Marcelo Ferreira

Summary

Country: Brazil

Publications

  1. ncbi Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations
    Taís N Sousa
    Laboratory of Malaria, Centro de Pesquisa Rene Rachou FIOCRUZ, Belo Horizonte, Brazil
    Malar J 9:334. 2010
  2. ncbi Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam
    Erika H E Hoffmann
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas da Universidade de Sao Paulo, Brazil
    Malar J 2:24. 2003
  3. ncbi Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence
    Daniel E Neafsey
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Genome Biol 9:R171. 2008
  4. ncbi Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies
    Pamela Orjuela-Sánchez
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    BMC Genet 11:65. 2010
  5. ncbi Stable patterns of allelic diversity at the Merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from southern Vietnam
    M U Ferreira
    Department of Medical Zoology, Nagoya University School of Medicine, Japan
    J Eukaryot Microbiol 45:131-6. 1998
  6. ncbi Antigenic diversity and immune evasion by malaria parasites
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, , Av. Prof. Lineu Prestes 1374, , Brazil
    Clin Diagn Lab Immunol 11:987-95. 2004
  7. ncbi Origins and evolution of antigenic diversity in malaria parasites
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Curr Mol Med 7:588-602. 2007
  8. ncbi Bottle feeding and exposure to Toxocara as risk factors for wheezing illness among under-five Amazonian children: a population-based cross-sectional study
    Marcelo Urbano Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, Sao Paulo, SP, Brazil
    J Trop Pediatr 53:119-24. 2007
  9. ncbi Plasmodium falciparum: worldwide sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-2 (MSP-2)
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900 São Paulo SP, Brazil
    Exp Parasitol 115:32-40. 2007
  10. ncbi A community-based survey of human toxoplasmosis in rural Amazonia: seroprevalence, seroconversion rate, and associated risk factors
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 81:171-6. 2009

Research Grants

  1. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Ferreira; Fiscal Year: 2009
  2. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Urbano Ferreira; Fiscal Year: 2010

Collaborators

Detail Information

Publications44

  1. ncbi Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations
    Taís N Sousa
    Laboratory of Malaria, Centro de Pesquisa Rene Rachou FIOCRUZ, Belo Horizonte, Brazil
    Malar J 9:334. 2010
    ..The erythrocyte-binding motif of PvDBP is a 170 amino-acid stretch located in its cysteine-rich region II (PvDBPII), which is the most variable segment of the protein...
  2. ncbi Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam
    Erika H E Hoffmann
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas da Universidade de Sao Paulo, Brazil
    Malar J 2:24. 2003
    ..Here we used microsatellite haplotyping to estimate the genetic distance between isolates carrying identical and nearly identical MSP-1 alleles...
  3. ncbi Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence
    Daniel E Neafsey
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Genome Biol 9:R171. 2008
    ..To that end, we have developed a high throughput single nucleotide polymorphism (SNP) genotyping platform for P. falciparum...
  4. ncbi Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies
    Pamela Orjuela-Sánchez
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    BMC Genet 11:65. 2010
    ..However, levels of genetic diversity and LD in field populations of the major human malaria parasite P. vivax remain little characterized...
  5. ncbi Stable patterns of allelic diversity at the Merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from southern Vietnam
    M U Ferreira
    Department of Medical Zoology, Nagoya University School of Medicine, Japan
    J Eukaryot Microbiol 45:131-6. 1998
    ..This argues against the prominence of frequency-dependent immune selection of PfMSP-1 polymorphisms in this parasite population...
  6. ncbi Antigenic diversity and immune evasion by malaria parasites
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, , Av. Prof. Lineu Prestes 1374, , Brazil
    Clin Diagn Lab Immunol 11:987-95. 2004
  7. ncbi Origins and evolution of antigenic diversity in malaria parasites
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Curr Mol Med 7:588-602. 2007
    ..This review focuses on molecular and evolutionary processes that promote allelic polymorphism and antigenic variation in natural malaria parasite populations and their implications for naturally acquired immunity and vaccine development...
  8. ncbi Bottle feeding and exposure to Toxocara as risk factors for wheezing illness among under-five Amazonian children: a population-based cross-sectional study
    Marcelo Urbano Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, Sao Paulo, SP, Brazil
    J Trop Pediatr 53:119-24. 2007
    ..21, 95% confidence interval (95% CI), 1.07-4.59, P = 0.033], and seropositivity to Toxocara (aOR = 2.37, 95% CI 1.17-4.77, P = 0.016), suggesting two potential targets for public health interventions...
  9. ncbi Plasmodium falciparum: worldwide sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-2 (MSP-2)
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900 São Paulo SP, Brazil
    Exp Parasitol 115:32-40. 2007
    ..1%) isolates, mostly from Africa. We found no evidence for an extremely ancient origin of allelic dimorphism at the msp-2 locus, predating P. falciparum speciation, in contrast with recent findings for other surface malarial antigens...
  10. ncbi A community-based survey of human toxoplasmosis in rural Amazonia: seroprevalence, seroconversion rate, and associated risk factors
    Marcelo U Ferreira
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 81:171-6. 2009
    ..The challenges for preventing human toxoplasmosis in tropical rural settings are discussed...
  11. ncbi Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms
    G Rubinsky-Elefant
    Laboratory of Seroepidemiology and Immunobiology, Institute of Tropical Medicine of São Paulo, Avenida Dr Eneas de Carvalho Aguiar 470, 05403 000, Sao Paulo, SP, Brazil
    Ann Trop Med Parasitol 104:3-23. 2010
    ....
  12. ncbi Evidence-based public health and prospects for malaria control in Brazil
    Marcelo Urbano Ferreira
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Infect Dev Ctries 4:533-45. 2010
    ..We review evidence from field and laboratory studies and identify gaps in our knowledge that require further investigation with well-designed large-scale trials...
  13. ncbi Sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-1 (MSP-1) of Plasmodium falciparum
    Marcelo U Ferreira
    Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900, Sao Paulo SP, Brazil
    Gene 304:65-75. 2003
    ..These results indicate a role for non-homologous recombination, such as strand-slippage mispairing during mitosis and gene conversion, in creating variation in a malarial antigen under strong diversifying selection...
  14. ncbi Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in southern Vietnam
    Marcelo U Ferreira
    Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1374, 05508 900 São Paulo SP, Brazil
    J Clin Microbiol 40:1854-7. 2002
    ..Temporal structure and linkage disequilibrium were also examined in this data set...
  15. ncbi The IgG-subclass distribution of naturally acquired antibodies to Plasmodium falciparum, in relation to malaria exposure and severity
    M U Ferreira
    Departamento de Parasitologia, Universidade de Sao Paulo, Brazil
    Ann Trop Med Parasitol 92:245-56. 1998
    ..75; 95% confidence interval = 1.31-17.42), and may explain, at least partially, the occurrence of defective, low-IgG1 antibody responses to P. falciparum in those subjects who had severe malaria...
  16. ncbi Allelic diversity at the merozoite surface protein-1 (MSP-1) locus in natural Plasmodium falciparum populations: a brief overview
    M U Ferreira
    Departamento de Parasitologia, ICB, Universidade de Sao Paulo, Brasil
    Mem Inst Oswaldo Cruz 93:631-8. 1998
    ..Some epidemiological consequences of these findings are discussed...
  17. ncbi [Secular trends in intestinal parasitic diseases of childhood in the city of São Paulo, Brazil (1984-1996)]
    M U Ferreira
    Departamento de Parasitologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, Sao Paulo, SP, Brasil
    Rev Saude Publica 34:73-82. 2000
    ..Data from two consecutive household surveys undertaken in mid-80s and mid-90s allow to characterize and analyse secular trends in infant and child intestinal parasitic diseases in the city of S. Paulo, Brazil...
  18. ncbi Origins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of Plasmodium falciparum
    Erika H E Hoffmann
    Department of Parasitology, Institute of Biomedical Sciences, , Av. Prof. Lineu Prestes 1374, , Brazil
    Gene 376:224-30. 2006
    ..We conclude that these nonreciprocal recombination events may represent a major source of antigenic diversity in MSP-2 in P. falciparum populations with low rates of classical meiotic recombination...
  19. ncbi Variant-specific antibodies to merozoite surface protein 2 and clinical expression of Plasmodium falciparum malaria in rural Amazonians
    Kézia K G Scopel
    Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Am J Trop Med Hyg 76:1084-91. 2007
    ....
  20. ncbi Plasmodium falciparum: IgG subclass antibody response to merozoite surface protein-1 among Amazonian gold miners, in relation to infection status and disease expression
    Kézia K G Scopel
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte MG, Brazil
    Exp Parasitol 109:124-34. 2005
    ..These negative results underscore the limits of conventional antibody assays to evaluate clinical immunity to malaria...
  21. ncbi Antigenic polymorphism and naturally acquired antibodies to Plasmodium vivax merozoite surface protein 1 in rural Amazonians
    Melissa S Bastos
    Laboratories of Immunoepidemology, Institute of Tropical Medicine of São Paulo, University of Sao Paulo, 05403 000 Sao Paulo, Brazil
    Clin Vaccine Immunol 14:1249-59. 2007
    ....
  22. ncbi Factors associated with immunoglobulin G subclass polarization in naturally acquired antibodies to Plasmodium falciparum merozoite surface proteins: a cross-sectional survey in Brazilian Amazonia
    Kézia K G Scopel
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte MG, Brazil
    Clin Vaccine Immunol 13:810-3. 2006
    ..IgG3 polarization was primarily epitope driven, being little affected by cumulative or current exposure to malaria and not affected by a subject's age and Fcgamma receptor IIA genotype...
  23. ncbi Differential recognition of Plasmodium falciparum merozoite surface protein 2 variants by antibodies from malaria patients in Brazil
    Kelly A Kanunfre
    , , , Brazil
    Clin Diagn Lab Immunol 10:973-6. 2003
    ..The results indicate that variation in MSP-2 repeats may represent a mechanism for parasite immune evasion...
  24. ncbi Evolutionary dynamics of the immunodominant repeats of the Plasmodium vivax malaria-vaccine candidate circumsporozoite protein (CSP)
    Aarti Patil
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Pestes 1374, 05508 900 São Paulo SP, Brazil
    Infect Genet Evol 10:298-303. 2010
    ..New repeat variants may be readily created by nonhomologous recombination even when meiotic recombination is rare, with potential implications for CSP-based vaccine development...
  25. ncbi Extense variant gene family repertoire overlap in Western Amazon Plasmodium falciparum isolates
    Letusa Albrecht
    , , , Brazil
    Mol Biochem Parasitol 150:157-65. 2006
    ..This is the first study that reveals that P. falciparum variant gene repertoires of certain areas can be limited. This has important implications for the strain-specific immunity against variant antigens occurring in these areas...
  26. ncbi Genetic diversity and differentiation in natural Plasmodium falciparum populations inferred by molecular typing of the merozoite surface proteins 1 and 2
    Fabrício J T Pereira
    Laboratorio de Parasitologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil
    Rev Soc Bras Med Trop 35:527-30. 2002
    ..falciparum, determines the variation in allele frequencies among populations...
  27. ncbi Human toxocariasis in rural Brazilian Amazonia: seroprevalence, risk factors, and spatial distribution
    Guita Rubinsky-Elefant
    Laboratory of Seroepidemiology and Immunobiology, Institute of Tropical Medicine of São Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 79:93-8. 2008
    ..The obstacles for controlling human toxocariasis in this and other tropical rural settings are discussed...
  28. ncbi Plasmodium vivax: microsatellite analysis of multiple-clone infections
    Tatiana Havryliuk
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Exp Parasitol 120:330-6. 2008
    ..Although microsatellite typing may detect minor alleles in clone mixtures, amplification biases may lead to inaccurate assignment of predominant haplotypes in multiple-clone P. vivax infections...
  29. ncbi Risk factors for dengue virus infection in rural Amazonia: population-based cross-sectional surveys
    Monica da Silva-Nunes
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 79:485-94. 2008
    ..Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population...
  30. ncbi A closer look at multiple-clone Plasmodium vivax infections: detection methods, prevalence and consequences
    Tatiana Havryliuk
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brasil, 05508 900
    Mem Inst Oswaldo Cruz 104:67-73. 2009
    ..vivax traits that represent major public health challenges, such as increased virulence, increased transmissibility and antimalarial drug resistance...
  31. ncbi Epidemiology and control of frontier malaria in Brazil: lessons from community-based studies in rural Amazonia
    Natal S da Silva
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Prof Lineu Prestes 1374, Cidade Universitaria, 05508 900 Sao Paulo, SP, Brazil
    Trans R Soc Trop Med Hyg 104:343-50. 2010
    ..By targeting one-quarter of the households, with selective indoor spraying or other house-protection measures, malaria incidence could be reduced by more than two-thirds in this community...
  32. ncbi CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses?
    Raquel M Gonçalves
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Infect Immun 78:4763-72. 2010
    ..We discuss the potential implications of these findings for species-specific pathogenesis and long-lasting protective immunity to malaria...
  33. ncbi Wheezing conditions in early childhood: prevalence and risk factors in the city of São Paulo, Brazil
    Maria Helena D Benício
    Department of Nutrition, School of Public Health, University of Sao Paulo, Avenue Dr Arnaldo 715, 01246 904, Sao Paulo, Brazil
    Bull World Health Organ 82:516-22. 2004
    ..To investigate the prevalence and risk factors for wheezing disorders in early childhood in São Paulo, Brazil, the largest metropolitan area of South America...
  34. ncbi Malaria on the Amazonian frontier: transmission dynamics, risk factors, spatial distribution, and prospects for control
    Monica da Silva-Nunes
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 79:624-35. 2008
    ....
  35. ncbi Anemia and iron deficiency in school children, adolescents, and adults: a community-based study in rural Amazonia
    Marcelo U Ferreira
    Departmento de Parasitologia, Instituto de Ciencias Biomedicas da Universidade de Sao Paulo, Sao Paulo, Brazil
    Am J Public Health 97:237-9. 2007
    ..7% of overall anemia was attributable to iron deficiency. Geo-helminth infection and a recent malaria episode were additional factors affecting iron status indicators in this population...
  36. ncbi Clinical spectrum of uncomplicated malaria in semi-immune Amazonians: beyond the " symptomatic " vs " asymptomatic " dichotomy
    Monica da Silva-Nunes
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brasil
    Mem Inst Oswaldo Cruz 102:341-7. 2007
    ..These factors are all likely to affect the effectiveness of malaria control strategies based on active or passive detection of febrile subjects in semi-immune populations...
  37. ncbi Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite
    Emilio F Merino
    Departamento de Parasitologia, , , Paulo, Av. Lineu Prestes 1374, , SP 05508-900, Brazil
    Mol Biochem Parasitol 149:10-6. 2006
    ..These results suggest that VIR proteins can have different subcellular localizations and functions. This is the first study on a population level of the P. vivax vir subtelomeric multigene superfamily...
  38. ncbi Child health and nutrition in the Western Brazilian Amazon: population-based surveys in two counties in Acre State
    Pascoal Torres Muniz
    Departamento de Ciências da Saúde, Universidade Federal do Acre, Rio Branco, Brazil
    Cad Saude Publica 23:1283-93. 2007
    ..In both towns, anemia and malnutrition were significantly more prevalent among children in the lowest socioeconomic stratum...
  39. ncbi pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin
    Pedro Paulo Vieira
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ, Ilha do Fundao, Rio de Janeiro, Gerencia de Malaria, Fundacao de Medicina Tropical do Amazonas, Manaus, Brazil
    J Infect Dis 190:417-24. 2004
    ..This study provides the first evidence of the Asian pfcrt allele in Brazil and a detailed analysis of P. falciparum populations, with respect to pfcrt haplotypes, in the Amazon Basin...
  40. ncbi The Acre Project: the epidemiology of malaria and arthropod-borne virus infections in a rural Amazonian population
    Mônica da Silva-Nunes
    Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cad Saude Publica 22:1325-34. 2006
    ..3%) with IgM antibodies to dengue virus detected by ELISA had a putative recent exposure to this virus...
  41. ncbi Molecular analysis of Plasmodium ovale variants
    Thin Thida Win
    Nagoya University Graduate School of Medicine, Japan
    Emerg Infect Dis 10:1235-40. 2004
    ..Results support grouping P. ovale into two groups, the classic type (including the Nigerian I/CDC strain) and the variant type (Cameroon, MAL/MAI, and LS isolates)...
  42. ncbi Naturally acquired antibodies to merozoite surface protein (MSP)-1(19) and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
    Simone Ladeia-Andrade
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz FIOCRUZ, 21045 900 Rio de Janeiro, Brasil
    Mem Inst Oswaldo Cruz 102:943-51. 2007
    ....
  43. ncbi Plasmodium falciparum: sequence diversity and antibody recognition of the Merozoite surface protein-2 (MSP-2) in Brazilian Amazonia
    Angela Pedroso Tonon
    Departamento de Parasitologia, , Av. Prof. Lineu Prestes 1374, , , Brazil
    Exp Parasitol 108:114-25. 2004
    ..The use of evolutionary models of MSP-2 is suggested to design vaccines that minimize differences between local parasites and vaccine antigens...
  44. ncbi Prevalence and spatial distribution of intestinal parasitic infections in a rural Amazonian settlement, Acre State, Brazil
    Estéfano Alves de Souza
    Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brasil
    Cad Saude Publica 23:427-34. 2007
    ..The observed spatial clustering of infections with soil-transmitted helminths provides valuable information for the spatial targeting of sanitary interventions in this area...

Research Grants3

  1. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Ferreira; Fiscal Year: 2009
    ....
  2. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Urbano Ferreira; Fiscal Year: 2010
    ....