Clovis Orlando da Fonseca

Summary

Country: Brazil

Publications

  1. doi request reprint Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma
    Clovis O Da Fonseca
    Departamento de Cirurgia Geral e Especializada, Unidade de Pesquisa Clínica, Hospital Universitario Antonio Pedro, Niteroi, RJ 24030 210, Brazil
    J Cancer Res Clin Oncol 137:287-93. 2011
  2. pmc Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niteroi, RJ, Brazil
    Arch Immunol Ther Exp (Warsz) 56:267-76. 2008
  3. doi request reprint Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niterói 24030 210, RJ, Brazil
    Surg Neurol 70:259-66; discussion 266-7. 2008
  4. ncbi request reprint Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review
    Clovis O Da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, 24030 210 Niterói, RJ, Brazil
    Surg Neurol 66:611-5. 2006
  5. ncbi request reprint Cytoplasmic c-Jun N-terminal immunoreactivity: a hallmark of retinal apoptosis
    Luciana B Chiarini
    Instituto de Biofisica da UFRJ, Rio de Janeiro, Brazil
    Cell Mol Neurobiol 22:711-26. 2002
  6. pmc Cellular prion protein transduces neuroprotective signals
    Luciana B Chiarini
    Instituto de Biofisica da UFRJ, CCS, Bloco G, Cidade Universitaria, 21949 900, Rio de Janeiro, Brasil
    EMBO J 21:3317-26. 2002
  7. doi request reprint Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage
    Hilda Petrs-Silva
    Instituto de Biofisica da UFRJ, CCS, Bloco G, Cidade Universitaria, 21941 900, Rio de Janeiro, Brazil
    Exp Neurol 213:202-9. 2008
  8. doi request reprint Interleukin-4 blocks proliferation of retinal progenitor cells and increases rod photoreceptor differentiation through distinct signaling pathways
    Ana Gabriela Ledo Santos da Silva
    Programa de Neurobiologia, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Bl G, Cidade Universitaria, 21949 900, Rio de Janeiro, RJ, Brazil
    J Neuroimmunol 196:82-93. 2008
  9. ncbi request reprint Differential effects of cyclin-dependent kinase blockers upon cell death in the developing retina
    Stevens K Rehen
    Instituto de Biofisica da UFRJ, Centro de Ciencias da Saude, Bloco G, Cidade Universitaria, 21949 900, Rio de Janeiro, Brazil
    Brain Res 947:78-83. 2002
  10. ncbi request reprint STI1 promotes glioma proliferation through MAPK and PI3K pathways
    Rafael B Erlich
    Departamento de Anatomia, Universidade Federal do Rio de Janeiro, Brazil
    Glia 55:1690-8. 2007

Collaborators

  • Thereza Quirico-Santos
  • G Schwartsmann
  • Rafael Linden
  • Luciana B Chiarini
  • Clovis O Da Fonseca
  • Débora Futuro
  • Clovis Orlando da Fonseca
  • Hilda Petrs-Silva
  • Cerli Rocha Gattass
  • Ana Gabriela Ledo Santos da Silva
  • Rafael B Erlich
  • Tatiana A Americo
  • Santiago Nahuel Villegas
  • Vilma R Martins
  • Vivaldo Moura Neto
  • Fabíola G de Freitas
  • Valeria M Borges
  • Stevens K Rehen
  • Elisabete Freire
  • Regina O Caetano
  • Igor R Lins
  • Marcela Simão
  • Juliana Fischer
  • Alfred Sholl-Franco
  • Janaina Nagel
  • Paula Campello-Costa
  • Angelita G Muras
  • Flavia R S Lima
  • Suzana A Kahn
  • Rodrigo A P Martins
  • Marcos Masini
  • Regina Caetano
  • Brian Njaine
  • Néstor Gabriel Carri
  • George A DosReis
  • José Henrique Leite-Júnior
  • Aviva Tolkovsky
  • Adriana R O Freitas
  • Mona Lisa Leal-Ferreira
  • Mariana Cid
  • Haroldo Falcão
  • Ricardo R Brentani
  • Marcela F Lopes
  • Lucianne Fragel-Madeira
  • Walter A Zin
  • Flavia C A Gomes
  • Tatiana Coelho-Sampaio
  • Patricia R M Rocco
  • Wendy F Davidson
  • Silvio M Zanata

Detail Information

Publications15

  1. doi request reprint Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma
    Clovis O Da Fonseca
    Departamento de Cirurgia Geral e Especializada, Unidade de Pesquisa Clínica, Hospital Universitario Antonio Pedro, Niteroi, RJ 24030 210, Brazil
    J Cancer Res Clin Oncol 137:287-93. 2011
    ..The present study aimed to investigate the efficacy of intranasal administration of monoterpene POH upon survival rate of patients with recurrent glioblastoma (GBM) in comparison with historical control group of GBM patients...
  2. pmc Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niteroi, RJ, Brazil
    Arch Immunol Ther Exp (Warsz) 56:267-76. 2008
    ..Intranasal delivery allows drugs that do not cross the blood-brain barrier to enter the central nervous system. Moreover, it eliminates the need for systemic delivery, thereby reducing unwanted systemic side effects...
  3. doi request reprint Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niterói 24030 210, RJ, Brazil
    Surg Neurol 70:259-66; discussion 266-7. 2008
    ..The intranasal delivery allows drugs that do not cross the BBB to enter the CNS; moreover, it eliminates the need for systemic delivery, thereby reducing unwanted systemic side effects...
  4. ncbi request reprint Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review
    Clovis O Da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, 24030 210 Niterói, RJ, Brazil
    Surg Neurol 66:611-5. 2006
    ..To explore therapeutic strategies and evaluate the clinical results, we report a case of a patient with anaplastic oligodendroglioma managed with intranasal delivery of POH...
  5. ncbi request reprint Cytoplasmic c-Jun N-terminal immunoreactivity: a hallmark of retinal apoptosis
    Luciana B Chiarini
    Instituto de Biofisica da UFRJ, Rio de Janeiro, Brazil
    Cell Mol Neurobiol 22:711-26. 2002
    ..5. Antibodies directed to c-Jun N-terminal (aa 91-105) are useful tools to follow apoptotic changes in retinal tissue...
  6. pmc Cellular prion protein transduces neuroprotective signals
    Luciana B Chiarini
    Instituto de Biofisica da UFRJ, CCS, Bloco G, Cidade Universitaria, 21949 900, Rio de Janeiro, Brasil
    EMBO J 21:3317-26. 2002
    ..Thus, engagement of PrP(c) transduces neuroprotective signals through a cAMP/PKA-dependent pathway. PrP(c) may function as a trophic receptor, the activation of which leads to a neuroprotective state...
  7. doi request reprint Nuclear proteasomal degradation and cytoplasmic retention underlie early nuclear exclusion of transcription factor Max upon axon damage
    Hilda Petrs-Silva
    Instituto de Biofisica da UFRJ, CCS, Bloco G, Cidade Universitaria, 21941 900, Rio de Janeiro, Brazil
    Exp Neurol 213:202-9. 2008
    ....
  8. doi request reprint Interleukin-4 blocks proliferation of retinal progenitor cells and increases rod photoreceptor differentiation through distinct signaling pathways
    Ana Gabriela Ledo Santos da Silva
    Programa de Neurobiologia, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Bl G, Cidade Universitaria, 21949 900, Rio de Janeiro, RJ, Brazil
    J Neuroimmunol 196:82-93. 2008
    ..Taken together, our results show, for the first time, that IL-4 directly modulates proliferation of retinal cells and rod photoreceptor differentiation, through distinct signaling pathways...
  9. ncbi request reprint Differential effects of cyclin-dependent kinase blockers upon cell death in the developing retina
    Stevens K Rehen
    Instituto de Biofisica da UFRJ, Centro de Ciencias da Saude, Bloco G, Cidade Universitaria, 21949 900, Rio de Janeiro, Brazil
    Brain Res 947:78-83. 2002
    ..Our results indicate that cyclin-dependent kinases are involved in the control of sensitivity to cell death in the retina, and that retinal cells present differentiation-dependent responses to modulation of CDK activity...
  10. ncbi request reprint STI1 promotes glioma proliferation through MAPK and PI3K pathways
    Rafael B Erlich
    Departamento de Anatomia, Universidade Federal do Rio de Janeiro, Brazil
    Glia 55:1690-8. 2007
    ..These results provide initial evidence of a new functional role for STI1 on the physiology of human gliomas, and may lead to the identification of new therapeutic targets in these tumors...
  11. ncbi request reprint Signaling induced by hop/STI-1 depends on endocytosis
    Tatiana A Americo
    Instituto de Biofisica da UFRJ, Centro de Ciencias da Saude, Bloco G, Cidade Universitaria, Rio de Janeiro, Brazil
    Biochem Biophys Res Commun 358:620-5. 2007
    ....
  12. ncbi request reprint Structure of laminin substrate modulates cellular signaling for neuritogenesis
    Elisabete Freire
    Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941 590, Brazil
    J Cell Sci 115:4867-76. 2002
    ..We propose that laminin can self-assemble independently of cell contact and that the assembling mode differentially modulates neuritogenesis and neuroplasticity...
  13. ncbi request reprint Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways
    Santiago Nahuel Villegas
    Molecular Biology, IMBICE, Camino Belgrano y 526, CC 403, 1900 La Plata, Argentina Instituto de Biofísica da UFRJ, CCS, Bloco G, Cidade Universitaria, 21949 900 Rio de Janeiro, Brazil
    Brain Res Bull 71:116-26. 2006
    ..These findings provide further insight into the mechanism involved in ethanol-induced apoptosis and the neurotrophic protection of glial cells...
  14. ncbi request reprint Early nuclear exclusion of the transcription factor max is associated with retinal ganglion cell death independent of caspase activity
    Hilda Petrs-Silva
    Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil
    J Cell Physiol 198:179-87. 2004
    ..The data show that nuclear exclusion of the transcription factor Max is an early event, which precedes and is independent of the activation of caspases, during apoptotic cell death in the central nervous system...
  15. ncbi request reprint Apoptosis underlies immunopathogenic mechanisms in acute silicosis
    Valeria M Borges
    Instituto de Biofisica Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil
    Am J Respir Cell Mol Biol 27:78-84. 2002
    ..These results suggest that silica-induced apoptosis plays an inflammatory role in the lung parenchyma, and creates immunologic abnormalities in regional lymph nodes, with pathogenic implications for the host...