Primavera Borelli

Summary

Country: Brazil

Publications

  1. ncbi Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
    Diego C Rossi
    Department of Parasitology, University of Sao Paulo, Sao Paulo, SP, Brazil
    BMC Microbiol 12:28. 2012
  2. ncbi Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates
    P Borelli
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Laboratório de Hematologia Experimental, Universidade de Sao Paulo, Sao Paulo, Brasil
    Braz J Med Biol Res 42:523-30. 2009
  3. ncbi Reduction of erythroid progenitors in protein-energy malnutrition
    Primavera Borelli
    Laboratório Hematologia Experimental, Departmento de Análises Clínicas e Toxicológicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Brazil
    Br J Nutr 97:307-14. 2007
  4. ncbi Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages
    Marcelo Macedo Rogero
    Department of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715, Sao Paulo, SP, 01246 904, Brazil
    Amino Acids 39:435-41. 2010
  5. ncbi Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages
    Ricardo Ambrósio Fock
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, Sao Paulo University, 05508 900, Sao Paulo, SP, Brazil
    Inflammation 33:101-9. 2010
  6. ncbi Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration
    Marco Aurélio Ramirez Vinolo
    Laboratory of Cellular Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Butanta, Sao Paulo, Brasil
    Nutr Res 28:791-7. 2008
  7. ncbi Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Nutr Sci Vitaminol (Tokyo) 54:371-7. 2008
  8. ncbi Dietary glutamine supplementation affects macrophage function, hematopoiesis and nutritional status in early weaned mice
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Nutr 27:386-97. 2008
  9. ncbi Dietary glutamine supplementation increases the activity of peritoneal macrophages and hemopoiesis in early-weaned mice inoculated with Mycobacterium bovis bacillus Calmette-Guérin
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Nutr 138:1343-8. 2008
  10. ncbi Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Sao Paulo University, Sao Paulo, Brazil
    Nutrition 26:1021-8. 2010

Collaborators

  • Marcelo Macedo Rogero
  • Rui Curi
  • B Beutler
  • Maria Carolina Borges
  • Regina P Markus
  • Ricardo Ambrósio Fock
  • Marco Aurélio Ramirez Vinolo
  • Diego C Rossi
  • Carlos M M P Leon
  • Karina Nakajima
  • Amanda Rabello Crisma
  • Maristella A Landgraf
  • Nilton Lincopan
  • Danielle M H Cavalcanti
  • Ana Paula Ligeiro de Oliveira
  • Ricardo M Oliveira-Filho
  • Wothan Tavares de Lima
  • Ana Maria Fialho de Araújo
  • Sirlei Daffre
  • Danielle D Carvalho
  • Bluma Faintuch
  • Julián E Muñoz
  • Antonio Miranda
  • Rodrigo Belmonte
  • Carlos P Taborda
  • Alice T Ferreira
  • Edgar J Paredes-Gamero
  • José S R de Oliveira
  • Christiano M V Barbosa
  • Giselle Z Justo
  • José Dias Resende
  • Francisco Erivaldo Vidal de Barros
  • Maristela Tsujita
  • Juliana Pereira
  • Solange Lúcia Blatt
  • Vanessa de Moura Sá Rocha
  • Rita de C A Tostes
  • Zuleica B Fortes
  • Maria Helena C Carvalho
  • Telma Maria Tenório Zorn
  • Dorothy Nigro
  • Luiz Carlos de Sá Rocha
  • Ana Marisa C Tavassi
  • Elsa M Mamizuka
  • Ricardo Fock
  • Sandra H P Farsky
  • Agostinho L M Pereira
  • Celina M C Lotufo
  • Ana M Carmona-Ribeiro
  • Ronald D Mathison
  • Ronald D Mathison
  • Aryene G Trezena

Detail Information

Publications18

  1. ncbi Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
    Diego C Rossi
    Department of Parasitology, University of Sao Paulo, Sao Paulo, SP, Brazil
    BMC Microbiol 12:28. 2012
    ..In this study, we evaluate the efficacy of gomesin treatment on disseminated and vaginal candidiasis as well as its toxicity and biodistribution...
  2. ncbi Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates
    P Borelli
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Laboratório de Hematologia Experimental, Universidade de Sao Paulo, Sao Paulo, Brasil
    Braz J Med Biol Res 42:523-30. 2009
    ..Thus, we conclude that PEM leads to the depletion of progenitor hemopoietic populations and changes in cellular development. We suggest that these changes are some of the primary causes of pancytopenia in cases of PEM...
  3. ncbi Reduction of erythroid progenitors in protein-energy malnutrition
    Primavera Borelli
    Laboratório Hematologia Experimental, Departmento de Análises Clínicas e Toxicológicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Brazil
    Br J Nutr 97:307-14. 2007
    ..These findings suggest that, in this protein-energy malnutrition model, anaemia is not caused by Fe deficiency or erythropoietin deficiency, but is a result of ineffective erythropoiesis...
  4. ncbi Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages
    Marcelo Macedo Rogero
    Department of Nutrition, School of Public Health, Sao Paulo University, Avenida Doutor Arnaldo, 715, Sao Paulo, SP, 01246 904, Brazil
    Amino Acids 39:435-41. 2010
    ..05). Glutamine modulates NF-kappaB signaling pathway by reducing the level of I kappaB-alpha, leading to an increase in NF-kappaB within the nucleus in peritoneal macrophages...
  5. ncbi Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages
    Ricardo Ambrósio Fock
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, Sao Paulo University, 05508 900, Sao Paulo, SP, Brazil
    Inflammation 33:101-9. 2010
    ..PEM also decreased TRAF-6 expression and NF-kappaB activation after LPS stimulation. These results led us to conclude that PEM changes NF-kB signalling pathway in macrophages to LPS stimulus...
  6. ncbi Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration
    Marco Aurélio Ramirez Vinolo
    Laboratory of Cellular Physiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Butanta, Sao Paulo, Brasil
    Nutr Res 28:791-7. 2008
    ..08 and P = .62, respectively). We report that malnourished mice display an impaired response to G-CSF, which contributes to the decreased production of leukocytes in protein-energy malnutrition...
  7. ncbi Protein-energy malnutrition modifies the production of interleukin-10 in response to lipopolysaccharide (LPS) in a murine model
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Nutr Sci Vitaminol (Tokyo) 54:371-7. 2008
    ..These findings suggest that malnourished mice present a deficient immune response to LPS. These alterations may be partly responsible for the immunodeficiency observed in these malnourished mice...
  8. ncbi Dietary glutamine supplementation affects macrophage function, hematopoiesis and nutritional status in early weaned mice
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Nutr 27:386-97. 2008
    ..To investigate the effect that early weaning associated with the ingestion of either a glutamine-free or supplemented diet has on the functioning of peritoneal macrophages, hematopoiesis and nutritional status of mice...
  9. ncbi Dietary glutamine supplementation increases the activity of peritoneal macrophages and hemopoiesis in early-weaned mice inoculated with Mycobacterium bovis bacillus Calmette-Guérin
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Nutr 138:1343-8. 2008
    ..These data have important implications for the design of breast milk substitutes for human infants...
  10. ncbi Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition
    Ricardo Ambrósio Fock
    Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Sao Paulo University, Sao Paulo, Brazil
    Nutrition 26:1021-8. 2010
    ..In this study, we evaluated the effect that PEM has on lymphocyte subtypes and the cell cycle of CD5(+) cells...
  11. ncbi Role of submandibular salivary glands in LPS-induced lung inflammation in rats
    Ana Maria Fialho de Araújo
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Neuroimmunomodulation 10:73-9. 2002
    ..In this paper we examined this possibility directly by studying the role of submandibular salivary glands in the temporal profile of lypopolysaccharide (LPS)-induced lung inflammation in rats...
  12. ncbi Requirement for PLCγ2 in IL-3 and GM-CSF-stimulated MEK/ERK phosphorylation in murine and human hematopoietic stem/progenitor cells
    Carlos M M P Leon
    Departamento de Biofisica, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    J Cell Physiol 226:1780-92. 2011
    ..Taken together, these data indicate a role for PLCγ2 and Ca(2+) signaling through the modulation of MEK in both murine and human hematopoietic stem/progenitor cells...
  13. ncbi Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone
    Ana Paula Ligeiro de Oliveira
    Department of Pharmacology, Institute of Biomedical Sciences, , , Brazil
    Neuroimmunomodulation 11:20-7. 2004
    ..CONCLUSION: Our results suggest that estradiol has proinflammatory actions on the allergic lung response, and these actions seem to be mediated, at least in part, by endogenous glucocorticoids...
  14. ncbi Adrenal deficiency alters mechanisms of neutrophil mobilization
    Danielle M H Cavalcanti
    Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, , Av. Prof. Lineu Prestes 580 Bl. 13 B, , SP, 05503-900, Brazil
    Mol Cell Endocrinol 249:32-9. 2006
    ....
  15. ncbi Glutamine in vitro supplementation partly reverses impaired macrophage function resulting from early weaning in mice
    Marcelo Macedo Rogero
    Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 24:589-98. 2008
    ....
  16. ncbi Mechanisms involved in the reduced leukocyte migration in intrauterine undernourishment
    Maristella A Landgraf
    Laboratory of Hypertension and Inflammation, Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 23:145-56. 2007
    ..We investigated factors that may be involved in the reduced leukocyte migration observed in intrauterine undernourished rats...
  17. ncbi Toxicity of an effective amphotericin B formulation at high cationic lipid to drug molar ratio
    Nilton Lincopan
    , , , CP 26077, Avenida Lineu Prestes 748 - Butant, , Brazil
    Exp Toxicol Pathol 58:175-83. 2006
    ..The majority of the toxic effects observed for the novel formulation were due to the DODAB carrier used at 10mg/mL, i.e., at a rather high concentration and further studies should minimize DODAB dose...
  18. ncbi Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in mice
    Ricardo Ambrósio Fock
    Experimental Haematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Brazil
    Cytokine 40:105-14. 2007
    ..These data lead us to infer that the nutritional state interferes with the activation of macrophages and with the capacity to mount an immune response...