Meyer Knobel

Summary

Country: Brazil

Publications

  1. ncbi Relevance of iodine intake as a reputed predisposing factor for thyroid cancer
    Meyer Knobel
    Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, and Department of Internal Medicine, University of Sao Paulo Medical School, SP, Brazil
    Arq Bras Endocrinol Metabol 51:701-12. 2007
  2. pmc The prevalence of thyroid dysfunction in elderly cardiology patients with mild excessive iodine intake in the urban area of São Paulo
    Glaucia C Duarte
    Thyroid Unit, Division of Endocrinology, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Clinics (Sao Paulo) 64:135-42. 2009
  3. doi Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil
    Rosalinda Y A Camargo
    Thyroid Unit LIM 25, Division of Endocrinology, Department of Clinical Medicine, University of Sao Paulo Medical School, Avenue Dr Arnaldo, 455 4A, 01246 000 Sao Paulo, SP, Brazil
    Eur J Endocrinol 159:293-9. 2008
  4. doi High prevalence of side effects after recombinant human thyrotropin-stimulated radioiodine treatment with 30 mCi in patients with multinodular goiter and subclinical/clinical hyperthyroidism
    Rossana Romão
    Thyroid Unit LIM 25, Division of Endocrinology, University of Sao Paulo Medical School, Hospital das Clinicas, Sao Paulo, Brazil
    Thyroid 19:945-51. 2009
  5. doi The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation
    Viviane Pardo
    Thyroid Unit LIM 25, University of Sao Paulo Medical School, Av Dr Arnaldo 455 4A, Sao Paulo, SP, Brazil
    J Clin Endocrinol Metab 94:2938-44. 2009
  6. ncbi A molecular analysis and long-term follow-up of two siblings with severe congenital hypothyroidism carrying the IVS30+1G>T intronic thyroglobulin mutation
    Ileana G S Rubio
    University of Sao Paulo Medical School, SP, Brazil
    Arq Bras Endocrinol Metabol 52:1337-44. 2008
  7. ncbi Cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation with recombinant human TSH
    Maria Fernanda Barca
    Thyroid Unit, Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, 01246 000, Brazil
    Endocrine 32:175-81. 2007
  8. doi Phenotypic variation among four family members with congenital hypothyroidism caused by two distinct thyroglobulin gene mutations
    Viviane Pardo
    Thyroid Study Unit LIM 25, Division of Endocrinology, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 18:783-6. 2008
  9. ncbi Human recombinant TSH preceding a therapeutic dose of radioiodine for multinodular goiters has no significant effect in the surge of TSH-receptor and TPO antibodies
    Ileana G S Rubio
    Thyroid Unit, Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 15:134-9. 2005
  10. doi An outline concerning the potential use of recombinant human thyrotropin for improving radioiodine therapy of multinodular goiter
    Geraldo Medeiros-Neto
    Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 155, PAmb 8 A, bl 3, Sao Paulo, SP, 05403 900, Brazil
    Endocrine 33:109-17. 2008

Collaborators

  • Geraldo Medeiros-Neto
  • Glaucia C Duarte
  • Hector M Targovnik
  • Maria Cristina Chammas
  • Danilo B Höfling
  • Debora Lucia Seguro Danilovic
  • Ileana G S Rubio
  • Viviane Pardo
  • Rosalinda Y A Camargo
  • Eduardo K Tomimori
  • Rossana Romão
  • Maria Silvia Cardia
  • Solange Caires Neves
  • Roberta F Possato
  • Ana Luiza Galrao
  • Cristina T Kanamura
  • Simone A Gomes
  • Ana Karina M B Sodré
  • Rosalinda Ya Camargo
  • Maria Fernanda Barca
  • Solange C Neves
  • Rosalinda Camargo
  • Antonio C Nascimento
  • Vera M A Dias
  • Maria Viana
  • Paola Rossi Mezalira
  • Antonio J Chagas
  • Jussara Vono-Toniolo
  • Peter Kopp
  • Rosalinda Y Camargo
  • Ana Luiza R Galrão
  • Carla R P Oliveira
  • Marcelo A Ferreira
  • Tomoco Watanabe
  • Venancio A F Alves
  • Marcos M Santos
  • Marco A V Kulcsar
  • Carlos A Buchpiguel
  • Manoel H Aguiar-Oliveira
  • Rosalinda R Y Camargo
  • Celso U M Friguglietti
  • Cesar Gruppi
  • Ileana Rubio
  • Mucio T Oliveira
  • Eduarto K Tomimori
  • Bruno H Perone
  • Marcia N C Silva
  • Nicolau Lima
  • Cecilia S Santos
  • Dulce R Guedes

Detail Information

Publications22

  1. ncbi Relevance of iodine intake as a reputed predisposing factor for thyroid cancer
    Meyer Knobel
    Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, and Department of Internal Medicine, University of Sao Paulo Medical School, SP, Brazil
    Arq Bras Endocrinol Metabol 51:701-12. 2007
    ....
  2. pmc The prevalence of thyroid dysfunction in elderly cardiology patients with mild excessive iodine intake in the urban area of São Paulo
    Glaucia C Duarte
    Thyroid Unit, Division of Endocrinology, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Clinics (Sao Paulo) 64:135-42. 2009
    ..To evaluate the prevalence of thyroid dysfunction in elderly cardiac patients in an outpatient setting...
  3. doi Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil
    Rosalinda Y A Camargo
    Thyroid Unit LIM 25, Division of Endocrinology, Department of Clinical Medicine, University of Sao Paulo Medical School, Avenue Dr Arnaldo, 455 4A, 01246 000 Sao Paulo, SP, Brazil
    Eur J Endocrinol 159:293-9. 2008
    ..Design This was a population-based, cross-sectional study with 1085 participants randomly selected from a metropolitan area in São Paulo, Brazil, and conducted during the first semester of 2004...
  4. doi High prevalence of side effects after recombinant human thyrotropin-stimulated radioiodine treatment with 30 mCi in patients with multinodular goiter and subclinical/clinical hyperthyroidism
    Rossana Romão
    Thyroid Unit LIM 25, Division of Endocrinology, University of Sao Paulo Medical School, Hospital das Clinicas, Sao Paulo, Brazil
    Thyroid 19:945-51. 2009
    ..In this study, we determined the outcome of 30 mCi RAI preceded by rhTSH (0.1 mg) in euthyroid (EU) and hyperthyroid (subclinical/clinical) patients with large MNGs...
  5. doi The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation
    Viviane Pardo
    Thyroid Unit LIM 25, University of Sao Paulo Medical School, Av Dr Arnaldo 455 4A, Sao Paulo, SP, Brazil
    J Clin Endocrinol Metab 94:2938-44. 2009
    ..Thyroglobulin (TG) is a large glycoprotein and functions as a matrix for thyroid hormone synthesis. TG gene mutations give rise to goitrous congenital hypothyroidism (CH) with considerable phenotype variation...
  6. ncbi A molecular analysis and long-term follow-up of two siblings with severe congenital hypothyroidism carrying the IVS30+1G>T intronic thyroglobulin mutation
    Ileana G S Rubio
    University of Sao Paulo Medical School, SP, Brazil
    Arq Bras Endocrinol Metabol 52:1337-44. 2008
    ..Nodular and non-nodular thyroid tissue specimens were collected. Specific thyroid genes expression was evaluated by real-timePCR and by immunohistochemistry...
  7. ncbi Cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation with recombinant human TSH
    Maria Fernanda Barca
    Thyroid Unit, Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, 01246 000, Brazil
    Endocrine 32:175-81. 2007
    ..In conclusion, rhTSH stimulated RAI treatment of MNG did not affect structural and functional parameters of the heart, despite transient high-serum levels of thyroid hormones...
  8. doi Phenotypic variation among four family members with congenital hypothyroidism caused by two distinct thyroglobulin gene mutations
    Viviane Pardo
    Thyroid Study Unit LIM 25, Division of Endocrinology, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 18:783-6. 2008
    ..At least 38 mutations have been described in the Tg gene that are associated with varying degrees of hypothyroidism. We studied the Tg gene in four related subjects with congenital hypothyroidism...
  9. ncbi Human recombinant TSH preceding a therapeutic dose of radioiodine for multinodular goiters has no significant effect in the surge of TSH-receptor and TPO antibodies
    Ileana G S Rubio
    Thyroid Unit, Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 15:134-9. 2005
    ..The antibodies to the TSH comprised a combination of agonist (stimulating) and antagonist (blocking) antibodies, which in most patients did not induce clinical and laboratory evidence of active Graves' disease...
  10. doi An outline concerning the potential use of recombinant human thyrotropin for improving radioiodine therapy of multinodular goiter
    Geraldo Medeiros-Neto
    Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 155, PAmb 8 A, bl 3, Sao Paulo, SP, 05403 900, Brazil
    Endocrine 33:109-17. 2008
    ..The use of rhTSH in benign goiter disease has not yet been approved worldwide, but its positive activity in MNG is remarkable and promising...
  11. ncbi Excessive iodine intake and ultrasonographic thyroid abnormalities in schoolchildren
    Glaucia C Duarte
    Thyroid Unit, Division of Endocrinology, Department of Clinical Medicine, University of Sao Paulo Medical School, Brazil
    J Pediatr Endocrinol Metab 22:327-34. 2009
    ..7%). Goiter was present in 1.9% of the children. Hypoechogenicity, a relevant marker of autoimmune thyroiditis, was the most common abnormality found in our study, and this may be linked to excessive iodine intake...
  12. doi Association of low sodium-iodide symporter messenger ribonucleic acid expression in malignant thyroid nodules with increased intracellular protein staining
    Ana Karina M B Sodré
    Hospital das Clinicas, Enéas Carvalho de Aguiar, Sao Paulo, Brazil
    J Clin Endocrinol Metab 93:4141-5. 2008
    ..Benign and malignant thyroid tumors have low iodide uptake. However, previous studies by RT-PCR or immunohistochemistry have shown divergent results of NIS expression in these nodules...
  13. doi Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial
    Danilo B Höfling
    Ultrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Clinicas, Sao Paulo, 05403 000, Brazil
    Lasers Med Sci 28:743-53. 2013
    ..No TgAb difference was observed. These findings suggest that LLLT was effective at improving thyroid function, promoting reduced TPOAb-mediated autoimmunity and increasing thyroid echogenicity in patients with CAT hypothyroidism...
  14. ncbi Monoallelic thyroid peroxidase gene mutation in a patient with congenital hypothyroidism with total iodide organification defect
    Solange Caires Neves
    Thyroid Unit, Cellular and Molecular Endocrinology Laboratory, Faculdade de Medicina da Universidade de Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 54:732-7. 2010
    ..A plausible explanation for the association between an autosomal recessive disorder with a single TPO-mutated allele is the presence of monoallelic TPO expression...
  15. ncbi Prevalence of chronic autoimmune thyroiditis in the urban area neighboring a petrochemical complex and a control area in Sao Paulo, Brazil
    Rosalinda Y A Camargo
    Thyroid Unit, Division of Endocrinology, Department of Clinical Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Clinics (Sao Paulo) 61:307-12. 2006
    ..To evaluate the prevalence of chronic autoimmune thyroiditis in 2 urban areas of metropolitan São Paulo (Brazil): Polo Area neighboring a large petrochemical complex and São Bernardo Campo Area (control area)...
  16. ncbi Evaluation of a coated-tube assay for antithyrotropin receptor antibodies in patients with Graves' disease and other thyroid disorders
    Maria Silvia Cardia
    Thyroid Unit, Endocrine Division, Department of Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 14:295-300. 2004
    ..An advantage of the pCT-TRAb assay may be because of the coating system itself that might expose more receptor sites for the antibody...
  17. ncbi Thyroperoxidase gene mutations in congenital goitrous hypothyroidism with total and partial iodide organification defect
    Antonio C Nascimento
    Thyroid Study Unit LIM 25, Division of Endocrinology, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 13:1145-51. 2003
    ..It is conceivable that these TPO gene sequence alterations may partially affect the functional state of the translated protein or affect its transport to the apical membrane...
  18. ncbi Preoperative assessment of thyroid nodules: role of ultrasonography and fine needle aspiration biopsy followed by cytology
    Rosalinda Ya Camargo
    Hospital das Clinicas, Endocrinology, Thyroid Unit LIM25, Brazil
    Clinics (Sao Paulo) 62:411-8. 2007
    ..To evaluate the preoperative assessment of thyroid nodules using ultrasound studies and cytology of nodular aspirates...
  19. doi Factitious thyrotoxicosis induced by mesotherapy: a case report
    Debora Lucia Seguro Danilovic
    Laboratório de Endocrinologia Celular e Molecular LIM 25, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brazil
    Thyroid 18:655-7. 2008
    ..These findings could be related to thyroid hormone metabolite absorption and systemic consequences in the reported case...
  20. ncbi An outline of inherited disorders of the thyroid hormone generating system
    Meyer Knobel
    Thyroid Unit, Division of Endocrinology, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Thyroid 13:771-801. 2003
    ....
  21. ncbi Iodine nutrition: more is better?
    Rosalinda Camargo
    Arq Bras Endocrinol Metabol 51:639-40. 2007
  22. ncbi [Disorders associated to chronic iodine deficiency]
    Meyer Knobel
    Unidade de Tiróide, Departamento de Clinica Medica, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP
    Arq Bras Endocrinol Metabol 48:53-61. 2004
    ..Universal salt iodination was implemented in Brazil in the early fifties but recently the system was considered effective for the supply of iodine to the Brazilian population...