A C Linhares

Summary

Affiliation: Instituto Evandro Chagas
Country: Brazil

Publications

  1. pmc Prevalence and clinical features of respiratory syncytial virus in children hospitalized for community-acquired pneumonia in northern Brazil
    Letícia Martins Lamarão
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, PA, Brazil
    BMC Infect Dis 12:119. 2012
  2. ncbi request reprint Neonatal rotavirus infection in Belém, northern Brazil: nosocomial transmission of a P[6] G2 strain
    Alexandre C Linhares
    Virology Section, Instituto Evandro Chagas, Fundacao Nacional de Saude, and University of Pará State, Belem, Para, Brazil
    J Med Virol 67:418-26. 2002
  3. ncbi request reprint Rotavirus serotype G9 is associated with more-severe disease in Latin America
    A C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, Brazil
    Clin Infect Dis 43:312-4. 2006
  4. ncbi request reprint Nutritional status in relation to the efficacy of the rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) in infants from Belém, pará state, Brazil
    Alexandre C Linhares
    Seção de Virologia, Instituto Evandro Chagas, Fundacao Nacional de Saude, Ministerio da Saude, Belem, Para, Brasil
    Rev Inst Med Trop Sao Paulo 44:13-6. 2002
  5. doi request reprint Effectiveness of the monovalent G1P[8] human rotavirus vaccine against hospitalization for severe G2P[4] rotavirus gastroenteritis in Belém, Brazil
    Maria Cleonice A Justino
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Belem, Brazil
    Pediatr Infect Dis J 30:396-401. 2011
  6. ncbi request reprint A short report on highlights of world-wide development of RIX4414: a Latin American experience
    A C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, MS, Av Almirante Barroso, 492, Marco CEP 66 090 000, Belem, Para, Brazil
    Vaccine 24:3784-5. 2006
  7. ncbi request reprint Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes
    J D P Mascarenhas
    Instituto Evandro Chagas, Fundacao Nacional de Saude, Belem, Para, Brazil
    J Trop Pediatr 48:300-2. 2002
  8. ncbi request reprint Reappraisal of the Peruvian and Brazilian lower titer tetravalent rhesus-human reassortant rotavirus vaccine efficacy trials: analysis by severity of diarrhea
    A C Linhares
    Instituto Evandro Chagas, Belem, Brazil
    Pediatr Infect Dis J 18:1001-6. 1999
  9. doi request reprint Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study
    Alexandre C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministry of Health, Belem, Para, Brazil
    Lancet 371:1181-9. 2008
  10. ncbi request reprint Rotavirus vaccines and vaccination in Latin America
    A C Linhares
    Fundacao Nacional de Saude, Instituto Evandro Chagas, Virology Section, Belem, Para, Brasil
    Rev Panam Salud Publica 8:305-31. 2000

Collaborators

Detail Information

Publications40

  1. pmc Prevalence and clinical features of respiratory syncytial virus in children hospitalized for community-acquired pneumonia in northern Brazil
    Letícia Martins Lamarão
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, PA, Brazil
    BMC Infect Dis 12:119. 2012
    ..This study is the first RSV epidemiological study in young children hospitalized with community-acquired pneumonia (CAP) in Belém city, Pará (Northern Brazil)...
  2. ncbi request reprint Neonatal rotavirus infection in Belém, northern Brazil: nosocomial transmission of a P[6] G2 strain
    Alexandre C Linhares
    Virology Section, Instituto Evandro Chagas, Fundacao Nacional de Saude, and University of Pará State, Belem, Para, Brazil
    J Med Virol 67:418-26. 2002
    ..This is the first report from Brazil describing nosocomial transmission of P[6]G2 rotavirus strains among neonates...
  3. ncbi request reprint Rotavirus serotype G9 is associated with more-severe disease in Latin America
    A C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, Brazil
    Clin Infect Dis 43:312-4. 2006
    ..Thus, demonstration of efficacy against G9 will be an important asset of any rotavirus vaccine to be introduced into a Latin American country or any country where G9 has been shown to be prevalent...
  4. ncbi request reprint Nutritional status in relation to the efficacy of the rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) in infants from Belém, pará state, Brazil
    Alexandre C Linhares
    Seção de Virologia, Instituto Evandro Chagas, Fundacao Nacional de Saude, Ministerio da Saude, Belem, Para, Brasil
    Rev Inst Med Trop Sao Paulo 44:13-6. 2002
    ..Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries...
  5. doi request reprint Effectiveness of the monovalent G1P[8] human rotavirus vaccine against hospitalization for severe G2P[4] rotavirus gastroenteritis in Belém, Brazil
    Maria Cleonice A Justino
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Belem, Brazil
    Pediatr Infect Dis J 30:396-401. 2011
    ..Brazil initiated universal immunization of infants with the G1P[8] human rotavirus (RV) vaccine in March 2006. This study evaluated vaccine effectiveness (VE) against severe rotavirus gastroenteritis (RVGE) hospitalizations...
  6. ncbi request reprint A short report on highlights of world-wide development of RIX4414: a Latin American experience
    A C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, MS, Av Almirante Barroso, 492, Marco CEP 66 090 000, Belem, Para, Brazil
    Vaccine 24:3784-5. 2006
    ..It is demonstrated that two doses of RIX4414 are highly efficacious against severe rotavirus gastroenteritis and hospitalization, including disease caused by non-G1 strains, namely G9 serotypes...
  7. ncbi request reprint Tetravalent rhesus-human rotavirus vaccine (RRV-TV) in Belém, Brazil: efficacy against prevailing P and G genotypes
    J D P Mascarenhas
    Instituto Evandro Chagas, Fundacao Nacional de Saude, Belem, Para, Brazil
    J Trop Pediatr 48:300-2. 2002
    ....
  8. ncbi request reprint Reappraisal of the Peruvian and Brazilian lower titer tetravalent rhesus-human reassortant rotavirus vaccine efficacy trials: analysis by severity of diarrhea
    A C Linhares
    Instituto Evandro Chagas, Belem, Brazil
    Pediatr Infect Dis J 18:1001-6. 1999
    ..Mild, moderate/severe and very severe rotavirus diarrhea were scored as 0 to 8, 9 to 14 and >14, respectively...
  9. doi request reprint Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study
    Alexandre C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministry of Health, Belem, Para, Brazil
    Lancet 371:1181-9. 2008
    ..We therefore aimed to assess the 2-year efficacy and safety of an oral live attenuated human rotavirus vaccine for prevention of severe gastroenteritis in infants...
  10. ncbi request reprint Rotavirus vaccines and vaccination in Latin America
    A C Linhares
    Fundacao Nacional de Saude, Instituto Evandro Chagas, Virology Section, Belem, Para, Brasil
    Rev Panam Salud Publica 8:305-31. 2000
    ....
  11. ncbi request reprint Safety, immunogenicity, and protective efficacy of two doses of RIX4414 live attenuated human rotavirus vaccine in healthy infants
    Eliete C Araujo
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, PA, Brasil
    J Pediatr (Rio J) 83:217-24. 2007
    ..To determine the safety, immunogenicity and efficacy of two doses of rotavirus vaccine in healthy Brazilian infants...
  12. ncbi request reprint Detection and characterization of rotavirus G and P types from children participating in a rotavirus vaccine trial in Belém, Brazil
    J D P Mascarenhas
    Instituto Evandro Chagas, Fundacao Nacional de Saude, 66090 000 Belém, PA, Brasil
    Mem Inst Oswaldo Cruz 97:113-7. 2002
    ..These results are of potential importance regarding future rotavirus vaccination strategies in Brazil...
  13. ncbi request reprint [Rotavirus infection in Brazil: epidemiology and challenges for its control]
    A C Linhares
    Serviço de Virologia Geral, Instituto Evandro Chagas, Fundacao Nacional de Saude, Belem, PA, 66090 000, Brasil
    Cad Saude Publica 16:629-46. 2000
    ..Therefore, further vaccine trials in Brazil will probably involve rotavirus candidate vaccines other than RRV-TV...
  14. pmc Immunogenicity, safety and efficacy of tetravalent rhesus-human, reassortant rotavirus vaccine in Belém, Brazil
    A C Linhares
    Instituto Evandro Chagas, Para, Brazil
    Bull World Health Organ 74:491-500. 1996
    ..These results are sufficiently encouraging to warrant further studies of this vaccine in developing countries using a higher dosage in an attempt to improve its immunogenicity and efficacy...
  15. ncbi request reprint Prevalence of human parvovirus (B19) and rubella virus infections in urban and remote rural areas in northern Brazil
    R B de Freitas
    Instituto Evandro Chagas, Fundacao Nacional de Saude, Brasil
    J Med Virol 32:203-8. 1990
    ..About a quarter of the skin rashes in Belém that were not attributable to infections with rubella, measles, or arboviruses were caused by recent B19 infections...
  16. ncbi request reprint Molecular characterization of VP4 and NSP4 genes from rotavirus strains infecting neonates and young children in Belém, Brazil
    Joana D arc P Mascarenhas
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Rodovia BR 316 KM 07, S N, Levilândia, 67 030 000 Ananindeua, Para, Brazil
    Virus Res 126:149-58. 2007
    ....
  17. ncbi request reprint Molecular epidemiology of astrovirus type 1 in Belém, Brazil, as an agent of infantile gastroenteritis, over a period of 18 years (1982-2000): identification of two possible new lineages
    Yvone B Gabbay
    Virology Section, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Rodovia BR 316, Km 07, S N, Levilândia 67030 000, Ananindeua, PA, Brazil
    Virus Res 129:166-74. 2007
    ..The data obtained in this study should be useful for further studies at molecular level, including improvement of disease surveillance based on molecular diagnostic tools, and vaccine development...
  18. ncbi request reprint Prevalence of human astrovirus genotypes associated with acute gastroenteritis among children in Belém, Brazil
    Yvone B Gabbay
    Virology Section, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Ananindeua, Para, Brazil
    J Med Virol 79:530-8. 2007
    ..6% of children had been infected by HAstV. The clinical symptoms registered during HAstV associated-diarrhea were usually mild. These data highlight the circulation of the different HAstV genotypes in Belém during the study period...
  19. ncbi request reprint Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil
    Ronaldo B Freitas
    Virology Section, Evandro Chagas Institute, National Foundation of Health, Ministry of Health, Belem, Para, Brazil
    Rev Inst Med Trop Sao Paulo 44:17-22. 2002
    ..Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women...
  20. ncbi request reprint Detection of a neonatal human rotavirus strain with VP4 and NSP4 genes of porcine origin
    Joana D arc P Mascarenhas
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, Brazil
    J Med Microbiol 56:524-32. 2007
    ..These findings strongly suggest the occurrence of interspecies transmission...
  21. ncbi request reprint Rotavirus G serotypes and p[],G genotypes identified in cases of reinfection among children participating in a trial with rhesus-human reassortant tetravalent vaccine (RRV-TV) in Belém, Brazil
    Joana D arc P Mascarenhas
    Instituto Evandro Chagas, Fundacao Nacional de Saude, Belem, Para, Brazil
    J Trop Pediatr 48:93-7. 2002
    ..The results obtained in the present investigation underscore the need to broaden our knowledge of the immunity in rotavirus reinfection. This should be useful regarding future rotavirus vaccination strategies in Brazil...
  22. ncbi request reprint Prevalence and genetic diversity of astroviruses in children with and without diarrhea in São Luís, Maranhão, Brazil
    Yvone B Gabbay
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, 67030 000 Ananindeua, PA, Brazil
    Mem Inst Oswaldo Cruz 100:709-14. 2005
    ..No seasonal pattern of occurrence was observed during these two years of study, and peak detection rate was observed in children aged between 3 and 6 months in the symptomatic group, and between 18 and 24 months in the controls...
  23. doi request reprint Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil
    Ronaldo B Freitas
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Rodovia BR 316 Km 7, S N Levilândia, 67037 000 Ananindeua, Para, Brazil
    J Clin Virol 43:60-5. 2008
    ..Human erythrovirus B19, endemic in the Amazon region since 1990, is associated with a wide spectrum of clinical presentations...
  24. ncbi request reprint Molecular analysis of VP4, VP7, and NSP4 genes of P[6]G2 rotavirus genotype strains recovered from neonates admitted to hospital in Belém, Brazil
    Joana D arc P Mascarenhas
    Virology Section, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Levilândia, Ananindeua, Brazil
    J Med Virol 78:281-9. 2006
    ....
  25. ncbi request reprint Prevalence of human herpesvirus 8 antibodies in the population of Belém, Pará, Brazil
    Ronaldo B Freitas
    Serviço de Virologia Geral, Instituto Evandro Chagas, Fundacao Nacional de Saude, Ministerio da Saude, Belem, Para, Brasil
    Rev Inst Med Trop Sao Paulo 44:309-13. 2002
    ..Our data suggest that transmission of HHV-8 occurs frequently in the general urban population of Belém, and that prevalence of antibody seems to increase with age...
  26. doi request reprint Evidence for zoonotic transmission of group C rotaviruses among children in Belém, Brazil
    Yvone B Gabbay
    Instituto Evandro Chagas, SVS, M S, Belem, PA, Brazil
    J Med Virol 80:1666-74. 2008
    ..This study is the first to provide evidence for transmission of RVC from swine to human. They also indicate that both human and porcine RVC were endemic in Belém...
  27. ncbi request reprint Evidence of active herpesvirus 6 (variant-A) infection in patients with lymphadenopathy in Belém, Pará, Brazil
    Ronaldo B Freitas
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, Para, Brasil
    Rev Inst Med Trop Sao Paulo 45:283-8. 2003
    ..3% of them the disease lasted 6-20 days. Our data suggest that it is worth seeking for HHV-6 infection whenever a patient (infant or adult) presents with lymphadenopathy as a prominent symptom in the course of an acute febrile illness...
  28. ncbi request reprint Human herpesvirus-7 as a cause of exanthematous ilnesses in Belém, Pará, Brazil
    Ronaldo B Freitas
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, Para, Brazil
    Rev Inst Med Trop Sao Paulo 46:139-43. 2004
    ..S. HHV-7 appears therefore to emerge as a newly recognized pathogen of exanthem in our region...
  29. ncbi request reprint First detection of a human astrovirus type 8 in a child with diarrhea in Belém, Brazil: comparison with other strains worldwide and identification of possible three lineages
    Yvone B Gabbay
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Ananindeua, PA, 67030 000, Brasil
    Mem Inst Oswaldo Cruz 102:531-4. 2007
    ..In ORF1a, homology values of 93-100% were detected, and in ORF2 96-99%. Considering the sequence variation (7%) observed in ORF2 region, it was suggested that HAstV-8 strains could be divided in three different lineages...
  30. ncbi request reprint Outbreaks of human-herpes virus 6 (HHV-6) infection in day-care centers in Belém, Pará, Brazil
    R B Freitas
    Serviço de Virologia Geral, Instituto Evandro Chagas, Fundacao Nacional de Saude, Ministerio da Saude, Belem, Para, Brasil
    Rev Inst Med Trop Sao Paulo 42:305-11. 2000
    ..0% (8/401) and 1. 5% (6/401) of the children, respectively. Our data provide strong evidence that HHV-6 is a common cause of outbreaks of febrile/exanthematous diseases among children attending DCCs in the Belém area...
  31. ncbi request reprint Detection of enteroviruses in cases of neurological disorders in the State of Pará, Brazil
    M L Gomes
    Seção de Virologia, Instituto Evandro Chagas, Fundação Nacional da Saúde, Belem, PA, Brasil
    Rev Inst Med Trop Sao Paulo 43:321-4. 2001
    ..6%) had motor deficiency and 3 (33.3%) developed aseptic meningitis. These results show that it is important to investigate enterovirus as cause of these syndromes...
  32. ncbi request reprint Vaccines against rotavirus and human papillomavirus (HPV)
    Alexandre C Linhares
    Instituto Evandro Chagas, Belem, PA, Brazil
    J Pediatr (Rio J) 82:S25-34. 2006
    ..To briefly review strategies aimed at the development of rotavirus and HPV vaccines, with emphasis on the current status of studies assessing the safety, reactogenicity, immunogenicity and efficacy of recently developed vaccines...
  33. ncbi request reprint Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil
    Olinda Macedo
    Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, Para, Brasil
    Rev Inst Med Trop Sao Paulo 46:13-7. 2004
    ..These findings provide evidence that both HTLV-I and HTLV-II play a role in the development of chronic myelopathy in Belém, Pará, Northern Brazil...
  34. ncbi request reprint Efficacy of the human rotavirus vaccine RIX4414 in malnourished children
    Irene Perez-Schael
    Instituto de Biomedicina Fuvesin, Universidad Central de Venezuela, Ministerio de Salud, Caracas, Venezuela
    J Infect Dis 196:537-40. 2007
    ..2% (95% CI, 10.4%-83.1%) for RVGE of any severity, respectively. RIX4414 significantly decreased the rate of RVGE regardless of nutritional status, which suggests that this patient group can also benefit from rotavirus vaccination...
  35. pmc Development and validation of DNA microarray for genotyping group A rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) genes
    Shinjiro Honma
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
    J Clin Microbiol 45:2641-8. 2007
    ..Moreover, because the hybridization patterns exhibited by rotavirus strains of different genotypes can vary, this method may be ideal for analyzing the genetic polymorphisms of the VP7 or VP4 genes of rotaviruses...
  36. pmc Development of a microtiter plate hybridization-based PCR-enzyme-linked immunosorbent assay for identification of clinically relevant human group A rotavirus G and P genotypes
    Norma Santos
    Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS Bl I, Ilha do Fundao, Rio de Janeiro 21 941 590, Brazil
    J Clin Microbiol 46:462-9. 2008
    ....
  37. ncbi request reprint Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis
    Guillermo M Ruiz-Palacios
    Instituto Nacional de Ciencas Medicas y Nutricion, Mexico Distrito Federal, Mexico
    N Engl J Med 354:11-22. 2006
    ..The safety and efficacy of an attenuated G1P[8] human rotavirus (HRV) vaccine were tested in a randomized, double-blind, phase 3 trial...
  38. ncbi request reprint Evaluation of safety, immunogenicity and efficacy of an attenuated rotavirus vaccine, RIX4414: A randomized, placebo-controlled trial in Latin American infants
    Belen Salinas
    Instituto de Biomedicina, Caracas, Venezuela
    Pediatr Infect Dis J 24:807-16. 2005
    ..A live attenuated monovalent rotavirus vaccine RIX4414 was developed with a human strain of G1P1A P[8] specificity to reduce the rotavirus burden in children...
  39. ncbi request reprint A rotavirus vaccine for prophylaxis of infants against rotavirus gastroenteritis
    Beatrice De Vos
    GlaxoSmithKline Biologicals, Rixensart, Belgium
    Pediatr Infect Dis J 23:S179-82. 2004
    ..05) in Latin America. These results show prospects for widespread use of Rotarix to reduce rotavirus disease burden and warrant continued worldwide evaluation...
  40. ncbi request reprint Rotavirus serotypes and electropherotypes identified among hospitalised children in São Luís, Maranhão, Brazil
    Cláudia Regina N E da Luz
    Hospital Universitario Materno Infantil, Universidade Federal do Maranhao, Sao Luis, Maranhao, Brazil
    Rev Inst Med Trop Sao Paulo 47:287-93. 2005
    ..These data underscore the importance of rotaviruses in the aetiology of severe infantile gastroenteritis in Northeastern Brazil and sustain the concept that a future vaccine should confer protection against more than one serotype...