Ivan Izquierdo

Summary

Country: Brazil

Publications

  1. pmc Posterior parietal cortex and long-term memory: some data from laboratory animals
    Jociane C Myskiw
    Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq, Porto Alegre RS, Brazil
    Front Integr Neurosci 6:8. 2012
  2. ncbi request reprint Exposure to novelty enhances retrieval of very remote memory in rats
    Luciana A Izquierdo
    Departamento de Bioquimica, Centro de Memoria, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 79:51-6. 2003
  3. pmc Pharmacological findings on the biochemical bases of memory processes: a general view
    Ivan Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600 anexo 90035 003 Porto Alegre, RS, Brasil
    Neural Plast 11:159-89. 2004
  4. ncbi request reprint Behavioural pharmacology and its contribution to the molecular basis of memory consolidation
    I Izquierdo
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 11:517-34. 2000
  5. ncbi request reprint The inhibition of acquired fear
    Ivan Izquierdo
    Centro de Memoria, ICBS, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brasil
    Neurotox Res 6:175-88. 2004
  6. ncbi request reprint LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance
    D M Barros
    Departamento de Ciencias Fisiologicas, Setor de Farmacologia, Fundação Universidade Federal de Rio Grande, Rio Grande, Brazil
    Behav Pharmacol 12:629-34. 2001
  7. ncbi request reprint Neuroscience. Zif and the survival of memory
    Ivan Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600 anexo, 90035 003 Porto Alegre, RS, Brazil
    Science 304:829-30. 2004
  8. ncbi request reprint Different molecular cascades in different sites of the brain control memory consolidation
    Ivan Izquierdo
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Hospital Sao Lucas, Av Ipiranga 6690, 2 andar, 90610 000 Porto Alegre, RS, Brasil
    Trends Neurosci 29:496-505. 2006
  9. ncbi request reprint Stress hormones enhance retrieval of fear conditioning acquired either one day or many months before
    L A Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Behav Pharmacol 13:203-13. 2002
  10. ncbi request reprint The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks
    Ivan Izquierdo
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    An Acad Bras Cienc 80:115-27. 2008

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. pmc Posterior parietal cortex and long-term memory: some data from laboratory animals
    Jociane C Myskiw
    Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq, Porto Alegre RS, Brazil
    Front Integr Neurosci 6:8. 2012
    ....
  2. ncbi request reprint Exposure to novelty enhances retrieval of very remote memory in rats
    Luciana A Izquierdo
    Departamento de Bioquimica, Centro de Memoria, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 79:51-6. 2003
    ....
  3. pmc Pharmacological findings on the biochemical bases of memory processes: a general view
    Ivan Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600 anexo 90035 003 Porto Alegre, RS, Brasil
    Neural Plast 11:159-89. 2004
    ..Another aspect in which major advances were made was retrieval and post-retrieval events, especially extinction, pointing to new therapeutic approaches to fear-motivated mental disorders...
  4. ncbi request reprint Behavioural pharmacology and its contribution to the molecular basis of memory consolidation
    I Izquierdo
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 11:517-34. 2000
    ..e. flexibility of response). We discuss the implications of these similarities and differences for understanding the neural bases of memory...
  5. ncbi request reprint The inhibition of acquired fear
    Ivan Izquierdo
    Centro de Memoria, ICBS, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brasil
    Neurotox Res 6:175-88. 2004
    ..Further, it is useful and desirable to device procedures by which the "no US" component of the extinction is strengthened in order to alleviate the symptoms of victims of acquired fear...
  6. ncbi request reprint LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance
    D M Barros
    Departamento de Ciencias Fisiologicas, Setor de Farmacologia, Fundação Universidade Federal de Rio Grande, Rio Grande, Brazil
    Behav Pharmacol 12:629-34. 2001
    ..This could be due to an interaction with the N-methyl-d-aspartate (NMDA) receptor complex or with activity of the extracellularly regulated protein kinase (ERK)-Ras signalling pathway...
  7. ncbi request reprint Neuroscience. Zif and the survival of memory
    Ivan Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600 anexo, 90035 003 Porto Alegre, RS, Brazil
    Science 304:829-30. 2004
  8. ncbi request reprint Different molecular cascades in different sites of the brain control memory consolidation
    Ivan Izquierdo
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Hospital Sao Lucas, Av Ipiranga 6690, 2 andar, 90610 000 Porto Alegre, RS, Brasil
    Trends Neurosci 29:496-505. 2006
    ..We propose that these molecular events might also be involved in many other memory types in animals and humans...
  9. ncbi request reprint Stress hormones enhance retrieval of fear conditioning acquired either one day or many months before
    L A Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Behav Pharmacol 13:203-13. 2002
    ..The oscillation of the sensitivity of retrieval to the hormones does not appear to depend on changes in anxiety levels with ageing or to effects of the hormones on locomotor activity...
  10. ncbi request reprint The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks
    Ivan Izquierdo
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    An Acad Bras Cienc 80:115-27. 2008
    ....
  11. pmc Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration
    Ivan Izquierdo
    Centro de Memoria, Instituto do Cérebro, Pontifícia Universidade Católica de Rio Grande do Sul, RS 90610 000, Porto Alegre, Brazil
    Proc Natl Acad Sci U S A 105:19504-7. 2008
    ..Methylphenidate (10 mg p.o.) given 12 hours after acquisition markedly enhanced persistence of the two memory types. This suggests an involvement of dopaminergic processes in persistence in the late posttraining period...
  12. ncbi request reprint Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
    ..No action of this drug on locomotor/exploratory activity or general anxiety state could be detected. The significance of these results is discussed in the context of others describing the independence of LTM from STM...
  13. ncbi request reprint Effects of an acute treatment with L-thyroxine on memory, habituation, danger avoidance, and on Na+, K+ -ATPase activity in rat brain
    Eleonora Araujo Dos Reis-Lunardelli
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Curr Neurovasc Res 4:259-67. 2007
    ..We propose the hypothesis that this increase of Na(+), K(+)-ATPase activity in parietal cortex may be correlated to our results in behavior tests, which suggest a role of THs as well as of the Na(+), K(+)-ATPase in the cognitive process...
  14. ncbi request reprint Inhibition of mRNA and protein synthesis in the CA1 region of the dorsal hippocampus blocks reinstallment of an extinguished conditioned fear response
    Martin Cammarota
    Memorial Center, Department of Biochemistry, Instituto de Ciências Biológicas e da Saúde, Federal University of Rio Grande do Sul, Porto Alegre 90035 003, RS, Brazil
    J Neurosci 23:737-41. 2003
    ....
  15. ncbi request reprint The molecular cascades of long-term potentiation underlie memory consolidation of one-trial avoidance in the CA1 region of the dorsal hippocampus, but not in the basolateral amygdala or the neocortex
    Ivan Izquierdo
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica de Rio Grande do Sul, Hospital Sao Lucas, Porto Alegre, RS, Brazil
    Neurotox Res 14:273-94. 2008
    ..Further, they point to the mechanisms that account for the enhanced consolidation usually seen for emotion-laden memories...
  16. ncbi request reprint Effects of inhibitory avoidance training and/or isolated foot-shock on ectonucleotidase activities in synaptosomes of the anterior and posterior cingulate cortex and the medial precentral area of adult rats
    Grace Schenatto Pereira
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre RS, Brazil
    Behav Brain Res 128:121-7. 2002
    ..05). These results suggest that the ectonucleotidase pathway responds to a mild foot-shock in AC, PC and Fr2 and may be involved in memory consolidation of step-down inhibitory avoidance in the cingulate cortex...
  17. ncbi request reprint Retrograde amnesia induced by drugs acting on different molecular systems
    Janine I Rossato
    Centro de Memoria, Departamento de Bioquimica, Institute de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    Behav Neurosci 118:563-8. 2004
    ..Thus, in all of them, NMDA receptors and the ERK pathway are indispensable for memory consolidation, and GABA-sub(A) receptor activation inhibits memory consolidation: but in each case, their influence is interwoven differently...
  18. ncbi request reprint Angiotensin II disrupts inhibitory avoidance memory retrieval
    Juliana S Bonini
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Horm Behav 50:308-13. 2006
    ..By themselves, neither PD123319 nor losartan had any effect on memory expression. Our data indicate that intra-CA1 A(II) hinders retrieval of avoidance memory through a process that involves activation of AT(2) receptors...
  19. doi request reprint Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory
    Julia R Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 90:374-81. 2008
    ..Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory...
  20. ncbi request reprint Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1
    Adriana S Coitinho
    Centro Universitário Feevale, Instituto de Ciências da Saúde, RS 239, 2755, 93352 000, Novo Hamburgo, RS, Brazil
    Neurobiol Dis 26:282-90. 2007
    ..Taken together, these results demonstrate that PrP(C)-STI1 interaction modulates both STM and LTM and suggests a potential use of ST11 peptide 230-245 as a pharmacological agent...
  21. ncbi request reprint A role for hippocampal gastrin-releasing peptide receptors in extinction of aversive memory
    Tatiana Luft
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neuroreport 17:935-9. 2006
    ..The results indicate that hippocampal gastrin-releasing peptide receptors are involved in memory extinction...
  22. doi request reprint Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas
    Natália Gindri Fiorenza
    Centro de Memoria, Instituto do Cérebro, Pontifical Catholic University of Rio Grande do Sul, and Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico, 90610 000 Porto Alegre, RS, Brazil
    Behav Brain Res 232:210-6. 2012
    ..In conclusion, extinction of two different aversive tasks is modulatable by various systems, which bears upon the behavioral and pharmacological treatment of fear-motivated brain disorders...
  23. doi request reprint Dopamine controls persistence of long-term memory storage
    Janine I Rossato
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Science 325:1017-20. 2009
    ..Thus, the persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points...
  24. doi request reprint Molecular mechanisms in hippocampus and basolateral amygdala but not in parietal or cingulate cortex are involved in extinction of one-trial avoidance learning
    Jociane C Myskiw
    Centro de Memoria, Instituto do Cérebro, Pontifical Catholic University of Rio Grande do Sul, Av Ipiranga 6690, 2nd Floor, 90610 000 Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 94:285-91. 2010
    ....
  25. doi request reprint Physical exercise can reverse the deficit in fear memory induced by maternal deprivation
    Pâmela Billig Mello
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 92:364-9. 2009
    ..Maternal deprivation is known to hinder hormonal mechanisms involved in coping with stress...
  26. ncbi request reprint The transition from memory retrieval to extinction
    Martin Cammarota
    Centro de Memoria, ICS, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brasil
    An Acad Bras Cienc 76:573-82. 2004
    ....
  27. ncbi request reprint The entorhinal cortex plays a role in extinction
    Lia R Bevilaqua
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica de Rio Grande do Sul, Porto Alegre, RS 90610 000, Brazil
    Neurobiol Learn Mem 85:192-7. 2006
    ..Our results also suggest that the ERK1/2 pathway does not play a role in this process...
  28. pmc Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala
    Martin Cammarota
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica de Rio Grande do Sul, Ipiranga Avenue 6690, RS 90610 000, Porto Alegre, Brazil
    Proc Natl Acad Sci U S A 105:10279-84. 2008
    ....
  29. ncbi request reprint Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory
    Weber C da Silva
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, Porto Alegre, Rio Grande do Sul, Brasil
    Hippocampus 18:29-39. 2008
    ....
  30. doi request reprint On the requirement of nitric oxide signaling in the amygdala for consolidation of inhibitory avoidance memory
    Carolina G Zinn
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica de Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 91:266-72. 2009
    ..Our data indicate that the NO-induced activation of PKG in the amygdala is a necessary step for consolidation of inhibitory avoidance memory...
  31. ncbi request reprint Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism
    Daniel S Kerr
    Center for Memory Research, ICBS, Department of Biochemistry, Federal University of Rio Grande do Sul, Ramiro Barcelos 2600 anexo, Porto Alegre, 90035 003, Brazil
    Psychopharmacology (Berl) 179:529-35. 2005
    ....
  32. ncbi request reprint Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism
    Weber C da Silva
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Neurobiol Learn Mem 86:100-6. 2006
    ....
  33. pmc The role of the entorhinal cortex in extinction: influences of aging
    Lia R M Bevilaqua
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Avenue Ipiranga 6690, 2nd Floor, 90610 000 Porto Alegre, RS, Brazil
    Neural Plast 2008:595282. 2008
    ..Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex...
  34. doi request reprint Beta-adrenergic receptors link NO/sGC/PKG signaling to BDNF expression during the consolidation of object recognition long-term memory
    Cristiane R Furini
    Centro de Memoria, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul and Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Porto Alegre, RS, Brasil
    Hippocampus 20:672-83. 2010
    ....
  35. ncbi request reprint Behavioral and genoprotective effects of Vaccinium berries intake in mice
    Daniela Barros
    Departamento de Ciencias Fisiologicas, Fundação Universidade Federal de Rio Grande, Rio Grande, RS, Brazil
    Pharmacol Biochem Behav 84:229-34. 2006
    ..These results suggest that supplementation with V. ashei berries to mice improves performance on memory tasks and has a protective effect on DNA damage, possibly due to the antioxidant activity of polyphenols, including anthocyanins...
  36. doi request reprint Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation
    Fernando Benetti
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga 6690, 2 andar, Porto Alegre, RS 90610 000, Brazil
    Neurobiol Learn Mem 97:54-8. 2012
    ..The present results suggest that the memory deficit induced by early postnatal maternal deprivation in rats may in part be due to an impairment of histamine mediated mechanisms in the CA1 region of the rat hippocampus...
  37. ncbi request reprint Inhibition of c-Jun N-terminal kinase in the CA1 region of the dorsal hippocampus blocks extinction of inhibitory avoidance memory
    Lia R M Bevilaqua
    Center for Memory Research, Biomedical Research Institute, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 18:483-9. 2007
    ..Our results suggest that, as happens during consolidation, extinction of IA long-term memory also requires c-Jun N-terminal kinase activity in the CA1 region of the dorsal hippocampus...
  38. ncbi request reprint A link between the hippocampal and the striatal memory systems of the brain
    Janine I Rossato
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brasil
    An Acad Bras Cienc 78:515-23. 2006
    ....
  39. ncbi request reprint Relationship between short- and long-term memory and short- and long-term extinction
    Martin Cammarota
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 84:25-32. 2005
    ....
  40. ncbi request reprint Effects of thyroid hormones on memory and on Na(+), K(+)-ATPase activity in rat brain
    Eleonora Araujo Dos Reis-Lunardelli
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Curr Neurovasc Res 4:184-93. 2007
    ..Our results showed that a hyper and hypothyroid state can alter animal behavior and they also might indicate an effect of THs on learning and memory...
  41. ncbi request reprint Inhibition of PKC in basolateral amygdala and posterior parietal cortex impairs consolidation of inhibitory avoidance memory
    Juliana S Bonini
    Center for Memory Research, ICBS, Department of Biochemistry, Federal University of Rio Grande do Sul, Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brazil
    Pharmacol Biochem Behav 80:63-7. 2005
    ..The findings on BLA are similar to those previously reported in the hippocampus, but those on PC suggest an entirely different molecular dynamics for memory formation in that area...
  42. doi request reprint Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine
    Fernando Benetti
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Av Ipiranga, 6690, 90610 000, Porto Alegre, RS, Brazil
    Int J Dev Neurosci 27:59-64. 2009
    ..The findings suggest that maternal deprivation affects memory processing at adulthood through a change in brain cholinergic systems...
  43. ncbi request reprint The interaction between prion protein and laminin modulates memory consolidation
    Adriana S Coitinho
    Centro Universitário Feevale, Instituto de Ciências da Saúde, RS 239, 2755, 93352 000, Novo Hamburgo, RS, and Centro de Cirurgia de Epilepsia do Estado de Santa Catarina, Hospital Governador Celso Ramos, SC, Brazil
    Eur J Neurosci 24:3255-64. 2006
    ..Our findings show that, through its interaction with LN, hippocampal PrPc plays a critical role in memory processing and suggest that this role is mediated by activation of both PKA and ERK1/2 signaling pathways...
  44. ncbi request reprint A link between role of two prefrontal areas in immediate memory and in long-term memory consolidation
    Luciana A Izquierdo
    Centro de Memoria, Instituto de Pesquisas Biologicas, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Av Ipiranga 6690, 2nd Floor, R90610 000, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 88:160-6. 2007
    ..In the dorsolateral prefrontal cortex the link between immediate and long-term memory appears to be direct; in the medial area the link suffers a 90 min delay...
  45. ncbi request reprint Temporary inactivation of the dorsal hippocampus induces a transient impairment in retrieval of aversive memory
    Olavo B Amaral
    Depto de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul Porto Alegre, RS, Brazil
    Behav Brain Res 180:113-8. 2007
    ..The implications of the findings to the interpretation of the phenomenon of transient retrieval impairment induced by post-reactivation pharmacological interventions on memory systems are discussed...
  46. ncbi request reprint Effects of chronic administered guanosine on behavioral parameters and brain glutamate uptake in rats
    Elsa R Vinadé
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    J Neurosci Res 79:248-53. 2005
    ..Altogether, these findings suggest a potential role of guanosine for treating diseases involving glutamatergic excitotoxicity such as epilepsy. These effects seem to be related to modulation of glutamate uptake...
  47. ncbi request reprint Blockade of adenosine A1 receptors in the posterior cingulate cortex facilitates memory in rats
    Grace S Pereira
    Laboratório de Enzimologia e Centro de Memória, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Eur J Pharmacol 437:151-4. 2002
    ..These results suggest that adenosine A1 receptors in the posterior cingulate cortex inhibit memory consolidation in a way that their blockade facilitates memory for inhibitory avoidance in rats...
  48. doi request reprint Infusion of protein synthesis inhibitors in the entorhinal cortex blocks consolidation but not reconsolidation of object recognition memory
    Ramón H Lima
    Centro de Memoria, Instituto do Cérebro, Pontifícia Universidade Católica de Rio Grande do Sul, RS, Brazil
    Neurobiol Learn Mem 91:466-72. 2009
    ..However, inhibition of protein synthesis in this cortical region after memory retrieval does not seem to affect the stability of the recognition trace...
  49. pmc Retrieval induces hippocampal-dependent reconsolidation of spatial memory
    Janine I Rossato
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Learn Mem 13:431-40. 2006
    ..Our results suggest the existence of a hippocampal protein synthesis-dependent reconsolidation process that operates to recover or update retrieval-weakened memories from incomplete extinction...
  50. pmc Behavioral tagging of extinction learning
    Jociane de Carvalho Myskiw
    National institute of Translational Neuroscience, National Research Council of Brazil, and Memory Center, Brain Institute, Pontifical Catholic University of Rio Grande do Sul, 90610 000 Porto Alegre, RS, Brazil
    Proc Natl Acad Sci U S A 110:1071-6. 2013
    ..Extinction learning produces a tag at the appropriate synapses, whereas novelty learning causes the synthesis of plasticity-related proteins that are captured by the tag, strengthening the synapses that generated this tag...
  51. ncbi request reprint Interactions between anandamide-induced anterograde amnesia and post-training memory modulatory systems
    Daniela Martí Barros
    Laboratório de Comportamento, Departamento de Ciencias Fisiologicas, CENPRE, Fundacao Universidade Federal do Rio Grande, Av Itália km 8, 96201 900 Rio Grande, RS, Brazil
    Brain Res 1016:66-71. 2004
    ....
  52. ncbi request reprint Retrieval and the extinction of memory
    Martin Cammarota
    Centro de Memoria, IPB, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Av Ipiranga 6690 2 Andar, 90610 000, Porto Alegre, RS, Brazil
    Cell Mol Neurobiol 25:465-74. 2005
    ....
  53. ncbi request reprint Cellular prion protein ablation impairs behavior as a function of age
    Adriana S Coitinho
    Centro de Memoria, Departmento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600, Porto Alegre, Brazil
    Neuroreport 14:1375-9. 2003
    ..These results suggest that systems involved in memory formation become more susceptible to mechanisms that require PrPc between the ages of 3 and 9 months in both mice and rats...
  54. ncbi request reprint On the participation of mTOR in recognition memory
    Jociane C Myskiw
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, Porto Alegre, RS 90610 000, Brazil
    Neurobiol Learn Mem 89:338-51. 2008
    ....
  55. pmc Retrieval induces reconsolidation of fear extinction memory
    Janine I Rossato
    Centro de Memoria, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul and Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico, RS90610 000 Porto Alegre, Brazil
    Proc Natl Acad Sci U S A 107:21801-5. 2010
    ..Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus...
  56. ncbi request reprint Oral administration of guanosine impairs inhibitory avoidance performance in rats and mice
    Elsa Regina Vinadé
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 81:137-43. 2004
    ..Guanosine presented no effects on locomotor activity and anxiety-related behaviors. This amnesic effect of guanosine may be compatible with inhibition of glutamatergic system and seems to be not mediated by adenosine...
  57. ncbi request reprint Clozapine and olanzapine but not risperidone impair the pre-frontal striatal system in relation to egocentric spatial orientation in a Y-maze
    Cibele Canal Castro
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Curr Neurovasc Res 4:235-9. 2007
    ..Thus, with regard to the delayed alternation requiring ESO, clozapine and olanzapine but not risperidone affects the prefronto-striatal system in a similar way as classical neuroleptics does...
  58. ncbi request reprint Intrahippocampal infusion of ebselen impairs retention of an inhibitory avoidance task in rats
    Lisiane O Porciuncula
    Departamento de Bioquímica and Centro de Memória, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Eur J Pharmacol 451:165-9. 2002
    ..Our results indicate that more studies must be performed to investigate the mechanisms of this amnesic effect and whether ebselen has a cognition-impairing effect when administered chronically...
  59. ncbi request reprint Anxiolytic-, antidepressant- and anticonvulsant-like effects of the alkaloid montanine isolated from Hippeastrum vittatum
    Ana Flávia Schürmann da Silva
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av Ipiranga 2752, 90 610 000, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 85:148-54. 2006
    ..Our results suggest that montanine, as other alkaloids isolated from Amaryllidaceae species, has psychopharmacological activities including anxiolytic, antidepressive and anticonvulsive effects...
  60. ncbi request reprint Modulation of working, short- and long-term memory by nicotinic receptors in the basolateral amygdala in rats
    Daniela Martí Barros
    Departamento de Ciencias Fisiologicas, Fundação Universidade Federal de Rio Grande, Rio Grande, RS, Brazil
    Neurobiol Learn Mem 83:113-8. 2005
    ..Again, mecamylamine inhibited and nicotine enhanced STM and LTM. The results indicate that nAChRs in BLA participate in the regulation of WM formation and STM and LTM acquisition and consolidation...
  61. pmc Plastic modifications induced by object recognition memory processing
    Julia Rosauro Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, 90610 000 Porto Alegre, Rio Grande do Sul, Brazil
    Proc Natl Acad Sci U S A 107:2652-7. 2010
    ..The late synaptic enhancement phase, on the other hand, would be a consequence of memory restabilization...
  62. ncbi request reprint Effects of acute and chronic physical exercise and stress on different types of memory in rats
    Pâmela Billig Mello
    Programa de Pós graduação em Ciências Biológicas Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 90050 170, Brazil
    An Acad Bras Cienc 80:301-9. 2008
    ..Our findings indicate that some care must be taken when interpreting effects of forced exercise on brain parameters since at least part of them may be due to the stress inherent to the training procedure...
  63. ncbi request reprint Inhibitory avoidance task reveals differences in ectonucleotidase activities between male and female rats
    Bárbara Rücker
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Res 29:2231-7. 2004
    ..There were no changes in ectonucleotidase activities from female rats. These findings provide support for the view that could exist biochemical differences in ectonucleotidase activities between males and females...
  64. pmc Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus
    Weber Cláudio da Silva
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, RS90610 000 Porto Alegre, Brazil
    Proc Natl Acad Sci U S A 110:6566-70. 2013
    ....
  65. doi request reprint Histamine facilitates consolidation of fear extinction
    Juliana Sartori Bonini
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Int J Neuropsychopharmacol 14:1209-17. 2011
    ..Taken together, our data indicate that the hippocampal histaminergic system modulates the consolidation of fear extinction through a mechanism involving the H2-dependent activation of ERK signalling...
  66. ncbi request reprint Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats
    Maria Rosana Ramirez
    Dep Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Res 52:457-62. 2005
    ....
  67. doi request reprint ERK1/2 and CaMKII-mediated events in memory formation: is 5HT regulation involved?
    Martin Cammarota
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, Andar 2, Porto Alegre, RS90610 000, Brasil
    Behav Brain Res 195:120-8. 2008
    ..Since this issue of the journal is dedicated to serotonin (5HT) regulation of behavior, we will comment on the so far scanty, but significant, evidence for a role of 5HT in the regulation of CaMKII and MAPK...
  68. ncbi request reprint Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat
    Grace Schenatto Pereira
    Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS
    Neurobiol Learn Mem 83:217-23. 2005
    ..These findings provide behavioral evidence for the role of adenosinergic system in the memory retrieval into PCC...
  69. ncbi request reprint Habituation to an open field alters ecto-nucleotidase activities in rat hippocampal synaptosomes
    Eduardo Luiz Pedrazza
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande do Sul Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Neurosci Lett 413:21-4. 2007
    ..5% for ATP and ADP hydrolysis, respectively) and ecto-5'-nucleotidase (40%) activities was observed. This study reveals the involvement of ecto-nucleotidase activities in different learning paradigms during memory processing...
  70. ncbi request reprint The extinction of conditioned fear: structural and molecular basis and therapeutic use
    Martin Cammarota
    Memory Center, Biomedical Research Institute, Pontícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 29:80-5. 2007
    ..In this article we review some of the most recent findings about the behavioral and biochemical properties of extinction...
  71. ncbi request reprint Different time course for the memory facilitating effect of bicuculline in hippocampus, entorhinal cortex, and posterior parietal cortex of rats
    Tatiana Luft
    Centro de Memoria, Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre RS, Brazil
    Neurobiol Learn Mem 82:52-6. 2004
    ..5h after training. In the entorhinal and parietal cortex memory-related activities include the participation of protein kinase A and extracellularly regulated kinase (ERK) twice, right after training and then again 3h later...
  72. ncbi request reprint Molecular pharmacological dissection of short- and long-term memory
    Luciana A Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Cell Mol Neurobiol 22:269-87. 2002
    ..These might include a hyperactivation of glutamate AMPA receptors, ribosome changes, or the exocytosis of glycoproteins that participate in cell addition...
  73. ncbi request reprint Role of the hippocampus and amygdala in the extinction of fear-motivated learning
    Monica R Vianna
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Rua Ramiro Barcelos, 2600 Porto Alegre, RS 90035 003 Brazil
    Curr Neurovasc Res 1:55-60. 2004
    ..Further research into the possibilities of enhancing extinction at the expense of the original fearsome learning is desirable...
  74. doi request reprint Reconsolidation and the fate of consolidated memories
    Lia R Bevilaqua
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6600, Porto Alegre, RS 90610 000, Brasil
    Neurotox Res 14:353-8. 2008
    ..Here we will address the consolidation-reconsolidation debate and discuss some controversial issues about the reconsolidation hypothesis, in particular the biological role of this process...
  75. ncbi request reprint Memory extinction requires gene expression in rat hippocampus
    Monica R Vianna
    Centro de Memoria, Departamento de Bioqui mica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, 90035 003, RS, Porto Alegre, Brazil
    Neurobiol Learn Mem 79:199-203. 2003
    ..These requirements are to be expected from learning that involves new synaptic associations...
  76. ncbi request reprint Intrahippocampal infusion of an inhibitor of protein kinase A separates short- from long-term memory
    M R Vianna
    Centro de Memoria, , , Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Behav Pharmacol 10:223-7. 1999
    ..The role of PKA in STM may well involve other substrates of the enzyme. This finding points to a cleavage between the mechanisms of STM and LTM formation...
  77. ncbi request reprint Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory
    J Quevedo
    , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 8:713-7. 1997
    ..The findings suggest that NMDA receptor-, NO- and PKA-mediated processes in the dorsal hippocampus, but not in the caudate nucleus, are involved in memory...
  78. ncbi request reprint Effects of post-training infusions of a mitogen-activated protein kinase kinase inhibitor into the hippocampus or entorhinal cortex on short- and long-term retention of inhibitory avoidance
    R Walz
    Centro de Memoria, Departamento de Bioquimica, ICBS, UFRIGS, Ramiro Barcellos, Porto Alegre, RS, Brazil
    Behav Pharmacol 10:723-30. 1999
    ..All effects were dose-dependent. These findings indicate that the MAPK cascade in the HIP and EC is differentially involved in short- and long-term retention of inhibitory avoidance in rats...
  79. ncbi request reprint On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of spatial memory
    J S Bonini
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, Porto Alegre, RS 90610 000, Brazil
    Neuroscience 147:37-45. 2007
    ....
  80. ncbi request reprint Duration of environmental enrichment influences the magnitude and persistence of its behavioral effects on mice
    Olavo B Amaral
    Depatmento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Brazil
    Physiol Behav 93:388-94. 2008
    ....
  81. ncbi request reprint Bombesin/gastrin-releasing peptide receptors in the basolateral amygdala regulate memory consolidation
    Rafael Roesler
    Preclinical Neuropharmacology Laboratory, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046 900 Porto Alegre, RS, Brazil
    Eur J Neurosci 19:1041-5. 2004
    ..The results suggest that bombesin/GRP receptors in the BLA are involved in the consolidation of aversive memory, and the BLA mediates the memory-impairing effect of systemic bombesin/GRP receptor blockade...
  82. pmc Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats
    Pedro Antônio Schmidt do Prado-Lima
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Laboratorio de Neurociencias, Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil
    J Psychiatry Neurosci 36:250-5. 2011
    ..Our hypothesis was that topiramate inhibits the consolidation and enhances the extinction of this fear memory...
  83. ncbi request reprint Effect of radicicol infusion on the Src tyrosine kinase activity of rat hippocampus before and after training in an inhibitory avoidance task
    Patricia Pereira
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600, Anexo, Porto Alegre, 90035 003, RS, Brazil
    Neurochem Res 32:1150-5. 2007
    ..The results suggest that Src-PTKs participate in memory acquisition, consolidation, and retrieval processes, but the timing of the role of the enzyme is different in each case...
  84. ncbi request reprint Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice
    Elsa Regina Vinadé
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Brain Res 977:97-102. 2003
    ..Adding to previously reported data, these findings suggest a potential role for chronic guanosine in the management of diseases associated with glutamatergic excitotoxicity, including epilepsy and anxiety...
  85. ncbi request reprint Pharmacological findings contribute to the understanding of the main physiological mechanisms of memory retrieval
    Daniela M Barros
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    Curr Drug Targets CNS Neurol Disord 2:81-94. 2003
    ..The effect of novelty is mediated by molecular mechanisms similar to those of retrieval itself...
  86. ncbi request reprint On the participation of hippocampal p38 mitogen-activated protein kinase in extinction and reacquisition of inhibitory avoidance memory
    J I Rossato
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6600, Porto Alegre, RS 90035 017, Brazil
    Neuroscience 143:15-23. 2006
    ....
  87. ncbi request reprint Dose-dependent impairment of inhibitory avoidance retention in rats by immediate post-training infusion of a mitogen-activated protein kinase kinase inhibitor into cortical structures
    R Walz
    Centro de Memoria, Departamento de Bioquimica, ICBS, U F R G S, Porto Alegre, RS, Brazil
    Behav Brain Res 105:219-23. 1999
    ..The effective dose is variable according to the neocortical structure studied...
  88. ncbi request reprint Effects of posttraining treatments in the posterior cingulate cortex on short- and long-term memory for inhibitory avoidance in rats
    M M Souza
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Ramiro Barcelos 2600, 90035 003 Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 77:202-10. 2002
    ..The same occurs by inhibiting PKA activity with regard to STM and possibly to LTM...
  89. ncbi request reprint Drugs acting upon the cyclic adenosine monophosphate/protein kinase A signalling pathway modulate memory consolidation when given late after training into rat hippocampus but not amygdala
    L Bevilaqua
    , Universidade Federal do Rio Grande do Sul U F R G S, Porto Alegre, RS, Brazil
    Behav Pharmacol 8:331-8. 1997
    ..This may be taken to suggest that the hippocampus, but not the amygdala, is involved in the long-term storage of step-down inhibitory avoidance in the rat...
  90. ncbi request reprint Different effect of high fat diet and physical exercise in the hippocampal signaling
    Alexandre Pastoris Muller
    Departamento de Bioquimica, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
    Neurochem Res 33:880-5. 2008
    ..The physiological relevance of these findings in brain function remains to be elucidated...
  91. ncbi request reprint Participation of CaMKII in neuronal plasticity and memory formation
    Martin Cammarota
    Centro de Memoria, Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brasil
    Cell Mol Neurobiol 22:259-67. 2002
    ..3. Here we review some of the more exciting discoveries related to the mechanisms involved in CaMKII activation and synaptic plasticity...
  92. ncbi request reprint Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats
    Joao Quevedo
    Laboratorio de Neurotoxicologia, Universidade do Extremo Sul Catarinense, Av Universitaria 1105, Criciúma 88806 000, SC, Brazil
    Behav Brain Res 154:339-43. 2004
    ..The results show that STM recruits PKA and MAPK, whereas, LTM depends on PKA activity and protein synthesis during the early post-training period...
  93. ncbi request reprint Pretraining but not preexposure to the task apparatus prevents the memory impairment induced by blockade of protein synthesis, PKA or MAP kinase in rats
    Joao Quevedo
    Laboratorio de Neurociencias, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Neurochem Res 30:61-7. 2005
    ....
  94. ncbi request reprint Differential effects of emotional arousal in short- and long-term memory in healthy adults
    Joao Quevedo
    Laboratorio de Neurotoxicologia, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Neurobiol Learn Mem 79:132-5. 2003
    ..The lack of effect of emotional arousal in STM suggests that amygdala is not related to STM mechanisms. Further studies using different approaches are needed to elucidate if STM processes are influenced by emotional arousal...
  95. ncbi request reprint Behavioural effects of acute phenylalanine and tyrosine depletion in healthy male volunteers
    Eugenio H Grevet
    Departamento de Psiquiatria, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul e Hospital de Clinicas de Porto Alegre, Brazil
    J Psychopharmacol 16:51-5. 2002
    ..022). These results suggest that tyrosine plasma levels and cathecholamines may be important factors in regulating mood and memory...
  96. ncbi request reprint Acute treatment with the antidepressants bupropion and sertraline do not influence memory retrieval in man
    André F Carvalho
    Centro de Memoria, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Eur Arch Psychiatry Clin Neurosci 256:320-5. 2006
    ..In the present study, we tested the hypothesis that acute monoaminergic re-uptake inhibition with these antidepressants might enhance retrieval of emotional memory in man...
  97. ncbi request reprint Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus
    I Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciências Básicas da Saúde ICBS, Universidade Federal do Rio Grande do Sul UFRGS, Ramiro Barcellos, Porto Allegre, Brazil
    Eur J Neurosci 11:3323-8. 1999
    ..The amnesic effect of novelty appears to rely on N-methyl-D-aspartate (NMDA) receptor- and calcium/calmodulin-dependent protein kinase II (CaMKII)-dependent, but not on PKA-dependent, aspects of its habituation learning...
  98. ncbi request reprint Effect of inhibitory avoidance training on [3H]-glutamate binding in the hippocampus and parietal cortex of rats
    N Schroder
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 33:229-32. 2000
    ..These results are consistent with previous evidence for the involvement of glutamatergic synaptic modification in the hippocampus in the early steps of memory formation...
  99. ncbi request reprint Different hippocampal molecular requirements for short- and long-term retrieval of one-trial avoidance learning
    L A Izquierdo
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600, 90035 003, RS, Porto Alegre, Brazil
    Behav Brain Res 111:93-8. 2000
    ..Both the PKA and MAPK signalling pathways are required for the retrieval of long-term but not short-term memory...
  100. ncbi request reprint Participation of hippocampal nicotinic receptors in acquisition, consolidation and retrieval of memory for one trial inhibitory avoidance in rats
    D Martí Barros
    Departamento de Ciencias Fisiologicas, Fundação Universidade Federal de Rio Grande, Av Itália km 8, CEP 96 201 900, Rio Grande, RS, Brazil
    Neuroscience 126:651-6. 2004
    ..Mecamylamine and DHbetaE impaired and nicotine enhanced STM, LTM and retrieval similarly. The results indicate that nAChRs in CA1 participate in the regulation of both STM and LTM formation, and on the retrieval of LTM...
  101. ncbi request reprint Effects of infusions of the tyrosine kinase inhibitor radicicol into the hippocampus on short- and long-term memory of the inhibitory avoidance task
    P Pereira
    , , , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 12:299-302. 2001
    ..Our results indicate that memory formation and retrieval in the hippocampus can involve PTK activity, but the present findings should be taken merely as a possible starting point for future investigations...