Rodrigo S Galhardo
Silva L, Lorenzetti A, Ribeiro R, Alves I, Leaden L, Galhardo R, et al
. OxyR and the hydrogen peroxide stress response in Caulobacter crescentus. Gene. 2019;700:70-84 pubmed publisher
..It is proposed that besides OxyR, a second layer of regulation may be achieved by a small regulatory RNA and other transcriptional regulators. ..
Lopes Kulishev C, Alves I, Valencia E, Pidhirnyj M, FernÃ¡ndez Silva F, Rodrigues T, et al
. Functional characterization of two SOS-regulated genes involved in mitomycin C resistance in Caulobacter crescentus. DNA Repair (Amst). 2015;33:78-89 pubmed publisher
..crescentus. Based on this data and on structural analysis of a close homolog, we propose that MmcB is an endonuclease which creates substrates for ImuABC-mediated TLS patches. ..
Fonseca M, Sato J, Lima Noronha M, Migliorini L, Fernández Silva F, Galhardo R. Increased mutability to fosfomycin resistance in Proteus mirabilis clinical isolates. Infect Genet Evol. 2018;58:27-33 pubmed publisher
..These strains also show high frequencies of single step mutants with clinically relevant FosR resistance levels (MIC ≥256μg/ml). Our findings point out to the risk of fosfomycin resistance emergence in P. mirabilis. ..
Valencia E, Esposito F, Spira B, Blazquez J, Galhardo R. Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa. ..
Martins Pinheiro M, Oliveira A, Valencia A, Fernández Silva F, Silva L, Lopes Kulishev C, et al
. Molecular characterization of Caulobacter crescentus mutator strains. Gene. 2017;626:251-257 pubmed publisher
..In spite of the limitations of using a single marker, possible reasons for the observed mutational bias are discussed in the light of the repertoire of DNA repair genes in this bacterium. ..
Alves I, Lima Noronha M, Silva L, FernÃ¡ndez Silva F, Freitas A, Marques M, et al
. Effect of SOS-induced levels of imuABC on spontaneous and damage-induced mutagenesis in Caulobacter crescentus. DNA Repair (Amst). 2017;59:20-26 pubmed publisher
..crescentus. Furthermore, these data also show that TLS mediated by ImuABC does not require RecA, unlike umuDC-dependent mutagenesis in E. coli. ..
Martins Pinheiro M, Galhardo R, Lage C, Lima Bessa K, Aires K, Menck C. Different patterns of evolution for duplicated DNA repair genes in bacteria of the Xanthomonadales group. BMC Evol Biol. 2004;4:29 pubmed
..Most of such duplications, in Xanthomonas, seem to have arisen from old events and possibly enlarge both functional and evolutionary genome potentiality. ..