Hernando A del Portillo

Summary

Country: Brazil

Publications

  1. ncbi request reprint A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax
    H A del Portillo
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Nature 410:839-42. 2001
  2. ncbi request reprint Variant genes and the spleen in Plasmodium vivax malaria
    Hernando A del Portillo
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Int J Parasitol 34:1547-54. 2004
  3. ncbi request reprint Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum
    Juliana Martha Sá
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo 05508 900, SP, Brazil
    Mol Biochem Parasitol 150:219-28. 2006
  4. ncbi request reprint Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential
    Stefanie C P Lopes
    Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    J Infect Dis 209:1403-7. 2014
  5. ncbi request reprint Extense variant gene family repertoire overlap in Western Amazon Plasmodium falciparum isolates
    Letusa Albrecht
    Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Mol Biochem Parasitol 150:157-65. 2006
  6. ncbi request reprint Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite
    Emilio F Merino
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de São, Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Mol Biochem Parasitol 149:10-6. 2006
  7. pmc Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region
    Pamela Orjuela-Sánchez
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Antimicrob Agents Chemother 53:3561-4. 2009
  8. pmc Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of Brazil
    Tatiane R Oliveira
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av, Prof, Lineu Prestes, 580, 05508 900, Sao Paulo, SP, Brazil
    Malar J 5:83. 2006
  9. pmc Pilot survey of expressed sequence tags (ESTs) from the asexual blood stages of Plasmodium vivax in human patients
    Emilio F Merino
    Departamento de Parasitologia, ICB, Universidade de Sao Paulo, Sao Paulo, Brazil
    Malar J 2:21. 2003
  10. ncbi request reprint Variant proteins of Plasmodium vivax are not clonally expressed in natural infections
    Carmen Fernandez-Becerra
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Avenida Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Mol Microbiol 58:648-58. 2005

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax
    H A del Portillo
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Nature 410:839-42. 2001
    ....
  2. ncbi request reprint Variant genes and the spleen in Plasmodium vivax malaria
    Hernando A del Portillo
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Int J Parasitol 34:1547-54. 2004
    ..vivax, are stored before their release into circulation to compensate for the anaemia associated with vivax malaria...
  3. ncbi request reprint Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum
    Juliana Martha Sá
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo 05508 900, SP, Brazil
    Mol Biochem Parasitol 150:219-28. 2006
    ..Our data support an effect of PvCRT-o on chloroquine transport and/or accumulation by P. vivax, independent of the K76T amino acid substitution...
  4. ncbi request reprint Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential
    Stefanie C P Lopes
    Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    J Infect Dis 209:1403-7. 2014
    ..These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration. ..
  5. ncbi request reprint Extense variant gene family repertoire overlap in Western Amazon Plasmodium falciparum isolates
    Letusa Albrecht
    Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Mol Biochem Parasitol 150:157-65. 2006
    ..This is the first study that reveals that P. falciparum variant gene repertoires of certain areas can be limited. This has important implications for the strain-specific immunity against variant antigens occurring in these areas...
  6. ncbi request reprint Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite
    Emilio F Merino
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de São, Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Mol Biochem Parasitol 149:10-6. 2006
    ..These results suggest that VIR proteins can have different subcellular localizations and functions. This is the first study on a population level of the P. vivax vir subtelomeric multigene superfamily...
  7. pmc Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine-resistant isolates from the Brazilian Amazon region
    Pamela Orjuela-Sánchez
    Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Antimicrob Agents Chemother 53:3561-4. 2009
    ..vivax and P. falciparum reinforce the idea that mechanisms other than mutations may explain this virulent phenotype in P. vivax...
  8. pmc Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of Brazil
    Tatiane R Oliveira
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av, Prof, Lineu Prestes, 580, 05508 900, Sao Paulo, SP, Brazil
    Malar J 5:83. 2006
    ..The naturally-acquired immune response to Plasmodium vivax variant antigens (VIR) was evaluated in individuals exposed to malaria and living in different endemic areas for malaria in the north of Brazil...
  9. pmc Pilot survey of expressed sequence tags (ESTs) from the asexual blood stages of Plasmodium vivax in human patients
    Emilio F Merino
    Departamento de Parasitologia, ICB, Universidade de Sao Paulo, Sao Paulo, Brazil
    Malar J 2:21. 2003
    ..Unfortunately, due to the impossibility of growing this parasite in continuous in vitro culture, research on P. vivax remains largely neglected...
  10. ncbi request reprint Variant proteins of Plasmodium vivax are not clonally expressed in natural infections
    Carmen Fernandez-Becerra
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Avenida Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Mol Microbiol 58:648-58. 2005
    ..Moreover, whereas our data are consistent with a major role of vir genes in natural infections, they are inconsistent with a predominant role in the strict sense of antigenic variation...
  11. pmc Promoter regions of Plasmodium vivax are poorly or not recognized by Plasmodium falciparum
    Mauro F Azevedo
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Malar J 6:20. 2007
    ..Here, the functional characterization of different Plasmodium vivax promoters in Plasmodium falciparum using luciferase as the reporter gene is presented...
  12. ncbi request reprint Clinical and molecular aspects of severe malaria
    Karin Kirchgatter
    Núcleo de Estudos em Malária, Superintendência de Controle de Endemias SUCEN, Instituto de Medicina Tropical de São Paulo IMTSP, Universidade de Sao Paulo USP, Sao Paulo, SP 05403 000, Brazil
    An Acad Bras Cienc 77:455-75. 2005
    ..Understanding the role of host receptors and parasite ligands in the development of different clinical syndromes is urgently needed to identify vaccination targets in order to decrease the mortality rates of this disease...
  13. ncbi request reprint Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS
    Anna Rosanas-Urgell
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 107:410-5. 2012
    ..Our results suggest a dual role for these receptors in parasite clearance and protection in 17X infection and lethality in 17XL infection...
  14. ncbi request reprint Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains
    Juliana Martha Sá
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Lineu Prestes 1374, Sao Paulo SP, 05508 900, Brazil
    Exp Parasitol 109:256-9. 2005
    ..Similarity and dendrogram analyses revealed that sequences could be grouped according to their geographical origin. Within each geographical group however, no correlation was found between chloroquine resistance and specific mutations...
  15. ncbi request reprint Plasmodium falciparum: new vector with bi-directional promoter activity to stably express transgenes
    Carmen Fernandez-Becerra
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Avenida Professor Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Exp Parasitol 103:88-91. 2003
  16. ncbi request reprint Computational methods in noncoding RNA research
    Ariane Machado-Lima
    Institute of Mathematics and Statistics, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Math Biol 56:15-49. 2008
    ..This motivated the development of specific methods for ncRNA research. This article reviews the main approaches used to identify ncRNAs and predict secondary structure...