Sergio Dj Pena

Summary

Affiliation: Belo Horizonte
Country: Brazil

Publications

  1. pmc The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected
    Sergio D J Pena
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    PLoS ONE 6:e17063. 2011
  2. pmc LSSP-PCR of Trypanosoma cruzi: how the single primer sequence affects the kDNA signature
    Marcela Segatto
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    BMC Res Notes 6:174. 2013
  3. pmc Recovering mitochondrial DNA lineages of extinct Amerindian nations in extant homopatric Brazilian populations
    Vanessa F Goncalves
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 31270 910 Belo Horizonte, Brazil
    Investig Genet 1:13. 2010
  4. ncbi request reprint Trypanosoma cruzi: ancestral genomes and population structure
    Sergio D J Pena
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 104:108-14. 2009
  5. ncbi request reprint A probability model for the meiosis I non-disjunction fraction in numerical chromosomal anomalies
    Glaura C Franco
    Departamento de Estatistica, ICEx, UFMG, Caixa Postal 702, Belo Horizonte, MG 31 270 901, Brazil
    Stat Med 22:2015-24. 2003
  6. pmc A worldwide phylogeography for the human X chromosome
    Simone S Santos Lopes
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 2:e557. 2007
  7. pmc Ancestral genomes, sex, and the population structure of Trypanosoma cruzi
    Jorge M de Freitas
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    PLoS Pathog 2:e24. 2006
  8. ncbi request reprint Color and genomic ancestry in Brazilians: a study with forensic microsatellites
    Juliana R Pimenta
    GENE Núcleo de Genética Médica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Hum Hered 62:190-5. 2006
  9. ncbi request reprint No association found between gr/gr deletions and infertility in Brazilian males
    Claudia M B Carvalho
    Departamento de Bioquimica e Imunologia, Belo Horizonte, Minas Gerais, Brazil
    Mol Hum Reprod 12:269-73. 2006
  10. ncbi request reprint Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations
    Luciana O Andrade
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901 MG, Brazil
    Exp Parasitol 100:269-75. 2002

Collaborators

  • A J G Simpson
  • Guilherme Suarez-Kurtz
  • Richard McCulloch
  • Ian J Wilson
  • Claudia M B Carvalho
  • Vanessa F Goncalves
  • Charles Anacleto
  • Andrea M Macedo
  • Carlos Renato Machado
  • Flavia C Parra
  • Luciana Bastos-Rodrigues
  • Juliana R Pimenta
  • Santuza M R Teixeira
  • Fernando A Soares
  • Benedito Rossi
  • Ademar Lopes
  • Marcela Segatto
  • Jose Claudio C Rocha
  • Otavia Caballero
  • Luiz Augusto-Pinto
  • Andréia M Leopoldino
  • Alice Machado-Silva
  • Sergio P Bydlowski
  • Simone S Santos Lopes
  • Luciana W Zuccherato
  • Alessandra D Clarizia
  • Jorge M de Freitas
  • Anamaria A Camargo
  • Jorge Rocha
  • Fabricio R Santos
  • Egler Chiari
  • Glaura C Franco
  • Marluce A Assunção Oliveira
  • Luciana O Andrade
  • Claudiney Melquíades Rodrigues
  • Andrea Mara Macedo
  • Glória Regina Franco
  • Higgor Gonçalves-Dornelas
  • Hilton P Silva
  • Claudia Rodrigues-Carvalho
  • Maria Catira Bortolini
  • Gloria R Franco
  • Rinaldo W Pereira
  • Heloísa B Pena
  • Rodrigo S Moura-Neto
  • Octavio Fernandes
  • Luciana Maselli
  • Rosângela P Soares
  • Anamaria Camargo
  • Angela C V Junqueira
  • Adriana A Debes
  • Riva P Oliveira
  • Carlos R Machado
  • Annamaria R Vago
  • Tatiana Freitas Paulo
  • José R Lambertucci
  • Sadao Kamidono
  • Matilde Cota Koury
  • Alvaro J Romanha
  • Carlos M Antunes
  • Roberto C Amado
  • Paulo S Lucio
  • Otavia L Caballero
  • Rudy A Harskeerl
  • Sidney E B Santos
  • Juliane Rocha
  • Toshiro Shirakawa
  • Masato Fujisawa
  • Akinobu Gotoh
  • Conceição R S Machado

Detail Information

Publications22

  1. pmc The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected
    Sergio D J Pena
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    PLoS ONE 6:e17063. 2011
    ..These findings, of both clinical and sociological importance for Brazil, should also be relevant to other countries with ancestrally admixed populations...
  2. pmc LSSP-PCR of Trypanosoma cruzi: how the single primer sequence affects the kDNA signature
    Marcela Segatto
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    BMC Res Notes 6:174. 2013
    ..We wondered whether these changes in the primer sequence could affect also the parasite LSSP-PCR profiles...
  3. pmc Recovering mitochondrial DNA lineages of extinct Amerindian nations in extant homopatric Brazilian populations
    Vanessa F Goncalves
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 31270 910 Belo Horizonte, Brazil
    Investig Genet 1:13. 2010
    ....
  4. ncbi request reprint Trypanosoma cruzi: ancestral genomes and population structure
    Sergio D J Pena
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 104:108-14. 2009
    ..This model should be useful to inform evolutionary and pathogenetic hypotheses regarding T. cruzi...
  5. ncbi request reprint A probability model for the meiosis I non-disjunction fraction in numerical chromosomal anomalies
    Glaura C Franco
    Departamento de Estatistica, ICEx, UFMG, Caixa Postal 702, Belo Horizonte, MG 31 270 901, Brazil
    Stat Med 22:2015-24. 2003
    ....
  6. pmc A worldwide phylogeography for the human X chromosome
    Simone S Santos Lopes
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 2:e557. 2007
    ....
  7. pmc Ancestral genomes, sex, and the population structure of Trypanosoma cruzi
    Jorge M de Freitas
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    PLoS Pathog 2:e24. 2006
    ..cruzi II and T. cruzi III produced evolutionarily viable progeny. In both events, the mitochondrial recipient (as identified by the mitochondrial clade of the hybrid strains) was T. cruzi II and the mitochondrial donor was T. cruzi III...
  8. ncbi request reprint Color and genomic ancestry in Brazilians: a study with forensic microsatellites
    Juliana R Pimenta
    GENE Núcleo de Genética Médica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Hum Hered 62:190-5. 2006
    ..These results corroborate and validate our previous conclusions using ancestry-informative markers that in Brazil at the individual level there is significant dissociation of color and genomic ancestry...
  9. ncbi request reprint No association found between gr/gr deletions and infertility in Brazilian males
    Claudia M B Carvalho
    Departamento de Bioquimica e Imunologia, Belo Horizonte, Minas Gerais, Brazil
    Mol Hum Reprod 12:269-73. 2006
    ..Taken together, these results show no evidence of association between the occurrence of gr/gr deletion and male infertility...
  10. ncbi request reprint Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations
    Luciana O Andrade
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901 MG, Brazil
    Exp Parasitol 100:269-75. 2002
    ....
  11. ncbi request reprint Lack of association between Y chromosome haplogroups and male infertility in Japanese men
    Claudia M B Carvalho
    Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Am J Med Genet A 116:152-8. 2003
    ..Contrary to previous reports, our data suggest that Y microdeletions and other molecular events causally associated with male infertility in Japan occur independently of the Y chromosome background...
  12. ncbi request reprint The mutational spectrum of human autosomal tetranucleotide microsatellites
    Andréia M Leopoldino
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Hum Mutat 21:71-9. 2003
    ..The variation of the length of the LRPR explained as much as 80% of the variance of the mutation rate of autosomal tetranucleotide microsatellites...
  13. pmc Color and genomic ancestry in Brazilians
    Flavia C Parra
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Brazil
    Proc Natl Acad Sci U S A 100:177-82. 2003
    ..Our data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers...
  14. pmc Single-nucleotide polymorphisms of the Trypanosoma cruzi MSH2 gene support the existence of three phylogenetic lineages presenting differences in mismatch-repair efficiency
    Luiz Augusto-Pinto
    Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Caixa Postal 486, Belo Horizonte, Brazil
    Genetics 164:117-26. 2003
    ..Altogether, our data suggest that strains belonging to haplogroups B and C may have decreased mismatch-repair ability when compared with strains assigned to the haplogroup A lineage...
  15. ncbi request reprint The phylogeography of African Brazilians
    Vanessa F Goncalves
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Hum Hered 65:23-32. 2008
    ..We have previously shown that while most White Brazilians carry Y chromosomes of European origin, they display high proportions of African and Amerindian mtDNA lineages, because of sex-biased genetic admixture...
  16. doi request reprint Mismatch repair in Trypanosoma brucei: heterologous expression of MSH2 from Trypanosoma cruzi provides new insights into the response to oxidative damage
    Alice Machado-Silva
    Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Departamento de Bioquimica e Imunologia, Belo Horizonte, Brazil
    Gene 411:19-26. 2008
    ..brucei cells to H2O2, suggests an additional role of MSH2 in dealing with oxidative damage in these parasites, which may occur independently of MMR...
  17. ncbi request reprint Low-stringency single specific primer PCR for identification of Leptospira
    Marluce A Assunção Oliveira
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, CP 486, CEP 31270 901, Belo Horizonte, Minas Gerais, Brazil
    J Med Microbiol 52:127-35. 2003
    ..The simplicity and accuracy of the LSSP-PCR technique were found to be suitable for identification of Leptospira species...
  18. ncbi request reprint Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer
    Alessandra D Clarizia
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Genet Mol Res 5:315-22. 2006
    ....
  19. ncbi request reprint Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
    Andrea M Macedo
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30161 970, Brasil
    Mem Inst Oswaldo Cruz 99:1-12. 2004
    ..In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model...
  20. ncbi request reprint Development and application of a multiplex PCR procedure for the detection of DNA methylation in colorectal cancer
    Charles Anacleto
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Oncol Rep 13:325-8. 2005
    ..This multiplex MSP constitutes a simple and inexpensive method for screening of molecular signatures in colorectal cancer and can be used profitably before employing more expensive and complex techniques such as microarray testing...
  21. ncbi request reprint Optimization of a multiplex minisequencing protocol for population studies and medical genetics
    Claudia M B Carvalho
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Genet Mol Res 4:115-25. 2005
    ..This optimized protocol permits rapid genotyping at low cost and can serve as a blueprint for the creation of multiplex minisequencing systems suitable to virtually any typing application in population studies and medical genetics...
  22. pmc Colorectal cancer "methylator phenotype": fact or artifact?
    Charles Anacleto
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270 910 Brazil
    Neoplasia 7:331-5. 2005
    ..Thus, our data do not support the independent existence of the so-called methylator phenotype and suggest that it rather may represent a statistical artifact caused by confounding of associations...