Orestes Vicente Forlenza

Summary

Country: Brazil

Publications

  1. ncbi request reprint Mild cognitive impairment. Part 1: clinical characteristics and predictors of dementia
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, Universidade de Sao Paulo USP, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 35:178-85. 2013
  2. ncbi request reprint Cognitive impairment and dementia in bipolar disorder
    Orestes Vicente Forlenza
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Front Biosci (Elite Ed) 5:258-65. 2013
  3. doi request reprint Does lithium prevent Alzheimer's disease?
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Drugs Aging 29:335-42. 2012
  4. pmc Diagnosis and biomarkers of predementia in Alzheimer's disease
    Orestes V Forlenza
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    BMC Med 8:89. 2010
  5. doi request reprint Diagnostic transitions in mild cognitive impairment subtypes
    Orestes Vicente Forlenza
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Int Psychogeriatr 21:1088-95. 2009
  6. ncbi request reprint Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment
    Orestes V Forlenza
    Department and Institute of Psychiatry, Universidade de Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 32:216-22. 2010
  7. doi request reprint Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 45:220-4. 2011
  8. ncbi request reprint Antidepressant efficacy and safety of low-dose sertraline and standard-dose imipramine for the treatment of depression in older adults: results from a double-blind, randomized, controlled clinical trial
    O V Forlenza
    Instituto de Psiquiatria do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Int Psychogeriatr 13:75-84. 2001
  9. doi request reprint Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27 Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    Br J Psychiatry 198:351-6. 2011
  10. ncbi request reprint Inhibition of phospholipase A2 reduces neurite outgrowth and neuronal viability
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, 05403 010 Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 76:47-55. 2007

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Mild cognitive impairment. Part 1: clinical characteristics and predictors of dementia
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, Universidade de Sao Paulo USP, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 35:178-85. 2013
    ..To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof...
  2. ncbi request reprint Cognitive impairment and dementia in bipolar disorder
    Orestes Vicente Forlenza
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Front Biosci (Elite Ed) 5:258-65. 2013
    ..We hypothesize that dementia may be considered as a long-term feature of BD, which is exacerbated in the presence of other risk factors...
  3. doi request reprint Does lithium prevent Alzheimer's disease?
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Drugs Aging 29:335-42. 2012
    ....
  4. pmc Diagnosis and biomarkers of predementia in Alzheimer's disease
    Orestes V Forlenza
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    BMC Med 8:89. 2010
    ..We further address recent developments in biomarker research to support the early diagnosis and prediction of dementia, and point out the challenges and perspectives for the translation of research data into clinical practice...
  5. doi request reprint Diagnostic transitions in mild cognitive impairment subtypes
    Orestes Vicente Forlenza
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Int Psychogeriatr 21:1088-95. 2009
    ..In this study we address the pattern of transitions between cognitive states in patients with MCI and healthy controls, prior to the conversion to dementia...
  6. ncbi request reprint Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment
    Orestes V Forlenza
    Department and Institute of Psychiatry, Universidade de Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 32:216-22. 2010
    ..To identify predictors of the progression from pre-dementia stages of cognitive impairment in Alzheimer's disease is relevant to clinical management and to substantiate the decision of prescribing antidementia drugs...
  7. doi request reprint Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 45:220-4. 2011
    ....
  8. ncbi request reprint Antidepressant efficacy and safety of low-dose sertraline and standard-dose imipramine for the treatment of depression in older adults: results from a double-blind, randomized, controlled clinical trial
    O V Forlenza
    Instituto de Psiquiatria do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Int Psychogeriatr 13:75-84. 2001
    ..These results indicate that imipramine and sertraline are equally effective for the treatment of major depression in later life, although adverse reactions are more frequent among subjects treated with imipramine than with sertraline...
  9. doi request reprint Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27 Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    Br J Psychiatry 198:351-6. 2011
    ..Two recent clinical studies support the feasibility of trials to evaluate the disease-modifying properties of lithium in Alzheimer's disease, although no benefits were obtained from short-term treatment...
  10. ncbi request reprint Inhibition of phospholipase A2 reduces neurite outgrowth and neuronal viability
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, 05403 010 Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 76:47-55. 2007
    ..We conclude that the functional integrity of both calcium-dependent and calcium-independent cytosolic PLA2 is necessary for the in vitro development of cortical and hippocampal neurons...
  11. ncbi request reprint [The use of antipsychotics in patients with dementia]
    Orestes Vicente Forlenza
    Laboratorio de Neurociencias, Departamento de Psiquiatria, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Rev Bras Psiquiatr 30:265-70. 2008
    ..We discuss the available evidence in the light of the high prevalence of behavioral and psychological symptoms of dementia in this population, along with the greater susceptibility of elderly patients to adverse events...
  12. ncbi request reprint Phospholipase A2 activity in rat embryonic brain and in primary cultures of cortical neurons
    O V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Neural Transm 109:623-31. 2002
    ..We believe that we have produced a useful model for the tissue culture study of PLA(2) metabolism and biochemistry, which can be further addressed to the investigation of the biology of neurodegenerative and neuropsychiatric disorders...
  13. doi request reprint Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment
    Orestes Vicente Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, SP, Brazil
    World J Biol Psychiatry 11:774-80. 2010
    ..We also address the impact of these variables on the progression of cognitive deficits within the MCI-AD continuum...
  14. doi request reprint Higher serum sTNFR1 level predicts conversion from mild cognitive impairment to Alzheimer's disease
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Alzheimers Dis 22:1305-11. 2010
    ..Abnormal activation of TNF-α signaling system, represented by increased expression of sTNFR1, is associated with a higher risk of progression from MCI to AD...
  15. doi request reprint Increased serum IL-1beta level in Alzheimer's disease and mild cognitive impairment
    Orestes Vicente Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Dement Geriatr Cogn Disord 28:507-12. 2009
    ..As these patients are at higher risk of conversion to dementia, we propose that an increased serum IL-1beta level is a stage marker of the ongoing brain neurodegeneration in the continuum between normal ageing and AD...
  16. doi request reprint Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Sao Paulo, Brazil
    World J Biol Psychiatry 11:550-5. 2010
    ..The aim of the present study is to investigate serum BDNF levels in older depressed patients as compared to healthy elderly controls...
  17. doi request reprint Optimizing the CAMCOG test in the screening for mild cognitive impairment and incipient dementia: saving time with relevant domains
    Ivan Aprahamian
    Psychogeriatric Clinic, Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Int J Geriatr Psychiatry 26:403-8. 2011
    ..To identify the CAMCOG sub-items that best contribute for the identification of patients with mild cognitive impairment (MCI) and incipient Alzheimer's disease (AD) in clinical practice...
  18. doi request reprint Profiles of functional deficits in mild cognitive impairment and dementia: benefits from objective measurement
    Fernanda Speggiorin Pereira
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    J Int Neuropsychol Soc 16:297-305. 2010
    ..The objective measurement of the functional state may help identify older adults with increased risk of developing dementia in the MCI-AD continuum...
  19. doi request reprint Verbal fluency in the detection of mild cognitive impairment and Alzheimer's disease among Brazilian Portuguese speakers: the influence of education
    Marcia Radanovic
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Int Psychogeriatr 21:1081-7. 2009
    ..The aim of this study was to compare the accuracy of two semantic categories (animals and fruits) in discriminating controls, MCI patients and Alzheimer's disease (AD) patients...
  20. ncbi request reprint Mild cognitive impairment: cognitive screening or neuropsychological assessment?
    Breno Satler Diniz
    Psychogeriatric Clinic and Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, School of Medicine, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 30:316-21. 2008
    ..We further address the diagnostic properties of the Mini-Mental State Examination and the Cambridge Cognitive Examination for the identification of the different mild cognitive impairment subtypes in clinical practice...
  21. doi request reprint Platelet GSK3B activity in patients with late-life depression: marker of depressive episode severity and cognitive impairment?
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    World J Biol Psychiatry 12:216-22. 2011
    ..The aims of the present study were to determine GSK3B activity in platelets of elderly patients with major depression, and the association between GSK3B activity and the severity of depressive symptoms and cognitive impairment...
  22. doi request reprint Cross-cultural adaptation, reliability and validity of the DAFS-R in a sample of Brazilian older adults
    Fernanda Speggiorin Pereira
    Department and Institute of Psychiatry, University of Sao Paulo, SP, Brazil
    Arch Clin Neuropsychol 25:335-43. 2010
    ..Results suggest that DAFS-BR can document degrees of severity of functional impairment among Brazilian older adults...
  23. doi request reprint Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 3rd Floor, 05403 010 Sao Paulo, S P, Brazil
    J Psychiatr Res 44:917-20. 2010
    ..There was no correlation between serum levels of these inflammatory markers and the severity of depression. Our findings provide additional evidence of the involvement of abnormal pro-inflammatory state in late-life depression...
  24. doi request reprint Diagnosis of mild cognitive impairment revisited after one year. Preliminary results of a prospective study
    Breno Satler Diniz
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Dement Geriatr Cogn Disord 27:224-31. 2009
    ..We aim to determine the cognitive outcome after 1 year of follow-up in a cohort of older adults...
  25. doi request reprint Language impairment in euthymic, elderly patients with bipolar disorder but no dementia
    Marcia Radanovic
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int Psychogeriatr 20:687-96. 2008
    ..The aim of this study is to examine the performance in language tests of a sample of elderly patients with bipolar disorder...
  26. doi request reprint Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease
    Camila Teixeira Mendes
    Laboratory of Neurosciences LIM27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:16-22. 2009
    ..Whereas the direct and indirect inhibitory effects of lithium over GSK3 activity have been documented by several groups, its effects over Gsk3 transcription have not yet been addressed...
  27. ncbi request reprint Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature
    Breno S O Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    World J Biol Psychiatry 9:172-82. 2008
    ..001), along with high T-tau (SMD: 1.52, CI 95% [1.25 to 1.79], P < 0.001), and high P-tau (SMD: 1.75, CI 95% [0.99 to 2.51], P < 0.001), help to predict the conversion to Alzheimer's disease as compared to controls subjects...
  28. ncbi request reprint Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil
    Izabella Dutra de Abreu
    Laboratory of Neuroscience LIM 27, Department of Psychiatry, School of Medicine, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 30:346-9. 2008
    ..To determine the diagnostic accuracy of the Mini-Mental State Examination combined to the Informant Questionnaire on Cognitive Decline in the Elderly for the identification of mild cognitive impairment...
  29. doi request reprint Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients
    Breno Satler Diniz
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Am J Geriatr Psychiatry 18:172-6. 2010
    ..To assess the serum levels of interleukin 1beta (IL-1beta) in elderly depressed patients in comparison with nondepressed healthy elderly subjects...
  30. doi request reprint To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Institute and Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Ovidio Pires de Campos, 785, 3th floor, Sao Paulo, SP, CEP 05403 010, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:248-56. 2009
    ..The objective of this study is to meta-analyze the RCTs conducted with ChEIs in order to assess whether pooled analysis could show the benefit of these drugs in delaying the progression from MCI to AD...
  31. doi request reprint Neurobiological correlates of apathy in Alzheimer's disease and mild cognitive impairment: a critical review
    Florindo Stella
    UNESP Universidade Estadual Paulista, Institute of Biosciences, Campus of Rio Claro SP, Brazil Laboratory of Neurosciences LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Alzheimers Dis 39:633-48. 2014
    ....
  32. doi request reprint White matter abnormalities associated with Alzheimer's disease and mild cognitive impairment: a critical review of MRI studies
    Marcia Radanovic
    Laboratory of Neurosciences, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Expert Rev Neurother 13:483-93. 2013
    ..It can be concluded that WM abnormalities are detectable in early stages of AD and MCI. Degeneration of WM networks causes disconnection among neural cells and the degree of such changes is related to cognitive decline...
  33. ncbi request reprint Formal Thought Disorder and language impairment in schizophrenia
    Marcia Radanovic
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Medical School, Universidade de Sao Paulo, Brazil
    Arq Neuropsiquiatr 71:55-60. 2013
    ..Such efforts may lead to a better understanding about the pathophysiology of this devastating mental disease. We present some current concepts related to FTD as opposed to primary neurolinguistic abnormalities in schizophrenia...
  34. doi request reprint Psychometric characteristics of the Rivermead Behavioural Memory Test (RBMT) as an early detection instrument for dementia and mild cognitive impairment in Brazil
    Monica Sanches Yassuda
    Gerontology Department, School of Arts, Sciences and Humanities, EACH, University of São Paulo corrected
    Int Psychogeriatr 22:1003-11. 2010
    ..The Rivermead Behavioural Memory Test (RBMT) assesses everyday memory by means of tasks which mimic daily challenges. The objective was to examine the validity of the Brazilian version of the RBMT to detect cognitive decline...
  35. ncbi request reprint Platelet phospholipase A(2) activity in Alzheimer's disease and mild cognitive impairment
    W F Gattaz
    Laboratory of Neuroscience, University of Sao Paulo, Brazil
    J Neural Transm 111:591-601. 2004
    ..Further longitudinal studies should investigate whether those MCI individuals with the lowest PLA(2) values in platelets would be at a higher risk to develop AD during a longitudinal follow up...
  36. doi request reprint Higher proportion of inactive Gsk3β in platelets of elderly patients with bipolar disorder: an effect of treatment?
    Rodolfo Braga Ladeira
    Universidade de Sao Paulo, School of Medicine, Department and Institute of Psychiatry, Laboratory of Neuroscience, São PauloSP, Brazil
    Rev Bras Psiquiatr 35:274-8. 2013
    ..Here, we compare Gsk3β inactivation (as indicated by Ser9-phosphorylation) in platelets of elderly patients with bipolar disorder undergoing clinical treatment and healthy elderly adults not taking medication...
  37. doi request reprint Cognitive-linguistic deficits in euthymic elderly patients with bipolar disorder
    Marcia Radanovic
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Affect Disord 150:691-4. 2013
    ..Based on previous findings of pervasive language impairment in euthymic elderly bipolar patients, the aim of this study was to comprise a more thorough investigation on the subject...
  38. ncbi request reprint Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons
    C T Mendes
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Neural Transm 112:1297-308. 2005
    ..We present a model of pharmacological challenge of PLA2 in vitro, which can be further used to address the involvement of the enzyme in neurodevelopment and neurodegeneration models...
  39. ncbi request reprint The role of phospholipase A2 in neuronal homeostasis and memory formation: implications for the pathogenesis of Alzheimer's disease
    O V Forlenza
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm 114:231-8. 2007
    ....
  40. doi request reprint Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment
    F S Pereira
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int Psychogeriatr 20:1104-15. 2008
    ..This study aims to examine the association between executive functions and functional status in a cross-section of older adults with varying degrees of cognitive impairment...
  41. doi request reprint The Brazilian version of the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity in dementia
    Florindo Stella
    Biosciences Institute, Universidade Estadual Paulista, Rio Claro, SP, Brazil
    Int Psychogeriatr 25:1503-11. 2013
    ..The present study is a follow-up to the original, cross-national NPI-C validation, evaluating the reliability and concurrent validity of the NPI-C in quantifying psychopathological symptoms in dementia in a large Brazilian cohort...
  42. doi request reprint The neuroprotective effect of dental pulp cells in models of Alzheimer's and Parkinson's disease
    C Apel
    Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm 116:71-8. 2009
    ..DPCs protected primary neurons in in vitro models of Alzheimer's and Parkinson's disease and can be viewed as possible candidates for studies on cell-based therapy...
  43. ncbi request reprint Reduced phospholipid breakdown in Alzheimer's brains: a 31P spectroscopy study
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27 Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Doutor Ovídio Pires de Campos 785, 05403 010, Sao Paulo, SP, Brazil
    Psychopharmacology (Berl) 180:359-65. 2005
    ..We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD...