Flavio Kapczinski

Summary

Country: Brazil

Publications

  1. pmc Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial
    Michael Berk
    Deakin University, School of Medicine, Barwon Health, P O Box 291, Geelong, 3220, Australia
    BMC Med 10:91. 2012
  2. ncbi request reprint CANMAT guidelines for bipolar disorder: a commentary from South America
    Flavio Kapczinski
    Bipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Bipolar Disord 7:87-8. 2005
  3. ncbi request reprint [Physiopathology of bipolar disorders: what have changed in the last 10 years?]
    Flavio Kapczinski
    Laboratorio de Psiquiatría Experimental, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS
    Rev Bras Psiquiatr 26:17-21. 2004
  4. doi request reprint Clinical implications of a staging model for bipolar disorders
    Flavio Kapczinski
    Bipolar Disorders Program, Laboratory of Molecular Psychiatry and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Avenida Ramiro Barcelos 2350, 90035 903 PortoAlegre RS, Brazil
    Expert Rev Neurother 9:957-66. 2009
  5. doi request reprint Peripheral biomarkers and illness activity in bipolar disorder
    Flavio Kapczinski
    Bipolar Disorders Program and INCT for Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 45:156-61. 2011
  6. doi request reprint The potential use of biomarkers as an adjunctive tool for staging bipolar disorder
    Flavio Kapczinski
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas, UFRGS, INCT Translational Medicine, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 33:1366-71. 2009
  7. doi request reprint Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
    Flavio Kapczinski
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas, Federal University UFRGS, Porto Alegre, Brazil
    Expert Rev Neurother 8:1101-13. 2008
  8. doi request reprint Allostatic load in bipolar disorder: implications for pathophysiology and treatment
    Flavio Kapczinski
    Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos 2350, 90035 000, Porto Alegre, RS, Brazil
    Neurosci Biobehav Rev 32:675-92. 2008
  9. pmc Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania
    Benicio N Frey
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, and the Bipolar Disorders Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    J Psychiatry Neurosci 31:326-32. 2006
  10. pmc Effects of mood stabilizers on DNA damage in an animal model of mania
    Ana Cristina Andreazza
    Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil
    J Psychiatry Neurosci 33:516-24. 2008

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. pmc Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial
    Michael Berk
    Deakin University, School of Medicine, Barwon Health, P O Box 291, Geelong, 3220, Australia
    BMC Med 10:91. 2012
    ..The current study aimed to investigate the maintenance effects of NAC following eight weeks of open-label treatment for bipolar disorder...
  2. ncbi request reprint CANMAT guidelines for bipolar disorder: a commentary from South America
    Flavio Kapczinski
    Bipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Bipolar Disord 7:87-8. 2005
  3. ncbi request reprint [Physiopathology of bipolar disorders: what have changed in the last 10 years?]
    Flavio Kapczinski
    Laboratorio de Psiquiatría Experimental, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS
    Rev Bras Psiquiatr 26:17-21. 2004
    ..This study aims to update the recent findings relative to the neurochemistry of BD...
  4. doi request reprint Clinical implications of a staging model for bipolar disorders
    Flavio Kapczinski
    Bipolar Disorders Program, Laboratory of Molecular Psychiatry and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Avenida Ramiro Barcelos 2350, 90035 903 PortoAlegre RS, Brazil
    Expert Rev Neurother 9:957-66. 2009
    ..Staging facilitates understanding of the mechanisms underlying progression of the disorder, assists in treatment planning and prognosis and, finally, underscores the imperative for early intervention...
  5. doi request reprint Peripheral biomarkers and illness activity in bipolar disorder
    Flavio Kapczinski
    Bipolar Disorders Program and INCT for Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 45:156-61. 2011
    ..In some cases, toxicity was as high in bipolar disorder as that seen in patients with sepsis. We believe these findings highlight the potential of using biomarkers to assess illness activity in bipolar disorder...
  6. doi request reprint The potential use of biomarkers as an adjunctive tool for staging bipolar disorder
    Flavio Kapczinski
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas, UFRGS, INCT Translational Medicine, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 33:1366-71. 2009
    ..Empirical testing will determine the ability of the present model to inform patients and clinicians about both prognosis and response to treatment...
  7. doi request reprint Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
    Flavio Kapczinski
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas, Federal University UFRGS, Porto Alegre, Brazil
    Expert Rev Neurother 8:1101-13. 2008
    ..The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BDNF as a biomarker in BD...
  8. doi request reprint Allostatic load in bipolar disorder: implications for pathophysiology and treatment
    Flavio Kapczinski
    Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos 2350, 90035 000, Porto Alegre, RS, Brazil
    Neurosci Biobehav Rev 32:675-92. 2008
    ....
  9. pmc Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania
    Benicio N Frey
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, and the Bipolar Disorders Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    J Psychiatry Neurosci 31:326-32. 2006
    ..We studied the effects of the mood stabilizers lithium and valproate on amphetamine-induced oxidative stress in an animal model of mania...
  10. pmc Effects of mood stabilizers on DNA damage in an animal model of mania
    Ana Cristina Andreazza
    Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil
    J Psychiatry Neurosci 33:516-24. 2008
    ..We investigated the effects of the mood stabilizers lithium and valproate on amphetamine-induced DNA damage in an animal model of mania and their correlation with oxidative stress markers...
  11. ncbi request reprint Evidence of astrogliosis in rat hippocampus after d-amphetamine exposure
    Benicio N Frey
    Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:1231-4. 2006
    ..Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization...
  12. ncbi request reprint Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania
    Benicio N Frey
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Behav Pharmacol 17:311-8. 2006
    ..These findings suggest that nerve growth factor may play a role in the neurotrophic effects of lithium but do not support the hypotheses that the nerve growth factor/TrkA pathway is involved in the pathophysiology of bipolar disorder...
  13. ncbi request reprint Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania
    Benicio N Frey
    Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, Zip code 90035 003, Porto Alegre, RS, Brazil
    Life Sci 79:281-6. 2006
    ..Our results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania...
  14. ncbi request reprint Polypharmacy and suicide attempts in bipolar disorder
    Fernando Kratz Gazalle
    Post Graduate Psychiatry Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 29:35-8. 2007
    ..The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder...
  15. ncbi request reprint Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania
    Julio C Walz
    Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, 2350, 90035 003 Porto Alegre, RS, Brazil
    J Psychiatr Res 42:416-21. 2008
    ..These results suggest that both Li and VPT modulate serum and central (hippocampal) NT-3 levels, and further support that the regulation of neurotrophic signaling systems may be related to the mechanisms of action of mood stabilizers...
  16. doi request reprint Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid
    Rose Mary Carvalho Pinheiro
    Department of Physiological Sciences, Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, Av Ipiranga, 6681 Predio 12D, Sala 340, Porto Alegre, RS 90619 900, Brazil
    J Neural Transm 119:627-37. 2012
    ..Here, we show that valproic acid ameliorated the cognitive deficits induced by AMPH, but it was not effective when the animals were exposed to both stressors: maternal deprivation and AMPH treatment...
  17. doi request reprint Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males
    Clarissa Severino Gama
    Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
    Neurosci Lett 433:270-3. 2008
    ..However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males...
  18. ncbi request reprint Bipolar depression: the importance of being on remission
    Fernando Kratz Gazalle
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 28:93-6. 2006
    ....
  19. ncbi request reprint Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects
    Rodrigo Machado-Vieira
    Mood Disorders Program, HMIPV, Fundacao Faculdade Federal Ciencias Medicas de Porto Alegre and Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil
    Neurosci Lett 421:33-6. 2007
    ..Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD...
  20. ncbi request reprint Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report
    Benicio N Frey
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 31:283-5. 2007
    ..In the present study we investigated the oxidative stress profile in two monozygotic twins during a manic episode...
  21. ncbi request reprint Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes
    Flavio Kapczinski
    Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 30:243-5. 2008
    ....
  22. pmc A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania
    Rodrigo Machado-Vieira
    Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, RS, Brazil
    J Clin Psychiatry 69:1237-45. 2008
    ..This study aimed to evaluate the efficacy and tolerability of the purinergic agents allopurinol and dipyridamole combined with lithium in bipolar mania...
  23. doi request reprint Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients
    Gislaine S de Oliveira
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    J Psychiatr Res 43:1171-4. 2009
    ..001. Results suggest that the association of lower serum BDNF and BD mood episodes is kept even in medicated patients, which strengthens the notion that BDNF serum levels may be considered a biomarker of mood episodes in BD...
  24. doi request reprint Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder
    Bianca Pfaffenseller
    Laboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Expert Rev Neurother 13:827-42. 2013
    ..Finally, the authors outline novel therapies that emerge from this new research and the assessment of multiple biomarkers as a potential approach to improving management strategies in bipolar disorder. ..
  25. ncbi request reprint Clinical impact of late diagnose of bipolar disorder
    Fernando Kratz Gazalle
    Psychiatry Research Unit, Post Graduate Psychiatry Program, Federal University of Rio Grande do Sul, Brazil
    J Affect Disord 86:313-6. 2005
    ..This study assessed the impact of number of years undiagnosed (NYU) on current morbidity in patients with bipolar disorder...
  26. ncbi request reprint Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder
    Adriane R Rosa
    Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, and Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Lett 407:146-50. 2006
    ..These results further support the role of neurotrophins in the pathophysiology of bipolar disorder. Whether the observed increase in GDNF immunocontent correspond to a pathological or an adaptive response remains to be determined...
  27. doi request reprint Cognitive impairment in school-aged children with early trauma
    Joana Bücker
    Laboratory of Molecular Psychiatry and Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Compr Psychiatry 53:758-64. 2012
    ..These findings further support the need for early interventions that can prevent cognitive impairment when childhood trauma occurs...
  28. ncbi request reprint Glial fibrillary acidic protein expression after electroconvulsive shocks in rat brain
    Keila M Ceresér
    Laboratorio de Psiquiatría Experimental, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:663-7. 2006
    ..The aim of the present study was to assess the effect of electroconvulsive shock (ECS) in glial fibrillary acidic protein (GFAP) expression in rat brain...
  29. ncbi request reprint Manic symptoms and quality of life in bipolar disorder
    Fernando Kratz Gazalle
    Psychiatric Research Unit, Post Graduate Psychiatry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Psychiatry Res 153:33-8. 2007
    ..In a separate analysis at the YMRS items, items 4 (irritability) and 5 (sleep) were associated with lower quality of life...
  30. ncbi request reprint A gastrin-releasing peptide receptor antagonist blocks D-amphetamine-induced hyperlocomotion and increases hippocampal NGF and BDNF levels in rats
    Ana Cristina Andreazza
    Laboratory of Experimental Psychiatry and Bipolar Disorders Program, Academic Hospital Research Center, Department of Biochemistry, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Peptides 28:1447-52. 2007
    ..Administration of D-AMPH did not affect NGF or BDNF levels by itself, but blocked the RC-3095 effects. The results suggest that GRPR antagonists might display anti-manic activity...
  31. doi request reprint Decreased serum neurotrophin 3 in chronically medicated schizophrenic males
    Haroldo Evangelista Vargas
    Programa de Pós Graduação em Medicina Psiquiatria, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 90035 003 Porto Alegre, RS, Brazil
    Neurosci Lett 440:197-201. 2008
    ..These findings suggest that the NT3 signaling system may play a role in the pathophysiology of SZ and might be related to the course of illness or to treatment variables. Longitudinal studies are warranted...
  32. doi request reprint Development and use of a biological rhythm interview
    Larriany Maria Falsin Giglio
    Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 118:161-5. 2009
    ..This report describes the validation of a new instrument, the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), designed to assess biological rhythms in the clinical setting...
  33. doi request reprint Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes
    Brisa Simões Fernandes
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, 90035 903 Porto Alegre, RS, Brazil
    J Psychiatr Res 44:561-5. 2010
    ..controls). There is no difference in serum BDNF between manic and depressive patients. Results suggest that increased serum NT-3 levels in BD are likely to be associated with the pathophysiology of manic and depressive symptoms...
  34. doi request reprint Mediators of allostasis and systemic toxicity in bipolar disorder
    Iria Grande
    National Institute for Translational Medicine, INCT TM, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2350 CEP 90035 903 Porto Alegre, Brazil
    Physiol Behav 106:46-50. 2012
    ..In the present review we examine the role of allostatic load in the illness progression that takes place in bipolar disorder...
  35. doi request reprint Serum brain-derived neurotrophic factor in bipolar and unipolar depression: a potential adjunctive tool for differential diagnosis
    Brisa Simões Fernandes
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, 90035 903 Porto Alegre, RS, Brazil
    J Psychiatr Res 43:1200-4. 2009
    ..Our results suggest the role of BDNF as an adjunctive tool to promote prompt and accurate diagnosis of BD. However, further investigation and replication of these results are warranted...
  36. doi request reprint Brain-derived neurotrophic factor serum levels before and after treatment for acute mania
    Juliana Fernandes Tramontina
    Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Brazil
    Neurosci Lett 452:111-3. 2009
    ..Further studies designed to validate the use of BDNF as a marker of treatment response in bipolar disorder are warranted...
  37. doi request reprint Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis
    Brisa Simões Fernandes
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    J Psychiatr Res 45:995-1004. 2011
    ..In euthymia, BDNF decreases with age and length of illness. These data suggest that peripheral BDNF could be used as a biomarker of mood states and disease progression for BD...
  38. doi request reprint Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia
    Mauricio Kunz
    Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Programa de Pós Graduação em Medicina Psiquiatria, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:1677-81. 2008
    ..There is an increasing body of evidence suggesting that oxidative stress may play a role in the pathophysiology of both schizophrenia (SZ) and bipolar disorder (BD)...
  39. ncbi request reprint The role of hippocampus in the pathophysiology of bipolar disorder
    Benicio N Frey
    Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brazil
    Behav Pharmacol 18:419-30. 2007
    ..In conclusion, the available evidence suggests that the hippocampus plays an important role in the pathophysiology of BD...
  40. doi request reprint BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells
    Anna Laura Schmidt
    Cancer Research Laboratory, University Hospital Research Center CPE HCPA, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 2350, 90035 003, Porto Alegre, RS, Brazil
    J Mol Neurosci 40:303-10. 2010
    ..The results suggest that BDNF/TrkB and PDE4, but not the GRPR, regulate the viability of medulloblastoma cells...
  41. ncbi request reprint Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder
    Clarissa Severino Gama
    Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035 003, Porto Alegre, RS, Brazil
    Neurosci Lett 420:45-8. 2007
    ..001) when compared to either controls or euthymic BD patients. Increased BDNF in SZ patients might be related to the course of illness or to treatment variables. Prospective studies are warranted...
  42. doi request reprint Peripheral toxicity in crack cocaine use disorders
    Joana C M Narvaez
    Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Neurosci Lett 544:80-4. 2013
    ..There were no significant differences in oxidative damage between patients and controls. These results represent a first demonstration that crack cocaine use disorders entail an activation of the reward, immune and inflammatory systems...
  43. ncbi request reprint Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania
    Benicio Noronha Frey
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Brazil
    Bipolar Disord 8:275-80. 2006
    ..Several studies have demonstrated that oxidative stress may play a role in the behavioral and neurochemical changes observed after AMPH administration...
  44. ncbi request reprint Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure
    Benicio N Frey
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Brain Res 1097:224-9. 2006
    ..Further studies assessing the effects of mood stabilizers and antipsychotics in preventing mitochondrial oxidative stress are necessary...
  45. doi request reprint Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity
    Mariana Pedrini
    Laboratory of Molecular Psychiatry, INCT for Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 46:819-24. 2012
    ..Our findings reinforce the need of assessment of individuals in ultra high risk to develop psychosis and first-episode population...
  46. ncbi request reprint Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode
    Rodrigo Machado-Vieira
    Mood Disorders Program, Fundação Faculdade Federal Ciências Medicas de Porto Alegre, Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, Brazil
    Biol Psychiatry 61:142-4. 2007
    ..Also, previous studies demonstrated a role for BDNF in the pathophysiology and clinical presentation of mood disorders...
  47. ncbi request reprint Cognitive impairment in a Brazilian sample of patients with bipolar disorder
    Júlia J Schneider
    Bipolar Disorder Program, Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 30:209-14. 2008
    ..Persistent neurocognitive deficits have been described in bipolar mood disorder. As far as we are aware, no study have examined whether the cognitive impairment is presented in the same way in a Brazilian sample...
  48. doi request reprint Validity of a short functioning test (FAST) in Brazilian outpatients with bipolar disorder
    Alice Aita Cacilhas
    Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Value Health 12:624-7. 2009
    ..Here we present data on the Portuguese validation of the Functioning Assessment Short Test (FAST), which was explicitly designed to gauge functioning dimensions empirically linked to bipolar disorder...
  49. ncbi request reprint Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation
    Clarissa Severino Gama
    Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 30:337-40. 2008
    ....
  50. ncbi request reprint Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance
    Mauricio Kunz
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 33:268-74. 2011
    ..The aim is to compare cytokine levels in both disorders...
  51. doi request reprint Sleep in bipolar patients
    Larriany M F Giglio
    Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, RS, Brazil
    Sleep Breath 13:169-73. 2009
    ..Most patients with BPD also report insomnia when in depression, but a significant percentage of patients report hypersomnia symptoms with prolonged nighttime sleep, difficulty in wakening, and excessive daytime sleepiness...
  52. ncbi request reprint [Prevalence of mental disorders at a referral center for the Family Health Program in Santa Cruz do Sul, Rio Grande do Sul State, Brazil]
    Daniel Maffasioli Goncalves
    Programa de Pós Graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    Cad Saude Publica 24:2043-53. 2008
    ..These results show the importance of including mental health care in the FHP in Brazil...
  53. doi request reprint Peripheral nucleotide hydrolysis in rats submitted to a model of electroconvulsive therapy
    João Vicente Busnello
    Departamento de Bioquimica, ICBS, UFRGS, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:1829-33. 2008
    ....
  54. ncbi request reprint Reduced NGF secretion by HT-29 human colon cancer cells treated with a GRPR antagonist
    Caroline Brunetto de Farias
    Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Protein Pept Lett 16:650-2. 2009
    ..The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative effects in cancer cells...
  55. doi request reprint Correlates and impact of obsessive-compulsive comorbidity in bipolar disorder
    Pedro V S Magalhaes
    Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, Brazil
    Compr Psychiatry 51:353-6. 2010
    ....
  56. ncbi request reprint Immunoassay for glial fibrillary acidic protein: antigen recognition is affected by its phosphorylation state
    Francine Tramontina
    Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    J Neurosci Methods 162:282-6. 2007
    ....
  57. ncbi request reprint Oxidative stress and S100B protein in cirrhotic children
    Luciana Ribeiro
    Laboratorio de Psiquiatría Experimental, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Neurochem Res 32:1600-3. 2007
    ..SOD activity and TBARS levels were higher; and CAT activity was lower in the cirrhotic group. A negative correlation between S100B and TBARS in the case group was found (r = -0.815, p = 0.001)...
  58. doi request reprint Early life stress decreases hippocampal BDNF content and exacerbates recognition memory deficits induced by repeated D-amphetamine exposure
    Maria Noemia Martins de Lima
    Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, 90619 900 Porto Alegre, RS, Brazil
    Behav Brain Res 224:100-6. 2011
    ....
  59. doi request reprint Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder
    Angelo B Cunha
    Department of Neuropsychiatry, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, Santa Maria, RS, 97105 900, Brazil
    Eur Arch Psychiatry Clin Neurosci 258:300-4. 2008
    ..001). These findings add to the notion that changes in the inflammatory system take place during acute episodes of mania...
  60. ncbi request reprint Serum S100B and antioxidant enzymes in bipolar patients
    Ana Cristina Andreazza
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    J Psychiatr Res 41:523-9. 2007
    ..This peripheral oxidative imbalance indicates that systemic changes are taking place during the active phases of the illness. Such changes appear to relate to astrocyte function, as indicated by serum S100B elevation...
  61. ncbi request reprint DNA damage in rats after treatment with methylphenidate
    Ana Cristina Andreazza
    Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 31:1282-8. 2007
    ..Hence, the present study aimed to investigate the index of cerebral and peripheral DNA damage in young and adult rats after acute and chronic MPH exposure...
  62. ncbi request reprint Anxiety comorbidity and quality of life in bipolar disorder patients
    Benicio N Frey
    Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Can J Psychiatry 52:175-81. 2007
    ..To assess the impact of anxiety comorbidity on the quality of life of patients with bipolar disorder (BD)...
  63. doi request reprint Childhood trauma, impulsivity, and executive functioning in crack cocaine users
    Joana C M Narvaez
    Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre CEP 90035 003, Brazil
    Compr Psychiatry 53:238-44. 2012
    ..This study had the objective of evaluating the relationship of childhood trauma with executive functioning and impulsivity in outpatients with crack cocaine use disorders...
  64. doi request reprint Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: a positive correlation
    Mariana Pedrini
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Neurosci Lett 491:207-10. 2011
    ..Serum BDNF levels concentration in SZ merits further investigations with regard to the role of neurotrophins in the cognitive response to treatment with CLZ and other atypical antipsychotics...
  65. ncbi request reprint Bipolar disorder and age-related functional impairment
    Alice Aita Cacilhas
    INCT Translational Medicine, Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 31:354-7. 2009
    ..The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard...
  66. doi request reprint Functional impact of biological rhythm disturbance in bipolar disorder
    Larriany M Giglio
    Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 44:220-3. 2010
    ..These results further the notion that biological rhythms may be interesting targets for diverse interventions aiming to improve functioning and prevent relapse in interepisodic bipolar disorder...
  67. doi request reprint Epidemiology and management of anxiety in patients with bipolar disorder
    Márcia Kauer-Sant'Anna
    Bipolar Disorders Program and Molecular Psychiatry Unit, INCT Translational Medicine, Hospital de Clinicas HCPA, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    CNS Drugs 23:953-64. 2009
    ..Careful screening for co-morbid anxiety symptoms and disorders is warranted when diagnosing and treating patients with bipolar disorder...
  68. ncbi request reprint Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology
    Juliana Tramontina
    Post Graduate Biochemistry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Bipolar Disord 9:128-35. 2007
    ....
  69. doi request reprint Abnormalities in serum chemokine levels in euthymic patients with bipolar disorder
    Elisa Brietzke
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Brain Behav Immun 23:1079-82. 2009
    ..The presence of chemokine abnormalities in patients with BD during euthymia suggests that these inflammatory mediators should be further investigated with regard to their potential role as longstanding markers of the disorder...
  70. doi request reprint Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder
    Elisa Brietzke
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas de Porto Alegre, UFRGS, Brazil
    J Affect Disord 116:214-7. 2009
    ..Previous reports have suggested the association of mania and bipolar depression with a proinflammatory state. However, they did not compare cytokine levels in all phases of bipolar disorder...
  71. doi request reprint Increased serum neurotrophin-4/5 levels in bipolar disorder
    Julio C Walz
    Bipolar Disorders Program and Molecular Psychiatry Laboratory, Hospital de Clínicas de Porto Alegre HCPA, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350, CEP 90035 003, Porto Alegre, RS, Brazil
    J Psychiatr Res 43:721-3. 2009
    ..As far as are aware, this is the first study showing NT-4/5 immunocontent alterations in bipolar disorder. A tentative explanation would be that NT-4/5 increases is compensating for ongoing oxidative damage in dopaminergic neurons...
  72. doi request reprint The impact of co-morbid alcohol use disorder in bipolar patients
    Betina Mariante Cardoso
    Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Brazil
    Alcohol 42:451-7. 2008
    ..This subgroup of bipolar patients requires a treatment tailored to address both conditions...
  73. ncbi request reprint Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder
    Julio C Walz
    Bipolar Disorders Program, Centro de Pesquisas, Hospital de Clinicas de Porto Alegre, and Department of Biochyemistry, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurosci Lett 415:87-9. 2007
    ..001) and depressed (p<0.001) BD patients, as compared with euthymic patients and normal controls. These findings suggest that the NT-3 signaling system may play a role in the pathophysiology of BD...
  74. doi request reprint Serum brain-derived neurotrophic factor (BDNF) is not associated with response to electroconvulsive therapy (ECT): a pilot study in drug resistant depressed patients
    Brisa Fernandes
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Neurosci Lett 453:195-8. 2009
    ..001). There were no changes in the serum BDNF before and after the ECT treatment (p=0.89). These results do not support the hypothesis that the clinical improvement following ECT is due to changes in the BDNF...
  75. ncbi request reprint Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder
    Juliana Fernandes Tramontina
    Bipolar Disorder Program, Molecular Psychiatry Laboratory, INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 31:136-40. 2009
    ....
  76. ncbi request reprint [Performance of the Self-Reporting Questionnaire as a psychiatric screening questionnaire: a comparative study with Structured Clinical Interview for DSM-IV-TR]
    Daniel Maffasioli Goncalves
    Hospital de Clinicas de Porto Alegre, Porto Alegre, Brasil
    Cad Saude Publica 24:380-90. 2008
    ..The optimum cutoff value for SRQ-20 was 7/8, with 86.33% sensitivity and 89.31% specificity. The discriminant power of SRQ-20 for psychiatric screening was 0.9, and Cronbach's alpha was 0.86...
  77. doi request reprint Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet
    Lísia Rejane Guimarães
    Psychiatry Post Graduation Program, Universidade Federal do Rio Grande do Sul UFRGS, Schizophrenia Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:1595-8. 2008
    ....
  78. doi request reprint Cognitive abilities and clinical variables in bipolar I depressed and euthymic patients and controls
    Denise Balem Yates
    Institute of Psychology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 45:495-504. 2011
    ..It is hypothesized that the cognitive deficits in rank order are: depressed BPs > euthymic BPs > controls...
  79. doi request reprint Serum brain-derived neurotrophic factor in patients with trauma psychopathology
    Simone Hauck
    Center for Study and Treatment of Traumatic Stress, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 34:459-62. 2010
    ..The aim of this study was to investigate levels of serum BDNF in patients with trauma psychopathology (acute and post-traumatic stress disorder) when compared to age and gender matched controls...
  80. ncbi request reprint Assessment of executive functions in a Brazilian sample of bipolar subjects
    Silvana Oliveira
    Institute of Psychology, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos 2600 room 120, Bairro Rio Branco, 90035 003 Porto Alegre, RS, Brazil
    Span J Psychol 14:859-68. 2011
    ..The findings suggest that the executive dysfunctions in Bipolar Disorder may be related to both transitory and permanent deficits...
  81. ncbi request reprint [Mental disorder, demographic variables and life satisfaction]
    Daniel Maffasioli Goncalves
    Programa de Pós Graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Rev Saude Publica 42:1060-6. 2008
    ..To evaluate the impact of positive screening of non-psychotic mental disorders, sociodemographic variables, and concomitant non-psychiatric chronic diseases on the Satisfaction with Life Scale scores...
  82. ncbi request reprint Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampus
    Thales Preissler
    Department of Pharmacology, Institute for Basic Health Sciences, Cellular and Molecular Neuropharmacology Research Group, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Res 32:1381-6. 2007
    ....
  83. ncbi request reprint Mismatch between self-reported quality of life and functional assessment in acute mania: a matter of unawareness of illness?
    Fernando Kratz Gazalle
    Post Graduate Psychiatry Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Affect Disord 103:247-52. 2007
    ..This study aims to investigate the self-reported QoL in manic, depressed, and euthymic BD subjects, as compared to matched healthy controls...
  84. doi request reprint Circadian preference in bipolar disorder
    Larriany Maria Falsin Giglio
    Molecular Psychiatry Laboratory and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Sleep Breath 14:153-5. 2010
    ..The present study assessed circadian preference, a subjective preference for activities in the morning or evening related to chronotype...
  85. ncbi request reprint Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania
    Benicio N Frey
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Neurochem Res 31:699-703. 2006
    ..Our findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum...
  86. ncbi request reprint [Neuropatological and neurochemical abnormalities in bipolar disorder]
    Benicio Noronha Frey
    Laboratorio de Psiquiatría Experimental, Hospital de Clinicas de Porto Alegre, Brazil
    Rev Bras Psiquiatr 26:180-8. 2004
    ..The objective of this paper is to review the findings in neuropathology and cellular biochemistry...
  87. ncbi request reprint Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine
    Clarissa Severino Gama
    Departamento de Psiquiatria, Hospital de Clínicas de Porto Alegre HCPA, Laboratório de Psiquiatria Experimental Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:512-5. 2006
    ..Additionally it could also address questions concerning a possible oxidant/antioxidant imbalance in schizophrenia...
  88. ncbi request reprint Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats
    Rafael Roesler
    GENOTOX Laboratory, Center for Biotechnology, Federal University of Rio Grande do Sul, 91501 970 Porto Alegre, RS, Brazil
    Brain Res 975:207-13. 2003
    ..These data suggest that hippocampal NMDA receptors might be involved in the contextual and spatial aspects, while amygdalar NMDA receptors might be involved in the aversive aspects of memory for IA...
  89. ncbi request reprint Cognitive-behavioral group therapy in obsessive-compulsive disorder: a randomized clinical trial
    Aristides Volpato Cordioli
    Department of Psychiatry, Hospital de Clinicas Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Psychother Psychosom 72:211-6. 2003
    ..The present study was designed to verify the efficacy of cognitive-behavioral group therapy (CBGT) in reducing obsessive-compulsive symptoms and the intensity of overvalued ideas, as well as in improving the patient's quality of life...
  90. ncbi request reprint An open trial of reboxetine in HIV-seropositive outpatients with major depressive disorder
    Adriana S Carvalhal
    Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Clin Psychiatry 64:421-4. 2003
    ..Reboxetine is a noradrenergic antidepressant that is not metabolized by CYP450 and may offer a valuable option in the treatment of MDD in HIV-seropositive patients...
  91. doi request reprint Brain creatine kinase activity in an animal model of mania
    Emilio L Streck
    Laboratório de Fisiopatologia Experimental, Programa de Pos Graduacao em Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Life Sci 82:424-9. 2008
    ..These findings reinforce the hypothesis that mitochondrial dysfunction plays an important role in the pathophysiology of BD...
  92. ncbi request reprint Changes in S100B cerebrospinal fluid levels of rats subjected to predator stress
    Regina Margis
    Department of Psychiatry, Faculty of Medicine, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035 003, Brazil
    Brain Res 1028:213-8. 2004
    ..These results indicate that CSF S100B is changed by stress, reinforcing the possibility that this protein is involved in the adaptive response to stress and/or in secondary neuropsychiatric disorders...
  93. ncbi request reprint The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders
    Rafael Roesler
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046 900 Porto Alegre, RS, Brazil
    Recent Pat CNS Drug Discov 2:125-9. 2007
    ..Recent patent applications on GRPR-related methods for treating brain disorders are introduced...
  94. ncbi request reprint [Psychodynamic group treatment for generalized social phobia]
    Daniela Zippin Knijnik
    Departamento de Psiquiatria, Universidade Federal do Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 26:77-81. 2004
    ..The aim of this study is to assess the effectiveness of psychodynamic group therapy in patients with generalized social phobia...
  95. ncbi request reprint Differential effects of emotional arousal in short- and long-term memory in healthy adults
    Joao Quevedo
    Laboratorio de Neurotoxicologia, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Neurobiol Learn Mem 79:132-5. 2003
    ..The lack of effect of emotional arousal in STM suggests that amygdala is not related to STM mechanisms. Further studies using different approaches are needed to elucidate if STM processes are influenced by emotional arousal...
  96. ncbi request reprint A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania
    Benicio N Frey
    Laboratorio de Psiquiatría Experimental, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brasil
    Hum Psychopharmacol 20:133-9. 2005
    ..N-acetyl-L-aspartate (NAA), choline-containing molecules (Cho), creatine plus phosphocreatine (Cr) and myoinositol (Ino) were measured...
  97. ncbi request reprint Acute and chronic electroconvulsive shock in rats: effects on peripheral markers of neuronal injury and glial activity
    João Vicente Busnello
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Ramiro Barcelos, 2600 Anexo 90035 003 Porto Alegre, RS, Brazil
    Life Sci 78:3013-7. 2006
    ..001). These results support the proposition that ECS does not produce neural damage, and suggest that the alterations in the levels of S100B and lactate may reflect an astrocytic activity of a protective nature...
  98. ncbi request reprint An open trial of adjunctive escitalopram in bipolar depression
    Manoela Fonseca
    Psychiatry Research Unit, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    J Clin Psychiatry 67:81-6. 2006
    ..This study was designed to evaluate the efficacy and safety of a highly potent and selective serotonergic antidepressant, escitalopram, in the treatment of bipolar depression...
  99. doi request reprint TNF-alpha as a molecular target in bipolar disorder
    Elisa Brietzke
    Bipolar Disorder Program and Molecular Psychiatry Unit, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:1355-61. 2008
    ..The present article reviews the therapeutic implications of TNF-alpha signaling pathways involvement in the pathophysiology of BD...
  100. ncbi request reprint Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes
    Angelo B M Cunha
    Department of Neuropsychiatry, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, Faixa de Camobi Km 9, 97105 900 Santa Maria, RS, Brazil
    Neurosci Lett 398:215-9. 2006
    ..37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD...
  101. ncbi request reprint Effects of gabapentin on anxiety induced by simulated public speaking
    Fernanda de-Paris
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    J Psychopharmacol 17:184-8. 2003
    ..In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin...