Hiro Goto

Summary

Country: Brazil

Publications

  1. pmc The interactions and essential effects of intrinsic insulin-like growth factor-I on Leishmania (Leishmania) major growth within macrophages
    L C Reis
    Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, IMTSP USP, Sao Paulo, Brazil
    Parasite Immunol 35:239-44. 2013
  2. doi Cutaneous and mucocutaneous leishmaniasis
    Hiro Goto
    Department of Preventive Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Infect Dis Clin North Am 26:293-307. 2012
  3. pmc Transmission potential, skin inflammatory response, and parasitism of symptomatic and asymptomatic dogs with visceral leishmaniasis
    B L A Verçosa
    Departamento de Clínica e Cirurgia Veterinária, Centro de Ciencias Agrarias, Universidade Federal do Piaui, Teresina PI, Brasil
    BMC Vet Res 4:45. 2008
  4. pmc T cells, adhesion molecules and modulation of apoptosis in visceral leishmaniasis glomerulonephritis
    Francisco A L Costa
    Departamento de Clínica e Cirurgia Veterinária, Centro de Ciencias Agrarias, Universidade Federal do Piaui, Teresina, PI, Brazil
    BMC Infect Dis 10:112. 2010
  5. pmc High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load
    Joanna R Santos-Oliveira
    Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz FIOCRUZ, Av, Brasil 4365, Rio de Janeiro CEP 21040 360, Brazil
    BMC Infect Dis 10:358. 2010
  6. ncbi Immunoactivation and immunopathogeny during active visceral leishmaniasis
    Hiro Goto
    Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 51:241-6. 2009
  7. doi Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis
    Hiro Goto
    Laboratório de Soroepidemiologia do Instituto de Medicina Tropical da Universidade de São Paulo, Avenida Dr Eneas de Carvalho Aguiar, prédio II, Sao Paulo, SP, Brazil
    Expert Rev Anti Infect Ther 8:419-33. 2010
  8. ncbi Immunity and immunosuppression in experimental visceral leishmaniasis
    H Goto
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo e Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Braz J Med Biol Res 37:615-23. 2004
  9. ncbi Tegumentary leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome in 2 patients with AIDS
    Maria P Posada-Vergara
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Departamento de Doencas Infecciosas e Parasitarias and Instituto de Infectologia Emilio Ribas, Brazil
    J Infect Dis 192:1819-22. 2005
  10. ncbi High-density lipoprotein inhibits the uptake of modified low- density lipoprotein and the expression of CD36 and FcgammaRI
    Márcia Dias Teixeira Carvalho
    Laboratório de Imunofisiopatologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Atheroscler Thromb 17:844-57. 2010

Collaborators

  • Teresa C Silva
  • J A L Lindoso
  • Marcia Ferraz Nogueira
  • Koichiro Abe
  • Tadafumi Kato
  • Masahiro Tomita
  • T Arai
  • Shigeko Torihashi
  • Hiroshi Kimura
  • Hugo P Monteiro
  • Claudia M C Gomes
  • F A L Costa
  • Beatriz Julieta Celeste
  • L C Reis
  • Márcia Dias Teixeira Carvalho
  • Francisco A L Costa
  • R S Torrinhas
  • Joanna R Santos-Oliveira
  • Valéria Marçal Felix de Lima
  • M Inaba
  • B L A Verçosa
  • M Kurahashi
  • Y Niwa
  • M G Prianti
  • M Gidlund
  • T Ando
  • C M V Vendrame
  • A M Da-Cruz
  • S M M S Silva
  • L C B Saldanha
  • Maria P Posada-Vergara
  • B J Celeste
  • Eduardo Milton Ramos-Sanchez
  • Francisco Assis Lima Costa
  • Maria Carmen Arroyo Sanchez
  • Luiz Guilherme M Castro
  • E M Ramos-Sanchez
  • T Onishi
  • K Nishino
  • R Mathias
  • Priscilla Alexandrino de Oliveira
  • Edite Hatsumi Yamashiro-Kanashiro
  • Silvana M M S Silva
  • M M Sales
  • José L Guerra
  • Fabiana Augusta Ikeda
  • Carmem B W Giacoia-Gripp
  • Mary Marcondes Feitosa
  • Daniel Francisco Jacon Ketelhuth
  • Maria G Prianti
  • T Jacintho
  • Célia Maria Vieira Vendrame
  • Valdir S Amato
  • Magnus Gidlund
  • Cláudio N Rossi
  • Marise S Mattos
  • Caris Maroni Nunes
  • Mariza G Morgado
  • Manoel P Oliveira-Neto
  • Alda M Da-Cruz
  • D L Waitzberg
  • Rosemeride Oliveira Vasconcelos
  • P A Oliveira
  • Beatriz Grinsztejn
  • C M Lemos
  • Y Yutani
  • A Fujita
  • Y Ohsaki
  • Y Kumeda
  • S M De Carvalho
  • J Cheng
  • T Fujimoto
  • Y Nishizawa
  • T Takahashi
  • F Hato
  • S Kitagawa
  • I L Mendonça
  • F J O Rios
  • K Ishiguro
  • M Yokoo
  • F Petitto-Assis
  • E R Manuli
  • Y Goto
  • N Hamajima
  • M D T Carvalho
  • O Maeda
  • N Ohmiya
  • E El-Omar
  • O Watanabe
  • M Mattos

Detail Information

Publications31

  1. pmc The interactions and essential effects of intrinsic insulin-like growth factor-I on Leishmania (Leishmania) major growth within macrophages
    L C Reis
    Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, IMTSP USP, Sao Paulo, Brazil
    Parasite Immunol 35:239-44. 2013
    ..This reduced expression was accompanied by a reduction in the cellular parasite load that was completely recovered with the addition of extrinsic IGF-I, which suggests an essential role for IGF-I in Leishmania growth. ..
  2. doi Cutaneous and mucocutaneous leishmaniasis
    Hiro Goto
    Department of Preventive Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Infect Dis Clin North Am 26:293-307. 2012
    ..This article highlights the diversity and complexity of tegumentary leishmaniases, which are worsened by human immunodeficiency virus/Leishmania coinfection...
  3. pmc Transmission potential, skin inflammatory response, and parasitism of symptomatic and asymptomatic dogs with visceral leishmaniasis
    B L A Verçosa
    Departamento de Clínica e Cirurgia Veterinária, Centro de Ciencias Agrarias, Universidade Federal do Piaui, Teresina PI, Brasil
    BMC Vet Res 4:45. 2008
    ..In this study we aimed to identify clinical parameters, reinforced by pathological parameters that characterize dogs with potential to transmit the parasite to the vector...
  4. pmc T cells, adhesion molecules and modulation of apoptosis in visceral leishmaniasis glomerulonephritis
    Francisco A L Costa
    Departamento de Clínica e Cirurgia Veterinária, Centro de Ciencias Agrarias, Universidade Federal do Piaui, Teresina, PI, Brazil
    BMC Infect Dis 10:112. 2010
    ..chagasi that causes visceral leishmaniasis (VL). The similarity of VL manifestation in humans and dogs renders the study of canine VL nephropathy of interest with regard to human pathology...
  5. pmc High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load
    Joanna R Santos-Oliveira
    Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz FIOCRUZ, Av, Brasil 4365, Rio de Janeiro CEP 21040 360, Brazil
    BMC Infect Dis 10:358. 2010
    ..We investigated whether leishmaniasis increases lymphocyte activation in HIV-1 co-infected patients. This might contribute to impaired cellular immune function...
  6. ncbi Immunoactivation and immunopathogeny during active visceral leishmaniasis
    Hiro Goto
    Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 51:241-6. 2009
    ..While current views only consider immunocomplex deposition, macrophages, T cells, cytokines, and immunoglobulins by diverse mechanism also play important roles in the pathogenesis...
  7. doi Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis
    Hiro Goto
    Laboratório de Soroepidemiologia do Instituto de Medicina Tropical da Universidade de São Paulo, Avenida Dr Eneas de Carvalho Aguiar, prédio II, Sao Paulo, SP, Brazil
    Expert Rev Anti Infect Ther 8:419-33. 2010
    ..In addition to a review of the drugs currently utilized, we describe differences in their effectiveness in Old and New World leishmaniasis. HIV/Leishmania coinfection is also presented in the context of diagnosis and treatment...
  8. ncbi Immunity and immunosuppression in experimental visceral leishmaniasis
    H Goto
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo e Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Braz J Med Biol Res 37:615-23. 2004
    ..A better understanding of this complex immune response and the mechanisms of immunosuppression in experimental visceral leishmaniasis will contribute to the study of human disease and to vaccine development...
  9. ncbi Tegumentary leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome in 2 patients with AIDS
    Maria P Posada-Vergara
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Departamento de Doencas Infecciosas e Parasitarias and Instituto de Infectologia Emilio Ribas, Brazil
    J Infect Dis 192:1819-22. 2005
    ..The lesions healed with anti-Leishmania therapy...
  10. ncbi High-density lipoprotein inhibits the uptake of modified low- density lipoprotein and the expression of CD36 and FcgammaRI
    Márcia Dias Teixeira Carvalho
    Laboratório de Imunofisiopatologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Atheroscler Thromb 17:844-57. 2010
    ..The aim of this work was to analyze both the influence of HDL on the uptake of mLDL and the expression of CD36 and Fcgamma I receptors on monocytic cell lines during cell differentiation...
  11. ncbi Characterization of the receptor for insulin-like growth factor on Leishmania promastigotes
    C M Gomes
    Laboratory of Pathology of Infectious Diseases, Department of Pathology, University of Sao Paulo, Brazil
    Exp Parasitol 99:190-7. 2001
    ..Activation of the IGF-I receptor also leads to phosphorylation of an 185-kDa molecule that is homologous to the substrate of the insulin receptor present in human cells, the insulin receptor substrate 1 (IRS-1)...
  12. ncbi Cell activation state influences the modulation of HLA-DR surface expression on human monocytes/macrophages by parenteral fish oil lipid emulsion
    R S Torrinhas
    Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Nutr Hosp 25:462-7. 2010
    ..Further clinical studies evaluating the ideal moment of fish oil LE infusion to modulate leukocyte functions may contribute to a better understanding of its immune modulatory properties...
  13. doi Unusual manifestations of tegumentary leishmaniasis in AIDS patients from the New World
    J A L Lindoso
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo da Universidade de São Paulo, Avenida Dr Enéas de Carvalho Aguiar 500, 05403 000 Sao Paulo, SP, Brazil
    Br J Dermatol 160:311-8. 2009
    ..Comorbidity from tegumentary leishmaniasis and AIDS is poorly characterized...
  14. ncbi Monoclonal antibodies against low density lipoprotein with various degrees of oxidative modifications
    - Gidlund
    Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 29:1625-8. 1996
    ..We conclude that these monoclonal antibodies could be useful to further investigate the role of oxLDL in inflammation and in the immune response...
  15. ncbi Apoptosis of Leishmania (Leishmania) chagasi amastigotes in hamsters infected with visceral leishmaniasis
    Jose A L Lindoso
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Avenida Dr Eneas de Carvalho Aguiar, 470, 05403 000 Sao Paulo, SP, Brazil
    Int J Parasitol 34:1-4. 2004
    ..Apoptosis of Leishmania amastigotes in vivo may constitute a mechanism that regulates growth of the parasite population during infection...
  16. pmc Recombinant Leishmania infantum heat shock protein 83 for the serodiagnosis of cutaneous, mucosal, and visceral leishmaniases
    Beatriz Julieta Celeste
    Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil Departamento de Dermatologia da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil Departamento de Clínica e Cirurgia Veterinária, Centro de Ciências Agrárias CCA, Universidade Federal do Piaui, Teresina, Piaui, Brazil Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 90:860-5. 2014
    ..infantum-rHsp83 as a routine confirmatory serological assay for the diagnosis of Leishmania infection because of the high sensitivity, the specificity, and the insignificant cross-reactivity with other infectious diseases...
  17. doi Diminished CD4+/CD25+ T cell and increased IFN-gamma levels occur in dogs vaccinated with Leishmune in an endemic area for visceral leishmaniasis
    Valéria Marçal Felix de Lima
    Departamento de Clinica, Cirugia e Reproduçãp Animal, Faculdade de Odontologia, Curso de Medicina Veterinaria, Universidade Estadual Paulista Julio de Mesquita Filho, Araçatuba Campus, SP, Brazil
    Vet Immunol Immunopathol 135:296-302. 2010
    ..05), and the vaccine reduced CD4+/CD25+ T cell presence compared to that observed before vaccination. These responses may constitute part of the immune mechanism induced by Leishmune...
  18. ncbi Leishmania (Leishmania) chagasi-infected mice as a model for the study of glomerular lesions in visceral leishmaniasis
    M G Prianti
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Faculdade de Medicina, Universidade de São PauloSão Paulo, SP, Brasil
    Braz J Med Biol Res 40:819-23. 2007
    ..Time-dependent IgG deposits were also seen in infected mice. We consider L. (L.) chagasi-infected mice to be a suitable model for studies of the immunopathogenesis of glomerular lesions in VL...
  19. ncbi Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis
    Marcia Ferraz Nogueira
    Departamento de Dermatologia, Faculdade de Medicina, Universidade de Santo Amaro, Sao Paulo, Brasil
    Rev Inst Med Trop Sao Paulo 50:333-7. 2008
    ..There was no significant difference in IFN-gamma expression between groups. The obtained results suggest the role of IL-4 and IL-5 in the maintenance of the immunopathogenic mechanism of the destructive lesions that characterize MCL...
  20. ncbi Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal inhibition of NOS2 pathway in macrophage in vitro
    C M V Vendrame
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil
    Scand J Immunol 66:287-96. 2007
    ....
  21. ncbi Histopathologic patterns of nephropathy in naturally acquired canine visceral leishmaniasis
    F A L Costa
    Laboratório de Soroepidemiologia e Imunobiologia Celular e Molecular, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil
    Vet Pathol 40:677-84. 2003
    ..Considering that the alterations of canine and human nephropathy in VL are very similar, the data obtained in this study constitute an important contribution to the understanding of canine and human VL nephropathy...
  22. ncbi Detection of immunoglobulin G in the lung and liver of hamsters with visceral leishmaniasis
    R Mathias
    , , , , 470, , , SP, Brazil
    Braz J Med Biol Res 34:539-43. 2001
    ..We conclude that IgG may participate in the pathogenesis of the inflammatory process of the lung and liver occurring in experimental visceral leishmaniasis and we discuss an alternative mechanism other than immune complex deposition...
  23. ncbi Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis
    B J Celeste
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 37:1591-3. 2004
    ..When cross-reactivity was tested, chronic Chagas' disease patients (N = 10) did not show any reactivity. Therefore, we consider this L. infantum Hsp 83 to be a good antigen for routine use for serodiagnosis of tegumentary leishmaniasis...
  24. ncbi A point mutation responsible for human erythrocyte AMP deaminase deficiency
    Y Yamada
    Department of Genetics, Institute for Developmental Research, Aichi Prefectural Colony, Kasugai, Japan
    Hum Mol Genet 3:331-4. 1994
    ..This mis-sense mutation reads to a catalytically inactive enzyme...
  25. ncbi Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a Myc-Max binding motif
    K Nishino
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Int J Cancer 91:851-6. 2001
    ..These results suggested that AdMycTK/GCV therapy is effective on SCLC patients whose tumors overexpress myc family oncogenes...
  26. ncbi An assessment of the immunological status of patients with renal cell carcinoma based on the relative abundance of T-helper 1- and -2 cytokine-producing CD4+ cells in peripheral blood
    T Onishi
    Department of Urology, Aoto University Hospital, Jikei University School of Medicine
    BJU Int 87:755-9. 2001
    ....
  27. ncbi Increased basal phosphorylation of mitogen-activated protein kinases and reduced responsiveness to inflammatory cytokines in neutrophils from patients with rheumatoid arthritis
    M Inaba
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Clin Exp Rheumatol 26:52-60. 2008
    ....
  28. ncbi The interaction of host genetic factors and Helicobacter pylori infection
    T Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Inflammopharmacology 15:10-4. 2007
    ..Prevention of gastric cancer requires the development of better screening strategies for determining eradication candidates and further improvement of treatments of Helicobacter pylori infection...
  29. ncbi [Immunopathologic changes in HIV-Leishmania co-infection]
    A M Da-Cruz
    Laboratorio de Imunoparasitologia, Departamento de Imunologia ioc
    Rev Soc Bras Med Trop 39:75-9. 2006
  30. doi Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut
    M Kurahashi
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
    Neurogastroenterol Motil 20:521-31. 2008
    ..The selective PDGF receptor inhibitor AG1295 suppressed the differentiation of LMC in gut explants. We conclude that PDGF signals play critical roles in the differentiation of LMC in mouse embryonic gut...
  31. ncbi Purine nucleoside kinases in human T- and B-lymphoblasts
    Y Yamada
    Biochim Biophys Acta 761:34-40. 1983
    ..Deoxyadenosine phosphorylating activity in B-lymphoblast extracts was more distinctly inhibited by dCTP than that in T-lymphoblast extracts...