Helton C Santiago

Summary

Affiliation: Belo Horizonte
Country: Brazil

Publications

  1. ncbi Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:8165-72. 2005
  2. ncbi The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5514-22. 2007
  3. ncbi IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
    Ester Roffe
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:649-60. 2012
  4. ncbi Platelet activating factor receptor-deficient mice present delayed interferon-gamma upregulation and high susceptibility to Leishmania amazonensis infection
    Helton C Santiago
    , , Universidade Federal de Minas Gerais, CP 486, Av. Antonio Carlos 6627, Pampulha, CEP 30161-970 Belo Horizonte, MG, Brazil
    Microbes Infect 8:2569-77. 2006
  5. ncbi Monocyte chemoattractant protein-1 involvement in the alpha-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice
    Maria C G Peluzio
    Departamento de Bioquimica e Imunologia, ICB, Universidade Federal de Minas Gerais, Caixa Postal 486, 30 161 970, Belo Horizonte MG, Brazil
    Br J Nutr 90:3-11. 2003
  6. ncbi Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice
    Luciane R Portugal
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Infect Immun 72:3571-6. 2004
  7. ncbi A DNA vaccine encoding CCL4/MIP-1beta enhances myocarditis in experimental Trypanosoma cruzi infection in rats
    Ester Roffe
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Pampulha, Belo Horizonte, Minas Gerais 31270 901, Brazil
    Microbes Infect 8:2745-55. 2006
  8. ncbi Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection
    Luciane R Portugal
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Microbes Infect 10:276-84. 2008

Collaborators

  • Julio Aliberti
  • Carl G Feng
  • Andre Bafica
  • Antonio Gigliotti Rothfuchs
  • Lis R V Antonelli
  • Gregory A Taylor
  • M M Teixeira
  • Vanessa Pinho
  • Ester Roffe
  • Luciane R Portugal
  • Jacqueline I Alvarez-Leite
  • Ricardo T Gazzinelli
  • Luciana R Fernandes
  • Rosa M E Arantes
  • Giovana C Cesar
  • Maria C G Peluzio
  • Flavia L Ribeiro-Gomes
  • Philip M Murphy
  • Ana Paula M P Marino
  • Michael Eckhaus
  • Vinícius S Pietra Pedroso
  • Herbert B Tanowitz
  • Oscar Bruna-Romero
  • Remo C Russo
  • Bráulia C Caetano
  • Adriano L S Souza
  • Danielle G Souza
  • Elisabeth R S Camargos
  • Luciola S Barcelos
  • Patrícia P Machado
  • Dirce R Oliveira
  • Neide M Silva
  • Andrea A Silva
  • Joseli Lannes-Vieira
  • Emir Miguel
  • Thaís C Drumond
  • Enio C Vieira

Detail Information

Publications8

  1. ncbi Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:8165-72. 2005
    ..Together, these data establish that LRG-47 can influence pathogen control by simultaneously regulating macrophage-microbicidal activity and hemopoietic function...
  2. ncbi The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5514-22. 2007
    ..Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter...
  3. ncbi IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
    Ester Roffe
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:649-60. 2012
    ..Adoptive transfer experiments indicated that T cells were a source of protective IL-10. Thus, in this system, IL-10 production by T cells promotes T. cruzi control and protection from fatal acute myocarditis...
  4. ncbi Platelet activating factor receptor-deficient mice present delayed interferon-gamma upregulation and high susceptibility to Leishmania amazonensis infection
    Helton C Santiago
    , , Universidade Federal de Minas Gerais, CP 486, Av. Antonio Carlos 6627, Pampulha, CEP 30161-970 Belo Horizonte, MG, Brazil
    Microbes Infect 8:2569-77. 2006
    ..amazonensis by PAFR(-/-) mice. We conclude that signaling through the PAFR is essential for the ability of the murine host to control L. amazonensis infection by driving an adequate immune response...
  5. ncbi Monocyte chemoattractant protein-1 involvement in the alpha-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice
    Maria C G Peluzio
    Departamento de Bioquimica e Imunologia, ICB, Universidade Federal de Minas Gerais, Caixa Postal 486, 30 161 970, Belo Horizonte MG, Brazil
    Br J Nutr 90:3-11. 2003
    ....
  6. ncbi Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice
    Luciane R Portugal
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Infect Immun 72:3571-6. 2004
    ..gondii-infected animals. These results suggest that infection with T. gondii accelerates atherosclerotic development by stimulating the proinflammatory response and oxidative stress, thereby increasing the area of aortic lesion...
  7. ncbi A DNA vaccine encoding CCL4/MIP-1beta enhances myocarditis in experimental Trypanosoma cruzi infection in rats
    Ester Roffe
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Pampulha, Belo Horizonte, Minas Gerais 31270 901, Brazil
    Microbes Infect 8:2745-55. 2006
    ..Our data suggest that CCL4/MIP-1beta plays a role in preventing excessive inflammation and pathology rather than in controlling parasite replication...
  8. ncbi Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection
    Luciane R Portugal
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Microbes Infect 10:276-84. 2008
    ..gondii parasites are able to acquire cholesterol-rich lipoproteins through an alternative host receptor, and overcome LDLr deficiency, favoring host parasitism and impairing lipid loading of foam cells...