Frederico G Graeff

Summary

Country: Brazil

Publications

  1. ncbi request reprint Comparison between two models of experimental anxiety in healthy volunteers and panic disorder patients
    F G Graeff
    Department of Neurology, Psychiatry and Medical Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, SP, Ribeirao Preto, Brazil
    Neurosci Biobehav Rev 25:753-9. 2001
  2. ncbi request reprint Pharmacology of human experimental anxiety
    F G Graeff
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 36:421-32. 2003
  3. ncbi request reprint Serotonin, the periaqueductal gray and panic
    Frederico G Graeff
    Department of Neurology, Psychiatry and Medical Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Brazil
    Neurosci Biobehav Rev 28:239-59. 2004
  4. ncbi request reprint On serotonin and experimental anxiety
    Frederico G Graeff
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, USP, Avenue Nove de Julho, 980, 14025 000 Ribeirão Preto, SP, Brazil
    Psychopharmacology (Berl) 163:467-76. 2002
  5. ncbi request reprint Does the panic attack activate the hypothalamic-pituitary-adrenal axis?
    Frederico G Graeff
    Departmento de Neurologia, Psiquiatria e Psicologia Medica, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14048 900, Brazil
    An Acad Bras Cienc 77:477-91. 2005
  6. ncbi request reprint [Biological basis of posttraumatic stress disorder]
    Frederico G Graef
    Departamento de Neurologia, Psiquiatria e Psicologia Médica Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo Ribeirão Preto, SP, Brasil
    Rev Bras Psiquiatr 25:21-4. 2003
  7. ncbi request reprint [Serotonin, periaqueductal gray matter and panic disorder]
    Frederico G Graeff
    Pós Graduação em Saúde Mental, Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Rev Bras Psiquiatr 25:42-5. 2003
  8. doi request reprint (1)H magnetic resonance spectroscopy imaging of the hippocampus in patients with panic disorder
    Clarissa Trzesniak
    Department of Neuroscience and Behavior, Division of Psychiatry, Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Psychiatry Res 182:261-5. 2010
  9. doi request reprint Regional gray matter abnormalities in panic disorder: a voxel-based morphometry study
    Ricardo R Uchida
    Division of Psychiatry, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Psychiatry Res 163:21-9. 2008
  10. ncbi request reprint Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking
    Cybele Garcia-Leal
    Department of Neurology, Psychiatry and Medical Psychology, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Av 9 de julho, 980, 14025 000 Ribeirão Preto, SP, Brazil
    Psychiatry Res 133:239-52. 2005

Collaborators

  • H Zangrossi
  • F S Guimaraes
  • João Pereira Leite
  • Clarissa Trzesniak
  • L L Melo
  • F M Leal
  • Cristina M Del-Ben
  • C M Del-Ben
  • Ricardo R Uchida
  • José A S Crippa
  • Alexandre C B V Parente
  • Cybele Garcia-Leal
  • Danielle C G de Oliveira
  • D M Vianna
  • Marcia K Kodama Higuchi
  • C Garcia-Leal
  • David Araujo
  • S N Pinheiro
  • Fabio L S Duran
  • R Shuhama
  • Rosana Shuhama
  • Simone H Pinheiro
  • J A S Crippa
  • Telma G C S Andrade
  • D Araujo
  • A C Santos
  • R R Uchida
  • Frederico G Graef
  • A W Zuardi
  • Draulio B de Araujo
  • M Silva
  • Cesar A Q Ferreira
  • L A Hetem
  • Regina H C Queiroz
  • Antonio W Zuardi
  • T G Andrade
  • Vinicius G Guapo
  • J Landeira-Fernandez
  • Wolme C Alves-Neto
  • Tiago A Sanchez
  • Cristina M Del Ben
  • José Fornari
  • R L Nunes-de-Souza
  • Geraldo Busatto-Filho
  • S R Loureiro
  • Antonio C Santos
  • Geraldo F Busatto
  • Sonia R Loureiro
  • Ayrton Custodio Moreira
  • Lucila Leico Kagohara Elias
  • P K McGuire
  • Carlos E A Macedo
  • R Uchida
  • G F Busatto
  • J A Crippa
  • J A Vilela
  • I R Pela
  • R V Fornari
  • A Canto-de-Souza
  • M da-Costa

Detail Information

Publications37

  1. ncbi request reprint Comparison between two models of experimental anxiety in healthy volunteers and panic disorder patients
    F G Graeff
    Department of Neurology, Psychiatry and Medical Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, SP, Ribeirao Preto, Brazil
    Neurosci Biobehav Rev 25:753-9. 2001
    ..Therefore, panic patients seem to process unconditioned fear abnormally, which may be due to lack of 5-HT inhibition in brain structures commanding flight from proximal danger stimuli...
  2. ncbi request reprint Pharmacology of human experimental anxiety
    F G Graeff
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 36:421-32. 2003
    ..In spite of ethical and economic constraints, human experimental anxiety constitutes a valuable tool for the study of the pathophysiology of anxiety disorders...
  3. ncbi request reprint Serotonin, the periaqueductal gray and panic
    Frederico G Graeff
    Department of Neurology, Psychiatry and Medical Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Brazil
    Neurosci Biobehav Rev 28:239-59. 2004
    ..Drugs that impair 5-HT function have the opposite effects. Thus, so far the predictions derived from the above hypothesis have been fulfilled...
  4. ncbi request reprint On serotonin and experimental anxiety
    Frederico G Graeff
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, USP, Avenue Nove de Julho, 980, 14025 000 Ribeirão Preto, SP, Brazil
    Psychopharmacology (Berl) 163:467-76. 2002
    ..B. Dews, W.H. Morse and R.T. Kelleher at the Harvard Medical School, and has evolved until this date...
  5. ncbi request reprint Does the panic attack activate the hypothalamic-pituitary-adrenal axis?
    Frederico G Graeff
    Departmento de Neurologia, Psiquiatria e Psicologia Medica, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14048 900, Brazil
    An Acad Bras Cienc 77:477-91. 2005
    ..Therefore, the panic attack does not seem to activate the HPAaxis, in contrast to anticipatory anxiety...
  6. ncbi request reprint [Biological basis of posttraumatic stress disorder]
    Frederico G Graef
    Departamento de Neurologia, Psiquiatria e Psicologia Médica Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo Ribeirão Preto, SP, Brasil
    Rev Bras Psiquiatr 25:21-4. 2003
    ..Neuroimaging studies evidenced a reduction of hippocampal volume in PTSD patients, which has been related to both cognitive changes and abnormalities of the HPA axis that are found in PTSD...
  7. ncbi request reprint [Serotonin, periaqueductal gray matter and panic disorder]
    Frederico G Graeff
    Pós Graduação em Saúde Mental, Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Rev Bras Psiquiatr 25:42-5. 2003
    ..The main clinical implications are that a 5-HT deficit in the PAG may participate in the pathophysiology of panic disorder and that an enhancement of 5-HT in the same region mediates the anti-panic action of antidepressant drugs...
  8. doi request reprint (1)H magnetic resonance spectroscopy imaging of the hippocampus in patients with panic disorder
    Clarissa Trzesniak
    Department of Neuroscience and Behavior, Division of Psychiatry, Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Psychiatry Res 182:261-5. 2010
    ..Moreover, lower left hippocampal NAA/Cr in panic disorder may possibly reflect neuronal loss and/or neuronal metabolic dysfunction, and could be related to a deficit in evaluating ambiguous cues...
  9. doi request reprint Regional gray matter abnormalities in panic disorder: a voxel-based morphometry study
    Ricardo R Uchida
    Division of Psychiatry, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Psychiatry Res 163:21-9. 2008
    ..The abnormal brain stem structures may be involved in the generation of panic attacks...
  10. ncbi request reprint Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking
    Cybele Garcia-Leal
    Department of Neurology, Psychiatry and Medical Psychology, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Av 9 de julho, 980, 14025 000 Ribeirão Preto, SP, Brazil
    Psychiatry Res 133:239-52. 2005
    ..Therefore, SPS does not seem to activate the HPA axis, as reported in panic attacks...
  11. ncbi request reprint Subjective and neurovegetative changes in healthy volunteers and panic patients performing simulated public speaking
    Alexandre C B V Parente
    Department of Neurology, Psychiatry and Medical Psychology, Medical School of Ribeirao Preto, University of Sao Paulo, FMRP USP, Av 9 de Julho 980, 14025 000, Ribeirao Preto, SP, Brazil
    Eur Neuropsychopharmacol 15:663-71. 2005
    ..Chronic treatment with serotonin uptake inhibitors attenuated the differences between panic patients and controls, supporting the participation of serotonin in panic disorder...
  12. ncbi request reprint Elevated mazes as animal models of anxiety: effects of serotonergic agents
    Simone H Pinheiro
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, 14048 900, Brasil
    An Acad Bras Cienc 79:71-85. 2007
    ..Therefore, the elevated T-maze is a promising animal model of generalized anxiety and panic disorder...
  13. doi request reprint Anxiolytic-like effect of oxytocin in the simulated public speaking test
    Danielle C G de Oliveira
    Department of Neurosciences and Behavior, Division of Psychiatry, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Psychopharmacol 26:497-504. 2012
    ..Other parameters evaluated were not significantly affected by OT. The present results show that OT reduces anticipatory anxiety, but does not affect public speaking fear, suggesting that this hormone has anxiolytic properties...
  14. ncbi request reprint Animal defense strategies and anxiety disorders
    Rosana Shuhama
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, 14048 900, Brasil
    An Acad Bras Cienc 79:97-109. 2007
    ..Such evolutionary approach offers a reliable theoretical framework for the study of the biological determinants of anxiety disorders, and a sound basis for psychiatric classification...
  15. doi request reprint Neurobiology of panic disorder: from animal models to brain neuroimaging
    Frederico G Graeff
    Department of Neurology, Psychiatry and Medical Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Neurosci Biobehav Rev 32:1326-35. 2008
    ..The insula and the ACC detect interoceptive stimuli, which are overestimated by panic patients. It is suggested that these brain areas and the PAG are involved in the pathophysiology of panic disorder...
  16. ncbi request reprint [Anxiety, panic and the hypothalamic-pituitary-adrenal axis]
    Frederico G Graeff
    Divisão de Psiquiatria, Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Rev Bras Psiquiatr 29:S3-6. 2007
    ..This article focuses on the differential activation of the hypothalamic-pituitary-adrenal axis in generalized anxiety disorder and panic disorder...
  17. ncbi request reprint The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders
    Frederico G Graeff
    Department of Neurosciences and Behavioral Sciences, Clinical Hospital of the Medical School of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Cent Nerv Syst Agents Med Chem 10:207-17. 2010
    ..This action would result in less activation of the amygdala, medial PFC and insula by warning signals, as shown by the reviewed results obtained with functional neuroimaging in healthy volunteers and patients with anxiety disorders...
  18. doi request reprint Effects of diazepam on BOLD activation during the processing of aversive faces
    Cristina M Del-Ben
    Division of Psychiatry, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Psychopharmacol 26:443-51. 2012
    ..These results suggest that benzodiazepines can differentially modulate brain activation to aversive stimuli, depending on the stimulus features and indicate a role of amygdala and insula in the anxiolytic action of benzodiazepines...
  19. pmc Reciprocal modulation of cognitive and emotional aspects in pianistic performances
    Marcia K Kodama Higuchi
    Department of Neurosciences and Behavior, University of São Paulo School of Medicine at Ribeirão Preto, Ribeirao Preto, Brazil
    PLoS ONE 6:e24437. 2011
    ..However, it is still unclear how cognitive states may influence the pianistic performance. The aim of the present study is to verify the influence of cognitive and affective attention in the piano performances...
  20. ncbi request reprint Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze
    Telma G C S Andrade
    Departamento de Ciencias Biologicas, FCLA, Universidade Estadual Paulista, Av Dom Antonio, 2100, 19 806 900 Assis, SP, Brazil
    Behav Brain Res 153:55-60. 2004
    ..Other neurotransmitter systems that either originate in or pass through the MRN may regulate unconditioned fear...
  21. ncbi request reprint Correlation between voxel based morphometry and manual volumetry in magnetic resonance images of the human brain
    Ricardo R Uchida
    Divisão de Psiquiatria, Faculdade de Medicina de Ribeirao Preto, Hospital das Clinicas, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    An Acad Bras Cienc 80:149-56. 2008
    ..Therefore, narrow filters increase the sensitivity of the correlation procedure, especially when small brain structures are analyzed. The two techniques seem to consistently measure structural volume...
  22. ncbi request reprint Do panic patients process unconditioned fear vs. conditioned anxiety differently than normal subjects?
    C M Del-Ben
    Department of Neurology, Psychiatry and Medical Psychology, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Psychiatry Res 104:227-37. 2001
    ..Nevertheless, conditioning of skin conductance responses to the tone was similar in both groups. Therefore, panic patients seemed to process unconditioned fear abnormally...
  23. ncbi request reprint The elevated T-maze as an experimental model of anxiety
    F G Graeff
    Laboratorio de Psicofarmacologia, FFCLRP e Núcleo de Neurociências e Comportamento da Universidade de São Paulo, Ribeirao Preto, Brazil
    Neurosci Biobehav Rev 23:237-46. 1998
    ..These behavioral and pharmacological results support the view that inhibitory avoidance in the elevated T-maze may be related to generalized anxiety disorder, while one-way escape may be associated with panic disorder...
  24. ncbi request reprint Opposite effects of nefazodone in two human models of anxiety
    M Silva
    Department of Neurology, Psychiatry and Medical Psychology, FFMRP, , Av. Nove de Julho, 980, , SP, Brazil
    Psychopharmacology (Berl) 156:454-60. 2001
    ....
  25. ncbi request reprint Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze
    H Zangrossi
    Faculdade de Medicina de Ribeirao Preto, Departamento de Farmacologia, University of Sao Paulo Ribeirao Preto, SP, Brazil
    Eur J Pharmacol 369:267-70. 1999
    ..The results further implicate gamma-aminobutyric acid (GABA)/benzodiazepine and serotonergic systems within the basolateral/lateral amygdala in the modulation of conditioned anxiety responses...
  26. ncbi request reprint Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam
    R L Nunes-de-Souza
    Laboratorio de Farmacologia, PANT, Fac Ciências Farmacêuticas de Araraquara UNESP, Araraquara, SP, Brazil
    Psychopharmacology (Berl) 150:300-10. 2000
    ..Mice exhibit antinociception after a single experience in the elevated plus maze (EPM), an animal model of anxiety...
  27. doi request reprint Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation
    C Garcia-Leal
    Department of Neurology, Psychiatry and Medical Psychology, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Psychopharmacol 24:683-94. 2010
    ....
  28. ncbi request reprint Bilateral ablation of the auditory cortex in the rat alters conditioned emotional suppression to a sound as appraised through a latent inhibition study
    L L Melo
    Departamento de Fisiologia e Biofisica, IB, CP 6109, UNICAMP, Campinas, SP, Brazil
    Behav Brain Res 88:59-65. 1997
    ..e. in these animals, the latent inhibition effect appeared to be enhanced. Conditioning from one day to the next also varied slightly. Thus, the auditory cortex appears to modulate learning when the conditioned stimulus is a sound...
  29. pmc Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray
    D M Vianna
    , Faculdade Filosofia, , , , SP, Brasil
    Learn Mem 8:164-9. 2001
    ..A discussion on different neural circuitries that might underlie different inhibitory and active defensive behavioral patterns that animals display during threatening situations is presented...
  30. ncbi request reprint Defensive responses to threat scenarios in Brazilians reproduce the pattern of Hawaiian Americans and non-human mammals
    R Shuhama
    Divisão de Psiquiatria, Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 41:324-32. 2008
    ..These data suggest that a basic repertoire of defensive strategies is conserved along the mammalian evolution because they share similar functional benefits in maintaining fitness...
  31. doi request reprint Anxiolytic and panicolytic effects of escitalopram in the elevated T-maze
    S N Pinheiro
    Division of Psychiatry, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Psychopharmacol 22:132-7. 2008
    ..Since no such effect was observed following subchronic administration, it is likely that the mechanisms of the early and late anxiolytic actions of escitalopram are different...
  32. ncbi request reprint Effect of electrolytic and neurotoxic lesions of the median raphe nucleus on anxiety and stress
    T G Andrade
    Departamento de Ciencias Biologicas, FCLA, Universidade Estadual Paulista, Av Dom Antonio, 2100, 19 800 000, SP, Assiz, Brazil
    Pharmacol Biochem Behav 70:1-14. 2001
    ..Restraint increased 5-HT levels. These results implicate 5-HT mechanisms of the median raphe nucleus in the regulation of anxiety and in the genesis of gastric stress ulcers...
  33. ncbi request reprint Defensive freezing evoked by electrical stimulation of the periaqueductal gray: comparison between dorsolateral and ventrolateral regions
    D M Vianna
    , Faculdade de Filosofia, , , 14049-900, , SP, Brazil
    Neuroreport 12:4109-12. 2001
    ..These results suggest that dlPAG and vlPAG are involved on defensive freezing probably through different neural circuitries...
  34. ncbi request reprint Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze
    H Zangrossi
    Department of Pharmacology, School of Medicine, University of Sao Paulo, 14049 901, SP, Ribeirao Preto, Brazil
    Neurosci Biobehav Rev 25:637-45. 2001
    ..Taken together, these results suggest that 5-HT exerts differential control on inhibitory avoidance and escape response in the elevated T-maze, mobilizing different types of 5-HT receptors in key structures implicated in fear/anxiety...
  35. ncbi request reprint Decreased left temporal lobe volume of panic patients measured by magnetic resonance imaging
    R R Uchida
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 36:925-9. 2003
    ..The present results show that panic patients have a decreased volume of the left temporal lobe and indicate the presence of volumetric abnormalities of temporal lobe structures...
  36. ncbi request reprint The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder
    J A S Crippa
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Facudade de Medicina de Ribeirão Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 37:371-4. 2004
    ..09, Fisher's exact test, one-tailed). Thus, we conclude that, while panic disorder may involve septo-hippocampal dysfunction, it is not associated with an increased prevalence or size of the cavum septum pellucidum...
  37. ncbi request reprint Role of 5-HT in stress, anxiety, and depression
    F G Graeff
    Laboratorio de Psicofarmacologia, FFCLRP, Universidade de Sao Paulo, Ribeirao Preto, Brasil
    Pharmacol Biochem Behav 54:129-41. 1996
    ..Clinical implications of these results are discussed, especially with regard to panic disorder and depression...