Sandro C Esteves


Country: Brazil


  1. Esteves S, Carvalho J, Martinhago C, Melo A, Bento F, Humaidan P, et al. Estimation of age-dependent decrease in blastocyst euploidy by next generation sequencing: development of a novel prediction model. Panminerva Med. 2018;: pubmed publisher
    ..This new resource based on female age and blastocyst cohort size will aid clinicians counsel and plan treatment of infertile couples undergoing IVF/ICSI. ..
  2. Esteves S, Roque M, Bedoschi G, Haahr T, Humaidan P. Intracytoplasmic sperm injection for male infertility and consequences for offspring. Nat Rev Urol. 2018;: pubmed publisher
    ..However, as subfertility probably influences the risk estimates, it remains to be determined to what extent the observed adverse outcomes are related to parental factors or associated with ICSI. ..
  3. Esteves S, Chan P. A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male. Int Urol Nephrol. 2015;47:1441-56 pubmed publisher
    ..Continuous efforts are needed to generate high-quality evidence to allow further development of these important guidelines for the evaluation and management of males suffering from infertility. ..
  4. Esteves S, Gosálvez J, López Fernández C, Núñez Calonge R, Caballero P, Agarwal A, et al. Diagnostic accuracy of sperm DNA degradation index (DDSi) as a potential noninvasive biomarker to identify men with varicocele-associated infertility. Int Urol Nephrol. 2015;47:1471-7 pubmed publisher
    ..It is therefore strongly recommended that such patients be referred to urologists in order to undergo a full andrological examination and be properly counseled. ..
  5. Esteves S. Should a Couple with Failed In Vitro Fertilization or Intracytoplasmic Sperm Injection and Elevated Sperm DNA Fragmentation Use Testicular Sperm for the Next Cycle?. Eur Urol Focus. 2018;: pubmed publisher
    ..Meta-analysis has shown that SDF rates are markedly lower in testicular sperm than in ejaculated sperm, and the odds of achieving pregnancy and a live birth are significantly higher. ..
  6. Esteves S, Miyaoka R, Orosz J, Agarwal A. An update on sperm retrieval techniques for azoospermic males. Clinics (Sao Paulo). 2013;68 Suppl 1:99-110 pubmed
    ..A critical analysis of the advantages and disadvantages of these sperm retrieval methods is provided, including the authors' methods of choice and anesthesia preferences. ..
  7. Feijo C, Esteves S. Diagnostic accuracy of sperm chromatin dispersion test to evaluate sperm deoxyribonucleic acid damage in men with unexplained infertility. Fertil Steril. 2014;101:58-63.e3 pubmed publisher
    ..It is important to distinguish between the methods because they differently evaluate sperm DNA damage. ..
  8. Esteves S, Sánchez Martín F, Sánchez Martín P, Schneider D, Gosalvez J. Comparison of reproductive outcome in oligozoospermic men with high sperm DNA fragmentation undergoing intracytoplasmic sperm injection with ejaculated and testicular sperm. Fertil Steril. 2015;104:1398-405 pubmed publisher
    ..Our results suggest that TESTI-ICSI is an effective option to overcome infertility when applied to selected men with oligozoospermia and high ejaculated SDF levels. ..
  9. Roque M, Esteves S. Effect of varicocele repair on sperm DNA fragmentation: a review. Int Urol Nephrol. 2018;50:583-603 pubmed publisher
    ..Varicocele repair should be offered as part of treatment option for male partners of infertile couples presenting with palpable varicoceles. ..

More Information


  1. Bertoncelli Tanaka M, Agarwal A, Esteves S. Paternal age and assisted reproductive technologies: problem solver or trouble maker?. Panminerva Med. 2018;: pubmed publisher
  2. Esteves S. Microdissection testicular sperm extraction (micro-TESE) as a sperm acquisition method for men with nonobstructive azoospermia seeking fertility: operative and laboratory aspects. Int Braz J Urol. 2013;39:440; discussion 441 pubmed publisher
    ..Micro-TESE allowed the identification and extraction of sperm-containing STs with minimum tissue excision and marked reduction in time processing of testicular specimens for sperm injection. ..
  3. Miyaoka R, Orosz J, Achermann A, Esteves S. Methods of surgical sperm extraction and implications for ART success. Panminerva Med. 2018;: pubmed publisher
    ..For the second part, we present and critically discuss the evidence concerning the success of ICSI using non-ejaculated sperm and the consequences of this approach to the health of resulting offspring. ..
  4. Sharma R, Ahmad G, Esteves S, Agarwal A. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay using bench top flow cytometer for evaluation of sperm DNA fragmentation in fertility laboratories: protocol, reference values, and quality control. J Assist Reprod Genet. 2016;33:291-300 pubmed publisher
    ..The results of this test could identify infertile men whose sperm DNA fragmentation does not contribute to their infertility and confirm that a man who tests positive is likely to be infertile due to elevated sperm DNA fragmentation. ..
  5. Esteves S. Novel concepts in male factor infertility: clinical and laboratory perspectives. J Assist Reprod Genet. 2016;33:1319-1335 pubmed
    ..Lastly, we critically discuss the current management of men with nonobstructive azoospermia seeking fertility and the new opportunities that emerged to help these men achieve biological fatherhood. ..
  6. Esteves S, Bento F. Implementation of cleanroom technology in reproductive laboratories: the question is not why but how. Reprod Biomed Online. 2016;32:9-11 pubmed publisher
  7. Esteves S, Miyaoka R, Agarwal A. Surgical treatment of male infertility in the era of intracytoplasmic sperm injection - new insights. Clinics (Sao Paulo). 2011;66:1463-78 pubmed
    ..New insights are provided with regard to each surgical treatment option in view of the availability of assisted conception to overcome male infertility. ..
  8. Esteves S, Roque M, Bradley C, Garrido N. Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis. Fertil Steril. 2017;108:456-467.e1 pubmed publisher
    ..Infertile couples may benefit from Testi-ICSI if male partners have confirmed high SDF in the ejaculate. ..
  9. Esteves S, Glina S. Recovery of spermatogenesis after microsurgical subinguinal varicocele repair in azoospermic men based on testicular histology. Int Braz J Urol. 2005;31:541-8 pubmed
    ..Analyze whether testicular histologic patterns from a group of azoospermic men with varicocele is predictive of treatment outcome after subinguinal microsurgical varicocele repair...
  10. Esteves S, Miyaoka R, Agarwal A. Sperm retrieval techniques for assisted reproduction. Int Braz J Urol. 2011;37:570-83 pubmed
    ..Lastly, we summarize the results from the current literature of sperm retrieval, as well as the clinical outcome of ICSI in the clinical scenario of obstructive and nonobstructive azoospermia. ..