Research Topics
| G H GoldmanSummaryCountry: Brazil Publications
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Detail Information
Publications
Transcriptional profiling of Saccharomyces cerevisiae exposed to propolisPatrícia Alves de Castro
Faculdade de Ciências Farmacêuticas de Ribeirão, Preto Universidade de São Paulo, Sao Paulo, Brazil
BMC Complement Altern Med 12:194. 2012..Here, we extended our understanding of propolis-mediated cell death in the yeast Saccharomyces cerevisiae by applying systems biology tools to analyze the transcriptional profiling of cells exposed to propolis...- Molecular characterization of the putative transcription factor SebA involved in virulence in Aspergillus fumigatusTaisa Magnani Dinamarco
Laboratório Nacional de Ciência e Tecnologia do Bioetanol CTBE, Sao Paulo, Brazil
Eukaryot Cell 11:518-31. 2012..A. fumigatus SebA plays a complex role, contributing to several stress tolerance pathways and growth under poor nutritional conditions, and seems to be integrated into different stress responses... - Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzAFrederico M Soriani
Centro de Ciência e Tecnologia do Bioetanol and Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Sao Paulo, Ribeirão Preto 14040 903, Brazil
BMC Microbiol 10:12. 2010..Here, we investigate which pathways are influenced by A. fumigatus AfCrzA during a short pulse of calcium by comparatively determining the transcriptional profile of A. fumigatus wild type and DeltaAfcrzA mutant strains... - A reliable measure of similarity based on dependency for short time series: an application to gene expression networksMônica G Campiteli
Departamento de Ciencias Farmacêuticas Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirao Preto, SP, Brazil
BMC Bioinformatics 10:270. 2009..This paper introduces a method to quantify dependency between data series composed of few sample points. The method is used to construct gene co-expression subnetworks of highly significant edges... 
Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazolesG H Goldman
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Brazil
Biochemistry 36:6488-94. 1997..These results together suggest that the nuclear fungal topoisomerase I may be sufficiently different from its human counterpart to serve as a molecular target for the development of antifungal drugs...- Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotesGustavo H Goldman
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Fungal Genet Biol 41:428-42. 2004..Furthermore, a comprehensive list of A. nidulans genes involved in different processes of the DNA damage response, as identified by homology of genome sequences with well-characterized human and yeast DNA repair genes, is shown... - Evaluation of fluconazole resistance mechanisms in candida albicans clinical isolates from HIV-infected patients in BrazilGustavo H Goldman
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Diagn Microbiol Infect Dis 50:25-32. 2004..This is the first comprehensive assessment at molecular level of mechanisms of fluconazole resistance in C. albicans isolates from South America... - Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: identification of putative homologues of Candida albicans virulence and pathogenicity genesGustavo H Goldman
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Eukaryot Cell 2:34-48. 2003..brasiliensis, and provide a broader basis for further progress in understanding its biological peculiarities... - Transcriptome analysis of Aspergillus niger grown on sugarcane bagasseWagner R de Souza
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
Biotechnol Biofuels 4:40. 2011..abstract:.. - Molecular characterization of ubiquitin genes from Aspergillus nidulans: mRNA expression on different stress and growth conditionsM A Noventa Jordão
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Universidade de Franca, Sao Paulo, Brazil
Biochim Biophys Acta 1490:237-44. 2000..The ubi1 gene was highly expressed in presence of hydrogen peroxide while the ubi4 mRNA level was not affected; several metals in our experimental conditions were not able to induce either ubi1 nor ubi4 genes... - In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistanceMárcia Eliana da Silva Ferreira
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
Antimicrob Agents Chemother 48:4405-13. 2004.... - Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosaM A Van Sluys
Instituto de Biociência, Universidade de Sao Paulo, R do Matão 227, 05508 900 Sao Paulo, Brazil
J Bacteriol 185:1018-26. 2003..We conclude that these two organisms have identical metabolic functions and are likely to use a common set of genes in plant colonization and pathogenesis, permitting convergence of functional genomic strategies... - Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesisA L T O Nascimento
Centro de Biotecnologia, Instituto Butantan, Universidade de Sao Paulo, Sao Paulo, Brazil
J Bacteriol 186:2164-72. 2004..Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identified as candidates for development of vaccines for the prevention of leptospirosis... - Virulence of Paracoccidioides brasiliensis and gp43 expression in isolates bearing known PbGP43 genotypeKátia C Carvalho
Departamento de Microbiologia, Imunologia e Parasitologia, Disciplina de Biologia Celular, UNIFESP, Rua Botucatu, 862, oitavo andar, Sao Paulo, SP 04023 062, Brazil
Microbes Infect 7:55-65. 2005..We present the first evidence of transcriptional regulation of gp43 expression, but our results suggest that gene expression is also regulated at the protein and/or secretion levels... - Transcriptome analysis of Aspergillus fumigatus exposed to voriconazoleMárcia Eliana da Silva Ferreira
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
Curr Genet 50:32-44. 2006.... - Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutantIran Malavazi
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Mol Microbiol 66:74-99. 2007..g. phospholipase D); in the ergosterol biosynthesis (plasma membrane microdomains, lipid rafts); and in intracellular trafficking... - Molecular characterization of ABC transporter-encoding genes in Aspergillus nidulansAdriana Mendes do Nascimento
, , , , SP, Brazil
Genet Mol Res 1:337-49. 2002..The abcD gene specifies a single transcript of approximately 5.0 kb; there was a two- to six-fold enhancement of mRNA levels following exposure to miconazole, camptothecin, methotrexate, and ethidium bromide... - Identification of a topoisomerase I mutant, scsA1, as an extragenic suppressor of a mutation in scaA(NBS1), the apparent homolog of human nibrin in Aspergillus nidulansMarcia R Z Kress Fagundes
, , , Brazil
Genetics 164:935-45. 2003..The scsA(TOP1) and the scaA(NBS1) gene products could functionally interact in pathways that either monitor or repair DNA double-strand breaks... - Functional characterization of the Aspergillus fumigatus calcineurinMárcia Eliana da Silva Ferreira
Faculdade de Ciências Farmacêuticas de Ribeirão, Universidade de Sao Paulo, Brazil
Fungal Genet Biol 44:219-30. 2007..These results suggest that calcineurin is involved in the regulation of the PHO pathway in A. fumigatus. Our work on calcineurin opens new venues for the research on sensing and nutrient acquisition in A. fumigatus... - Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmAIran Malavazi
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Genetics 173:99-109. 2006..Our results suggest that AtmA regulates the function and/or localization of landmark proteins required for the formation of a polarity axis. We propose that a similar function may contribute to the establishment of neuronal polarity... - Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifoliaDenise O Guimarães
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, USP, Ribeirao Preto, SP, Brazil
FEMS Immunol Med Microbiol 52:134-44. 2008..The cytotoxic extract produced by the strain VA1 (Glomerella cingulata) was fractionated and yielded nectriapyrone and tyrosol. Nectriapyrone showed relevant cytotoxic activity against both human T leukemia and melanoma tumor cell lines... - Transcriptome analysis and molecular studies on sulfur metabolism in the human pathogenic fungus Paracoccidioides brasiliensisMárcia Eliana da Silva Ferreira
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903 Ribeirao Preto, Sao Paulo, Brazil
Mol Genet Genomics 276:450-63. 2006..brasiliensis cannot use inorganic sulfur as a single sulfur source to initiate both M-Y transition and Y growth, the fungus can somehow use both organic and inorganic pathways during these growth processes... 
The Paracoccidioides brasiliensis gp70 antigen is encoded by a putative member of the flavoproteins monooxygenase familyJuliana T Maricato
Discipline of Immunology, Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, UNIFESP, Rua Botucatu, 862, Sao Paulo, SP, Brazil
Fungal Genet Biol 47:179-89. 2010..Therefore, gp70 might play a dual role in P. brasiliensis by both eliciting immune cellular and humoral responses in the host and protecting the fungus from oxidative stress generated by phagocytic cells...- Detection and selection of microsatellites in the genome of Paracoccidioides brasiliensis as molecular markers for clinical and epidemiological studiesErika Nascimento
, , Brazil
J Clin Microbiol 42:5007-14. 2004..We did not observe any correlation between the clinical form of human PCM and four simple sequence repeat patterns analyzed... - Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlingsM A Noventa Jordão
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
Microbiology 145:3229-34. 1999..It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress... - A genomic approach to the understanding of Xylella fastidiosa pathogenicityM R Lambais
Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Av Pádua Dias 11, Cx Postal 09, CEP 13 418 900 Piracicaba, Sao Paulo, Brazil
Curr Opin Microbiol 3:459-62. 2000..Neither genes encoding members of the type III protein secretion system nor avirulence-like genes have been identified in X. fastidiosa... - Analysis of the Nicotiana tabacum stigma/style transcriptome reveals gene expression differences between wet and dry stigma speciesAndréa C Quiapim
Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, 14040 901 São Paulo, Brazil
Plant Physiol 149:1211-30. 2009.... - Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazoleAdriana M Nascimento
, , , , Brazil
Antimicrob Agents Chemother 47:1719-26. 2003..fumigatus and/or selection of drug target site mutations are linked to high-level itraconazole resistance and are mechanistic considerations for the emergence of clinical resistance to itraconazole... - Molecular identification of Paracoccidioides brasiliensis by 5' nuclease assayCamile P Semighini
, , , , Brazil
Diagn Microbiol Infect Dis 44:383-6. 2002..The assay could detect at least 10 copies of this DNA sequence, providing efficient accuracy to be useful for diagnosis of paracoccidioidomycosis... - The Aspergillus nidulans npkA gene encodes a Cdc2-related kinase that genetically interacts with the UvsBATR kinaseMarcia R V Z Kress Fagundes
, , , CEP 14040-903, , , Brazil
Genetics 167:1629-41. 2004..Our results suggest that the npkA gene plays a role in cell cycle progression during S-phase as well as in a DNA damage signal transduction pathway in A. nidulans... - Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiaePatrícia Alves de Castro
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Ribeirao Preto, Sao Paulo, Brazil
Eukaryot Cell 10:398-411. 2011..Validation studies indicated that propolis sensitivity is dependent on the mitochondrial function and that vacuolar acidification and autophagy are important for yeast cell death caused by propolis... - The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell deathBárbara de Castro Pimentel Figueiredo
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
Eukaryot Cell 10:276-83. 2011..Our results suggest that NucA is not involved in cell death, but it plays a role in the DNA-damaging response in A. nidulans... - Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxy-phenyl pyruvate dioxygenase from Aspergillus nidulansMárcia Eliana da Silva Ferreira
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Eukaryot Cell 5:1441-5. 2006..We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype... - Occurrence of insertion sequences within the genomes and Tn1546-like elements of glycopeptide-resistant enterococci isolated in Brazil, and identification of a novel element, ISEfa5Ilana L B C Camargo
, , Monte Alegre, , SP, Brazil
Int J Med Microbiol 294:513-9. 2005..However, the presence of IS-modified Tn1546-like elements, which appear to be rare in Brazil, could be a useful molecular marker in local epidemiological studies to monitor the evolution and horizontal transmission of VanA elements... - Identification and complete sequencing of novel human transcripts through the use of mouse orthologs and testis cDNA sequencesElisa N Ferreira
Laboratory of Molecular Biology and Genomics, Ludwig Institute for Cancer Research, , SP, Brazil
Genet Mol Res 3:493-511. 2004..In silico expression analysis suggests that some of these transcripts are expressed at low levels and in a restricted set of tissues... - The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatusMárcia Eliana da Silva Ferreira
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Departamento de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av do Cafe S N, CEP 14040 903, Ribeirao Preto, Sao Paulo, Brazil
Eukaryot Cell 5:207-11. 2006..fumigatus strain. Deletion of akuB(KU80) had no influence on pathogenicity in a low-dose murine infection model... - The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensisDaliang Chen
Centre for Infectious Diseases, Wolfson Research Institute, School of Biological and Biomedical Sciences, University of Durham Queen s Campus, Stockton on Tees TS17 6BH, UK
Mol Microbiol 65:761-79. 2007..We have interpreted our findings in terms of a novel signalling mechanism in which the activity of AC is differentially modulated by Gpa1 and Gpb1 to maintain the signal over the 10 days needed for the morphological switch... - SepBCTF4 is required for the formation of DNA-damage-induced UvsCRAD51 foci in Aspergillus nidulansScott E Gygax
Department of Microbiology, University of Connecticut Health Center, Farmington, 06030 3205, USA
Genetics 169:1391-402. 2005..We also provide evidence that implicates SepB in sister-chromatid cohesion, thereby suggesting that cohesion may play a role in regulating the localization and/or assembly of UvsC(RAD51) complexes... - Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatusWilliam C Nierman
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Nature 438:1151-6. 2005..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus... - Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpACamile P Semighini
Plant Science Initiative and Department of Plant Pathology, University of Nebraska, Lincoln 68588 0660, USA
Genetics 173:87-98. 2006..Collectively, our results provide a gateway for probing the diverse functions of PARP in a sophisticated microbial genetic system... - Identification of transcription elements in the 5' intergenic region shared by LON and MDJ1 heat shock genes from the human pathogen Paracoccidioides brasiliensis. Evaluation of gene expressionWagner L Batista
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, UNIFESP, Brazil
Fungal Genet Biol 44:347-56. 2007..In Pb18, PbMDJ1 seemed to be preferentially expressed in yeast. Our study might help understand regulation of genes involved in fungal adaptation to the host... - Transcriptome analysis of Paracoccidioides brasiliensis cells undergoing mycelium-to-yeast transitionLuiz R Nunes
, Universidade de Mogi das Cruzes, Brazil
Eukaryot Cell 4:2115-28. 2005.... - The DNA damage response in filamentous fungiGustavo H Goldman
Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Fungal Genet Biol 35:183-95. 2002..Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth... - A transcript finishing initiative for closing gaps in the human transcriptomeMari Cleide Sogayar
Genome Res 14:1413-23. 2004.... - Analysis and functional annotation of an expressed sequence tag collection for tropical crop sugarcaneAndre L Vettore
Centro de Biologia Molecular e Engenharia Genetica, Instituto da Computação, Universidade Estadual de Campinas, 13083 970 Campinas SP, Brazil
Genome Res 13:2725-35. 2003..This indicated that possibly 33,620 unique genes had been identified and indicated that >90% of the sugarcane expressed genes were tagged... - Analysis of gene expression in two growth states of Xylella fastidiosa and its relationship with pathogenicityAlessandra A de Souza
Empresa Brasileira de Pesquisa Agropecuária Embrapa, Cordeirópolis SP, Brazil
Mol Plant Microbe Interact 16:867-75. 2003..This report represents the first study of the transcriptome of this pathogen, which has recently gained more importance, since the genome of several strains has been either partially or entirely sequenced... - Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzaeJames E Galagan
The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA
Nature 438:1105-15. 2005..These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation... - Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatusNatalie D Fedorova
The J Craig Venter Institute, Rockville, Maryland, United States of America
PLoS Genet 4:e1000046. 2008.... - Microsatellite analysis of three phylogenetic species of Paracoccidioides brasiliensisDaniel R Matute
, , Colombia
J Clin Microbiol 44:2153-7. 2006..brasiliensis. In addition, this system provides an unambiguous tool for strain discrimination between two (S1 and PS2) of the three phylogenetic species...