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Genomes and Genes | Flavio KapczinskiSummaryCountry: Brazil Publications
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Publications
CANMAT guidelines for bipolar disorder: a commentary from South AmericaFlavio Kapczinski
Bipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Bipolar Disord 7:87-8. 2005
Allostatic load in bipolar disorder: implications for pathophysiology and treatmentFlavio Kapczinski
Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos 2350, 90035 000, Porto Alegre, RS, Brazil
Neurosci Biobehav Rev 32:675-92. 2008....- Brain-derived neurotrophic factor and neuroplasticity in bipolar disorderFlavio Kapczinski
Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas, Federal University UFRGS, Porto Alegre, Brazil
Expert Rev Neurother 8:1101-13. 2008..The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BDNF as a biomarker in BD... - Peripheral biomarkers and illness activity in bipolar disorderFlavio Kapczinski
Bipolar Disorders Program and INCT for Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Psychiatr Res 45:156-61. 2011..In some cases, toxicity was as high in bipolar disorder as that seen in patients with sepsis. We believe these findings highlight the potential of using biomarkers to assess illness activity in bipolar disorder... - Clinical implications of a staging model for bipolar disordersFlavio Kapczinski
Bipolar Disorders Program, Laboratory of Molecular Psychiatry and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Avenida Ramiro Barcelos 2350, 90035 903 PortoAlegre RS, Brazil
Expert Rev Neurother 9:957-66. 2009..Staging facilitates understanding of the mechanisms underlying progression of the disorder, assists in treatment planning and prognosis and, finally, underscores the imperative for early intervention... - The potential use of biomarkers as an adjunctive tool for staging bipolar disorderFlavio Kapczinski
Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas, UFRGS, INCT Translational Medicine, Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 33:1366-71. 2009..Empirical testing will determine the ability of the present model to inform patients and clinicians about both prognosis and response to treatment... - [Physiopathology of bipolar disorders: what have changed in the last 10 years?]Flavio Kapczinski
Laboratorio de Psiquiatría Experimental, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS
Rev Bras Psiquiatr 26:17-21. 2004..This study aims to update the recent findings relative to the neurochemistry of BD... 
Effects of mood stabilizers on DNA damage in an animal model of maniaAna Cristina Andreazza
Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil
J Psychiatry Neurosci 33:516-24. 2008..We investigated the effects of the mood stabilizers lithium and valproate on amphetamine-induced DNA damage in an animal model of mania and their correlation with oxidative stress markers...- Evidence of astrogliosis in rat hippocampus after d-amphetamine exposureBenicio N Frey
Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 30:1231-4. 2006..Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization... - Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of maniaBenicio N Frey
Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Behav Pharmacol 17:311-8. 2006..These findings suggest that nerve growth factor may play a role in the neurotrophic effects of lithium but do not support the hypotheses that the nerve growth factor/TrkA pathway is involved in the pathophysiology of bipolar disorder... - Effects of mood stabilizers on hippocampus BDNF levels in an animal model of maniaBenicio N Frey
Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, Zip code 90035 003, Porto Alegre, RS, Brazil
Life Sci 79:281-6. 2006..Our results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania... - Polypharmacy and suicide attempts in bipolar disorderFernando Kratz Gazalle
Post Graduate Psychiatry Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 29:35-8. 2007..The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder... - Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of maniaJulio C Walz
Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90035 003 Porto Alegre, RS, Brazil
J Psychiatr Res 42:416-21. 2008..These results suggest that both Li and VPT modulate serum and central (hippocampal) NT-3 levels, and further support that the regulation of neurotrophic signaling systems may be related to the mechanisms of action of mood stabilizers... - Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acidRose Mary Carvalho Pinheiro
Department of Physiological Sciences, Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, Av Ipiranga, 6681 Predio 12D, Sala 340, Porto Alegre, RS 90619 900, Brazil
J Neural Transm 119:627-37. 2012..Here, we show that valproic acid ameliorated the cognitive deficits induced by AMPH, but it was not effective when the animals were exposed to both stressors: maternal deprivation and AMPH treatment... - Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic malesClarissa Severino Gama
Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
Neurosci Lett 433:270-3. 2008..However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males... - Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effectsRodrigo Machado-Vieira
Mood Disorders Program, HMIPV, Fundacao Faculdade Federal Ciencias Medicas de Porto Alegre and Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil
Neurosci Lett 421:33-6. 2007..Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD... - A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar maniaRodrigo Machado-Vieira
Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, RS, Brazil
J Clin Psychiatry 69:1237-45. 2008..This study aimed to evaluate the efficacy and tolerability of the purinergic agents allopurinol and dipyridamole combined with lithium in bipolar mania... - Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodesFlavio Kapczinski
Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 30:243-5. 2008.... - Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patientsGislaine S de Oliveira
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
J Psychiatr Res 43:1171-4. 2009..001. Results suggest that the association of lower serum BDNF and BD mood episodes is kept even in medicated patients, which strengthens the notion that BDNF serum levels may be considered a biomarker of mood episodes in BD... - Cognitive impairment in school-aged children with early traumaJoana Bücker
Laboratory of Molecular Psychiatry and Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Compr Psychiatry 53:758-64. 2012..These findings further support the need for early interventions that can prevent cognitive impairment when childhood trauma occurs... - Glial fibrillary acidic protein expression after electroconvulsive shocks in rat brainKeila M Ceresér
Laboratorio de Psiquiatría Experimental, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 30:663-7. 2006..The aim of the present study was to assess the effect of electroconvulsive shock (ECS) in glial fibrillary acidic protein (GFAP) expression in rat brain... - Decreased serum neurotrophin 3 in chronically medicated schizophrenic malesHaroldo Evangelista Vargas
Programa de Pós Graduação em Medicina Psiquiatria, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 90035 003 Porto Alegre, RS, Brazil
Neurosci Lett 440:197-201. 2008..These findings suggest that the NT3 signaling system may play a role in the pathophysiology of SZ and might be related to the course of illness or to treatment variables. Longitudinal studies are warranted... - Manic symptoms and quality of life in bipolar disorderFernando Kratz Gazalle
Psychiatric Research Unit, Post Graduate Psychiatry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Psychiatry Res 153:33-8. 2007..In a separate analysis at the YMRS items, items 4 (irritability) and 5 (sleep) were associated with lower quality of life... - Development and use of a biological rhythm interviewLarriany Maria Falsin Giglio
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Affect Disord 118:161-5. 2009..This report describes the validation of a new instrument, the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), designed to assess biological rhythms in the clinical setting... - A gastrin-releasing peptide receptor antagonist blocks D-amphetamine-induced hyperlocomotion and increases hippocampal NGF and BDNF levels in ratsAna Cristina Andreazza
Laboratory of Experimental Psychiatry and Bipolar Disorders Program, Academic Hospital Research Center, Department of Biochemistry, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Peptides 28:1447-52. 2007..Administration of D-AMPH did not affect NGF or BDNF levels by itself, but blocked the RC-3095 effects. The results suggest that GRPR antagonists might display anti-manic activity... - Increased oxidative stress and DNA damage in bipolar disorder: a twin-case reportBenicio N Frey
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 31:283-5. 2007..In the present study we investigated the oxidative stress profile in two monozygotic twins during a manic episode... - Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodesBrisa Simões Fernandes
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, 90035 903 Porto Alegre, RS, Brazil
J Psychiatr Res 44:561-5. 2010..controls). There is no difference in serum BDNF between manic and depressive patients. Results suggest that increased serum NT-3 levels in BD are likely to be associated with the pathophysiology of manic and depressive symptoms... - Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of maniaBenicio Noronha Frey
Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Brazil
Bipolar Disord 8:275-80. 2006..Several studies have demonstrated that oxidative stress may play a role in the behavioral and neurochemical changes observed after AMPH administration... - Mediators of allostasis and systemic toxicity in bipolar disorderIria Grande
National Institute for Translational Medicine, INCT TM, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2350 CEP 90035 903 Porto Alegre, Brazil
Physiol Behav 106:46-50. 2012..In the present review we examine the role of allostatic load in the illness progression that takes place in bipolar disorder... - The role of hippocampus in the pathophysiology of bipolar disorderBenicio N Frey
Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brazil
Behav Pharmacol 18:419-30. 2007..In conclusion, the available evidence suggests that the hippocampus plays an important role in the pathophysiology of BD... - Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorderClarissa Severino Gama
Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035 003, Porto Alegre, RS, Brazil
Neurosci Lett 420:45-8. 2007..001) when compared to either controls or euthymic BD patients. Increased BDNF in SZ patients might be related to the course of illness or to treatment variables. Prospective studies are warranted... - Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophreniaMauricio Kunz
Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Programa de Pós Graduação em Medicina Psiquiatria, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:1677-81. 2008..There is an increasing body of evidence suggesting that oxidative stress may play a role in the pathophysiology of both schizophrenia (SZ) and bipolar disorder (BD)... - Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysisBrisa Simões Fernandes
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
J Psychiatr Res 45:995-1004. 2011..In euthymia, BDNF decreases with age and length of illness. These data suggest that peripheral BDNF could be used as a biomarker of mood states and disease progression for BD... - Brain-derived neurotrophic factor serum levels before and after treatment for acute maniaJuliana Fernandes Tramontina
Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Brazil
Neurosci Lett 452:111-3. 2009..Further studies designed to validate the use of BDNF as a marker of treatment response in bipolar disorder are warranted... - Serum brain-derived neurotrophic factor in bipolar and unipolar depression: a potential adjunctive tool for differential diagnosisBrisa Simões Fernandes
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, 90035 903 Porto Alegre, RS, Brazil
J Psychiatr Res 43:1200-4. 2009..Our results suggest the role of BDNF as an adjunctive tool to promote prompt and accurate diagnosis of BD. However, further investigation and replication of these results are warranted... - BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cellsAnna Laura Schmidt
Cancer Research Laboratory, University Hospital Research Center CPE HCPA, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 2350, 90035 003, Porto Alegre, RS, Brazil
J Mol Neurosci 40:303-10. 2010..The results suggest that BDNF/TrkB and PDE4, but not the GRPR, regulate the viability of medulloblastoma cells... - Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicityMariana Pedrini
Laboratory of Molecular Psychiatry, INCT for Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Psychiatr Res 46:819-24. 2012..Our findings reinforce the need of assessment of individuals in ultra high risk to develop psychosis and first-episode population... - Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episodeRodrigo Machado Vieira
Mood Disorders Program, Fundação Faculdade Federal Ciências Medicas de Porto Alegre, Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil
Biol Psychiatry 61:142-4. 2007..Also, previous studies demonstrated a role for BDNF in the pathophysiology and clinical presentation of mood disorders... - Validity of a short functioning test (FAST) in Brazilian outpatients with bipolar disorderAlice Aita Cacilhas
Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Value Health 12:624-7. 2009..Here we present data on the Portuguese validation of the Functioning Assessment Short Test (FAST), which was explicitly designed to gauge functioning dimensions empirically linked to bipolar disorder... - Cognitive impairment in a Brazilian sample of patients with bipolar disorderJúlia J Schneider
Bipolar Disorder Program, Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 30:209-14. 2008..Persistent neurocognitive deficits have been described in bipolar mood disorder. As far as we are aware, no study have examined whether the cognitive impairment is presented in the same way in a Brazilian sample... - Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlationClarissa Severino Gama
Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 30:337-40. 2008.... - Increased oxidative stress in submitochondrial particles after chronic amphetamine exposureBenicio N Frey
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
Brain Res 1097:224-9. 2006..Further studies assessing the effects of mood stabilizers and antipsychotics in preventing mitochondrial oxidative stress are necessary... - Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balanceMauricio Kunz
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 33:268-74. 2011..The aim is to compare cytokine levels in both disorders... - Serum S100B and antioxidant enzymes in bipolar patientsAna Cristina Andreazza
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
J Psychiatr Res 41:523-9. 2007..This peripheral oxidative imbalance indicates that systemic changes are taking place during the active phases of the illness. Such changes appear to relate to astrocyte function, as indicated by serum S100B elevation... - Sleep in bipolar patientsLarriany M F Giglio
Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, RS, Brazil
Sleep Breath 13:169-73. 2009..Most patients with BPD also report insomnia when in depression, but a significant percentage of patients report hypersomnia symptoms with prolonged nighttime sleep, difficulty in wakening, and excessive daytime sleepiness... - Peripheral nucleotide hydrolysis in rats submitted to a model of electroconvulsive therapyJoão Vicente Busnello
Departamento de Bioquimica, ICBS, UFRGS, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:1829-33. 2008.... - Reduced NGF secretion by HT-29 human colon cancer cells treated with a GRPR antagonistCaroline Brunetto de Farias
Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Protein Pept Lett 16:650-2. 2009..The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative effects in cancer cells... - Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorderAngelo B Cunha
Department of Neuropsychiatry, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, Santa Maria, RS, 97105 900, Brazil
Eur Arch Psychiatry Clin Neurosci 258:300-4. 2008..001). These findings add to the notion that changes in the inflammatory system take place during acute episodes of mania... - Immunoassay for glial fibrillary acidic protein: antigen recognition is affected by its phosphorylation stateFrancine Tramontina
Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
J Neurosci Methods 162:282-6. 2007.... - Correlates and impact of obsessive-compulsive comorbidity in bipolar disorderPedro V S Magalhaes
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, Brazil
Compr Psychiatry 51:353-6. 2010.... - Early life stress decreases hippocampal BDNF content and exacerbates recognition memory deficits induced by repeated D-amphetamine exposureMaria Noemia Martins de Lima
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, 90619 900 Porto Alegre, RS, Brazil
Behav Brain Res 224:100-6. 2011.... - Anxiety comorbidity and quality of life in bipolar disorder patientsBenicio N Frey
Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Can J Psychiatry 52:175-81. 2007..To assess the impact of anxiety comorbidity on the quality of life of patients with bipolar disorder (BD)... - Oxidative stress and S100B protein in cirrhotic childrenLuciana Ribeiro
Laboratorio de Psiquiatría Experimental, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
Neurochem Res 32:1600-3. 2007..001). CONCLUSIONS: This study didn't indicate a possible role of S100B serum levels as marker of brain damage in cirrhotic children but suggest a possible relation between astrocyte function and oxidative damage in cirrhotic children... - DNA damage in rats after treatment with methylphenidateAna Cristina Andreazza
Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 31:1282-8. 2007..Hence, the present study aimed to investigate the index of cerebral and peripheral DNA damage in young and adult rats after acute and chronic MPH exposure... - [Prevalence of mental disorders at a referral center for the Family Health Program in Santa Cruz do Sul, Rio Grande do Sul State, Brazil]Daniel Maffasioli Goncalves
Programa de Pós Graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
Cad Saude Publica 24:2043-53. 2008..These results show the importance of including mental health care in the FHP in Brazil... - Childhood trauma, impulsivity, and executive functioning in crack cocaine usersJoana C M Narvaez
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre CEP 90035 003, Brazil
Compr Psychiatry 53:238-44. 2012..This study had the objective of evaluating the relationship of childhood trauma with executive functioning and impulsivity in outpatients with crack cocaine use disorders... - The impact of co-morbid alcohol use disorder in bipolar patientsBetina Mariante Cardoso
Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Brazil
Alcohol 42:451-7. 2008..This subgroup of bipolar patients requires a treatment tailored to address both conditions... - Abnormalities in serum chemokine levels in euthymic patients with bipolar disorderElisa Brietzke
Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
Brain Behav Immun 23:1079-82. 2009..The presence of chemokine abnormalities in patients with BD during euthymia suggests that these inflammatory mediators should be further investigated with regard to their potential role as longstanding markers of the disorder... - Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: a positive correlationMariana Pedrini
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Neurosci Lett 491:207-10. 2011..Serum BDNF levels concentration in SZ merits further investigations with regard to the role of neurotrophins in the cognitive response to treatment with CLZ and other atypical antipsychotics... - Bipolar disorder and age-related functional impairmentAlice Aita Cacilhas
INCT Translational Medicine, Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 31:354-7. 2009..The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard... - Epidemiology and management of anxiety in patients with bipolar disorderMárcia Kauer-Sant'Anna
Bipolar Disorders Program and Molecular Psychiatry Unit, INCT Translational Medicine, Hospital de Clinicas HCPA, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
CNS Drugs 23:953-64. 2009..Careful screening for co-morbid anxiety symptoms and disorders is warranted when diagnosing and treating patients with bipolar disorder... - Functional impact of biological rhythm disturbance in bipolar disorderLarriany M Giglio
Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Psychiatr Res 44:220-3. 2010..These results further the notion that biological rhythms may be interesting targets for diverse interventions aiming to improve functioning and prevent relapse in interepisodic bipolar disorder... - Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorderElisa Brietzke
Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas de Porto Alegre, UFRGS, Brazil
J Affect Disord 116:214-7. 2009..Previous reports have suggested the association of mania and bipolar depression with a proinflammatory state. However, they did not compare cytokine levels in all phases of bipolar disorder... - Increased serum neurotrophin-4/5 levels in bipolar disorderJulio C Walz
Bipolar Disorders Program and Molecular Psychiatry Laboratory, Hospital de Clínicas de Porto Alegre HCPA, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350, CEP 90035 003, Porto Alegre, RS, Brazil
J Psychiatr Res 43:721-3. 2009..As far as are aware, this is the first study showing NT-4/5 immunocontent alterations in bipolar disorder. A tentative explanation would be that NT-4/5 increases is compensating for ongoing oxidative damage in dopaminergic neurons... - Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathologyJuliana Tramontina
Post Graduate Biochemistry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Bipolar Disord 9:128-35. 2007.... - Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric dietLísia Rejane Guimarães
Psychiatry Post Graduation Program, Universidade Federal do Rio Grande do Sul UFRGS, Schizophrenia Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:1595-8. 2008.... - Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorderJulio C Walz
Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, and Department of Biochyemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Neurosci Lett 415:87-9. 2007..001) and depressed (p<0.001) BD patients, as compared with euthymic patients and normal controls. These findings suggest that the NT-3 signaling system may play a role in the pathophysiology of BD... - Serum brain-derived neurotrophic factor (BDNF) is not associated with response to electroconvulsive therapy (ECT): a pilot study in drug resistant depressed patientsBrisa Fernandes
Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Neurosci Lett 453:195-8. 2009..001). There were no changes in the serum BDNF before and after the ECT treatment (p=0.89). These results do not support the hypothesis that the clinical improvement following ECT is due to changes in the BDNF... - Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorderJuliana Fernandes Tramontina
Bipolar Disorder Program, Molecular Psychiatry Laboratory, INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 31:136-40. 2009.... - [Performance of the Self-Reporting Questionnaire as a psychiatric screening questionnaire: a comparative study with Structured Clinical Interview for DSM-IV-TR]Daniel Maffasioli Goncalves
Hospital de Clinicas de Porto Alegre, Porto Alegre, Brasil
Cad Saude Publica 24:380-90. 2008..The optimum cutoff value for SRQ-20 was 7/8, with 86.33% sensitivity and 89.31% specificity. The discriminant power of SRQ-20 for psychiatric screening was 0.9, and Cronbach's alpha was 0.86... - Assessment of executive functions in a Brazilian sample of bipolar subjectsSilvana Oliveira
Institute of Psychology, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos 2600 room 120, Bairro Rio Branco, 90035 003 Porto Alegre, RS, Brazil
Span J Psychol 14:859-68. 2011..The findings suggest that the executive dysfunctions in Bipolar Disorder may be related to both transitory and permanent deficits... - Serum brain-derived neurotrophic factor in patients with trauma psychopathologySimone Hauck
Center for Study and Treatment of Traumatic Stress, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 34:459-62. 2010..The aim of this study was to investigate levels of serum BDNF in patients with trauma psychopathology (acute and post-traumatic stress disorder) when compared to age and gender matched controls... - Cognitive abilities and clinical variables in bipolar I depressed and euthymic patients and controlsDenise Balem Yates
Institute of Psychology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Psychiatr Res 45:495-504. 2011..It is hypothesized that the cognitive deficits in rank order are: depressed BPs > euthymic BPs > controls... - Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of maniaBenicio N Frey
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
Neurochem Res 31:699-703. 2006..Our findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum... - Circadian preference in bipolar disorderLarriany Maria Falsin Giglio
Molecular Psychiatry Laboratory and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Sleep Breath 14:153-5. 2010..The present study assessed circadian preference, a subjective preference for activities in the morning or evening related to chronotype... - Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampusThales Preissler
Department of Pharmacology, Institute for Basic Health Sciences, Cellular and Molecular Neuropharmacology Research Group, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Neurochem Res 32:1381-6. 2007.... - [Neuropatological and neurochemical abnormalities in bipolar disorder]Benicio Noronha Frey
Laboratorio de Psiquiatría Experimental, Hospital de Clinicas de Porto Alegre, Brazil
Rev Bras Psiquiatr 26:180-8. 2004..The objective of this paper is to review the findings in neuropathology and cellular biochemistry... - Mismatch between self-reported quality of life and functional assessment in acute mania: a matter of unawareness of illness?Fernando Kratz Gazalle
Post Graduate Psychiatry Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
J Affect Disord 103:247-52. 2007..This study aims to investigate the self-reported QoL in manic, depressed, and euthymic BD subjects, as compared to matched healthy controls... - [Mental disorder, demographic variables and life satisfaction]Daniel Maffasioli Goncalves
Programa de Pós Graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
Rev Saude Publica 42:1060-6. 2008..To evaluate the impact of positive screening of non-psychotic mental disorders, sociodemographic variables, and concomitant non-psychiatric chronic diseases on the Satisfaction with Life Scale scores... - Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapineClarissa Severino Gama
Departamento de Psiquiatria, Hospital de Clínicas de Porto Alegre HCPA, Laboratório de Psiquiatria Experimental Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 30:512-5. 2006..Additionally it could also address questions concerning a possible oxidant/antioxidant imbalance in schizophrenia... - Cognitive-behavioral group therapy in obsessive-compulsive disorder: a randomized clinical trialAristides Volpato Cordioli
Department of Psychiatry, Hospital de Clinicas Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Psychother Psychosom 72:211-6. 2003..The present study was designed to verify the efficacy of cognitive-behavioral group therapy (CBGT) in reducing obsessive-compulsive symptoms and the intensity of overvalued ideas, as well as in improving the patient's quality of life... - Brain creatine kinase activity in an animal model of maniaEmilio L Streck
Laboratório de Fisiopatologia Experimental, Programa de Pos Graduacao em Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
Life Sci 82:424-9. 2008..These findings reinforce the hypothesis that mitochondrial dysfunction plays an important role in the pathophysiology of BD... - Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in ratsRafael Roesler
GENOTOX Laboratory, Center for Biotechnology, Federal University of Rio Grande do Sul, 91501 970 Porto Alegre, RS, Brazil
Brain Res 975:207-13. 2003..These data suggest that hippocampal NMDA receptors might be involved in the contextual and spatial aspects, while amygdalar NMDA receptors might be involved in the aversive aspects of memory for IA... - An open trial of reboxetine in HIV-seropositive outpatients with major depressive disorderAdriana S Carvalhal
Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Clin Psychiatry 64:421-4. 2003..Reboxetine is a noradrenergic antidepressant that is not metabolized by CYP450 and may offer a valuable option in the treatment of MDD in HIV-seropositive patients... - [Psychodynamic group treatment for generalized social phobia]Daniela Zippin Knijnik
Departamento de Psiquiatria, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 26:77-81. 2004..The aim of this study is to assess the effectiveness of psychodynamic group therapy in patients with generalized social phobia... - Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activityJoão Vicente Busnello
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Ramiro Barcelos, 2600 Anexo 90035 003 Porto Alegre, RS, Brazil
Life Sci 78:3013-7. 2006..001). These results support the proposition that ECS does not produce neural damage, and suggest that the alterations in the levels of S100B and lactate may reflect an astrocytic activity of a protective nature... - Differential effects of emotional arousal in short- and long-term memory in healthy adultsJoao Quevedo
Laboratorio de Neurotoxicologia, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
Neurobiol Learn Mem 79:132-5. 2003..The lack of effect of emotional arousal in STM suggests that amygdala is not related to STM mechanisms. Further studies using different approaches are needed to elucidate if STM processes are influenced by emotional arousal... - The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disordersRafael Roesler
Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046 900 Porto Alegre, RS, Brazil
Recent Pat CNS Drug Discov 2:125-9. 2007..Recent patent applications on GRPR-related methods for treating brain disorders are introduced... - A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute maniaBenicio N Frey
Laboratorio de Psiquiatría Experimental, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brasil
Hum Psychopharmacol 20:133-9. 2005..N-acetyl-L-aspartate (NAA), choline-containing molecules (Cho), creatine plus phosphocreatine (Cr) and myoinositol (Ino) were measured... - Changes in S100B cerebrospinal fluid levels of rats subjected to predator stressRegina Margis
Department of Psychiatry, Faculty of Medicine, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035 003, Brazil
Brain Res 1028:213-8. 2004..These results indicate that CSF S100B is changed by stress, reinforcing the possibility that this protein is involved in the adaptive response to stress and/or in secondary neuropsychiatric disorders... - An open trial of adjunctive escitalopram in bipolar depressionManoela Fonseca
Psychiatry Research Unit, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
J Clin Psychiatry 67:81-6. 2006..This study was designed to evaluate the efficacy and safety of a highly potent and selective serotonergic antidepressant, escitalopram, in the treatment of bipolar depression... - Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodesAngelo B M Cunha
Department of Neuropsychiatry, , Universidade Federal de Santa Maria, Faixa de Camobi Km 9, 97105 900 Santa Maria, RS, Brazil
Neurosci Lett 398:215-9. 2006..37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD... - TNF-alpha as a molecular target in bipolar disorderElisa Brietzke
Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:1355-61. 2008..The present article reviews the therapeutic implications of TNF-alpha signaling pathways involvement in the pathophysiology of BD... - Effects of gabapentin on anxiety induced by simulated public speakingFernanda de-Paris
, , , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
J Psychopharmacol 17:184-8. 2003..In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin... - Perspectives for the development of animal models of bipolar disorderRodrigo Machado-Vieira
Laboratory of Experimental Psychiatry, Hospital de Clinicas de Porto Alegre, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 28:209-24. 2004..In this review, we propose that new genetics approaches involving potential animal models of BD are a promising new area for further development...