Breno S Diniz

Summary

Country: Brazil

Publications

  1. doi request reprint Circulating Glial-derived neurotrophic factor is reduced in late-life depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 3rd Floor, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 46:135-9. 2012
  2. doi request reprint Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos, 785 3rd floor, Sao Paulo, SP, 05403 010, Brazil
    Neuromolecular Med 13:217-22. 2011
  3. doi request reprint Platelet GSK3B activity in patients with late-life depression: marker of depressive episode severity and cognitive impairment?
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    World J Biol Psychiatry 12:216-22. 2011
  4. doi request reprint Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 3rd Floor, 05403 010 Sao Paulo, S P, Brazil
    J Psychiatr Res 44:917-20. 2010
  5. doi request reprint Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Sao Paulo, Brazil
    World J Biol Psychiatry 11:550-5. 2010
  6. doi request reprint Higher serum sTNFR1 level predicts conversion from mild cognitive impairment to Alzheimer's disease
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Alzheimers Dis 22:1305-11. 2010
  7. doi request reprint Current pharmacological approaches and perspectives in the treatment of geriatric mood disorders
    Breno S Diniz
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Curr Opin Psychiatry 24:473-7. 2011
  8. doi request reprint Diagnosis of mild cognitive impairment revisited after one year. Preliminary results of a prospective study
    Breno Satler Diniz
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Dement Geriatr Cogn Disord 27:224-31. 2009
  9. doi request reprint To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Institute and Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Ovidio Pires de Campos, 785, 3th floor, Sao Paulo, SP, CEP 05403 010, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:248-56. 2009
  10. ncbi request reprint Mild cognitive impairment. Part 2: Biological markers for diagnosis and prediction of dementia in Alzheimer's disease
    Orestes V Forlenza
    Universidade de Sao Paulo, Laboratory of Neuroscience, Department and Institute of Psychiatry, School of Medicine, São PauloSP, Brazil
    Rev Bras Psiquiatr 35:284-94. 2013

Collaborators

Detail Information

Publications30

  1. doi request reprint Circulating Glial-derived neurotrophic factor is reduced in late-life depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 3rd Floor, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 46:135-9. 2012
    ..The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders...
  2. doi request reprint Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos, 785 3rd floor, Sao Paulo, SP, 05403 010, Brazil
    Neuromolecular Med 13:217-22. 2011
    ..Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes...
  3. doi request reprint Platelet GSK3B activity in patients with late-life depression: marker of depressive episode severity and cognitive impairment?
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    World J Biol Psychiatry 12:216-22. 2011
    ..The aims of the present study were to determine GSK3B activity in platelets of elderly patients with major depression, and the association between GSK3B activity and the severity of depressive symptoms and cognitive impairment...
  4. doi request reprint Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 3rd Floor, 05403 010 Sao Paulo, S P, Brazil
    J Psychiatr Res 44:917-20. 2010
    ..There was no correlation between serum levels of these inflammatory markers and the severity of depression. Our findings provide additional evidence of the involvement of abnormal pro-inflammatory state in late-life depression...
  5. doi request reprint Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Sao Paulo, Brazil
    World J Biol Psychiatry 11:550-5. 2010
    ..The aim of the present study is to investigate serum BDNF levels in older depressed patients as compared to healthy elderly controls...
  6. doi request reprint Higher serum sTNFR1 level predicts conversion from mild cognitive impairment to Alzheimer's disease
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Alzheimers Dis 22:1305-11. 2010
    ..Abnormal activation of TNF-α signaling system, represented by increased expression of sTNFR1, is associated with a higher risk of progression from MCI to AD...
  7. doi request reprint Current pharmacological approaches and perspectives in the treatment of geriatric mood disorders
    Breno S Diniz
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Curr Opin Psychiatry 24:473-7. 2011
    ..This work aims to review the most recent developments in the treatment of mood disorders (major depression and bipolar disorder) in the elderly...
  8. doi request reprint Diagnosis of mild cognitive impairment revisited after one year. Preliminary results of a prospective study
    Breno Satler Diniz
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Dement Geriatr Cogn Disord 27:224-31. 2009
    ..We aim to determine the cognitive outcome after 1 year of follow-up in a cohort of older adults...
  9. doi request reprint To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease
    Breno Satler Diniz
    Laboratory of Neuroscience LIM 27, Institute and Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Ovidio Pires de Campos, 785, 3th floor, Sao Paulo, SP, CEP 05403 010, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:248-56. 2009
    ..The objective of this study is to meta-analyze the RCTs conducted with ChEIs in order to assess whether pooled analysis could show the benefit of these drugs in delaying the progression from MCI to AD...
  10. ncbi request reprint Mild cognitive impairment. Part 2: Biological markers for diagnosis and prediction of dementia in Alzheimer's disease
    Orestes V Forlenza
    Universidade de Sao Paulo, Laboratory of Neuroscience, Department and Institute of Psychiatry, School of Medicine, São PauloSP, Brazil
    Rev Bras Psiquiatr 35:284-94. 2013
    ..To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD)...
  11. doi request reprint Reduced platelet amyloid precursor protein ratio (APP ratio) predicts conversion from mild cognitive impairment to Alzheimer's disease
    Isis A Zainaghi
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm 119:815-9. 2012
    ..However, diagnostic accuracy was relatively low. Therefore, studies in larger samples are needed to determine whether APPr may warrant its use as a biomarker to support the early diagnosis of AD...
  12. doi request reprint Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27 Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    Br J Psychiatry 198:351-6. 2011
    ..Two recent clinical studies support the feasibility of trials to evaluate the disease-modifying properties of lithium in Alzheimer's disease, although no benefits were obtained from short-term treatment...
  13. ncbi request reprint Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment
    Orestes V Forlenza
    Department and Institute of Psychiatry, Universidade de Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 32:216-22. 2010
    ..To identify predictors of the progression from pre-dementia stages of cognitive impairment in Alzheimer's disease is relevant to clinical management and to substantiate the decision of prescribing antidementia drugs...
  14. doi request reprint Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 45:220-4. 2011
    ....
  15. doi request reprint Reduced serum levels of adiponectin in elderly patients with major depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Psychiatr Res 46:1081-5. 2012
    ..Additional studies are required to determine whether this abnormality pertains to the pathophysiology of geriatric depression per se, or is a consequence of the morbid state...
  16. doi request reprint Does lithium prevent Alzheimer's disease?
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Drugs Aging 29:335-42. 2012
    ....
  17. doi request reprint Long-term sertraline treatment increases expression and decreases phosphorylation of glycogen synthase kinase-3B in platelets of patients with late-life major depression
    Helena P G Joaquim
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Sao Paulo, SP, Brazil
    J Psychiatr Res 46:1053-8. 2012
    ..The aim of the present study was to investigate the effect of short-and long-term sertraline treatment on the expression and phosphorylation of GSK3B in platelets of patients with late-life major depression...
  18. ncbi request reprint Mild cognitive impairment. Part 1: clinical characteristics and predictors of dementia
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, Universidade de Sao Paulo USP, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 35:178-85. 2013
    ..To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof...
  19. pmc Combining cognitive screening tests for the evaluation of mild cognitive impairment in the elderly
    Rodolfo B Ladeira
    Laboratory of Neuroscience LIM 27, Institute of Psychiatry, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 64:967-73. 2009
    ..To determine the accuracy of the Mini-Mental State Examination combined with the Verbal Fluency Test and Clock Drawing Test for the identification of patients with mild cognitive impairment and Alzheimer's disease (AD)...
  20. ncbi request reprint Neurostructural predictors of Alzheimer's disease: a meta-analysis of VBM studies
    Luiz K Ferreira
    Laboratory of Psychiatric Neuroimaging LIM 21, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Neurobiol Aging 32:1733-41. 2011
    ..In conclusion, left medial temporal lobe atrophy is the most consistent neurostructural biomarker to predict conversion from aMCI to AD...
  21. pmc Diagnosis and biomarkers of predementia in Alzheimer's disease
    Orestes V Forlenza
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    BMC Med 8:89. 2010
    ..We further address recent developments in biomarker research to support the early diagnosis and prediction of dementia, and point out the challenges and perspectives for the translation of research data into clinical practice...
  22. doi request reprint Alzheimer's disease
    Vanessa J De-Paula
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Terceiro Andar Ala Norte, 05403 010, Sao Paulo SP, Brazil
    Subcell Biochem 65:329-52. 2012
    ..Therefore, the cumulative knowledge on the pathogenesis of AD derived from basic science models will hopefully be translated into clinical practice in the forthcoming years...
  23. doi request reprint Reduced serum nerve growth factor in patients with late-life depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department of Mental Health, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Am J Geriatr Psychiatry 21:493-6. 2013
    ..Nerve growth factor (NGF) is one of the most abundant neurotrophic factors in the central nervous system and has been involved in several neuropsychiatric disorders...
  24. doi request reprint A radioenzymatic assay to identify three groups of phospholipase A(2) in platelets
    Leda L Talib
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 86:149-53. 2012
    ....
  25. doi request reprint Lithium increases plasma brain-derived neurotrophic factor in acute bipolar mania: a preliminary 4-week study
    Rafael T de Sousa
    Laboratory of Neurosciences LIM27, Department and Institute of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Neurosci Lett 494:54-6. 2011
    ..Further studies with larger samples and longer period may confirm whether this biological effect is involved in the therapeutic efficacy of lithium in BPD...
  26. doi request reprint CAMcog as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education
    Paula V Nunes
    Psychogeriatric Clinic and Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int J Geriatr Psychiatry 23:1127-33. 2008
    ..Given the need for an earlier diagnosis of mild dementia, new cut-off values are also necessary, taking into account cultural and educational effects...
  27. doi request reprint Cognitive impairment in euthymic older adults with bipolar disorder: a controlled study using cognitive screening tests
    Ivan Aprahamian
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Am J Geriatr Psychiatry 22:389-97. 2014
    ..The aim of this study was to investigate the performance on cognitive screening tests in a sample of older adults with BD, as compared to non-BD subjects...
  28. doi request reprint Low platelet iPLA₂ activity predicts conversion from mild cognitive impairment to Alzheimer's disease: a 4-year follow-up study
    Wagner F Gattaz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm 121:193-200. 2014
    ..Moreover, low sPLA₂ and cPLA₂ were related to cognitive decline in healthy controls, suggesting a relationship with the very early stages of the disease...
  29. pmc Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease
    Aderbal R T Silva
    Research Center CIPE, A C Camargo Hospital, Sao Paulo, Brazil
    PLoS ONE 7:e48751. 2012
    ....
  30. doi request reprint Voxel-based morphometry in Alzheimer's disease
    Geraldo F Busatto
    Centro de Medicina Nuclear, Sao Paulo, SP, Brazil
    Expert Rev Neurother 8:1691-702. 2008
    ....