Research Topics

Genomes and Genes


Gisele F Bomfim


Country: Brazil


  1. Echem C, Costa T, Oliveira V, Giglio Colli L, Landgraf M, Rodrigues S, et al. Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension. Pharmacol Res. 2019;144:142-150 pubmed publisher
    ..This study contributes to the understanding of a need for more personalized therapeutic strategies for men and women with hypertension. Keywords: Sex differences, Arterial hypertension, Mitochondrial DNA, Toll-Like receptor 9. ..
  2. Nascimento M, Piran R, da Costa R, Giordani M, Carneiro F, Aguiar D, et al. Hepatic injury induced by thioacetamide causes aortic endothelial dysfunction by a cyclooxygenase-dependent mechanism. Life Sci. 2018;212:168-175 pubmed publisher
    ..Therefore, there is an essential contribution of COX-2 activation in extra-hepatic vascular dysfunction and inflammation present in cirrhosis induced by TAA. ..
  3. Bomfim G, Echem C, Martins C, Costa T, Sartoretto S, dos Santos R, et al. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015;122:1-7 pubmed publisher
    ..Together, these results suggest that TLR4 is a key player in hypertension and vascular inflammatory process by a NFκB signaling pathway. ..
  4. Bomfim G, dos Santos R, Oliveira M, Giachini F, Akamine E, Tostes R, et al. Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats. Clin Sci (Lond). 2012;122:535-43 pubmed publisher
    ..Our results suggest that TLR4 activation contributes to increased BP, low-grade inflammation and plays a role in the augmented vascular contractility displayed by SHR. ..