G H Goldman

Summary

Country: Brazil

Publications

  1. ncbi Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles
    G H Goldman
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Biochemistry 36:6488-94. 1997
  2. pmc The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response
    Nádia Graciele Krohn
    Laboratório Nacional de Ciência e Tecnologia do Bioetanol CTBE, Caixa Postal 6170, 13083 970 Campinas, Sao Paulo, Brazil
    G3 (Bethesda) 4:49-62. 2014
  3. pmc Identification of glucose transporters in Aspergillus nidulans
    Thaila Fernanda Dos Reis
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 8:e81412. 2013
  4. pmc Functional characterization of an Aspergillus fumigatus calcium transporter (PmcA) that is essential for fungal infection
    Taisa Magnani Dinamarco
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e37591. 2012
  5. pmc Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans
    Wagner R de Souza
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    PLoS ONE 8:e62088. 2013
  6. pmc Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis
    Ricardo S Almeida
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Brazil
    G3 (Bethesda) 3:1129-41. 2013
  7. pmc The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF)
    Juliana I Hori
    Departmento de Biologia Celular, Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, FMRP USP, 14049 900 Ribeirao Preto, SP, Brazil
    Evid Based Complement Alternat Med 2013:418508. 2013
  8. pmc Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production
    Neil Andrew Brown
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Biotechnol Biofuels 6:91. 2013
  9. pmc Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis
    Patrícia Alves de Castro
    Faculdade de Ciências Farmacêuticas de Ribeirão, Preto Universidade de São Paulo, Sao Paulo, Brazil
    BMC Complement Altern Med 12:194. 2012
  10. pmc Molecular characterization of the putative transcription factor SebA involved in virulence in Aspergillus fumigatus
    Taisa Magnani Dinamarco
    Laboratório Nacional de Ciência e Tecnologia do Bioetanol CTBE, Sao Paulo, Brazil
    Eukaryot Cell 11:518-31. 2012

Collaborators

Detail Information

Publications61

  1. ncbi Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles
    G H Goldman
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Biochemistry 36:6488-94. 1997
    ..These results together suggest that the nuclear fungal topoisomerase I may be sufficiently different from its human counterpart to serve as a molecular target for the development of antifungal drugs...
  2. pmc The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response
    Nádia Graciele Krohn
    Laboratório Nacional de Ciência e Tecnologia do Bioetanol CTBE, Caixa Postal 6170, 13083 970 Campinas, Sao Paulo, Brazil
    G3 (Bethesda) 4:49-62. 2014
    ..Thus, AtmA may represent a link between mitochondrial function and cell cycle or growth, possibly through the influence of the TOR and XprG function. ..
  3. pmc Identification of glucose transporters in Aspergillus nidulans
    Thaila Fernanda Dos Reis
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 8:e81412. 2013
    ..However, only the ΔhxtB mutant strain showed a detectable decreased rate of glucose consumption at low concentrations and an increased resistance to 2-deoxyglucose. ..
  4. pmc Functional characterization of an Aspergillus fumigatus calcium transporter (PmcA) that is essential for fungal infection
    Taisa Magnani Dinamarco
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e37591. 2012
    ..The pmcA-C genes have decreased mRNA abundance into the alveoli in the ΔcalA and ΔcrzA mutant strains. However, only the A. fumigatus ΔpmcA was avirulent in the murine model of invasive pulmonary aspergillosis...
  5. pmc Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans
    Wagner R de Souza
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    PLoS ONE 8:e62088. 2013
    ..The data suggested an intimate relationship among different G-protein coupled receptors, fine-tune regulation of secondary and amino acid metabolisms, and fungal development...
  6. pmc Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis
    Ricardo S Almeida
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Brazil
    G3 (Bethesda) 3:1129-41. 2013
    ..These results stress that in A. nidulans there are calcineurin-dependent and CrzA-independent pathways. In addition, it is possible that CrzA is able to contribute to the modulation of folic acid biosynthesis. ..
  7. pmc The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF)
    Juliana I Hori
    Departmento de Biologia Celular, Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, FMRP USP, 14049 900 Ribeirao Preto, SP, Brazil
    Evid Based Complement Alternat Med 2013:418508. 2013
    ..Altogether, these data indicate that Brazilian green propolis (EPP-AF) extract has a role in regulating the inflammasomes...
  8. pmc Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production
    Neil Andrew Brown
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Biotechnol Biofuels 6:91. 2013
    ..Therefore, the role played by non-essential protein kinases (NPK) and phosphatases (NPP) in the sensing of carbon and/or energetic status was investigated in the model filamentous fungus Aspergillus nidulans...
  9. pmc Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis
    Patrícia Alves de Castro
    Faculdade de Ciências Farmacêuticas de Ribeirão, Preto Universidade de São Paulo, Sao Paulo, Brazil
    BMC Complement Altern Med 12:194. 2012
    ..Here, we extended our understanding of propolis-mediated cell death in the yeast Saccharomyces cerevisiae by applying systems biology tools to analyze the transcriptional profiling of cells exposed to propolis...
  10. pmc Molecular characterization of the putative transcription factor SebA involved in virulence in Aspergillus fumigatus
    Taisa Magnani Dinamarco
    Laboratório Nacional de Ciência e Tecnologia do Bioetanol CTBE, Sao Paulo, Brazil
    Eukaryot Cell 11:518-31. 2012
    ..A. fumigatus SebA plays a complex role, contributing to several stress tolerance pathways and growth under poor nutritional conditions, and seems to be integrated into different stress responses...
  11. pmc Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA
    Frederico M Soriani
    Centro de Ciência e Tecnologia do Bioetanol and Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Sao Paulo, Ribeirão Preto 14040 903, Brazil
    BMC Microbiol 10:12. 2010
    ..Here, we investigate which pathways are influenced by A. fumigatus AfCrzA during a short pulse of calcium by comparatively determining the transcriptional profile of A. fumigatus wild type and DeltaAfcrzA mutant strains...
  12. pmc A reliable measure of similarity based on dependency for short time series: an application to gene expression networks
    Mônica G Campiteli
    Departamento de Ciencias Farmacêuticas Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirao Preto, SP, Brazil
    BMC Bioinformatics 10:270. 2009
    ..This paper introduces a method to quantify dependency between data series composed of few sample points. The method is used to construct gene co-expression subnetworks of highly significant edges...
  13. pmc Transcriptome analysis of Aspergillus niger grown on sugarcane bagasse
    Wagner R de Souza
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Biotechnol Biofuels 4:40. 2011
    ..abstract:..
  14. ncbi Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes
    Gustavo H Goldman
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Fungal Genet Biol 41:428-42. 2004
    ..Furthermore, a comprehensive list of A. nidulans genes involved in different processes of the DNA damage response, as identified by homology of genome sequences with well-characterized human and yeast DNA repair genes, is shown...
  15. ncbi Evaluation of fluconazole resistance mechanisms in candida albicans clinical isolates from HIV-infected patients in Brazil
    Gustavo H Goldman
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 50:25-32. 2004
    ..This is the first comprehensive assessment at molecular level of mechanisms of fluconazole resistance in C. albicans isolates from South America...
  16. pmc Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: identification of putative homologues of Candida albicans virulence and pathogenicity genes
    Gustavo H Goldman
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Eukaryot Cell 2:34-48. 2003
    ..brasiliensis, and provide a broader basis for further progress in understanding its biological peculiarities...
  17. ncbi Identification of genes preferentially expressed in the pathogenic yeast phase of Paracoccidioides brasiliensis, using suppression subtraction hybridization and differential macroarray analysis
    E R Marques
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Mol Genet Genomics 271:667-77. 2004
    ..Although their levels of expression could be different in rich and minimal media, there was a general tendency for these genes to be more highly expressed in the yeast cells...
  18. ncbi The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus
    M E da Silva Ferreira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Med Mycol 43:S313-9. 2005
    ..Although the numbers of ABC transporter encoding genes are comparable, again the Aspergillus spp. have more ABC transporters related to multidrug permease than the other fungal species...
  19. ncbi Molecular characterization of ubiquitin genes from Aspergillus nidulans: mRNA expression on different stress and growth conditions
    M A Noventa-Jordão
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Universidade de Franca, Sao Paulo, Brazil
    Biochim Biophys Acta 1490:237-44. 2000
    ..The ubi1 gene was highly expressed in presence of hydrogen peroxide while the ubi4 mRNA level was not affected; several metals in our experimental conditions were not able to induce either ubi1 nor ubi4 genes...
  20. pmc In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance
    Márcia Eliana da Silva Ferreira
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Antimicrob Agents Chemother 48:4405-13. 2004
    ....
  21. pmc Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa
    M A Van Sluys
    Instituto de Biociência, Universidade de Sao Paulo, R do Matão 227, 05508 900 Sao Paulo, Brazil
    J Bacteriol 185:1018-26. 2003
    ..We conclude that these two organisms have identical metabolic functions and are likely to use a common set of genes in plant colonization and pathogenesis, permitting convergence of functional genomic strategies...
  22. pmc Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis
    A L T O Nascimento
    Centro de Biotecnologia, Instituto Butantan, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Bacteriol 186:2164-72. 2004
    ..Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identified as candidates for development of vaccines for the prevention of leptospirosis...
  23. ncbi Virulence of Paracoccidioides brasiliensis and gp43 expression in isolates bearing known PbGP43 genotype
    Kátia C Carvalho
    Departamento de Microbiologia, Imunologia e Parasitologia, Disciplina de Biologia Celular, UNIFESP, Rua Botucatu, 862, oitavo andar, Sao Paulo, SP 04023 062, Brazil
    Microbes Infect 7:55-65. 2005
    ..We present the first evidence of transcriptional regulation of gp43 expression, but our results suggest that gene expression is also regulated at the protein and/or secretion levels...
  24. doi Jasmonates are phytohormones with multiple functions, including plant defense and reproduction
    N C Avanci
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Genet Mol Res 9:484-505. 2010
    ..is briefly discussed, since some of the main enzymes of the jasmonic acid biosynthesis pathway were identified in a stigma/style expressed sequence tag database (TOBEST) of this Solanaceae species...
  25. ncbi Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole
    Márcia Eliana da Silva Ferreira
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Curr Genet 50:32-44. 2006
    ....
  26. pmc Identification of a topoisomerase I mutant, scsA1, as an extragenic suppressor of a mutation in scaA(NBS1), the apparent homolog of human nibrin in Aspergillus nidulans
    Marcia R Z Kress Fagundes
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, CEP 14040 903 São Paulo, Brazil
    Genetics 164:935-45. 2003
    ..The scsA(TOP1) and the scaA(NBS1) gene products could functionally interact in pathways that either monitor or repair DNA double-strand breaks...
  27. ncbi Molecular characterization of ABC transporter-encoding genes in Aspergillus nidulans
    Adriana Mendes do Nascimento
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Genet Mol Res 1:337-49. 2002
    ..The abcD gene specifies a single transcript of approximately 5.0 kb; there was a two- to six-fold enhancement of mRNA levels following exposure to miconazole, camptothecin, methotrexate, and ethidium bromide...
  28. ncbi Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant
    Iran Malavazi
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Mol Microbiol 66:74-99. 2007
    ..g. phospholipase D); in the ergosterol biosynthesis (plasma membrane microdomains, lipid rafts); and in intracellular trafficking...
  29. ncbi A tobacco cDNA reveals two different transcription patterns in vegetative and reproductive organs
    I daSilva
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:861-8. 2002
    ..Our results suggest that the shorter transcript is related to stress while the larger one is a flower predominant and nonstress-inducible messenger...
  30. ncbi Identification of an unusual VanA element in glycopeptide-resistant Enterococcus faecium in Brazil following international transfer of a bone marrow transplant patient
    I L B C Camargo
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Can J Microbiol 50:767-70. 2004
    ..The genotype and association with a patient previously treated in the USA suggest that this VRE was introduced from abroad, probably through inter-hospital strain spread...
  31. ncbi Functional characterization of the Aspergillus fumigatus calcineurin
    Márcia Eliana da Silva Ferreira
    Faculdade de Ciências Farmacêuticas de Ribeirão, Universidade de Sao Paulo, Brazil
    Fungal Genet Biol 44:219-30. 2007
    ..These results suggest that calcineurin is involved in the regulation of the PHO pathway in A. fumigatus. Our work on calcineurin opens new venues for the research on sensing and nutrient acquisition in A. fumigatus...
  32. ncbi Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia
    Denise O Guimarães
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, USP, Ribeirao Preto, SP, Brazil
    FEMS Immunol Med Microbiol 52:134-44. 2008
    ..The cytotoxic extract produced by the strain VA1 (Glomerella cingulata) was fractionated and yielded nectriapyrone and tyrosol. Nectriapyrone showed relevant cytotoxic activity against both human T leukemia and melanoma tumor cell lines...
  33. pmc Detection and selection of microsatellites in the genome of Paracoccidioides brasiliensis as molecular markers for clinical and epidemiological studies
    Erika Nascimento
    Departamento de Ciências Farmacêuticas de Ribeirão Preto, Universidade de Sao Paulo, Brazil
    J Clin Microbiol 42:5007-14. 2004
    ..We did not observe any correlation between the clinical form of human PCM and four simple sequence repeat patterns analyzed...
  34. pmc Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmA
    Iran Malavazi
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Genetics 173:99-109. 2006
    ..Our results suggest that AtmA regulates the function and/or localization of landmark proteins required for the formation of a polarity axis. We propose that a similar function may contribute to the establishment of neuronal polarity...
  35. doi The Paracoccidioides brasiliensis gp70 antigen is encoded by a putative member of the flavoproteins monooxygenase family
    Juliana T Maricato
    Discipline of Immunology, Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, UNIFESP, Rua Botucatu, 862, Sao Paulo, SP, Brazil
    Fungal Genet Biol 47:179-89. 2010
    ..Therefore, gp70 might play a dual role in P. brasiliensis by both eliciting immune cellular and humoral responses in the host and protecting the fungus from oxidative stress generated by phagocytic cells...
  36. ncbi Transcriptome analysis and molecular studies on sulfur metabolism in the human pathogenic fungus Paracoccidioides brasiliensis
    Márcia Eliana da Silva Ferreira
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903 Ribeirao Preto, Sao Paulo, Brazil
    Mol Genet Genomics 276:450-63. 2006
    ..brasiliensis cannot use inorganic sulfur as a single sulfur source to initiate both M-Y transition and Y growth, the fungus can somehow use both organic and inorganic pathways during these growth processes...
  37. ncbi Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings
    M A Noventa-Jordão
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Microbiology 145:3229-34. 1999
    ..It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress...
  38. ncbi A genomic approach to the understanding of Xylella fastidiosa pathogenicity
    M R Lambais
    Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Av Pádua Dias 11, Cx Postal 09, CEP 13 418 900 Piracicaba, Sao Paulo, Brazil
    Curr Opin Microbiol 3:459-62. 2000
    ..Neither genes encoding members of the type III protein secretion system nor avirulence-like genes have been identified in X. fastidiosa...
  39. pmc Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole
    Adriana M Nascimento
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Antimicrob Agents Chemother 47:1719-26. 2003
    ..fumigatus and/or selection of drug target site mutations are linked to high-level itraconazole resistance and are mechanistic considerations for the emergence of clinical resistance to itraconazole...
  40. pmc Analysis of the Nicotiana tabacum stigma/style transcriptome reveals gene expression differences between wet and dry stigma species
    Andréa C Quiapim
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, 14040 901 São Paulo, Brazil
    Plant Physiol 149:1211-30. 2009
    ....
  41. pmc The Aspergillus nidulans npkA gene encodes a Cdc2-related kinase that genetically interacts with the UvsBATR kinase
    Marcia R V Z Kress Fagundes
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Genetics 167:1629-41. 2004
    ..Our results suggest that the npkA gene plays a role in cell cycle progression during S-phase as well as in a DNA damage signal transduction pathway in A. nidulans...
  42. ncbi Molecular identification of Paracoccidioides brasiliensis by 5' nuclease assay
    Camile P Semighini
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 44:383-6. 2002
    ..The assay could detect at least 10 copies of this DNA sequence, providing efficient accuracy to be useful for diagnosis of paracoccidioidomycosis...
  43. pmc Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae
    Patrícia Alves de Castro
    Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Ribeirao Preto, Sao Paulo, Brazil
    Eukaryot Cell 10:398-411. 2011
    ..Validation studies indicated that propolis sensitivity is dependent on the mitochondrial function and that vacuolar acidification and autophagy are important for yeast cell death caused by propolis...
  44. pmc The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death
    Bárbara de Castro Pimentel Figueiredo
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Eukaryot Cell 10:276-83. 2011
    ..Our results suggest that NucA is not involved in cell death, but it plays a role in the DNA-damaging response in A. nidulans...
  45. ncbi Occurrence of insertion sequences within the genomes and Tn1546-like elements of glycopeptide-resistant enterococci isolated in Brazil, and identification of a novel element, ISEfa5
    Ilana L B C Camargo
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Monte Alegre, Ribeirao Preto, SP, Brazil
    Int J Med Microbiol 294:513-9. 2005
    ..However, the presence of IS-modified Tn1546-like elements, which appear to be rare in Brazil, could be a useful molecular marker in local epidemiological studies to monitor the evolution and horizontal transmission of VanA elements...
  46. ncbi Identification and complete sequencing of novel human transcripts through the use of mouse orthologs and testis cDNA sequences
    Elisa N Ferreira
    Laboratory of Molecular Biology and Genomics, Ludwig Institute for Cancer Research, Sao Paulo, SP, Brazil
    Genet Mol Res 3:493-511. 2004
    ..In silico expression analysis suggests that some of these transcripts are expressed at low levels and in a restricted set of tissues...
  47. pmc Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxy-phenyl pyruvate dioxygenase from Aspergillus nidulans
    Márcia Eliana da Silva Ferreira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Eukaryot Cell 5:1441-5. 2006
    ..We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype...
  48. pmc The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus
    Márcia Eliana da Silva Ferreira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Departamento de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Eukaryot Cell 5:207-11. 2006
    ..fumigatus strain. Deletion of akuB(KU80) had no influence on pathogenicity in a low-dose murine infection model...
  49. pmc Transcriptome analysis of Paracoccidioides brasiliensis cells undergoing mycelium-to-yeast transition
    Luiz R Nunes
    Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes, Brazil
    Eukaryot Cell 4:2115-28. 2005
    ....
  50. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    ..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
  51. pmc The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensis
    Daliang Chen
    Centre for Infectious Diseases, Wolfson Research Institute, School of Biological and Biomedical Sciences, University of Durham Queen s Campus, Stockton on Tees TS17 6BH, UK
    Mol Microbiol 65:761-79. 2007
    ..We have interpreted our findings in terms of a novel signalling mechanism in which the activity of AC is differentially modulated by Gpa1 and Gpb1 to maintain the signal over the 10 days needed for the morphological switch...
  52. ncbi The DNA damage response in filamentous fungi
    Gustavo H Goldman
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Fungal Genet Biol 35:183-95. 2002
    ..Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth...
  53. pmc Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA
    Camile P Semighini
    Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln 68588 0660, USA
    Genetics 173:87-98. 2006
    ..Collectively, our results provide a gateway for probing the diverse functions of PARP in a sophisticated microbial genetic system...
  54. ncbi Identification of transcription elements in the 5' intergenic region shared by LON and MDJ1 heat shock genes from the human pathogen Paracoccidioides brasiliensis. Evaluation of gene expression
    Wagner L Batista
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, UNIFESP, Brazil
    Fungal Genet Biol 44:347-56. 2007
    ..In Pb18, PbMDJ1 seemed to be preferentially expressed in yeast. Our study might help understand regulation of genes involved in fungal adaptation to the host...
  55. pmc SepBCTF4 is required for the formation of DNA-damage-induced UvsCRAD51 foci in Aspergillus nidulans
    Scott E Gygax
    Department of Microbiology, University of Connecticut Health Center, Farmington, 06030 3205, USA
    Genetics 169:1391-402. 2005
    ..We also provide evidence that implicates SepB in sister-chromatid cohesion, thereby suggesting that cohesion may play a role in regulating the localization and/or assembly of UvsC(RAD51) complexes...
  56. pmc A transcript finishing initiative for closing gaps in the human transcriptome
    Mari Cleide Sogayar
    Genome Res 14:1413-23. 2004
    ....
  57. pmc Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
    Natalie D Fedorova
    The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000046. 2008
    ..The role of duplication in the origin of lineage-specific genes is further underlined by the discovery of genomic islands that seem to function as designated "gene dumps" and, perhaps, simultaneously, as "gene factories"...
  58. ncbi Analysis of gene expression in two growth states of Xylella fastidiosa and its relationship with pathogenicity
    Alessandra A de Souza
    Empresa Brasileira de Pesquisa Agropecuária Embrapa, Cordeirópolis SP, Brazil
    Mol Plant Microbe Interact 16:867-75. 2003
    ..This report represents the first study of the transcriptome of this pathogen, which has recently gained more importance, since the genome of several strains has been either partially or entirely sequenced...
  59. pmc Microsatellite analysis of three phylogenetic species of Paracoccidioides brasiliensis
    Daniel R Matute
    Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
    J Clin Microbiol 44:2153-7. 2006
    ..brasiliensis. In addition, this system provides an unambiguous tool for strain discrimination between two (S1 and PS2) of the three phylogenetic species...
  60. ncbi Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
    James E Galagan
    The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA
    Nature 438:1105-15. 2005
    ..These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation...
  61. pmc Analysis and functional annotation of an expressed sequence tag collection for tropical crop sugarcane
    Andre L Vettore
    Centro de Biologia Molecular e Engenharia Genetica, Instituto da Computação, Universidade Estadual de Campinas, 13083 970 Campinas SP, Brazil
    Genome Res 13:2725-35. 2003
    ..This indicated that possibly 33,620 unique genes had been identified and indicated that >90% of the sugarcane expressed genes were tagged...