Thiago M Cunha
Silva R, Silveira G, Wanderlei C, Cecílio N, Maganin A, Franchin M, et al
. DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor. Toxicol Appl Pharmacol. 2019;368:63-71 pubmed publisher
Carvalho T, Borghi S, Pinho Ribeiro F, Mizokami S, Cunha T, Ferreira S, et al
. Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFÎ±, IL-1Î² and IL-10. Eur J Pharmacol. 2015;749:62-72 pubmed publisher
..Therefore, this study advances in the understanding of G-CSF-induced hyperalgesia and suggests therapeutic approaches for its control. ..
Araujo A, Antunes M, Mattos M, Diniz A, Alvarenga D, Nakagaki B, et al
. Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose. Cells. 2018;7: pubmed publisher
..We demonstrated a novel loop involving DNA recognition by hepatic NPCs and additional IFN-1 mediated hepatocyte death. ..
Guerrero A, Pinto L, Cunha F, Ferreira S, Alves Filho J, Verri W, et al
. Mechanisms underlying the hyperalgesic responses triggered by joint activation of TLR4. Pharmacol Rep. 2016;68:1293-1300 pubmed publisher
..Thus, TLR4/MyD88 signaling pathway inhibitors might be useful for the treatment of inflammatory joint pain. ..
Cunha T, Talbot J, Pinto L, Vieira S, Souza G, Guerrero A, et al
. Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1? maturation. Mol Pain. 2010;6:63 pubmed publisher
..Because caspase-1 is involved in the induction of COX-2 expression and PGE? production, our data support the assertion that caspase-1 is a key target to control inflammatory pain. ..
Cunha T, Souza G, Domingues A, Carreira E, Lotufo C, Funez M, et al
. Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3K?/AKT/nNOS/NO signaling pathway. Mol Pain. 2012;8:10 pubmed publisher
..This study extends a previously study of our group suggesting that PI3K?/AKT/nNOS/NO is an important analgesic pathway in primary nociceptive neurons. ..
Aguiar C, Rocha Franco J, Sousa P, Santos A, Ladeira M, Rocha Resende C, et al
. Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation. Cell Commun Signal. 2014;12:78 pubmed publisher
..These results show for the first time that succinate plays an important role in cardiomyocyte hypertrophy through GPR91 activation, and extend our understanding of how ischemia can induce hypertrophic cardiomyopathy. ..
Pinto L, Talbot J, Peres R, Franca R, Ferreira S, Ryffel B, et al
. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1Î² production. Arthritis Res Ther. 2015;17:235 pubmed publisher
..These results suggest that IL-22 plays a pro-inflammatory/pathogenic role in the onset of AIA through an ASC-dependent stimulation of IL-1Î² production. ..
Peres R, Santos G, Cecílio N, Jabor V, Niehues M, Torres B, et al
. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017;19:47 pubmed publisher
..Therefore, LAP could be considered as a potential immunosuppressive lead candidate with potential therapeutic implications for RA. ..