Rui Curi

Summary

Country: Brazil

Publications

  1. ncbi request reprint Evidence that glutamine is involved in neutrophil function
    Tania C Pithon-Curi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
    Cell Biochem Funct 20:81-6. 2002
  2. ncbi request reprint Requirement for glutamine in the expression of alpha-actin and type IV collagen in mesangial cells
    Tania C Pithon-Curi
    Camilo Castelo Branco University, Sao Paulo, and Methodist University of Piracicaba FACIS, Brazil
    Cell Biochem Funct 24:217-21. 2006
  3. ncbi request reprint Glutamine delays spontaneous apoptosis in neutrophils
    Tania C Pithon-Curi
    Methodist University of Piracicaba, FACEF, Sao Paulo, SP, Brazil
    Am J Physiol Cell Physiol 284:C1355-61. 2003
  4. ncbi request reprint Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils
    Tania Cristina Pithon-Curi
    Camilo Castelo Branco University and Methodist University of Piracicaba FACEF, Rua Carolina Fonseca 584, 08230 030 São Paulo, Brazil
    Clin Sci (Lond) 103:403-8. 2002
  5. ncbi request reprint Effect of lipid infusion on metabolism and force of rat skeletal muscles during intense contractions
    Leonardor Silveira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Botantã, Sao Paulo, Brazil
    Cell Physiol Biochem 20:213-26. 2007
  6. ncbi request reprint Short-term modulation of extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun NH2-terminal kinase in pancreatic islets by glucose and palmitate: possible involvement of ceramide
    Tatiane C A Nogueira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo USP, Sao Paulo, Brazil
    Pancreas 38:585-92. 2009
  7. ncbi request reprint Effect of fish oil supplementation for two generations on changes of lymphocyte function induced by Walker 256 cancer cachexia in rats
    Alessandra Folador
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Nutr Cancer 61:670-9. 2009
  8. doi request reprint Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation
    Augusto D Luchessi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Cell Physiol 218:480-9. 2009
  9. ncbi request reprint Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells
    Rozangela Verlengia
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Lipids 39:857-64. 2004
  10. doi request reprint The effect of mate tea (Ilex paraguariensis) on metabolic and inflammatory parameters in high-fat diet-fed Wistar rats
    Maria Carolina Borges
    Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo 01246 904, Brazil
    Int J Food Sci Nutr 64:561-9. 2013

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Evidence that glutamine is involved in neutrophil function
    Tania C Pithon-Curi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
    Cell Biochem Funct 20:81-6. 2002
    ..Glutamine alone at 2 mM did not modify the production of TNF but in the presence of LPS caused a significant decrease. So, glutamine may preserve the function of neutrophils during infections and injuries...
  2. ncbi request reprint Requirement for glutamine in the expression of alpha-actin and type IV collagen in mesangial cells
    Tania C Pithon-Curi
    Camilo Castelo Branco University, Sao Paulo, and Methodist University of Piracicaba FACIS, Brazil
    Cell Biochem Funct 24:217-21. 2006
    ..This suggests that glutamine is required for the expression of important proteins of the extracellular matrix in cultured mesangial cells...
  3. ncbi request reprint Glutamine delays spontaneous apoptosis in neutrophils
    Tania C Pithon-Curi
    Methodist University of Piracicaba, FACEF, Sao Paulo, SP, Brazil
    Am J Physiol Cell Physiol 284:C1355-61. 2003
    ..Therefore, glutamine protects from events associated with triggering and executing apoptosis in both rat and human neutrophils...
  4. ncbi request reprint Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils
    Tania Cristina Pithon-Curi
    Camilo Castelo Branco University and Methodist University of Piracicaba FACEF, Rua Carolina Fonseca 584, 08230 030 São Paulo, Brazil
    Clin Sci (Lond) 103:403-8. 2002
    ..We postulate that glutamine leads to O(2)(-) production in neutrophils, probably via the generation of ATP and regulation of the expression of components of NADPH oxidase...
  5. ncbi request reprint Effect of lipid infusion on metabolism and force of rat skeletal muscles during intense contractions
    Leonardor Silveira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Botantã, Sao Paulo, Brazil
    Cell Physiol Biochem 20:213-26. 2007
    ..05). We concluded that as mitochondrial function becomes limited by the FFA-uncoupling effect, the ATP demand is mainly supplied by anaerobic glucose metabolism preventing an expected decrease in muscle contraction performance...
  6. ncbi request reprint Short-term modulation of extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun NH2-terminal kinase in pancreatic islets by glucose and palmitate: possible involvement of ceramide
    Tatiane C A Nogueira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo USP, Sao Paulo, Brazil
    Pancreas 38:585-92. 2009
    ....
  7. ncbi request reprint Effect of fish oil supplementation for two generations on changes of lymphocyte function induced by Walker 256 cancer cachexia in rats
    Alessandra Folador
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Nutr Cancer 61:670-9. 2009
    ....
  8. doi request reprint Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation
    Augusto D Luchessi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Cell Physiol 218:480-9. 2009
    ..These results reveal a new physiological role for eIF5A and contribute to elucidate the molecular mechanisms involved in muscle regeneration...
  9. ncbi request reprint Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells
    Rozangela Verlengia
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Lipids 39:857-64. 2004
    ..However, remarkable differences were observed between DHA and EPA, demonstrating that specific effects of these FA may be responsible for the marked differences in edible oil effects on immune function in vivo reported by others...
  10. doi request reprint The effect of mate tea (Ilex paraguariensis) on metabolic and inflammatory parameters in high-fat diet-fed Wistar rats
    Maria Carolina Borges
    Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo 01246 904, Brazil
    Int J Food Sci Nutr 64:561-9. 2013
    ..In summary, the consumption of mate tea had no consistent effect in the inflammatory response of peritoneal macrophages, but reduced cardiometabolic risk markers. ..
  11. doi request reprint Effects of exercise on leukocyte death: prevention by hydrolyzed whey protein enriched with glutamine dipeptide
    Maria Fernanda Cury-Boaventura
    Post Graduate Program in Human Movement Science, Physical Education Post Graduate Studies, Biological Sciences and Health Center, Cruzeiro do Sul University, Rua Galvão Bueno, 868, Sao Paulo, CEP 01506 000, Brazil
    Eur J Appl Physiol 103:289-94. 2008
    ..MGln supplementation partially prevented lymphocyte apoptosis induced by exhaustive exercise possibly by a protective effect on mitochondrial function...
  12. doi request reprint Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion
    Tatiane C A Nogueira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo USP, Sao Paulo, Brazil
    Pancreas 37:309-15. 2008
    ..In the present study, a novel pathway by which palmitate potentiates glucose-induced insulin secretion by pancreatic beta cells was investigated...
  13. doi request reprint Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway
    Eliane Filiputti
    Department of Anatomy, Cell Biology and Physiology and Biophysics, Institute of Biology, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Metabolism 59:635-44. 2010
    ..These findings indicate that leucine supplementation can augment islet function in malnourished rats and that activation of the PI3K/mammalian target protein of rapamycin pathway may play a role in this process...
  14. ncbi request reprint Effect of indole-3-acetic acid administration by gavage and by subcutaneous injection on rat leukocytes
    Silvana M P Pugine
    Department of Basic Science, Faculty of Animal Science and Food Engineering FZEA, Pirassununga, SP, Brazil
    Cell Biochem Funct 25:723-30. 2007
    ..In conclusion, IAA administration either subcutaneously or by gavage could increase the phagocytic capacity by neutrophils and this acid administration did not have prooxidant effects or cytotoxic effects on neutrophils and lymphocytes...
  15. ncbi request reprint Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
    Anna Karenina Azevedo-Martins
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, CEP 05508 900 Butantan, Sao Paulo, Brazil
    Toxicol In Vitro 20:1106-13. 2006
    ..The results of this study contribute to the understanding of the role of FA in the impairment of pancreatic beta cell function that occurs in type 2 diabetes and obesity...
  16. ncbi request reprint Effect of olive oil-based emulsion on human lymphocyte and neutrophil death
    Maria Fernanda Cury-Boaventura
    Post Graduate Program in Human Movement Science, Biological Sciences and Health Center, Cruzeiro do Sul University, Sao Paulo, Brazil
    JPEN J Parenter Enteral Nutr 32:81-7. 2008
    ..In this study, the toxicity of an olive oil-based emulsion (OOE) on lymphocytes and neutrophils from healthy volunteers was investigated...
  17. pmc Oleic, linoleic and linolenic acids increase ros production by fibroblasts via NADPH oxidase activation
    Elaine Hatanaka
    Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
    PLoS ONE 8:e58626. 2013
    ..In conclusion, oleic, linoleic and γ-linolenic acids stimulated ROS production via activation of the NADPH oxidase enzyme complex in fibroblasts...
  18. doi request reprint Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats
    Hosana Gomes Rodrigues
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, Sao Paulo University, Avenida Prof Lineu Prestes, 1524, Butanta, Sao Paulo, SP, 05508 900, Brazil
    Lipids 45:809-19. 2010
    ..In conclusion, OLA and LNA modulate several functions of neutrophils and can influence the inflammatory process...
  19. doi request reprint Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes
    Fernando F Anhê
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Mol Cell Endocrinol 319:30-8. 2010
    ..The present study indicates that Smad5 regulates glucose uptake in skeletal muscle by controlling Akt2 expression and phosphorylation. These finding reveals Smad5 as a potential target for the therapeutic of type 2 diabetes...
  20. ncbi request reprint Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells
    Rafael Herling Lambertucci
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Cell Physiol 216:796-804. 2008
    ..The participation of this enzyme complex was confirmed through an increase of p47(phox) phosphorylation after treatment with PA...
  21. doi request reprint Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
    Sandro M Hirabara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Butanta, Sao Paulo, Brazil
    J Cell Physiol 222:187-94. 2010
    ..These results show that in muscle cells saturated FFA-induced mitochondrial dysfunction associated with impaired insulin-induced glucose metabolism...
  22. ncbi request reprint Toxicity of a soybean oil emulsion on human lymphocytes and neutrophils
    Maria Fernanda Cury-Boaventura
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, and the Division of Clinical Emergency, Faculty of Medicine, University of Sao Paulo, Av Prof Lineu Prestes 1524, CEP 05508 900 São Paulo, Brazil
    JPEN J Parenter Enteral Nutr 30:115-23. 2006
    ..In this study, the toxicity of a lipid emulsion rich (60%) in triacylglycerol of omega-6 polyunsaturated fatty acids on leukocytes from healthy volunteers was investigated...
  23. doi request reprint Fish oil supplementation for two generations increases insulin sensitivity in rats
    Sandro M Hirabara
    Institute of Physical Activity Sciences and Sport, Cruzeiro do Sul University, Sao Paulo, Brazil
    J Nutr Biochem 24:1136-45. 2013
    ....
  24. ncbi request reprint Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race
    Vinicius Coneglian Santos
    Inst of Physical Activity and Sports Sciences, Cruzeiro do Sul University, Sao Paulo, SP, Brazil
    Int J Sport Nutr Exerc Metab 23:161-9. 2013
    ..To investigate the effects of docosahexaenoic-(DHA)-rich fish oil (FO) supplementation on lymphocyte function before and after a marathon race...
  25. ncbi request reprint Apolipoprotein E genotype is related to nitric oxide production in platelets
    Tania Marcourakis
    Department of Clinical Chemistry and Toxicology, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Brazil
    Cell Biochem Funct 26:852-8. 2008
    ..These results suggest a possible influence of APOE genotype on nitric oxide (NO) production that might enhance the effects of age-related specific factor(s) associated with neurodegenerative disorders...
  26. ncbi request reprint Comparative toxicity of oleic and linoleic acid on human lymphocytes
    Maria F Cury-Boaventura
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, Av Prof Lineu Prestes, 1524, CEP 05508 900, University of Sao Paulo, SP, Brazil
    Life Sci 78:1448-56. 2006
    ..OA may offer an immunological less problematic alternative to LA with respect to fatty acid composition of parenteral nutritional emulsions...
  27. doi request reprint Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration
    Anderson C Marçal
    Departamento de Fisiologia e Biofisica, Instituto de Ciências Biomédicas ICB, Universidade de Sao Paulo USP, SP, Brazil
    Cell Biochem Funct 31:65-74. 2013
    ..We discuss these possibilities in further detail and advocate the use of this animal model for further understanding relationships between retinopathy, metabolic syndrome and type 2 diabetes...
  28. doi request reprint Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice
    Marco Aurélio Ramirez Vinolo
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, 05508 900, Butanta, Sao Paulo, SP, Brazil
    Am J Physiol Endocrinol Metab 303:E272-82. 2012
    ..The results, reported herein, suggest that Tb may be useful for the treatment and prevention of obesity-related metabolic disorders...
  29. doi request reprint Effects of short chain fatty acids on effector mechanisms of neutrophils
    Marco A R Vinolo
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, Sao Paulo University, SP, Brazil
    Cell Biochem Funct 27:48-55. 2009
    ..albicans. Propionate had no effect on the parameters studied. These results suggest that butyrate can modulate neutrophil function and thus could be important in inflammatory neutrophil-associated diseases...
  30. ncbi request reprint Effect of fish oil supplementation for 2 generations on changes in macrophage function induced by Walker 256 cancer cachexia in rats
    Alessandra Folador
    Department of Physiology and Biophysics, Institute de Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Int J Cancer 120:344-50. 2007
    ..These results suggest that fish oil supplementation for 2 generations improves macrophage function in association to reduced tumor growth and attenuated cancer cachexia, maintaining food intake and increasing animal survival...
  31. doi request reprint Gene expression reprogramming protects macrophage from septic-induced cell death
    Edielle Sant Anna Melo
    Emergency Medicine Department, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Mol Immunol 47:2587-93. 2010
    ..Thus, in the current study we provide evidence for the selective reprogramming of the gene expression of cell death pathways during LPS tolerance and link these changes to protection from cell death and enhanced survival rates...
  32. doi request reprint Decreased ABCB1 mRNA expression induced by atorvastatin results from enhanced mRNA degradation in HepG2 cells
    Alice Cristina Rodrigues
    Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 580, Sao Paulo, SP 05508 900, Brazil
    Eur J Pharm Sci 37:486-91. 2009
    ..Therefore, evidence is provided that decreased mRNA stability by atorvastatin treatment may explain the decrease in ABCB1 transcript levels...
  33. ncbi request reprint Regulation of interleukin-2 signaling by fatty acids in human lymphocytes
    Renata Gorjao
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Lipid Res 48:2009-19. 2007
    ..The inhibition of JAK1, JAK3, STAT5, ERK1/2, and Akt phosphorylation caused by DHA, SA, and PA is associated with an alteration of CD25 expression at the cell surface...
  34. doi request reprint Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid
    Hilton Kenji Takahashi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Cell Physiol 227:339-50. 2012
    ..These findings may explain aspects of lymphocyte dysfunction associated with diabetes...
  35. doi request reprint UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells
    José Edgar Nicoletti-Carvalho
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Prof Lineu Prestes Ave 1524, 05508 900 Sao Paulo, SP, Brazil
    J Endocrinol 206:183-93. 2010
    ..In this way, CHOP and ATF4 might mediate PA-induced TRIB3 expression and, by extension, the suppression of IL6 activation of pro-survival kinase AKT...
  36. ncbi request reprint Mechanisms by which fatty acids regulate leucocyte function
    Thais Martins De Lima
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Clin Sci (Lond) 113:65-77. 2007
    ....
  37. doi request reprint Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: a randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer
    Raquel Susana Matos de Miranda Torrinhas
    Department of Gastroenterology, Medical School, LIM 35, University of Sao Paulo, Sao Paulo, Brazil
    Clin Nutr 32:503-10. 2013
    ..Fish oil-based lipid emulsions (FOLEs) have shown post-operative immunological and clinical benefits in parenteral nutrition...
  38. ncbi request reprint Genes regulated by arachidonic and oleic acids in Raji cells
    Rozangela Verlengia
    Methodist University of Piracicaba, Faculty of Sciences of Health, Physical Education, Sao Paulo, Brazil
    Lipids 38:1157-65. 2003
    ..These results led us to conclude that the effect of these FA on B-lymphocytes includes regulation of gene expression. Thus, diets enriched with fat containing OA or AA may affect B lymphocyte function in vivo...
  39. ncbi request reprint Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats
    Rafael H Lambertucci
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1524, 05508 900 Sao Paulo, SP, Brazil
    Mech Ageing Dev 128:267-75. 2007
    ..These findings support the proposition that exercise training presents an antioxidant stress effect on skeletal muscle from both young and aged rats...
  40. doi request reprint Local injections of adipose-derived mesenchymal stem cells modulate inflammation and increase angiogenesis ameliorating the dystrophic phenotype in dystrophin-deficient skeletal muscle
    Carlos Hermano da Justa Pinheiro
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524 Prédio Biomédicas I Cidade Universitária, Butanta, São Paulo CEP 05508 900, Brazil
    Stem Cell Rev 8:363-74. 2012
    ..These results suggest that ADMSC transplantation modulates inflammation and improves muscle tissue regeneration, ameliorating the dystrophic phenotype in dystrophin-deficient mice...
  41. doi request reprint Effects of moderate electrical stimulation on reactive species production by primary rat skeletal muscle cells: cross talk between superoxide and nitric oxide production
    Rafael Herling Lambertucci
    Post graduate Program in Human Movement Sciences, Biological Sciences and Health Center, Cruzeiro do Sul University, Sao Paulo, Brazil
    J Cell Physiol 227:2511-8. 2012
    ..The cross talk between these reactive species likely plays a role in exercise-induced maintenance and adaptation by regulating muscular glucose metabolism, force of contraction, fatigue, and antioxidant systems activities...
  42. ncbi request reprint Glutamine, gene expression, and cell function
    Rui Curi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brasil
    Front Biosci 12:344-57. 2007
    ..In this review, we have attempted to identify some of the common mechanisms underlying glutamine dependent changes in gene and protein expression and cellular function...
  43. doi request reprint Neutrophil death induced by a triathlon competition in elite athletes
    Adriana Cristina Levada-Pires
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Med Sci Sports Exerc 40:1447-54. 2008
    ..The effect of a triathlon competition on death of neutrophils from elite athletes was investigated...
  44. doi request reprint Induction of lymphocyte death by short- and long-duration triathlon competitions
    Adriana Cristina Levada-Pires
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Med Sci Sports Exerc 41:1896-901. 2009
    ..The effect of triathlon competitions on death of lymphocytes from elite athletes was investigated...
  45. ncbi request reprint Palmitate activates insulin signaling pathway in pancreatic rat islets
    Maria Fernanda R Graciano
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Pancreas 38:578-84. 2009
    ..The following proteins were studied: IR substrate-1 and -2 (IRS1 and IRS2), phosphatidylinositol 3-kinase, extracellular signal-regulated protein kinase-1 and -2 (ERK1/2), and signal transducer and activator of transcription 3 (STAT3)...
  46. ncbi request reprint Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle
    Sandro M Hirabara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, Av Professor Lineu Prestes, 1524 Butanta, Sao Paulo, SP 05508 900, Brazil
    Biochim Biophys Acta 1757:57-66. 2006
    ..Palmitic acid increased oxygen consumption by anesthetized rats. These results suggest that long-chain FFA acutely lead to mitochondrial uncoupling in skeletal muscle...
  47. ncbi request reprint Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function
    Renata Gorjao
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butanta, Sao Paulo, SP, Brazil
    Clin Nutr 25:923-38. 2006
    ..The effect of a docosahexaenoic acid (DHA)-rich fish oil (FO) supplementation on human leukocyte function was investigated...
  48. ncbi request reprint Toxicity of a mixture of fatty acids on human blood lymphocytes and leukaemia cell lines
    Rosemari Otton
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900 Butantan, Sao Paulo, SP, Brazil
    Toxicol In Vitro 19:749-55. 2005
    ..Evidence is presented herein that mitochondria from leukaemic cells are more susceptible to the toxicity of the fatty acids than mitochondria from human circulating lymphocytes...
  49. doi request reprint Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice
    Talita Romanatto
    Laboratory for Lipid Medicine and Technology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Biochim Biophys Acta 1842:186-91. 2014
    ..These findings support the beneficial effects of elevated tissue n-3 fatty acid status in the prevention and treatment of age-related chronic metabolic diseases...
  50. pmc Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats
    Adriana C Lambertucci
    Institute of Physical Activity Sciences and Sports, Post graduate Program in Human Movement Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
    PLoS ONE 7:e50390. 2012
    ..The data suggest that glutamine supplementation is potentially useful for slowing the progression of muscle atrophy in patients with diabetes...
  51. doi request reprint High-fat diet blunts activation of the nuclear factor-κB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats
    Maria C Borges
    Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 29:443-9. 2013
    ..The present study was designed to investigate the effect of a high-fat diet (HFD) on the inflammatory response of peritoneal macrophages...
  52. doi request reprint Oral administration of oleic or linoleic acids modulates the production of inflammatory mediators by rat macrophages
    Juliana Magdalon
    Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Prof Lineu Prestes 1524, Cidade Universitaria, Sao Paulo, SP, Brazil
    Lipids 47:803-12. 2012
    ..Neither fatty acid affected the production of superoxide anion, hydrogen peroxide, nitrite, TNF-α, PGE(2), LTB(4) or 15(S)-HETE. Thus, OLA and LNA influence the production of several inflammatory mediators by macrophages...
  53. ncbi request reprint The mechanism of indole acetic acid cytotoxicity
    Mariza Pires de Melo
    Department of Basic Science, Faculty of Zootechny and Food Engineering, University of Sao Paulo, Av Duque de Caxias Norte, 225, 13635 000 Pirassununga, SP, Brazil
    Toxicol Lett 148:103-11. 2004
    ..The addition of exogenous antioxidant enzymes (SOD and CAT) prevented the loss of cell membrane integrity induced by IAA. Therefore, the process of cell death induced by IAA involves ROS production...
  54. doi request reprint Influence of the bilayer composition on the binding and membrane disrupting effect of Polybia-MP1, an antimicrobial mastoparan peptide with leukemic T-lymphocyte cell selectivity
    Marcia Perez Dos Santos Cabrera
    UNESP Sao Paulo State University, Center of Studies of Social Insects, Institute of Biosciences, 13506 900 Rio Claro, SP, Brazil
    Biochemistry 51:4898-908. 2012
    ..Additionally, the absence of cholesterol resulted in enhanced pore activity. These findings may drive the selective toxicity of MP-1 to Jurkat cells...
  55. doi request reprint Mammalian target of rapamycin complex 1 is involved in differentiation of regenerating myofibers in vivo
    Elen H Miyabara
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Muscle Nerve 42:778-87. 2010
    ..This study indicates that mTORC1 plays a key role in the recovery of muscle mass and the differentiation of regenerating myofibers, independently of necrosis and satellite cell proliferation mechanisms...
  56. doi request reprint Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages
    Marcelo Macedo Rogero
    Department of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715, Sao Paulo, SP, 01246 904, Brazil
    Amino Acids 39:435-41. 2010
    ..05). Glutamine modulates NF-kappaB signaling pathway by reducing the level of I kappaB-alpha, leading to an increase in NF-kappaB within the nucleus in peritoneal macrophages...
  57. doi request reprint In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1
    Cristina B Hebeda
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 0550 900, Av Prof Lineu Prestes 580 BI13 B, SP, Brazil
    Biochem Biophys Res Commun 377:694-8. 2008
    ..Our results show that NO, produced at physiological levels, controls expression of constitutive adhesion molecules expressions in cell membranes by different mechanisms of action...
  58. ncbi request reprint Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases
    Igor L Baptista
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, Butanta, CEP 05508 900, Sao Paulo, Brazil
    Muscle Nerve 41:800-8. 2010
    ..It is notable that leucine supplementation does not restore decreased protein synthesis driven by immobilization...
  59. ncbi request reprint Postpartum glycemic homeostasis in early lactating rats is accompanied by transient and specific increase of soleus insulin response through IRS2/AKT pathway
    Gabriel F Anhê
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Am J Physiol Regul Integr Comp Physiol 292:R2225-33. 2007
    ..These results suggest that improved insulin action in oxidative, but not in glycolytic muscle might contribute to achievement of glucose homeostasis postpartum...
  60. ncbi request reprint Time-dependent effects of fatty acids on skeletal muscle metabolism
    Sandro M Hirabara
    Department of Physiology and Biophysics, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Cell Physiol 210:7-15. 2007
    ..In this review, we discuss the differences between the effects of acute and prolonged exposure to FFA on skeletal muscle glucose metabolism and the possible mechanisms involved in the FFA-induced insulin resistance...
  61. ncbi request reprint Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells
    Rozangela Verlengia
    Methodist University of Piracicaba, Faculty of Physical Education, Faculdade de Educação Física, Sao Paulo, Brazil
    J Nutr Biochem 15:657-65. 2004
    ..Marked differences were observed between the effects of EPA and DHA, indicating that it is an over-simplification to generalize the effects of n-3 fatty acids...
  62. pmc Sunflower oil supplementation has proinflammatory effects and does not reverse insulin resistance in obesity induced by high-fat diet in C57BL/6 mice
    Laureane Nunes Masi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Avenu Professor Lineu Prestes, Butanta, 1524 Sao Paulo, SP, Brazil
    J Biomed Biotechnol 2012:945131. 2012
    ..In conclusion, sunflower oil supplementation improves lipid profile, but it does not prevent or attenuate insulin resistance and inflammation induced by HFD in C57BL/6 mice...
  63. doi request reprint Inflammatory response and neutrophil functions in players after a futsal match
    Nivaldo R de Moura
    Post graduate Program in Human Movement Sciences, Institute of Physical Activity and Sport Sciences ICAFE, Cruzeiro do Sul University, Sao Paulo, Brazil
    J Strength Cond Res 26:2507-14. 2012
    ..5-fold), and the phagocytic capacity (1.6-fold). We concluded that playing futsal induces inflammation, primes and activates neutrophils, and reduces the efficiency of neutrophil phagocytosis immediately after a match...
  64. ncbi request reprint Expression of NADPH oxidase in human pancreatic islets
    Eduardo Rebelato
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Life Sci 91:244-9. 2012
    ..In this study, the presence of this enzyme in human pancreatic islets and the importance of NADPH oxidase in human β-cell function were investigated...
  65. doi request reprint The β2-adrenoceptor agonist formoterol improves structural and functional regenerative capacity of skeletal muscles from aged rat at the early stages of postinjury
    Talita C Conte
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Gerontol A Biol Sci Med Sci 67:443-55. 2012
    ..Furthermore, formoterol may have therapeutic benefits in recovery following muscle damage in senescent individuals...
  66. doi request reprint ABCA1 and ABCG1 expressions are regulated by statins and ezetimibe in Caco-2 cells
    Fabiana D V Genvigir
    Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Drug Metabol Drug Interact 26:33-6. 2011
    ..We hypothesized that these drugs could modulate the expression of intestinal ABCA1 and ABCG1, two genes involved in HDL metabolism...
  67. doi request reprint Comparative effects of DHA and EPA on cell function
    Renata Gorjao
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Pharmacol Ther 122:56-64. 2009
    ..Substantial improvement in the therapeutic usage of omega-3 fatty acid-rich FO will be possible with the discovery of the different mechanisms of actions of DHA and EPA...
  68. ncbi request reprint Mechanisms involved in Jurkat cell death induced by oleic and linoleic acids
    Maria Fernanda Cury-Boaventura
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, Av Prof Lineu Prestes, 1524, CEP 05508 900, University of Sao Paulo, SP, Brazil
    Clin Nutr 25:1004-14. 2006
    ..The mechanisms involved in the toxicity induced by OA and LA on Jurkat cells were determined in vitro...
  69. ncbi request reprint Modulation of lymphocyte proliferation by macrophages and macrophages loaded with arachidonic acid
    Carmem Maldonado Peres
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Cell Biochem Funct 23:373-81. 2005
    ..These findings support the proposition that AA can directly modulate lymphocyte proliferation and the interaction between macrophages and lymphocytes...
  70. pmc Control of the intracellular redox state by glucose participates in the insulin secretion mechanism
    Eduardo Rebelato
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 6:e24507. 2011
    ..In the present study, a systematic investigation in rat pancreatic islets about the changes in the redox environment induced by acute exposure to glucose was carried out...
  71. doi request reprint Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage
    Thais Martins de Lima-Salgado
    Laboratory of Clinical Emergency, Emergency Medicine Department, Medical School, University of Sao Paulo, SP, Brazil
    Cell Biochem Biophys 59:89-97. 2011
    ....
  72. doi request reprint NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets
    Maria Fernanda R Graciano
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Cell Physiol 226:1110-7. 2011
    ..In conclusion, NAD(P)H oxidase is an important source of superoxide in pancreatic islets and the activity of NAD(P)H oxidase is involved in the control of insulin secretion by palmitate...
  73. doi request reprint Oleic acid modulates metabolic substrate channeling during glucose-stimulated insulin secretion via NAD(P)H oxidase
    Laila R B Santos
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil 05880 900
    Endocrinology 152:3614-21. 2011
    ..Thus, ROS derived from OA metabolism via NAD(P)H oxidase are an inhibitor of glucose oxidation. Put together, these results indicate that OA acts as a modulator of glucose oxidation via ROS derived from its own metabolism in β-cells...
  74. ncbi request reprint Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging
    Augusto D Luchessi
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, Sao Paulo, SP, Brazil
    Brain Res 1228:6-13. 2008
    ..Detection of high eIF5A content was revealed in dendritic varicosities of Purkinje cells. Evidence is presented herein that a reduction of eIF5A content is associated to brain aging...
  75. ncbi request reprint Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats
    Tatiana Carolina Alba-Loureiro
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Shock 30:308-10. 2008
    ..These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states...
  76. ncbi request reprint Induction of apoptosis in rat lymphocytes by starvation
    Juliana Pires
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, Butantan 05508 900, Sao Paulo, SP, Brazil
    Clin Sci (Lond) 112:59-67. 2007
    ..These findings support the hypothesis that conditions that raise plasma fatty acids levels (e.g. diabetes and starvation) may impair immune function by causing lymphocyte death...
  77. ncbi request reprint Effect of a single session of electrical stimulation on activity and expression of citrate synthase and antioxidant enzymes in rat soleus muscle
    Aurélio da Silva Pimenta
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Eur J Appl Physiol 102:119-26. 2007
    ..This increase in expression of CAT may play an important role in counteracting the potential deleterious effects of elevated oxidative stress induced by a high oxidative demand in skeletal muscles subjected to exercise training...
  78. ncbi request reprint Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression
    Claudia J Lagranha
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Cell Biochem Funct 25:563-9. 2007
    ..Glutamine supplementation prevents these effects of exercise and reduces apoptosis...
  79. ncbi request reprint Exercise training raises expression of the cytosolic components of NADPH oxidase in rat neutrophils
    Adriana C Levada-Pires
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Eur J Appl Physiol 100:153-60. 2007
    ..Therefore, moderate exercise might enable neutrophils to respond more efficiently when exposed to pathogens...
  80. doi request reprint Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells
    Fabiana Dalla Vecchia Genvigir
    Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Pharmacogenomics 11:1235-46. 2010
    ....
  81. doi request reprint Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
    Marciane Milanski
    Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil
    J Neurosci 29:359-70. 2009
    ....
  82. ncbi request reprint Cachexia induced by Walker 256 tumor growth causes rat lymphocyte death
    Thais Martins de Lima
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, AV Professor Lineu Prestes 1524, 05508 900, Sao Paulo, Brazil
    Cancer Immunol Immunother 54:179-86. 2005
    ..Evidence was found for the involvement of mitochondria and important proapoptotic genes in the process of lymphocyte death by Walker 256 tumor cachexia...
  83. doi request reprint Soybean and sunflower oil-induced insulin resistance correlates with impaired GLUT4 protein expression and translocation specifically in white adipose tissue
    Ana Cláudia Poletto
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Cell Biochem Funct 28:114-21. 2010
    ..These alterations are likely to be caused due to the specific local increase in saturated fatty acids that occurred as a consequence of oil daily injections...
  84. ncbi request reprint Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes
    Claudia R Cavaglieri
    Biomedical Sciences Group, Health Sciences Faculty, Methodist University of Piracicaba, SP, Brazil
    Life Sci 73:1683-90. 2003
    ..A combination of the three SCFA causes a shift in the T helper lymphocyte phenotype towards a more anti-inflammatory phenotype and this might explain the protective effects of fiber...
  85. ncbi request reprint Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets
    Esther P Haber
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, Av Prof Lineu Prestes 1524, Butanta, Brazil
    FEBS Lett 544:185-8. 2003
    ..This result supports the proposition that protein acylation may be an important mechanism by which palmitate exerts its modulating effect on the intracellular insulin signalling pathway in rat pancreatic islets...
  86. doi request reprint Modulation of rat neutrophil function in vitro by cis- and trans-MUFA
    Renato Padovese
    Post graduate Program in Human Movement Sciences, Cruzeiro do Sul University, Rua Galvão Bueno, 868 Bloco B, 11 andar, São Paulo 01506 000, SP, Brazil
    Br J Nutr 101:1351-9. 2009
    ..Experiments using Zn2+, an inhibitor of NADPH oxidase H+ channel, indicated that MUFA activate the NADPH oxidase complex in rat neutrophil due to opening of H+ channel...
  87. ncbi request reprint The effect of glutamine supplementation on the function of neutrophils from exercised rats
    Claudia Jacques Lagranha
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
    Cell Biochem Funct 23:101-7. 2005
    ..Glutamine supplementation presents a significant effect on neutrophil function including changes induced by exercise...
  88. ncbi request reprint Effect of arachidonic acid on proliferation, cytokines production and pleiotropic genes expression in Jurkat cells--a comparison with oleic acid
    Rozangela Verlengia
    Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900, Butanta, Sao Paulo, SP, Brazil
    Life Sci 73:2939-51. 2003
    ..Therefore, the effect of AA on T-lymphocyte function does involve regulation of expression of important genes, whereas oleic acid did not markedly affect gene expression of Jurkat cells...
  89. ncbi request reprint Glucose and glutamine utilization by rat lymphocytes, monocytes and neutrophils in culture: a comparative study
    Tania Cristina Pithon-Curi
    Methodist University of Piracicaba Facis, Sao Paulo, Brazil
    Cell Biochem Funct 22:321-6. 2004
    ..Under conditions closer to physiological when the availability of a variety of metabolites and vitamins is not restricted, glucose is the preferred substrate for lymphocytes, monocytes and neutrophils...
  90. ncbi request reprint Palmitate acutely raises glycogen synthesis in rat soleus muscle by a mechanism that requires its metabolization (Randle cycle)
    Sandro Massao Hirabara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, Butanta, Brazil
    FEBS Lett 541:109-14. 2003
    ..The inhibitory effect of palmitate on insulin-stimulated protein phosphorylation might play an important role for the development of insulin resistance in conditions of chronic exposure to high levels of fatty acids...
  91. ncbi request reprint Systematic study on ROS production induced by oleic, linoleic, and gamma-linolenic acids in human and rat neutrophils
    Elaine Hatanaka
    Institute of Biomedical Sciences, Department of Physiology and Biophysics, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524, 05508 900 Butanta, Sao Paulo, SP, Brazil
    Free Radic Biol Med 41:1124-32. 2006
    ..Oleic, linoleic, and gamma-linolenic acids do stimulate ROS production by neutrophils; however, measurements using the luminol-amplified chemiluminescence and cytochrome c reduction techniques require further analysis...
  92. ncbi request reprint Indole-3-acetic acid increases glutamine utilization by high peroxidase activity-presenting leukocytes
    Mariza P De Melo
    Department of Basic Science, Faculty of Zootechny and Food Engineering FZEA, University of Sao Paulo, Pirassununga, Brazil
    Life Sci 75:1713-25. 2004
    ..The toxic results presented here show that the affect of IAA in association with peroxidase involves activation of glutamine metabolism...
  93. doi request reprint Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells
    Monique Nouailhetas Simon
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, Brazil
    Toxicol In Vitro 22:1018-24. 2008
    ..Besides, when this activation is persistent, it may overcome a posterior induction of death pathways...
  94. ncbi request reprint NBD-cholesterol incorporation by rat macrophages and lymphocytes: a process dependent on the activation state of the cells
    Erica P Portioli Silva
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
    Cell Biochem Funct 22:23-8. 2004
    ..The findings presented herein led us to conclude that the uptake of NBD-cholesterol by Ma and LY is markedly affected by the activation state of the cells...
  95. ncbi request reprint Modulation of lipopolysaccharide-induced acute lung inflammation: Role of insulin
    Joilson de Oliveira Martins
    Research Division, Heart Institute InCor, LIM 11, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil
    Shock 25:260-6. 2006
    ..Data presented suggest that insulin modulates the production/release of cytokines and the expression of adhesion molecules controlling, therefore, neutrophil migration during the course of LPS-induced acute lung inflammation...
  96. ncbi request reprint Beneficial effect of glutamine on exercise-induced apoptosis of rat neutrophils
    Claudia J Lagranha
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1524, 05508 900 Sao Paulo, SP, Brazil
    Med Sci Sports Exerc 36:210-7. 2004
    ..The experiments were performed in sexually immature and sexually mature male rats as to examine the possible involvement of sexual maturation in the effect of exercise...
  97. ncbi request reprint Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth
    Miriam G Jasiulionis
    Department of Micro Immuno Parasitology, Federal University of Sao Paulo, 04023 062, Sao Paulo, Brazil
    Cell Biochem Funct 25:109-14. 2007
    ..Exposure to GC7 also decreased viability to both cell lines. This study also describes, for the first time, the in vivo antitumour effect of GC7, as indicated by impaired melanoma growth in C57BL/6 mice...
  98. doi request reprint Testosterone suppresses oxidative stress in human neutrophils
    Douglas Popp Marin
    Postgraduate Program Human Movement Sciences Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Sao Paulo, SP 01506 000, Brazil
    Cell Biochem Funct 28:394-402. 2010
    ..Therefore, the plasma levels of testosterone are important regulators of neutrophil function and so of the inflammatory response...
  99. ncbi request reprint Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells
    Thais Martins de Lima
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, 05508 900 Sao Paulo, Brazil
    Toxicol In Vitro 21:1678-85. 2007
    ..These results indicate that long-term pre-treatment with DHA makes Bcr-Abl HL-60 cells more susceptible to the toxic effect of imatinib...
  100. ncbi request reprint Role of fatty acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise
    Sandro M Hirabara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1524, CEP 05508 900 Butanta, Sao Paulo, SP, Brazil
    Cell Biochem Funct 24:475-81. 2006
    ....
  101. doi request reprint Microcystins -LA, -YR, and -LR action on neutrophil migration
    Paula Kujbida
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Avenida Prof Lineu Prestes, 580 bloco 13 B, 05508 900 Butanta, Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 382:9-14. 2009
    ..In conclusion, our results show that MCs act on specific pathways of neutrophil recruitment, indicating their potential effect on neutrophils activation...