Edecio Cunha-Neto

Summary

Country: Brazil

Publications

  1. pmc Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy
    Priscila Camillo Teixeira
    Laboratory of Immunology, Heart Institute, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 5:e1205. 2011
  2. pmc Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10
    Luciana Gabriel Nogueira
    Laboratory of Immunology, Heart Institute InCor, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 6:e1867. 2012
  3. pmc Evidence for T Cell Help in the IgG Response against Tandemly Repetitive Trypanosoma cruzi B13 Protein in Chronic Chagas Disease Patients
    Márcia Duranti
    Laboratory of Immunology, Heart Institute InCor, School of Medicine, University of Sao Paulo, 05403 900 Sao Paulo, SP, Brazil
    J Parasitol Res 2012:635873. 2012
  4. ncbi request reprint Cytokine production profile of heart-infiltrating T cells in Chagas' disease cardiomyopathy
    E Cunha-Neto
    Laboratório de Imunologia de Transplantes, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 31:133-7. 1998
  5. doi request reprint Myocardial gene and protein expression profiles after autoimmune injury in Chagas' disease cardiomyopathy
    Edecio Cunha-Neto
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Autoimmun Rev 10:163-5. 2011
  6. ncbi request reprint Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry
    Edecio Cunha-Neto
    Heart Institute InCor, Laboratory of Immunology, Sao Paulo, Brazil
    Autoimmunity 39:41-54. 2006
  7. ncbi request reprint Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy
    Edecio Cunha-Neto
    Laboratorio de Imunologia, Instituto do Coracao, Hospital das Clinicas, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 104:252-8. 2009
  8. ncbi request reprint Heart-infiltrating and peripheral T cells in the pathogenesis of human Chagas' disease cardiomyopathy
    E Cunha-Neto
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo School of Medicine, SP, Brazil
    Autoimmunity 34:187-92. 2001
  9. ncbi request reprint MHC-restricted antigen presentation and recognition: constraints on gene, recombinant and peptide vaccines in humans
    E Cunha-Neto
    Laboratório de Imunologia de Transplantes, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 32:199-205. 1999
  10. pmc Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides
    Rafael Ribeiro Almeida
    Laboratory of Clinical Immunology and Allergy LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    PLoS ONE 7:e45267. 2012

Research Grants

Collaborators

Detail Information

Publications47

  1. pmc Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy
    Priscila Camillo Teixeira
    Laboratory of Immunology, Heart Institute, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 5:e1205. 2011
    ....
  2. pmc Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10
    Luciana Gabriel Nogueira
    Laboratory of Immunology, Heart Institute InCor, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 6:e1867. 2012
    ..Even though the Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis, little is known about the factors controlling inflammatory cell migration to CCC myocardium...
  3. pmc Evidence for T Cell Help in the IgG Response against Tandemly Repetitive Trypanosoma cruzi B13 Protein in Chronic Chagas Disease Patients
    Márcia Duranti
    Laboratory of Immunology, Heart Institute InCor, School of Medicine, University of Sao Paulo, 05403 900 Sao Paulo, SP, Brazil
    J Parasitol Res 2012:635873. 2012
    ..In addition, the finding of increased anti-B13 IgG levels in sera from CCC patients indicates that clinical presentation is associated with increased anti-B13 antibody levels...
  4. ncbi request reprint Cytokine production profile of heart-infiltrating T cells in Chagas' disease cardiomyopathy
    E Cunha-Neto
    Laboratório de Imunologia de Transplantes, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 31:133-7. 1998
    ..The bulk of evidence points to a significant production of IFN-gamma and TNF-alpha which may be linked to T. cruzi-induced IL-12 production...
  5. doi request reprint Myocardial gene and protein expression profiles after autoimmune injury in Chagas' disease cardiomyopathy
    Edecio Cunha-Neto
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Autoimmun Rev 10:163-5. 2011
    ..It can be hypothesized that cytokine-induced modulation of cardiomyocyte gene/protein expression may be a novel disease mechanism in CCC, in addition to direct inflammatory damage...
  6. ncbi request reprint Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry
    Edecio Cunha-Neto
    Heart Institute InCor, Laboratory of Immunology, Sao Paulo, Brazil
    Autoimmunity 39:41-54. 2006
    ..The authors will review the evidence in support of an autoimmune basis for CCC pathogenesis in humans and experimental animals, with a special emphasis on molecular mimicry as a fundamental mechanism of autoimmunity...
  7. ncbi request reprint Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy
    Edecio Cunha-Neto
    Laboratorio de Imunologia, Instituto do Coracao, Hospital das Clinicas, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 104:252-8. 2009
    ..We will review the molecular and immunological mechanisms of myocardial damage in human CCC in light of recent findings...
  8. ncbi request reprint Heart-infiltrating and peripheral T cells in the pathogenesis of human Chagas' disease cardiomyopathy
    E Cunha-Neto
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo School of Medicine, SP, Brazil
    Autoimmunity 34:187-92. 2001
    ..Furthermore, the distinct recognition repertoire and the high frequency of IFN-gamma producing among CCC patients could be important factors leading to the differential development of CCC among T. cruzi infected individuals...
  9. ncbi request reprint MHC-restricted antigen presentation and recognition: constraints on gene, recombinant and peptide vaccines in humans
    E Cunha-Neto
    Laboratório de Imunologia de Transplantes, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 32:199-205. 1999
    ..In this short review, we will discuss the several concepts related to selection of amino acid sequences to be included in DNA and peptide vaccines...
  10. pmc Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides
    Rafael Ribeiro Almeida
    Laboratory of Clinical Immunology and Allergy LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    PLoS ONE 7:e45267. 2012
    ..This vaccine concept may cope with HIV-1 genetic diversity as well as provide increased population coverage, which are desirable features for an efficacious strategy against HIV-1/AIDS...
  11. doi request reprint Polymorphisms in the gene for lymphotoxin-alpha predispose to chronic Chagas cardiomyopathy
    Rajendranath Ramasawmy
    Heart Institute InCor, Department of Clinical Medicine, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Infect Dis 196:1836-43. 2007
    ..Proinflammatory cytokines play a key role in the development of CCC. Clinical, genetic, and epidemiological studies have linked lymphotoxin-alpha (LTA), a proinflammatory cytokine, to coronary artery disease and myocardial infarction...
  12. pmc T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals
    Leo Kei Iwai
    Laboratory of Immunolgoy, Heart Institute InCor, Millenium Institutes, Sao Paulo, Brazil
    Clin Vaccine Immunol 14:474-6. 2007
    ....
  13. ncbi request reprint BAT1, a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy
    Rajendranath Ramasawmy
    Heart Institute InCor, University of Sao Paulo, Brazil
    J Infect Dis 193:1394-9. 2006
    ..BAT1, a putative anti-inflammatory gene, presents functional polymorphisms in its promoter region that influence its transcriptional level...
  14. ncbi request reprint The monocyte chemoattractant protein-1 gene polymorphism is associated with cardiomyopathy in human chagas disease
    Rajendranath Ramasawmy
    Laboratory of Immunology, Heart Institute InCor, Sao Paulo, SP, Brazil
    Clin Infect Dis 43:305-11. 2006
    ..cruzi in murine macrophages and to up-regulate the inducible nitric oxide synthase/nitric oxide system, with a consequent increased production of nitric oxide that controls the replication of the parasite...
  15. ncbi request reprint TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients
    Sandra A Drigo
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar 44, Bloco 2, 9 andar, CEP 05403 001 São Paulo, Brazil
    Microbes Infect 8:598-603. 2006
    ..The association of TNF genotype with earlier death in CCC should be taken into account when planning therapeutic intervention...
  16. pmc Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions
    Luiza Guilherme
    Laboratorio de Imunologia, Instituto do Coracao, HC FMUSP, Av Dr Eneas de Carvalho Aguiar, 44 9 andar, Sao Paulo SP, 05403 000, Brazil
    Am J Pathol 165:1583-91. 2004
    ..3; odds ratio, 15.8). The lack of IL-4 in vitro production by valve-derived HIL also emphasizes the more severe tissue destruction in valves observed in RHD...
  17. ncbi request reprint Lack of association of tumor necrosis factor-alpha polymorphisms with Chagas disease in Brazilian patients
    Sandra A Drigo
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Immunol Lett 108:109-11. 2007
    ..These results indicate that TNF polymorphisms are associated neither to CCC development nor to progression to more severe forms of cardiomyopathy in Brazilian Chagas disease patients...
  18. ncbi request reprint Identification of novel consensus CD4 T-cell epitopes from clade B HIV-1 whole genome that are frequently recognized by HIV-1 infected patients
    Simone G Fonseca
    Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, Brazil
    AIDS 20:2263-73. 2006
    ..To identify promiscuous and potentially protective human CD4 T-cell epitopes in most conserved regions within the protein-coding genome of HIV-1 clade B consensus sequence...
  19. ncbi request reprint T cell epitope characterization in tandemly repetitive Trypanosoma cruzi B13 protein
    Lucia C J Abel
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo School of Medicine, Av Dr Eneas de Carvalho Aguiar, 44, Bloco II, 9th andar, Sao Paulo, SP 05403 000, Brazil
    Microbes Infect 7:1184-95. 2005
    ..This is the first thorough characterization of T cell epitopes of a tandemly repetitive protozoan antigen and may suggest a role for T cell help in the immunodominance of protozoan repetitive antigens...
  20. ncbi request reprint Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals
    Rajendranath Ramasawmy
    Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Mol Immunol 45:283-8. 2008
    ..3-6.0]. The haplotype -262A -62A was prevalent in patients with CCC (40% versus 24%; OR 2.1 [95% CI 1.4-3.3]; Pc=0.0014). The IKBL locus itself or another critical gene in this region may confer susceptibility to the development of CCC...
  21. ncbi request reprint Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients
    Simone G Fonseca
    Laboratorio de Imunologia, Heart Institute, Instituto do Coração InCor, Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Eneas de Carvalho Aguiar, 44 BL 2, 9 andar, São Paulo SP 05403 000, Brazil
    Microbes Infect 7:688-97. 2005
    ..Thus, our results suggest that the recognition of CD8+ T cell epitopes in cruzipain and FL-160 may have a pathogenic or protective role in chronic Chagas disease...
  22. ncbi request reprint TNF blockade aggravates experimental chronic Chagas disease cardiomyopathy
    Angelina M B Bilate
    Heart Institute InCor, University of Sao Paulo, São Paulo 05403 000, Brazil
    Microbes Infect 9:1104-13. 2007
    ..cruzi-induced chronic cardiomyopathy and the absence of TNF signaling may be deleterious to the failing heart in Chagas disease cardiomyopathy...
  23. ncbi request reprint Pathogenesis of chronic Chagas heart disease
    Jose Antonio Marin-Neto
    Cardiology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Circulation 115:1109-23. 2007
    ..Despite nearly 1 century of research, the pathogenesis of chronic Chagas cardiomyopathy is incompletely understood, the most intriguing challenge of which is the complex host-parasite interaction...
  24. doi request reprint Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy
    Rajendranath Ramasawmy
    Heart Institute, InCor, Sao Paulo, Brazil
    J Infect Dis 199:1838-45. 2009
    ..cruzi-infected individuals...
  25. pmc CXCL9/Mig mediates T cells recruitment to valvular tissue lesions of chronic rheumatic heart disease patients
    Kellen C Fae
    Heart Institute, School of Medicine, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar, 44, 05403 000, Sao Paulo, SP, Brazil
    Inflammation 36:800-11. 2013
    ..Collectively, our results show that a diverse milieu of chemokines is expressed in myocardium and valvular tissue lesions and emphasize the role of CXCL9/Mig in mediating T cell recruitment to the site of inflammation in the heart. ..
  26. pmc A vaccine encoding conserved promiscuous HIV CD4 epitopes induces broad T cell responses in mice transgenic to multiple common HLA class II molecules
    Susan Pereira Ribeiro
    Laboratory of Clinical Immunology and Allergy LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    PLoS ONE 5:e11072. 2010
    ..The vaccine may thus be a source of cognate help for HIV-specific CD8+ T cells elicited by conventional immunogens, in a wide proportion of vaccinees...
  27. ncbi request reprint Epitope mapping of a single repetitive unit of the B13 Trypanosoma cruzi antigen as fusions to Escherichia coli LamB protein
    Catia M Pereira
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, Rua Botucatu 862, CEP 04023 062 São Paulo, SP, Brazil
    FEMS Microbiol Lett 235:237-42. 2004
    ..6 repeats for binding to chagasic antibodies. These results strengthen previous conclusions on the immunodominant epitope of B13 and provide a comparison of two methods for epitope mapping...
  28. ncbi request reprint Short communication: Trypanosoma cruzi lineage I in endomyocardial biopsy from a north-eastern Brazilian patient at end-stage chronic Chagasic cardiomyopathy
    Marta M G Teixeira
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Trop Med Int Health 11:294-8. 2006
    ..Our finding should alert clinicians to the possibility of severe Chagas disease in all regions where T. cruzi circulates, regardless of its lineage...
  29. ncbi request reprint T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain
    Leo Kei Iwai
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 44, Bloco 2, 9 o andar, Cerqueira Cesar, Sao Paulo, SP 05403 000, Brazil
    J Autoimmun 24:111-7. 2005
    ....
  30. ncbi request reprint [New concepts on the pathogenesis of chronic Chagas cardiomyopathy: myocardial gene and protein expression profiles]
    Edecio Cunha-Neto
    Instituto do Coracao, Universidade de Sao Paulo, Sao Paulo, Brasil
    Rev Soc Bras Med Trop 39:59-62. 2006
    ..The results suggest that direct modulation of myocardium gene and protein expression by inflammatory cytokines may be a new pathogenic mechanism in CCC, with therapeutic implications...
  31. ncbi request reprint T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and -negative Vogt-Koyanagi-Harada uveitis
    Francisco Max Damico
    Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Invest Ophthalmol Vis Sci 46:2465-71. 2005
    ..This study was undertaken to analyze T-cell recognition and the cytokine expression profile induced by melanocyte epitopes in HLA-DRB1*0405-positive and -negative patients with VKH uveitis...
  32. doi request reprint Distinct outcomes of Trypanosoma cruzi infection in hamsters are related to myocardial parasitism, cytokine/chemokine gene expression, and protein expression profile
    Angelina M Bilate
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Infect Dis 198:614-23. 2008
    ..We tested whether myocarditis, its mediators, and myocardial protein expression are related to the severity of the acute phase of T. cruzi infection in the hamster model...
  33. pmc A DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responses
    Daniela Santoro Rosa
    Laboratory of Clinical Immunology and Allergy LIM60, Division of Clinical Immunology and Allergy, Department of Medicine, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    PLoS ONE 6:e16921. 2011
    ....
  34. pmc Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy
    Edecio Cunha-Neto
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo, Sao Paulo, Brazil
    Am J Pathol 167:305-13. 2005
    ..IFN-gamma and other cytokine pathways may thus be novel therapeutic targets in Chagas' cardiomyopathy...
  35. ncbi request reprint Immunogenicity of a recombinant protein containing the Plasmodium vivax vaccine candidate MSP1(19) and two human CD4+ T-cell epitopes administered to non-human primates (Callithrix jacchus jacchus)
    Daniela S Rosa
    CINTERGEN, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu 862, 6th Floor, Sao Paulo, SP 04023 062, Brazil
    Microbes Infect 8:2130-7. 2006
    ..These results indicated that under the circumstances evaluated, adjuvants were key for the immunogenicity of the recombinant protein His6MSP1(19)-DYDVVYLKPLAGMYK-PADRE...
  36. doi request reprint Autoimmunity
    Edecio Cunha-Neto
    Laboratorio de Imunologia, Instituto do Coracao, Hospital das Clinicas, Universidade de Sao Paulo, Brazil
    Adv Parasitol 76:129-52. 2011
    ..Here, we critically review evidence for autoimmune phenomena and their possible pathogenetic role in human Chagas disease and animal models, with a focus on chronic Chagas disease cardiomyopathy...
  37. ncbi request reprint PDIA3, HSPA5 and vimentin, proteins identified by 2-DE in the valvular tissue, are the target antigens of peripheral and heart infiltrating T cells from chronic rheumatic heart disease patients
    Kellen C Fae
    Heart Institute InCor, University of Sao Paulo, Sao Paulo, Brazil
    J Autoimmun 31:136-41. 2008
    ..The identified cardiac proteins are likely relevant antigens involved in T cell-mediated autoimmune responses in RF/RHD that may contribute to the development of RHD...
  38. pmc The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
    Walace de Souza Pimentel
    Unidade Clínica de Miocardiopatias, Hospital das Clínicas Instituto do Coração, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 67:1063-9. 2012
    ..We evaluated the role of carvedilol in cardiac remodeling and mortality in a Chagas' cardiomyopathy animal model...
  39. doi request reprint CD4+ T cell epitope discovery and rational vaccine design
    Daniela Santoro Rosa
    Division of Clinical Immunology and Allergy, Department of Internal Medicine, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil
    Arch Immunol Ther Exp (Warsz) 58:121-30. 2010
    ..In this paper the need for CD4(+) T cell help in vaccine development, the selection of CD4(+) T cell epitopes for an epitope-based vaccine, and how the approach can be used to induce a protective effect are reviewed...
  40. ncbi request reprint The Syrian hamster as a model for the dilated cardiomyopathy of Chagas' disease: a quantitative echocardiographical and histopathological analysis
    Angelina M B Bilate
    Laboratory of Immunology, Heart Institute InCor, University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 44 Bloco II 90 andar, 05403 000 Sao Paulo, SP, Brazil
    Microbes Infect 5:1116-24. 2003
    ....
  41. ncbi request reprint Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/"indeterminate" and Chagas disease cardiomyopathy patients
    Renata Cristina Ferreira
    Divisão de Cardiopatias Gerais, Instituto do Coracao, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, 05403 000, Brasil
    Mem Inst Oswaldo Cruz 98:407-11. 2003
    ..In Chagas disease, chronic TNF-a production prior to heart failure may play a role in CCC progression...
  42. pmc Polymorphism in the alpha cardiac muscle actin 1 gene is associated to susceptibility to chronic inflammatory cardiomyopathy
    Amanda Farage Frade
    Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Sao Paulo, Brazil Institute for Investigation in Immunology iii, Instituto Nacional de ciencias e tecnologia, Sao Paulo, Sao Paulo, Brazil Aix Marseille Université, Marseille, France
    PLoS ONE 8:e83446. 2013
    ..Since mutations in multiple sarcomeric genes, including alpha-cardiac actin (ACTC1) have been involved in hereditary dilated cardiomyopathy, we investigated the involvement of the ACTC1 gene in CCC pathogenesis...
  43. doi request reprint Proteins differentially expressed in human beta-cells-enriched pancreatic islet cultures and human insulinomas
    Letícia F Terra
    Instituto de Quimica, Departamento de Bioquimica, Universidade de Sao Paulo USP, Sao Paulo, Brazil
    Mol Cell Endocrinol 381:16-25. 2013
    ....
  44. pmc Bicistronic DNA vaccines simultaneously encoding HIV, HSV and HPV antigens promote CD8⁺ T cell responses and protective immunity
    Vinícius C Santana
    Department of Microbiology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 8:e71322. 2013
    ....
  45. pmc In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of Paracoccidioides brasiliensis frequently recognized in primary peripheral blood mononuclear cell responses from sensitized ind
    Leo Kei Iwai
    Laboratory of Immunology, Heart Institute InCor, Millenium Institutes, Brazil
    Mol Med 9:209-19. 2003
    ..brasiliensis. The combination of several such epitopes may increase the frequency of positive responses and allow the immunization of genetically distinct populations...
  46. ncbi request reprint Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens
    Lain Pontes-de-Carvalho
    Fundacao Oswaldo Cruz, Centro de Pesquisas Goncalo Moniz, Salvador, Brazil
    J Autoimmun 18:131-8. 2002
    ..cruzi -infected human beings...
  47. ncbi request reprint Chagas disease cardiomyopathy: current concepts of an old disease
    Angelina M B Bilate
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Rev Inst Med Trop Sao Paulo 50:67-74. 2008
    ..This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy...

Research Grants2

  1. HIV-1 PROTEASE CD4+ T CELL EPITOPES AND DRUG-INDUCED MUTATIONS
    Edecio Cunha Neto; Fiscal Year: 2007
    ..The information to be obtained may help develop immune strategies that could be applied to enhance the immune response against mutant HIV-1 and fight the emergence of Pi-resistant HIV-1 strains. ..