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- Gattás G, de Carvalho M, Siraque M, Curioni O, Kohler P, Eluf Neto J, et al. Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. Head Neck. 2006;28:819-26 pubmed..4; 95% CI, 1.13-5.10). GSTM1 null alone or associated with CYP1A1 increased the risk of head and neck cancer; the CYP2E1PstI mutated allele increased the risk for only oral cancer. ..