Maria Helena C Carvalho
Araujo P, Costa T, Echem C, Aparecida de Oliveira M, Santos Eichler R, Colli L, et al
. Treatment with Standard and Low Dose of Conjugated Equine Estrogen Differentially Modulates Estrogen Receptor Expression and Response to Angiotensin II in Mesenteric Venular Bed of Surgically Postmenopausal Hypertensive Rats. J Pharmacol Exp Ther. 2017;362:98-107 pubmed publisher
..Our data suggest that estrogen dose is an important factor for venous function. Although CEE-LD reversed deleterious effects of OVX, CEE-SD showed null effects despite its ability to increase eNOS activity. ..
Echem C, Costa T, Oliveira V, Giglio Colli L, Landgraf M, Rodrigues S, et al
. Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension. Pharmacol Res. 2019;144:142-150 pubmed publisher
..This study contributes to the understanding of a need for more personalized therapeutic strategies for men and women with hypertension. Keywords: Sex differences, Arterial hypertension, Mitochondrial DNA, Toll-Like receptor 9. ..
Bomfim G, Echem C, Martins C, Costa T, Sartoretto S, dos Santos R, et al
. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015;122:1-7 pubmed publisher
..Together, these results suggest that TLR4 is a key player in hypertension and vascular inflammatory process by a NFÎºB signaling pathway. ..
Costa T, Ceravolo G, dos Santos R, de Oliveira M, AraÃºjo P, Giaquinto L, et al
. Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells. Am J Physiol Heart Circ Physiol. 2015;308:H723-32 pubmed publisher