Fernando Fratelli

Summary

Affiliation: Instituto Butantan
Country: Brazil

Publications

  1. ncbi Effect of medium composition on the production of tetanus toxin by Clostridium tetani
    Fernando Fratelli
    Division of Technology and Production Development of Institute Butantan, Av Vital Brazil, 1500, 05504 900 São Paulo SP, Brazil
    Biotechnol Prog 21:756-61. 2005
  2. doi Fed-batch production of tetanus toxin by Clostridium tetani
    Fernando Fratelli
    Div of Technology and Production Development of Institute Butantan, Av Vital Brasil, 1500, 05503 900 Sao Paulo, SP, Brazil
    Biotechnol Prog 26:88-92. 2010
  3. ncbi Development of an operational synaptobrevin-based fluorescent substrate for tetanus neurotoxin quantification
    Elen A Perpetuo
    Laboratory of Biochemistry and Biophysics, Center of Applied Toxinology, CEPID, Av Vital Brasil, 1500 Butantan, 05503 900 Sao Paulo, SP, Brazil
    Biotechnol Appl Biochem 36:155-61. 2002

Collaborators

  • A Converti
  • Elen A Perpetuo
  • Sally M Prado
  • Irene Fernandes
  • Ivo Lebrun
  • Luis Juliano

Detail Information

Publications3

  1. ncbi Effect of medium composition on the production of tetanus toxin by Clostridium tetani
    Fernando Fratelli
    Division of Technology and Production Development of Institute Butantan, Av Vital Brazil, 1500, 05504 900 São Paulo SP, Brazil
    Biotechnol Prog 21:756-61. 2005
    ..The highest final average yield of tetanus toxin (72 Lf/mL), achieved at G0= 9.7 g/L and NZ0= 43.5 g/L, was 80% higher than that obtained with standard cultivations (G0= 8.0 g/L and NZ0= 25.0 g/L)...
  2. doi Fed-batch production of tetanus toxin by Clostridium tetani
    Fernando Fratelli
    Div of Technology and Production Development of Institute Butantan, Av Vital Brasil, 1500, 05503 900 Sao Paulo, SP, Brazil
    Biotechnol Prog 26:88-92. 2010
    ..The results of this work promise to substantially improve the present production of tetanus toxin and may be adopted for human vaccine production after detoxification and purification...
  3. ncbi Development of an operational synaptobrevin-based fluorescent substrate for tetanus neurotoxin quantification
    Elen A Perpetuo
    Laboratory of Biochemistry and Biophysics, Center of Applied Toxinology, CEPID, Av Vital Brasil, 1500 Butantan, 05503 900 Sao Paulo, SP, Brazil
    Biotechnol Appl Biochem 36:155-61. 2002
    ..It is a good alternative to some of the existing methods such as flocculation assay, and it can replace, under some conditions, the biological assays (minimal mortal dose)...