Research Topics

Genomes and Genes


Maria Helena C Carvalho


Country: Brazil


  1. Araujo P, Costa T, Echem C, Aparecida de Oliveira M, Santos Eichler R, Colli L, et al. Treatment with Standard and Low Dose of Conjugated Equine Estrogen Differentially Modulates Estrogen Receptor Expression and Response to Angiotensin II in Mesenteric Venular Bed of Surgically Postmenopausal Hypertensive Rats. J Pharmacol Exp Ther. 2017;362:98-107 pubmed publisher
    ..Our data suggest that estrogen dose is an important factor for venous function. Although CEE-LD reversed deleterious effects of OVX, CEE-SD showed null effects despite its ability to increase eNOS activity. ..
  2. Echem C, Costa T, Oliveira V, Giglio Colli L, Landgraf M, Rodrigues S, et al. Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension. Pharmacol Res. 2019;144:142-150 pubmed publisher
    ..This study contributes to the understanding of a need for more personalized therapeutic strategies for men and women with hypertension. Keywords: Sex differences, Arterial hypertension, Mitochondrial DNA, Toll-Like receptor 9. ..
  3. Bomfim G, Echem C, Martins C, Costa T, Sartoretto S, dos Santos R, et al. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015;122:1-7 pubmed publisher
    ..Together, these results suggest that TLR4 is a key player in hypertension and vascular inflammatory process by a NFκB signaling pathway. ..
  4. Costa T, Ceravolo G, dos Santos R, de Oliveira M, Araújo P, Giaquinto L, et al. Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells. Am J Physiol Heart Circ Physiol. 2015;308:H723-32 pubmed publisher