Daniel Pens Gelain

Summary

Country: Brazil

Publications

  1. ncbi request reprint Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Laboratório 32, Rua Ramiro Barcelos 2600 anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:1123-7. 2008
  2. pmc Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
    Lucindo Quintans-Júnior
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, 90035 003 Porto Alegre, RS, Brazil
    ISRN Toxicol 2013:459530. 2013
  3. pmc Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways
    Daniel Pens Gelain
    Center for Oxidative Stress Research, Department of Biochemistry, Federal University of Rio Grande do Sul Porto Alegre, RS, Brazil
    Acta Pharmacol Sin 33:558-67. 2012
  4. ncbi request reprint Evidence of increased reactive species formation by retinol, but not retinoic acid, in PC12 cells
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Lab 32 Rua Ramiro Bracelos, 2600, Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:553-8. 2008
  5. ncbi request reprint Serum heat shock protein 70 levels, oxidant status, and mortality in sepsis
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Shock 35:466-70. 2011
  6. ncbi request reprint Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells
    Daniel P Gelain
    Centro de Estudos em Estresse Oxidativo, Brazil
    Cell Signal 18:1685-94. 2006
  7. ncbi request reprint Effects of follicle-stimulating hormone and vitamin A upon purinergic secretion by rat Sertoli cells
    Daniel Pens Gelain
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Cell Biochem 278:185-94. 2005
  8. ncbi request reprint Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Toxicology 289:38-44. 2011
  9. ncbi request reprint Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Chem Biol Interact 174:38-43. 2008
  10. pmc Major components of energy drinks (caffeine, taurine, and guarana) exert cytotoxic effects on human neuronal SH-SY5Y cells by decreasing reactive oxygen species production
    Fares Zeidán-Chuliá
    Department of Biochemistry, Center of Oxidative Stress Research, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Oxid Med Cell Longev 2013:791795. 2013

Collaborators

  • Fabio Klamt
  • Alfeu Zanotto-Filho
  • Felipe Dal-Pizzol
  • Fares Zeidán-Chuliá
  • Fernanda Freitas Caregnato
  • Guilherme Antonio Behr
  • Rafael Calixto Bortolin
  • Veli Jukka Uitto
  • Ulvi Kahraman Gursoy
  • Fabiana Horn
  • Elizandra Braganhol
  • Flavio Kapczinski
  • Rodrigo J S Dalmolin
  • Joao Quevedo
  • Ivana Grivicich
  • Carmem Gottfried
  • Martin Cammarota
  • Ivan Izquierdo
  • Alexandra Latini
  • Leonardo R Bonjardim
  • Rodrigo B Leal
  • Juciano Gasparotto
  • Jose Claudio Fonseca Moreira
  • Matheus Augusto de Bittencourt Pasquali
  • Ramatis Birnfeld de Oliveira
  • Matheus A B Pasquali
  • Nauana Somensi
  • Jose C F Moreira
  • Alice Kunzler
  • Carolina Saibro Girardi
  • Carlos Eduardo Schnorr
  • Ricardo Fagundes da Rocha
  • André Simões Pires
  • Lucindo José Quintans-Junior
  • Leonardo da Silva Bittencourt
  • Valquiria Linck Bassani
  • Karla Suzana Moresco
  • Francini Kiyono Jorge Yatsu
  • Marcelo Sartori Grunwald
  • Mario Roberto Senger
  • André Simões-Pires
  • Francis Jackson O Paludo
  • Lucindo Quintans-Júnior
  • Laura Milán Vasques
  • Maurílio da Silva Morrone
  • Luiz F Souza
  • Rafael Schröder
  • Mario Luiz Conte da Frota Junior
  • Marcos Roberto de Oliveira
  • Fernanda Martins Lopes
  • André Quincozes-Santos
  • Jose Claudio F Moreira
  • Amâncio Romanelli Ferreira
  • Alfeu Zanotto Filho
  • Glória R R F Kaiser
  • Cristiane Ritter
  • Emerson André Casali
  • Adriana Degrossoli
  • Salvatore Giovanni De Simone
  • Celeste da Silva Freitas de Souza
  • Floriano Paes Silva-Jr
  • Kátia da Silva Calabrese
  • Vitor Miranda Ramos
  • Maria do Carmo Bassols Raseira
  • Thallita Kelly Rabelo
  • Eduardo Antônio Kolling
  • Cinthia Maria Schöler
  • José Cláudio Fonseca Moreira
  • Diogo Ribeiro Demartini
  • Paulo Ivo Homem de Bittencourt
  • André Simões Pires
  • Alexsandro Branco
  • Marcia Vizzotto
  • Soheyla M S Rabie
  • Reinaldo Nóbrega de Almeida
  • Clarice S Alho
  • Andressa Córneo Gazola
  • Pollyana S S Lima
  • Freddy A Ramos
  • Lucindo José Quintans Júnior
  • André S Pires
  • Jullyana S S Quintans
  • Geison Modesti Costa
  • Adriano Martimbianco de Assis
  • Adriano A S Araújo
  • Flávio Henrique Reginatto
  • João Paulo Almeida dos Santos
  • Thallita K Rabelo
  • Floriano Paes Silva
  • Silvana Maria Zucolotto

Detail Information

Publications49

  1. ncbi request reprint Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Laboratório 32, Rua Ramiro Barcelos 2600 anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:1123-7. 2008
    ....
  2. pmc Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
    Lucindo Quintans-Júnior
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, 90035 003 Porto Alegre, RS, Brazil
    ISRN Toxicol 2013:459530. 2013
    ....
  3. pmc Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways
    Daniel Pens Gelain
    Center for Oxidative Stress Research, Department of Biochemistry, Federal University of Rio Grande do Sul Porto Alegre, RS, Brazil
    Acta Pharmacol Sin 33:558-67. 2012
    ..Thus, we investigated the pathways involved in the induction of proliferation, deformation and proliferative focus formation by retinol in cultured Sertoli cells of rats...
  4. ncbi request reprint Evidence of increased reactive species formation by retinol, but not retinoic acid, in PC12 cells
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Lab 32 Rua Ramiro Bracelos, 2600, Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:553-8. 2008
    ..These results suggest that vitamin A-associated cytotoxicity is probably related to an oxidant mechanism dependent on iron and calcium, and the formation of intracellular reactive species is related to retinol, but not to RA...
  5. ncbi request reprint Serum heat shock protein 70 levels, oxidant status, and mortality in sepsis
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Shock 35:466-70. 2011
    ..We concluded that serum HSP70 levels are modulated according to the patient oxidant status, and increased serum HSP70 is associated to mortality in sepsis...
  6. ncbi request reprint Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells
    Daniel P Gelain
    Centro de Estudos em Estresse Oxidativo, Brazil
    Cell Signal 18:1685-94. 2006
    ....
  7. ncbi request reprint Effects of follicle-stimulating hormone and vitamin A upon purinergic secretion by rat Sertoli cells
    Daniel Pens Gelain
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Cell Biochem 278:185-94. 2005
    ..These data indicate that purinergic signaling may be involved in the control and/or regulation of some of the reproductive-related actions of these hormones...
  8. ncbi request reprint Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Toxicology 289:38-44. 2011
    ..Altogether, these data indicate that RAGE up-regulation by retinol is mediated by the free radical-dependent activation of p38 and Akt...
  9. ncbi request reprint Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Chem Biol Interact 174:38-43. 2008
    ....
  10. pmc Major components of energy drinks (caffeine, taurine, and guarana) exert cytotoxic effects on human neuronal SH-SY5Y cells by decreasing reactive oxygen species production
    Fares Zeidán-Chuliá
    Department of Biochemistry, Center of Oxidative Stress Research, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Oxid Med Cell Longev 2013:791795. 2013
    ..To elucidate the morphological and biochemical in vitro effects exerted by caffeine, taurine, and guarana, alone or in combination, since they are major components in energy drinks (EDs)...
  11. ncbi request reprint In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox
    Mario Luiz Conte da Frota Junior
    Center of Oxidative Stress Research, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brazil
    Mol Cell Biochem 358:325-34. 2011
    ..Therefore, our data demonstrate that concomitant decreases in basal reactive oxygen species (ROS) production could exert a positive effect on the neuritogenic process of RA-treated SH-SY5Y cells...
  12. ncbi request reprint Can electrons travel through actin microfilaments and generate oxidative stress in retinol treated Sertoli cell?
    Ramatis Birnfeld de Oliveira
    Departamento de Bioquimica, Centro de Estudos em Estresse Oxidativo, Laboratório 32, ICBS Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS, Brazil
    Mol Cell Biochem 301:33-45. 2007
    ..Our results suggested that actin cytoskeleton is essential to oxidative stress production induced by retinol treatment, and electrons conduction through actin microfilaments can be the key of this correlation...
  13. ncbi request reprint Extracellular inosine is modulated by H2O2 and protects sertoli cells against lipoperoxidation and cellular injury
    Daniel Pens Gelain
    Laboratório de Transdução de Sinal em Células Testiculares, Departamento de Bioquimica, Institute de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Free Radic Res 38:37-47. 2004
    ..These effects were abolished in the presence of nucleoside uptake inhibitors, indicating that nucleoside internalisation is essential for its action in preventing cell damage...
  14. ncbi request reprint Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells
    Matheus Augusto de Bittencourt Pasquali
    Centro de Estudos em Estresse Oxidativo Lab 32, Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Cell Signal 25:939-54. 2013
    ..Taken together, our results indicate a pro-oxidant effect of retinol on A549 cells, and suggest that modulation of RAGE expression by retinol is mediated by the redox-dependent activation of p38/NF-kB signaling pathway...
  15. ncbi request reprint Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice
    Ramatis Birnfeld de Oliveira
    Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, Centro de Estudos em Estresse Oxidativo, Porto Alegre, RS, Brazil
    Int J Parasitol 43:371-9. 2013
    ..We believe that these results demonstrate for the first time that changes in the redox profile and expression of tissue-specific proteins of organs such as heart, lungs and brain are observed in early stages of S. mansoni infection...
  16. ncbi request reprint Morphological and oxidative alterations on Sertoli cells cytoskeleton due to retinol-induced reactive oxygen species
    Ramatis Birnfeld de Oliveira
    Departamento de Bioquimica, Centro de Estudos em Estresse Oxidativo, ICBS Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos 2600 anexo, CEP 90035 003, Porto Alegre, Brasil
    Mol Cell Biochem 271:189-96. 2005
    ..We believe that the results from this study indicate an adaptation of the cytoskeleton to oxidative imbalance since there was not a loss of its function...
  17. ncbi request reprint Modulation in reproductive tissue redox profile in sexually receptive female rats after short-term exposure to male chemical cues
    Guilherme Antonio Behr
    Centro de Estudos em Estresse Oxidativo Lab 32, Depto Bioquímica, Universidade Federal do Rio Grande do Sul Av Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Chem Senses 34:317-23. 2009
    ..It is possible that the modifications in the oxidative profile of the female genital tract may have important implications in the process of fertilization...
  18. ncbi request reprint Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models
    Maurílio da Silva Morrone
    Centro de Estudos de Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil Electronic address
    Food Chem Toxicol 60:45-51. 2013
    ..In summary, P. manicata aqueous leaf extract possess protective properties against reactive oxygen species and also protein glycation, and could be considered a new source of natural antioxidants...
  19. ncbi request reprint Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages
    Juciano Gasparotto
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul Porto Alegre, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Cell Biol Toxicol 29:175-87. 2013
    ..These data indicate that STP is able to modulate inflammatory parameters at doses that do not interfere in cell viability...
  20. ncbi request reprint Vitamin A supplementation for different periods alters oxidative parameters in lungs of rats
    Matheus Augusto de Bittencourt Pasquali
    Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, Porte Alegre, Rio Grande do Sul, Brazil
    J Med Food 12:1375-80. 2009
    ..Together, these results suggest that vitamin A supplementation causes significant changes in redox balance, which are frequently associated with severe lung dysfunction...
  21. ncbi request reprint Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage
    Juciano Gasparotto
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul UFRGS Brazil Electronic address
    J Nutr Biochem 25:1282-95. 2014
    ....
  22. ncbi request reprint Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies
    Fernanda Martins Lopes
    Department of Biochemistry, ICBS UFRGS, Porto Alegre RS, Brazil
    Brain Res 1337:85-94. 2010
    ..Our data suggest that SH-SY5Y cells differentiated by 7 days with the protocol described here represent a more suitable experimental model for studying the molecular and cellular mechanisms underlying the pathophysiology of PD...
  23. ncbi request reprint Participation of 47C>T SNP (Ala-9Val polymorphism) of the SOD2 gene in the intracellular environment of human peripheral blood mononuclear cells with and without lipopolysaccharides
    Francis Jackson O Paludo
    Centro de Estudos em Estresse Oxidativo CEEO, Department of Biochemistry, Institute of Basic Health Sciences ICBS, Federal University of Rio Grande do Sul UFRGS, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brazil
    Mol Cell Biochem 372:127-35. 2013
    ....
  24. ncbi request reprint Transcriptomic analysis reveals pH-responsive antioxidant gene networks
    Rodrigo Juliani Siqueira Dalmolin
    Unidade de Bioinformática, Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Front Biosci (Schol Ed) 4:1556-67. 2012
    ..We anticipate that this antioxidant gene network model can be helpful to describe stress-responsive expression profiles in different cell types...
  25. ncbi request reprint Changes in ectonucleotidase activities in rat Sertoli cells during sexual maturation
    Emerson André Casali
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Cell Biochem 247:111-9. 2003
    ..Our results show an increase in the extracellular purine cascade during the Sertoli cell development, indicating a rise in the purine communication inside the seminiferous tubules with rat sexual maturation...
  26. ncbi request reprint L-NAME co-treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation
    Matheus Augusto de Bittencourt Pasquali
    Centro de Estudos em Estresse Oxidativo Lab 32, Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Cell Biochem Funct 30:256-63. 2012
    ....
  27. ncbi request reprint Vitamin A treatment induces apoptosis through an oxidant-dependent activation of the mitochondrial pathway
    Fabio Klamt
    Center of Oxidative Stress Research, Department of Biochemistry, ICBS Federal University of Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Cell Biol Int 32:100-6. 2008
    ..All parameters tested were attenuated or blocked by trolox co-administration, suggesting that retinol induces apoptosis through oxidative damage, which mitochondria plays a pivotal role...
  28. ncbi request reprint Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis
    Juciano Gasparotto
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Brain Behav Immun 43:37-45. 2015
    ..This is the first demonstration of alterations in biochemical parameters of neurodegeneration in an experimental model of Leishmania infection. ..
  29. ncbi request reprint Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring
    Amâncio Romanelli Ferreira
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Life Sci 80:43-50. 2006
    ..Our results suggest that, under our experimental conditions, UHF-EMF is able to induce a genotoxic response in hematopoietic tissue during the embryogenesis through an unknown mechanism...
  30. ncbi request reprint Guarana (Paullinia cupana Mart.) Prevents β-amyloid aggregation, generation of advanced Glycation-end Products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells
    Leonardo da Silva Bittencourt
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Phytother Res 28:1615-24. 2014
    ..Since these are considered typical AD pathological hallmarks, we propose that guarana may deserve further research as a potential therapeutic agent in such a neurodegenerative disease...
  31. ncbi request reprint Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the a549 human lung cancer cell line
    Juciano Gasparotto
    Street Address Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Anticancer Agents Med Chem 14:1128-35. 2014
    ..These data indicate that hecogenin acetate is able to exert anti-cancer effects by modulating reactive species production, inducing cell cycle arrest and senescence and also modulating ERK1/2 phosphorylation and MMP-2 production. ..
  32. ncbi request reprint NFκB inhibitors induce cell death in glioblastomas
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Biochem Pharmacol 81:412-24. 2011
    ..These findings support NFκB as a potential target to cell death induction in GBMs, and that the NFκB inhibitors may be considered for in vivo testing on animal models and possibly on GBM therapy...
  33. ncbi request reprint Effects of chronic elevated ozone concentration on the redox state and fruit yield of red pepper plant Capsicum baccatum
    Rafael Calixto Bortolin
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Istituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul UFRGS, Av Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brasil Electronic address
    Ecotoxicol Environ Saf 100:114-21. 2014
    ..Through a correlation analysis it was possible to observe that polyphenols content was more important to protect pepper plants against oxidative damages to lipids than to proteins...
  34. ncbi request reprint Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line
    Fabio Klamt
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, ICBS Universidade Federal do Rio Grande do Sul, Av Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brazil
    Toxicol In Vitro 22:873-8. 2008
    ..Our data point a role to the use of retinol as an adjuvant in the treatment of tumors with MDR phenotype...
  35. ncbi request reprint Extracellular purines from cells of seminiferous tubules
    Daniel Pens Gelain
    Laboratório de Transdução de Sinal em Células Testiculares, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Cell Biochem 245:1-9. 2003
    ..4 nmol/mg protein). This differential secretion depending on the cellular type suggests that these molecules may be involved in the paracrine regulation and/or control of the maturation processes of these cells...
  36. ncbi request reprint The NF kappa B-mediated control of RS and JNK signaling in vitamin A-treated cells: duration of JNK-AP-1 pathway activation may determine cell death or proliferation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Biochem Pharmacol 77:1291-301. 2009
    ..Taken together, data presented here show that NFkappaB mediates cellular resistance to the pro-oxidant effects of vitamin A by inhibiting RS accumulation and the persistent and redox-dependent activation of JNK-AP-1 cascade...
  37. ncbi request reprint Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells: possible participation in TNF-alpha modulation of ERK 1/2
    Luiz F Souza
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, ICBS UFRGS, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Life Sci 77:3117-26. 2005
    ..These results show that extracellular inosine modulates ERK 1/2 and p38 in cultured Sertoli cells, possible trough A1 adenosine receptor activation. This nucleoside also participates in TNF-alpha modulation of ERK 1/2...
  38. ncbi request reprint Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability
    Lucindo José Quintans-Junior
    Departamento de Fisiologia, Universidade Federal de Sergipe, Campus Universitario, Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, Brazil
    J Orofac Pain 24:305-12. 2010
    ..To evaluate the antinociceptive effects of citronellal (CTL) on formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice and to investigate whether such effects might involve a change in neural excitability...
  39. ncbi request reprint Retinoic acid induces apoptosis by a non-classical mechanism of ERK1/2 activation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Toxicol In Vitro 22:1205-12. 2008
    ..The non-canonical RA signaling presented in this work evokes new perspectives of RA action, which may play an important role in mediating early biological effects of RA modulating cell death in normal and tumor cells...
  40. ncbi request reprint The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity
    Marcelo Sartori Grunwald
    Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Porto Alegre, Rio Grande do Sul, CEP 90035 003, Brazil
    Cell Stress Chaperones 19:913-25. 2014
    ..These results indicate that oxidation of extracellular HSP70 modified its signaling properties, causing alterations on its modulatory effects on macrophage function and viability. ..
  41. ncbi request reprint Retinol and retinoic acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms
    Matheus A B Pasquali
    CEEO, Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Laboratório 32, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, CEP 90035003, Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:1177-83. 2008
    ..In vitro incubation of purified CAT with retinol or RA did not alter enzyme activity...
  42. ncbi request reprint Focussed microarray analysis of apoptosis in periodontitis and its potential pharmacological targeting by carvacrol
    Fares Zeidán-Chuliá
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil Electronic address
    Arch Oral Biol 59:461-9. 2014
    ....
  43. ncbi request reprint Plasma oxidative parameters and mortality in patients with severe burn injury
    Cristiane Ritter
    Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Intensive Care Med 29:1380-3. 2003
    ..To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury...
  44. ncbi request reprint The janus face of resveratrol in astroglial cells
    André Quincozes-Santos
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS, 90035 003, Brazil
    Neurotox Res 16:30-41. 2009
    ..In summary, these findings showed that resveratrol, a redox-active compound, was able to modulate important neurotrophic function of astroglial cells under different oxidative conditions...
  45. ncbi request reprint Metabolism of amino acids by cultured rat Sertoli cells
    Glória R R F Kaiser
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS Rua Ramiro Barcelos, Porto Alegre, Brazil
    Metabolism 54:515-21. 2005
    ..Our present findings show that Sertoli cells can adapt its energy metabolism to the oxidative substrates available to fulfill their role in spermatogenic energetic supply...
  46. ncbi request reprint Vitamin A supplementation induces oxidative stress and decreases the immunocontent of catalase and superoxide dismutase in rat lungs
    Matheus A B Pasquali
    Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, Porto Alegre, Brazil
    Exp Lung Res 35:427-38. 2009
    ..These results altogether suggest that vitamin A supplementation causes significant changes in redox balance the free radical status in lungs, which are frequently associated to severe lung dysfunction...
  47. ncbi request reprint Cadmium stimulates MAPKs and Hsp27 phosphorylation in bovine adrenal chromaffin cells
    Rodrigo B Leal
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicology 234:34-43. 2007
    ..Additionally, Hsp27 is highly phosphorylated in response to the metal exposure, due to p38(MAPK) activation. These biochemical effects of Cd(2+) might disrupt the normal secretory function of these cells...
  48. ncbi request reprint A systematic review of human antioxidant genes
    Daniel P Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos 2600 anexo, Porto Alegre 90035 003, Brazil
    Front Biosci (Landmark Ed) 14:4457-63. 2009
    ..ufrgs.br/icbs/hag we provide a network-based model of human antioxidant genes, which can be used as reference tool to access several database resources (e.g., RefSeq, Ensembl, HGNC and the NCBI Entrez database)...