Leopoldo de Meis

Summary

Country: Brazil

Publications

  1. ncbi ATP synthesis and heat production during Ca(2+) efflux by sarcoplasmic reticulum Ca(2+)-ATPase
    L de Meis
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Cidade Universitaria, 21941 590, Brazil
    Biochem Biophys Res Commun 276:35-9. 2000
  2. ncbi Uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase. Regulation by ADP
    L de Meis
    Instituto de Ciencias Biomedicas, Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ 21941 590, Brazil
    J Biol Chem 276:25078-87. 2001
  3. ncbi Ca2+-ATPases (SERCA): energy transduction and heat production in transport ATPases
    L de Meis
    Departamento de Bioquimica Medica, Institute de Ciencias Biomedicas, Centre de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 590, Brazil
    J Membr Biol 188:1-9. 2002
  4. ncbi Brown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity
    Leopoldo de Meis
    Instituto de Ciencias Biomedicas, Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ 21941 590, Brazil
    J Biol Chem 278:41856-61. 2003
  5. ncbi The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Prédio do CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, Brazil
    IUBMB Life 57:337-45. 2005
  6. doi Cold tolerance in hypothyroid rabbits: role of skeletal muscle mitochondria and sarcoplasmic reticulum Ca2+ ATPase isoform 1 heat production
    Ana Paula Arruda
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro 21941 590, Brazil
    Endocrinology 149:6262-71. 2008
  7. ncbi Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone
    Luisa A Ketzer
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro 21941 590, Brazil
    Am J Physiol Heart Circ Physiol 297:H556-63. 2009
  8. ncbi Identification of a Ca2+-ATPase in brown adipose tissue mitochondria: regulation of thermogenesis by ATP and Ca2+
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Prédio CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ 21941 590, Brazil
    J Biol Chem 281:16384-90. 2006
  9. doi Ca2+ transport and heat production in vesicles derived from the sarcoplasmic reticulum terminal cisternae: regulation by K+
    Mariana Nigro
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 902, Brazil
    Biochim Biophys Acta 1788:1517-22. 2009
  10. ncbi Heat of PPi hydrolysis varies depending on the enzyme used. Yeast and corn vacuolar pyrophosphatase
    Wagner S da-Silva
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro RJ, 21941 590, Brasil
    J Biol Chem 279:45613-7. 2004

Collaborators

Detail Information

Publications32

  1. ncbi ATP synthesis and heat production during Ca(2+) efflux by sarcoplasmic reticulum Ca(2+)-ATPase
    L de Meis
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Cidade Universitaria, 21941 590, Brazil
    Biochem Biophys Res Commun 276:35-9. 2000
    ..As a result, there is no ATP synthesis and no heat production or absorption during Ca(2+) efflux. The Ca(2+) efflux, ATP synthesis, and heat production were inhibited by thapsigargin, a specific inhibitor of the Ca(2+)-ATPase...
  2. ncbi Uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase. Regulation by ADP
    L de Meis
    Instituto de Ciencias Biomedicas, Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ 21941 590, Brazil
    J Biol Chem 276:25078-87. 2001
    ..With a high ADP/ATP ratio, the uncoupled ATPase activity is abolished, and the Ca2+ transport is endothermic. The possible correlation of these findings with thermogenesis and anoxia is discussed...
  3. ncbi Ca2+-ATPases (SERCA): energy transduction and heat production in transport ATPases
    L de Meis
    Departamento de Bioquimica Medica, Institute de Ciencias Biomedicas, Centre de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 590, Brazil
    J Membr Biol 188:1-9. 2002
    ..Heat is either produced or released during the leakage, depending on whether or not the Ca2+ efflux is coupled to the synthesis of ATP from ADP and Pi...
  4. ncbi Brown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity
    Leopoldo de Meis
    Instituto de Ciencias Biomedicas, Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ 21941 590, Brazil
    J Biol Chem 278:41856-61. 2003
    ..The data reported suggest that in addition to storing Ca2+ inside the endoplasmic reticulum, the Ca2+-ATPase may represent a source of heat production contributing to the thermogenic function of brown adipose tissue...
  5. ncbi The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Prédio do CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, Brazil
    IUBMB Life 57:337-45. 2005
    ....
  6. doi Cold tolerance in hypothyroid rabbits: role of skeletal muscle mitochondria and sarcoplasmic reticulum Ca2+ ATPase isoform 1 heat production
    Ana Paula Arruda
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro 21941 590, Brazil
    Endocrinology 149:6262-71. 2008
    ..We conclude that rabbit cold tolerance is probably related to increased muscle oxidative metabolism and heat production by SERCA1 and that these changes are not completely dependent on normal thyroid function...
  7. ncbi Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone
    Luisa A Ketzer
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro 21941 590, Brazil
    Am J Physiol Heart Circ Physiol 297:H556-63. 2009
    ..We hypothesize that the transient rise in serum T3 contributes to the short-term response to cold exposure...
  8. ncbi Identification of a Ca2+-ATPase in brown adipose tissue mitochondria: regulation of thermogenesis by ATP and Ca2+
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Prédio CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ 21941 590, Brazil
    J Biol Chem 281:16384-90. 2006
    ..In conclusion, this is the first report of a Ca(2+)-ATPase in mitochondria that is BAT-specific and can generate heat in the presence of Ca(2+) concentrations similar to those noted in the cell during adrenergic stimulation...
  9. doi Ca2+ transport and heat production in vesicles derived from the sarcoplasmic reticulum terminal cisternae: regulation by K+
    Mariana Nigro
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 902, Brazil
    Biochim Biophys Acta 1788:1517-22. 2009
    ..It is suggested that an increase of K+ in the assay medium alters the interactions among the various proteins found in HSR, thus modifying the properties of both the ryanodine channel and SERCA1...
  10. ncbi Heat of PPi hydrolysis varies depending on the enzyme used. Yeast and corn vacuolar pyrophosphatase
    Wagner S da-Silva
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro RJ, 21941 590, Brasil
    J Biol Chem 279:45613-7. 2004
    ..The data support the proposal that enzymes are able to handle the energy derived from phosphate compound hydrolysis in such a way as to determine the parcel that is used for work and the fraction that is converted into heat...
  11. pmc Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase
    Ana Paula Arruda
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 590, Brasil
    Biochem J 375:753-60. 2003
    ..6 in white muscles and 12.0 in red muscles. The data presented suggest that the Ca2+-ATPase uncoupled activity may represent one of the heat sources that contributes to the enhanced thermogenesis noted in hyperthyroidism...
  12. doi Heat production by skeletal muscles of rats and rabbits and utilization of glucose 6-phosphate as ATP regenerative system by rats and rabbits heart Ca2+-ATPase
    Luisa Andrea Ketzer
    Instituto de Bioquimica Medica, Prédio do CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, RJ 21941 590, Brazil
    Biochem Biophys Res Commun 369:265-9. 2008
    ..The rates of Ca(2+)-uptake and ATP hydrolysis measured with glucose 6-phosphate and hexokinase is four to six times slower than that measured with phosphoenolpyruvate and pyruvate kinase as ATP regenerative system...
  13. ncbi Thermogenic activity of Ca2+-ATPase from skeletal muscle heavy sarcoplasmic reticulum: the role of ryanodine Ca2+ channel
    Ana Paula Arruda
    From the Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, Brazil
    Biochim Biophys Acta 1768:1498-505. 2007
    ....
  14. pmc Brown adipose tissue mitochondria: modulation by GDP and fatty acids depends on the respiratory substrates
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Laboratório de Bioenergética, Programa de Bioquimica e Biofisica Celular, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 902, Brazil
    Biosci Rep 32:53-9. 2012
    ..These effects are not related to the production of ROS (reactive oxygen species). We suggest that succinate could stimulate a new route to heat production in BAT mitochondria...
  15. ncbi The thermogenic function of the sarcoplasmic reticulum Ca2+-ATPase of normal and hyperthyroid rabbit
    Leopoldo de Meis
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Brasil
    Ann N Y Acad Sci 986:481-8. 2003
    ....
  16. ncbi Role of sarco/endoplasmic reticulum Ca(2+)-ATPase in thermogenesis
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, 21941 590 RJ, Brasil
    Biosci Rep 25:181-90. 2005
    ..Modulation of heat production by SERCA might be one of the mechanisms involved in the increased thermogenesis found in hyperthyroidism...
  17. ncbi Uncoupled ATP hydrolysis and thermogenic activity of the sarcoplasmic reticulum Ca2+-ATPase: coupling effects of dimethyl sulfoxide and low temperature
    Hosana Barata
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro 21941 590, Brazil
    J Biol Chem 277:16868-72. 2002
    ..3 to 1.3-1.4. It is concluded that the uncoupled Ca(2+)-ATPase is responsible for both the low Ca(2+)/ATP ratio measured during transport and the difference of heat produced during ATP hydrolysis in the presence and absence of a gradient...
  18. ncbi Correlation between uncoupled ATP hydrolysis and heat production by the sarcoplasmic reticulum Ca2+-ATPase: coupling effect of fluoride
    M Reis
    , , , Universidade Federal do Rio de Janeiro, , RJ, 21941 590, Brasil
    J Biol Chem 276:42793-800. 2001
    ..Thus, uncoupled ATPase activity appears to be the mechanistic feature underlying the ability of the Ca(2+)-ATPase to modulated heat production...
  19. ncbi Maize tonoplast PP(i)-dependent H(+)/Ca(2+) exchange: two K(s) for Ca(2+) and inhibition by thapsigargin
    Wagner S da-Silva
    Departamento de Bioqui mica Médica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro 21941 590, Brazil
    Biochem Biophys Res Commun 307:472-6. 2003
    ..Thapsigargin, a specific inhibitor of Ca(2+)-ATPase, inhibits the Ca(2+) uptake driven by H(+) gradient but does not inhibit the hydrolysis of PP(i) nor the formation of a H(+) gradient...
  20. ncbi Control of heat produced during ATP hydrolysis by the sarcoplasmic reticulum Ca(2+)-ATPase in the absence of a Ca2+ gradient
    L de Meis
    Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Brasil
    Biochem Biophys Res Commun 243:598-600. 1998
    ..Thus, Ca2+ seems to regulate the ATPase in such a way as to vary the fraction of energy derived from ATP hydrolysis which is converted into heat and that which is conserved as chemical energy...
  21. ncbi Thermogenesis and energy expenditure: control of heat production by the Ca(2+)-ATPase of fast and slow muscle
    Marcelo Reis
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, 21941 590, Brazil
    Mol Membr Biol 19:301-10. 2002
    ..The findings described in this report raise the possibility that one of the mechanisms of thermogenesis control may be related to the regulation of Ca(2+)-ATPase isoforms expression by T3...
  22. ncbi Ca2+-transport in sea urchin unfertilized eggs: regulation by endogenous sulfated polysaccharides and K+
    Ana M Landeira-Fernandez
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1760:1529-35. 2006
    ..These data suggest that the regulation of the SERCA pump by K(+) and sulfated polysaccharides is not restricted to few marine invertebrates but is widespread...
  23. pmc Proton transport in maize tonoplasts supported by fructose-1,6-bisphosphate cleavage. Pyrophosphate-dependent phosphofructokinase as a pyrophosphate-regenerating system
    Anelise Costa dos Santos
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brazil
    Plant Physiol 133:885-92. 2003
    ..The maximal Delta pH attained by the pyrophosphatase coupled to the PFP reaction can be maintained by PFP activities far below those found in higher plants tissues...
  24. ncbi Control of energy fluxes by the sarcoplasmic reticulum Ca2+-ATPase: ATP hydrolysis, ATP synthesis and heat production
    L de Meis
    Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Brazil
    FEBS Lett 406:201-4. 1997
    ....
  25. ncbi A change in liver metabolism but not in brown adipose tissue thermogenesis is an early event in ovariectomy-induced obesity in rats
    Mariana Nigro
    Laboratório de Bioenergética M N, A T S, C S B, L A K, L D M, Instituto de Bioquimica Medica, Laboratório de Radiobiologia Molecular R S F and Laboratório de Fisiologia Endócrina Doris Rosenthal R A N L, D P C, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 902, Brazil
    Endocrinology 155:2881-91. 2014
    ..In conclusion, the disrupted liver glucose homeostasis after ovariectomy is neither caused by estradiol deficiency nor is related to increased body mass. ..
  26. ncbi Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis
    L de Meis
    Instituto de Ciencias Biomedicas, Departamento de Bioquimica Medica Universidade Federal do Rio de Janeiro, Cidade Universitaria, RJ, Brazil
    Biosci Rep 21:113-37. 2001
    ..Drugs such as heparin and dimethyl sulfoxide are able to modify the fraction of the chemical energy released during ATP hydrolysis which is used for Ca2+ transport and the fraction which is dissipated in the surrounding medium as heat...
  27. ncbi Ca2+ mobilization induced by ouabain in thymocytes involves intracellular and extracellular Ca2+ pools
    Juliana Echevarria-Lima
    Laboratório de Imunologia Tumoral, Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Brazil
    Hypertension 41:1386-92. 2003
    ....
  28. ncbi The impact of science in Brazil
    Leopoldo de Meis
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, Brazil
    IUBMB Life 59:227-34. 2007
  29. ncbi Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria
    Wagner Seixas da-Silva
    Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, Rio de Janeiro 21941 590, Brazil
    J Biol Chem 279:39846-55. 2004
    ....
  30. ncbi Conformational fluctuations of the Ca2+-ATPase in the native membrane environment. Effects of pH, temperature, catalytic substrates, and thapsigargin
    Giuseppe Inesi
    California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Biol Chem 283:1189-96. 2008
    ..2Ca(2+) to E2-P transition, thereby disrupting high affinity binding and allowing luminal diffusion of Ca(2+). The E2 state and luminal path closure follow removal of conformational constraint by phosphate...
  31. ncbi Thyroid hormones differentially regulate the distribution of rabbit skeletal muscle Ca(2+)-ATPase (SERCA) isoforms in light and heavy sarcoplasmic reticulum
    Ana Paula Arruda
    Instituto de Bioquimica Medica, Rio de Janiero, Brazil
    Mol Membr Biol 22:529-37. 2005
    ..These changes might correspond to the molecular basis of the altered contraction and relaxation rates detected in thyroid dysfunction...
  32. ncbi Status epilepticus induced by pilocarpine and Ca2+ transport by microsome in the hippocampus of rats
    Maricilia S Costa
    Disciplina de Neurologia Experimental, UNIFESP EPM, Sao Paulo, Brazil
    Neurosci Lett 366:292-6. 2004
    ..The Ca(2+)-ATPase activity measured in all hippocampal formation was not modified by SE. These results suggest that SE promotes a redistribution of SERCA2b in the hippocampus as a compensatory Ca(2+)-transport mechanism...