Primavera Borelli

Summary

Country: Brazil

Publications

  1. pmc Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
    Diego C Rossi
    Department of Parasitology, University of Sao Paulo, Sao Paulo, SP, Brazil
    BMC Microbiol 12:28. 2012
  2. ncbi request reprint Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates
    P Borelli
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Laboratório de Hematologia Experimental, Universidade de Sao Paulo, Sao Paulo, Brasil
    Braz J Med Biol Res 42:523-30. 2009
  3. ncbi request reprint Reduction of erythroid progenitors in protein-energy malnutrition
    Primavera Borelli
    Laboratório Hematologia Experimental, Departmento de Análises Clínicas e Toxicológicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Brazil
    Br J Nutr 97:307-14. 2007
  4. doi request reprint Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages
    Marcelo Macedo Rogero
    Department of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715, Sao Paulo, SP, 01246 904, Brazil
    Amino Acids 39:435-41. 2010
  5. doi request reprint Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages
    Ricardo Ambrósio Fock
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, Sao Paulo University, 05508 900, Sao Paulo, SP, Brazil
    Inflammation 33:101-9. 2010
  6. doi request reprint A high-fat diet increases interleukin-3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in Wistar rats
    Luciana Simão do Carmo
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, 05508 070
    Exp Biol Med (Maywood) 238:375-84. 2013
  7. doi request reprint Dietary glutamine supplementation affects macrophage function, hematopoiesis and nutritional status in early weaned mice
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Nutr 27:386-97. 2008
  8. ncbi request reprint Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Nutr Sci Vitaminol (Tokyo) 54:371-7. 2008
  9. doi request reprint Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration
    Marco Aurélio Ramirez Vinolo
    Laboratory of Cellular Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Butanta, Sao Paulo, Brasil
    Nutr Res 28:791-7. 2008
  10. ncbi request reprint Dietary glutamine supplementation increases the activity of peritoneal macrophages and hemopoiesis in early-weaned mice inoculated with Mycobacterium bovis bacillus Calmette-Guérin
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Nutr 138:1343-8. 2008

Collaborators

  • Marcelo Macedo Rogero
  • Julio Tirapegui
  • Rui Curi
  • Inar Alves de Castro
  • Maria Carolina Borges
  • B Beutler
  • Regina P Markus
  • Ricardo Ambrósio Fock
  • Marco Aurélio Ramirez Vinolo
  • Fabiana da Silva Lima
  • Mayara Cortez
  • Mayara Caldas Ramos Cunha
  • Patrícia Silva Jacob
  • Luciana Simão do Carmo
  • Diego C Rossi
  • Carlos M M P Leon
  • Ricardo Fock
  • Karina Nakajima
  • Amanda Rabello Crisma
  • Maristella A Landgraf
  • Nilton Lincopan
  • Danielle M H Cavalcanti
  • Ana Paula Ligeiro de Oliveira
  • Wothan Tavares de Lima
  • Ricardo M Oliveira-Filho
  • Ana Maria Fialho de Araújo
  • Monica Yamada
  • Amanda Nogueira-Pedro
  • Edgar Julian Paredes-Gamero
  • Lucas Carminatti Pantaleão
  • José Guilherme Xavier
  • Mayara Caldas Ramos
  • Araceli Hastreiter
  • Luciana Simão Carmo
  • Tatiane Mieko de Meneses Fujii
  • Tatiane Mieko Fujii
  • Bluma Faintuch
  • Carlos P Taborda
  • Sirlei Daffre
  • Danielle D Carvalho
  • Antonio Miranda
  • Rodrigo Belmonte
  • Julián E Muñoz
  • José Dias Resende
  • Edgar J Paredes-Gamero
  • Alice T Ferreira
  • Giselle Z Justo
  • José S R de Oliveira
  • Christiano M V Barbosa
  • Maristela Tsujita
  • Juliana Pereira
  • Solange Lúcia Blatt
  • Francisco Erivaldo Vidal de Barros
  • Vanessa de Moura Sá Rocha
  • Maria Helena C Carvalho
  • Zuleica B Fortes
  • Dorothy Nigro
  • Rita de C A Tostes
  • Telma Maria Tenório Zorn
  • Luiz Carlos de Sá Rocha
  • Ana Marisa C Tavassi
  • Celina M C Lotufo
  • Ana M Carmona-Ribeiro
  • Elsa M Mamizuka
  • Agostinho L M Pereira
  • Sandra H P Farsky
  • Zilma Lucia da Silva
  • Aryene G Trezena
  • Ronald D Mathison

Detail Information

Publications24

  1. pmc Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
    Diego C Rossi
    Department of Parasitology, University of Sao Paulo, Sao Paulo, SP, Brazil
    BMC Microbiol 12:28. 2012
    ..In this study, we evaluate the efficacy of gomesin treatment on disseminated and vaginal candidiasis as well as its toxicity and biodistribution...
  2. ncbi request reprint Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates
    P Borelli
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Laboratório de Hematologia Experimental, Universidade de Sao Paulo, Sao Paulo, Brasil
    Braz J Med Biol Res 42:523-30. 2009
    ..Thus, we conclude that PEM leads to the depletion of progenitor hemopoietic populations and changes in cellular development. We suggest that these changes are some of the primary causes of pancytopenia in cases of PEM...
  3. ncbi request reprint Reduction of erythroid progenitors in protein-energy malnutrition
    Primavera Borelli
    Laboratório Hematologia Experimental, Departmento de Análises Clínicas e Toxicológicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Brazil
    Br J Nutr 97:307-14. 2007
    ..These findings suggest that, in this protein-energy malnutrition model, anaemia is not caused by Fe deficiency or erythropoietin deficiency, but is a result of ineffective erythropoiesis...
  4. doi request reprint Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages
    Marcelo Macedo Rogero
    Department of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715, Sao Paulo, SP, 01246 904, Brazil
    Amino Acids 39:435-41. 2010
    ..05). Glutamine modulates NF-kappaB signaling pathway by reducing the level of I kappaB-alpha, leading to an increase in NF-kappaB within the nucleus in peritoneal macrophages...
  5. doi request reprint Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages
    Ricardo Ambrósio Fock
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, Sao Paulo University, 05508 900, Sao Paulo, SP, Brazil
    Inflammation 33:101-9. 2010
    ..PEM also decreased TRAF-6 expression and NF-kappaB activation after LPS stimulation. These results led us to conclude that PEM changes NF-kB signalling pathway in macrophages to LPS stimulus...
  6. doi request reprint A high-fat diet increases interleukin-3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in Wistar rats
    Luciana Simão do Carmo
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, 05508 070
    Exp Biol Med (Maywood) 238:375-84. 2013
    ..These data led us to infer that the HFD induces leukocytosis and neutrophilia suggesting alterations in hematopoiesis system modulation...
  7. doi request reprint Dietary glutamine supplementation affects macrophage function, hematopoiesis and nutritional status in early weaned mice
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Nutr 27:386-97. 2008
    ..To investigate the effect that early weaning associated with the ingestion of either a glutamine-free or supplemented diet has on the functioning of peritoneal macrophages, hematopoiesis and nutritional status of mice...
  8. ncbi request reprint Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Nutr Sci Vitaminol (Tokyo) 54:371-7. 2008
    ..These findings suggest that malnourished mice present a deficient immune response to LPS. These alterations may be partly responsible for the immunodeficiency observed in these malnourished mice...
  9. doi request reprint Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration
    Marco Aurélio Ramirez Vinolo
    Laboratory of Cellular Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Butanta, Sao Paulo, Brasil
    Nutr Res 28:791-7. 2008
    ..08 and P = .62, respectively). We report that malnourished mice display an impaired response to G-CSF, which contributes to the decreased production of leukocytes in protein-energy malnutrition...
  10. ncbi request reprint Dietary glutamine supplementation increases the activity of peritoneal macrophages and hemopoiesis in early-weaned mice inoculated with Mycobacterium bovis bacillus Calmette-Guérin
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Nutr 138:1343-8. 2008
    ..These data have important implications for the design of breast milk substitutes for human infants...
  11. doi request reprint Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Sao Paulo University, Sao Paulo, Brazil
    Nutrition 26:1021-8. 2010
    ..In this study, we evaluated the effect that PEM has on lymphocyte subtypes and the cell cycle of CD5(+) cells...
  12. doi request reprint High-fat diet blunts activation of the nuclear factor-κB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats
    Maria C Borges
    Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 29:443-9. 2013
    ..The present study was designed to investigate the effect of a high-fat diet (HFD) on the inflammatory response of peritoneal macrophages...
  13. ncbi request reprint Role of submandibular salivary glands in LPS-induced lung inflammation in rats
    Ana Maria Fialho de Araújo
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Neuroimmunomodulation 10:73-9. 2002
    ..In this paper we examined this possibility directly by studying the role of submandibular salivary glands in the temporal profile of lypopolysaccharide (LPS)-induced lung inflammation in rats...
  14. doi request reprint A high-fat diet increases IL-1, IL-6, and TNF-α production by increasing NF-κB and attenuating PPAR-γ expression in bone marrow mesenchymal stem cells
    Mayara Cortez
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508 900, Sao Paulo, Sao Paulo, Brazil
    Inflammation 36:379-86. 2013
    ..MSCs from HFD animals showed increased production of IL-1, IL-6, and TNF-α and increased NF-κB and reduced PPAR-γ expression. Therefore, ingestion of an HFD induces alterations in MSCs that may influence modulation of hematopoiesis...
  15. doi request reprint Requirement for PLCγ2 in IL-3 and GM-CSF-stimulated MEK/ERK phosphorylation in murine and human hematopoietic stem/progenitor cells
    Carlos M M P Leon
    Departamento de Biofisica, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    J Cell Physiol 226:1780-92. 2011
    ..Taken together, these data indicate a role for PLCγ2 and Ca(2+) signaling through the modulation of MEK in both murine and human hematopoietic stem/progenitor cells...
  16. ncbi request reprint Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone
    Ana Paula Ligeiro de Oliveira
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Neuroimmunomodulation 11:20-7. 2004
    ..Since asthma is characterized by lung inflammation and bronchopulmonary hyperresponsiveness, we investigated the role played by estradiol in allergic lung inflammation...
  17. pmc Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure
    Mayara Caldas Ramos Cunha
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 8:e58872. 2013
    ....
  18. doi request reprint Modulation of the nuclear factor-kappa B (NF-κB) signalling pathway by glutamine in peritoneal macrophages of a murine model of protein malnutrition
    Fabiana da Silva Lima
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Avenida Lineu Prestes, Sao Paulo, SP, Brazil
    Eur J Nutr 52:1343-51. 2013
    ..The aim of this study was to evaluate the effect of glutamine on the expression of proteins involved in the nuclear factor-kappa B (NF-κB) signalling pathway of peritoneal macrophages from malnourished mice...
  19. ncbi request reprint Adrenal deficiency alters mechanisms of neutrophil mobilization
    Danielle M H Cavalcanti
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 580 Bl 13 B, Sao Paulo, SP, 05503 900, Brazil
    Mol Cell Endocrinol 249:32-9. 2006
    ....
  20. doi request reprint Isocaloric intake of a high-fat diet promotes insulin resistance and inflammation in Wistar rats
    Patrícia Silva Jacob
    Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    Cell Biochem Funct 31:244-53. 2013
    ..02). In conclusion, the isocaloric intake from the HFD induced insulin resistance, associated with impaired insulin signalling in the liver and an inflammatory response in the muscle...
  21. doi request reprint Glutamine in vitro supplementation partly reverses impaired macrophage function resulting from early weaning in mice
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 24:589-98. 2008
    ....
  22. ncbi request reprint Mechanisms involved in the reduced leukocyte migration in intrauterine undernourishment
    Maristella A Landgraf
    Laboratory of Hypertension and Inflammation, Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 23:145-56. 2007
    ..We investigated factors that may be involved in the reduced leukocyte migration observed in intrauterine undernourished rats...
  23. ncbi request reprint Toxicity of an effective amphotericin B formulation at high cationic lipid to drug molar ratio
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970 Sao Paulo, Brazil
    Exp Toxicol Pathol 58:175-83. 2006
    ..The majority of the toxic effects observed for the novel formulation were due to the DODAB carrier used at 10mg/mL, i.e., at a rather high concentration and further studies should minimize DODAB dose...
  24. ncbi request reprint Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in mice
    Ricardo Ambrósio Fock
    Experimental Haematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Brazil
    Cytokine 40:105-14. 2007
    ..These data lead us to infer that the nutritional state interferes with the activation of macrophages and with the capacity to mount an immune response...