J Hypertens 23:249-54. 2010
    ..However, it is not clear whether the frequency of masked hypertension in patients with OSA and whether OSA have an independent role on arterial stiffness taking into account ambulatory blood pressure (BP) monitoring (ABPM)...
  12. ncbi Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension
    Luciano F Drager
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil
    Am J Cardiol 105:1135-9. 2010
    ....
  13. ncbi The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome
    Luciano F Drager
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    PLoS ONE 5:e12065. 2010
    ..Therefore, it is not clear whether OSA exacerbates the metabolic abnormalities in a representative sample of patients with MetS...
  14. ncbi Consequences of comorbid sleep apnea in the metabolic syndrome--implications for cardiovascular risk
    Ivani C Trombetta
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Sleep 33:1193-9. 2010
    ..We examined how the presence of OSA in patients with MetSyn affected hemodynamic and autonomic variables associated with poor cardiovascular outcome...
  15. ncbi Lack of circadian variation of pulse wave velocity measurements in healthy volunteers
    Luciano F Drager
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Clin Hypertens (Greenwich) 13:19-22. 2011
    ..016). In young healthy volunteers, there is no significant circadian variation of carotid-femoral PWV. These findings support the concept that it does not appear mandatory to perform PWV measurements at exactly the same period of the day...
  16. ncbi The effects of continuous positive airway pressure on prehypertension and masked hypertension in men with severe obstructive sleep apnea
    Luciano F Drager
    Hypertension Unit, Heart Institute, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar 44, 05403 904 São Paulo, Brazil
    Hypertension 57:549-55. 2011
    ..In conclusion, effective CPAP therapy promotes significant reduction in the frequency of prehypertension and masked hypertension by promoting significant blood pressure reductions in patients with severe obstructive sleep apnea...
  17. ncbi Obstructive sleep apnea in patients on conventional and short daily hemodialysis
    Rosilene Motta Elias
    Division of Nephrology, Hospital das Clinicas, Universtiy of São Paulo School of Medicine, Sao Paulo, Brazil
    Am J Nephrol 29:493-500. 2009
    ..Among these patients, OSA is associated with difficult BP control and heart remodeling suggesting that OSA may contribute to poor cardiovascular outcome...
  18. ncbi Obstructive sleep apnea is common and independently associated with atrial fibrillation in patients with hypertrophic cardiomyopathy
    Rodrigo P Pedrosa
    Sleep Laboratory, Pulmonary Division, Heart Institute InCor, Av Enéas Carvalho de Aguiar, 44, Sao Paulo, Brazil
    Chest 137:1078-84. 2010
    ..Obstructive sleep apnea (OSA) is independently associated with heart remodeling and arrhythmias in other populations. We hypothesized that OSA is common and is associated with heart remodeling and AF in patients with HCM...
  19. ncbi Effects of exercise training in patients with chronic heart failure and sleep apnea
    Linda M Ueno
    School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil
    Sleep 32:637-47. 2009
    ..To test the effects of exercise training on sleep and neurovascular control in patients with systolic heart failure with and without sleep disordered breathing...
  20. ncbi Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling
    Luciano F Drager
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar 44, CEP 05403 904, Sao Paulo, Brazil
    Chest 131:1379-86. 2007
    ..We sought to investigate the impact of OSA, hypertension, and their association with arterial stiffness and heart structure...
  21. ncbi Evidence that the degree of obstructive sleep apnea may not increase myocardial ischemia and arrhythmias in patients with stable coronary artery disease
    Cristiana Marques de Araujo
    Departament of Clinical Cardiology, Instituto do Coração do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo São Paulo SP, Brazil
    Clinics (Sao Paulo) 64:223-30. 2009
    ..There is controversy regarding whether obstructive sleep apnea is responsible for triggering myocardial ischemia, arrhythmias and heart rate variability in patients with coronary artery disease...
  22. ncbi Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome
    Kátia C Guimarães
    Sleep Laboratory, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas Carvalho de Aguiar, 44, CEP 05403 904, Sao Paulo, Brazil
    Am J Respir Crit Care Med 179:962-6. 2009
    ..Preliminary results suggested that oropharyngeal exercises derived from speech therapy may be an effective treatment option for patients with moderate OSAS...
  23. ncbi Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema
    Marcelo Park
    Division of Emergency Medicine, Heart Institute InCor, Hospital das Clinicas, University of Sao Paulo, Brazil
    Crit Care Med 32:2407-15. 2004
    ..To compare the effects of oxygen, continuous positive airway pressure (CPAP), and bilevel positive airway pressure (bilevel-PAP) on the rate of endotracheal intubation in patients with acute cardiogenic pulmonary edema...
  24. ncbi Obstructive sleep apnea syndrome in truck drivers
    Lucia Castro Lemos
    University of São Paulo School of Public Health, Sao Paulo, SP, Brasil
    J Bras Pneumol 35:500-6. 2009
    ..To determine the prevalence of obstructive sleep apnea syndrome (OSAS), as well as to identify factors associated with a greater risk of developing OSAS, among truck drivers...
  25. ncbi [Quality of sleep of climacteric women in São Paulo: some significant aspects]
    Carmen Lúcia Souza
    Departamento de Psicología Clínica, Istituto de Psicologia, Universidade de Sao Paulo, Rua Inhambu 1307, Moema, Sao Paulo, CEP 04520 010 Brazil
    Rev Assoc Med Bras 51:170-6. 2005
    ..To subjectively evaluate the quality of sleep in menopausal women (35 to 65 years of age)..
  26. ncbi Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension
    Rodrigo P Pedrosa
    Sleep Laboratory, Pulmonary Division, Heart Institute, Av Enéas Carvalho de Aguiar 44, Sao Paulo, Brazil
    Hypertension 58:811-7. 2011
    ..Age >50 years, large neck circumference measurement, and snoring are good predictors of obstructive sleep apnea in this population...
  27. ncbi Pharyngeal dimensions in healthy men and women
    Mauro Miguel Daniel
    Department of Radiology, Neuroradiology Division, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 62:5-10. 2007
    ..Epidemiological studies reveal a high male prevalence of obstructive sleep apnea syndrome. A possible explanation for this male predominance is the existence of anatomical differences in the upper airway between men and women...
  28. ncbi Short-term effects of nCPAP on nasal mucociliary clearance and mucus transportability in healthy subjects
    Luciana R de Oliveira
    Experimental Air Pollution Laboratory, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Respir Med 100:183-5. 2006
    ..62 min; P=0.70). Mucus transportability was not significantly affected by nCPAP. Our results suggest that nCPAP can acutely increase nasal mucociliary clearance but does not affect in vitro mucus transportability in healthy subjects...
  29. ncbi Sputum induction as a research tool for the study of human respiratory mucus
    Claudia S Albertini-Yagi
    Division of Respiratory Diseases, Heart Institution InCor HC, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Respir Physiol Neurobiol 145:101-10. 2005
    ..025). (4) Rheological properties (no significant difference obtained between SI and DC). These results indicated that SI changes mucus physical properties and transportability in non-expectorators...
  30. ncbi [Reduction of central sleep apnea in heart failure patients with beta-blockers therapy]
    Christiano Pereira Silva
    Instituto do Coracao, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Cardiol 94:223-9, 239-45, 226-32. 2010
    ..Sleep apneas are frequent in patients with heart failure (HF). Estimate of the pre-beta blocker age (BB) point out to 45% of central apneas in these patients...
  31. ncbi Acute cardiopulmonary alterations induced by fine particulate matter of São Paulo, Brazil
    Dolores Helena Rodriguez Ferreira Rivero
    Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Toxicol Sci 85:898-905. 2005
    ..Pulmonary vasculature was markedly affected by particle instillation, resulting in significant vasoconstriction in healthy rats...
  32. ncbi Influence of Cheyne-Stokes respiration on cardiovascular oscillations in heart failure
    Richard S T Leung
    Toronto General Hospital/UHN, NU 9-112, 200 Elizabeth Street, Toronto ON, M5G 2C4, Canada
    Am J Respir Crit Care Med 167:1534-9. 2003
    ..Cheyne-Stokes respiration is therefore one of the mechanisms that contributes to the very low-frequency oscillations in heart rate and blood pressure observed in patients with heart failure...
  33. ncbi Provocation of ventricular ectopy by cheyne-stokes respiration in patients with heart failure
    Richard S T Leung
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Ontario, Canada
    Sleep 27:1337-43. 2004
    ..Such an increase in ventricular premature beats might contribute to the higher mortality rates reported in heart failure patients with CSR-CSA...
  34. ncbi Influence of Cheyne-Stokes respiration on ventricular response to atrial fibrillation in heart failure
    Richard S T Leung
    Toronto Rehabilitation Institute Sleep Research Laboratory, Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Appl Physiol 99:1689-96. 2005
    ....
  35. ncbi Sympathetic activity, heart failure, obesity, and metabolic syndrome: is there any role for obstructive sleep apnea?
    Luciano F Drager
    Hypertension 49:e38; author reply e39. 2007
  36. ncbi Obstructive sleep apnea and atherosclerosis: a new paradigm
    Geraldo Lorenzi-Filho
    Am J Respir Crit Care Med 175:1219-21. 2007
  37. ncbi A new straw in the genesis of Cheyne-Stokes respiration
    Geraldo Lorenzi-Filho
    Chest 134:7-9. 2008
  38. ncbi [Obstructive sleep apnea syndrome and its relation with systemic arterial hypertension]
    Luciano Ferreira Drager
    Arq Bras Cardiol 78:531-6. 2002