Sergio C Oliveira

Summary

Affiliation: Belo Horizonte
Country: Brazil

Publications

  1. doi Recent advances in vaccine research against schistosomiasis in Brazil
    Sergio C Oliveira
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
    Acta Trop 108:256-62. 2008
  2. ncbi Co-administration of plasmid expressing IL-12 with 14-kDa Schistosoma mansoni fatty acid-binding protein cDNA alters immune response profiles and fails to enhance protection induced by Sm14 DNA vaccine alone
    Cristina T Fonseca
    Departamento de Bioquimica e Imunologia, Instituto de Investigação em Imunologia Instituto do Milênio, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte 31270 901, MG, Brazil
    Microbes Infect 8:2509-16. 2006
  3. pmc MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection
    Leonardo A de Almeida
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
    PLoS ONE 6:e23135. 2011
  4. pmc Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice
    Leonardo A de Almeida
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
    Infect Immun 81:1654-62. 2013
  5. ncbi Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production
    Lucila G G Pacifico
    Departamento de Bioquimica e Imunologia, Instituto de Investigação em Imunologia, Instituto Millennium, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:365-8. 2006
  6. pmc The Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces protection superior to that of vaccine strain 19 in immunocompromised and immunocompetent mice
    Cyntia G M C Trant
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
    Infect Immun 78:2283-91. 2010
  7. pmc Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection
    Fernanda C Cardoso
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 2:e308. 2008
  8. doi Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
    Marco Túlio R Gomes
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270 901 Brazil
    J Immunol 190:3629-38. 2013
  9. pmc Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient mice
    Ana Paula M S Brandão
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Clin Dev Immunol 2012:589494. 2012
  10. pmc Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses
    Natalia B Carvalho
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:1638-46. 2011

Collaborators

Detail Information

Publications32

  1. doi Recent advances in vaccine research against schistosomiasis in Brazil
    Sergio C Oliveira
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
    Acta Trop 108:256-62. 2008
    ..Lastly, we reviewed the S. mansoni genomic projects developed in the country and the recent advances in the identification of new molecules with potential as vaccine targets...
  2. ncbi Co-administration of plasmid expressing IL-12 with 14-kDa Schistosoma mansoni fatty acid-binding protein cDNA alters immune response profiles and fails to enhance protection induced by Sm14 DNA vaccine alone
    Cristina T Fonseca
    Departamento de Bioquimica e Imunologia, Instituto de Investigação em Imunologia Instituto do Milênio, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte 31270 901, MG, Brazil
    Microbes Infect 8:2509-16. 2006
    ....
  3. pmc MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection
    Leonardo A de Almeida
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
    PLoS ONE 6:e23135. 2011
    ..This resistance phenotype is accompanied by increased IFN-γ and NO production by IFN-αβR KO spleen cells and reduced apoptosis...
  4. pmc Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice
    Leonardo A de Almeida
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
    Infect Immun 81:1654-62. 2013
    ..In summary, the results presented here indicate that TLR6 is required to trigger innate immune responses against B. abortus in vivo and is required for the full activation of DCs to induce robust proinflammatory cytokine production...
  5. ncbi Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production
    Lucila G G Pacifico
    Departamento de Bioquimica e Imunologia, Instituto de Investigação em Imunologia, Instituto Millennium, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:365-8. 2006
    ..In conclusion, we did not observe the adjuvant effect of aluminum hydroxide associated with rSm22.6 in protective immunity...
  6. pmc The Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces protection superior to that of vaccine strain 19 in immunocompromised and immunocompetent mice
    Cyntia G M C Trant
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
    Infect Immun 78:2283-91. 2010
    ..Finally, the results shown here demonstrated that Brucella PGK is critical for full bacterial virulence and that a Delta pgk mutant may serve as a potential vaccine candidate in future studies...
  7. pmc Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection
    Fernanda C Cardoso
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 2:e308. 2008
    ..In this study, we investigated murine cellular immune responses to recombinant (r) Sm29 and tested this protein as a vaccine candidate...
  8. doi Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
    Marco Túlio R Gomes
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270 901 Brazil
    J Immunol 190:3629-38. 2013
    ..Taken together, our results indicate that Brucella is sensed by ASC inflammasomes that collectively orchestrate a robust caspase-1 activation and proinflammatory response...
  9. pmc Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient mice
    Ana Paula M S Brandão
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Clin Dev Immunol 2012:589494. 2012
    ..However, the lack of endogenous IFN-γ was found to be more important to control brucellosis than CD8+ T cells and IL-12-dependent IFN-γ deficiencies...
  10. pmc Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses
    Natalia B Carvalho
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:1638-46. 2011
    ..In summary, our data demonstrated that the involvement of TLR9 in the control of M. avium infection is not related to the induction of Th1 responses...
  11. pmc Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection
    Fernanda S Oliveira
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 79:4688-95. 2011
    ..In summary, the results shown in this study demonstrated that IRAK-4 is critical to trigger the initial immune response against B. abortus but not at later phases of infection...
  12. ncbi Human T cell epitope mapping of the Schistosoma mansoni 14-kDa fatty acid-binding protein using cells from patients living in areas endemic for schistosomiasis
    Cristina T Fonseca
    Departamento de Bioquimica e Imunologia, Instituto de Investigação em Imunologia Instituto do Milênio, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 31270 901, Brazil
    Microbes Infect 7:204-12. 2005
    ..Among Sm14 synthetic peptides tested in this study, we identified Sm14(32-48) and Sm14(53-69) as promising candidates to compose an anti-schistosomiasis vaccine, since they seem to be related to resistance to human schistosomiasis...
  13. ncbi Induction of partial protection in mice after oral administration of Lactococcus lactis producing Brucella abortus L7/L12 antigen
    Daniela S Pontes
    Department of General Biology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
    J Drug Target 11:489-93. 2003
    ..Nevertheless, the vaccinated mice showed a partial protective immunity against B. abortus virulent strain (S2308) challenged by intraperitoneal inoculation...
  14. ncbi The role of the vacB gene in the pathogenesis of Brucella abortus
    Anderson Miyoshi
    Department of General Biology, Federal University of Minas Gerais, Minas Gerais, Pampulha, Belo Horizonte, MG, Brazil
    Microbes Infect 9:375-81. 2007
    ..In summary, this study reports that the vacB gene in B. abortus has no impact on bacterial pathogenesis...
  15. doi Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice
    Teresa C M Garcia
    Department of Biochemistry and Immunology and Institute for Investigation in Immunology Millenium Institute, Federal University of Minas Gerais, Avenue Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
    Acta Trop 106:162-7. 2008
    ..In contrast, paramyosin peptide vaccination did not engender protective immunity or liver pathology reduction and immunization was associated with a Th2 type of immune response...
  16. pmc In vivo insertional mutagenesis in Corynebacterium pseudotuberculosis: an efficient means to identify DNA sequences encoding exported proteins
    Fernanda A Dorella
    Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Appl Environ Microbiol 72:7368-72. 2006
    ..Thirty-four out of 1,500 mutants had detectable alkaline phosphatase (PhoZ) activity. This activity was from 21 C. pseudotuberculosis loci that code for fimbrial and transport subunits and for hypothetical and unknown-function proteins...
  17. pmc Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10
    Lucila G G Pacifico
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
    Infect Immun 77:98-107. 2009
    ..Neutralization of IL-10 receptor or depletion of CD25(+) T cells in vivo confirmed the critical role of CD4(+) CD25(+) Foxp3(+) regulatory T cells in experimental asthma modulation independent of IL-10...
  18. doi Sm21.6 a novel EF-hand family protein member located on the surface of Schistosoma mansoni adult worm that failed to induce protection against challenge infection but reduced liver pathology
    Debora O Lopes
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Pampulha, Belo Horizonte 31270 901, MG, Brazil
    Vaccine 27:4127-35. 2009
    ..In conclusion, Sm21.6 is a new tegument protein from S. mansoni that plays an important role in reducing pathology induced by parasite infection...
  19. doi IL-12 and TNF-alpha production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and MyD88-dependent
    Fernanda V Durães
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, A Belo Horizonte, Minas Gerais, Brazil
    Immunol Lett 125:72-7. 2009
    ..Finally, our findings lead us to conclude that TLR4 is a key receptor involved in Smteg induction of pro-inflammatory cytokines...
  20. doi Toll-like receptor 6 senses Mycobacterium avium and is required for efficient control of mycobacterial infection
    Fábio A V Marinho
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Eur J Immunol 43:2373-85. 2013
    ..avium infected DCs. Finally, the lack of TLR6 reduced activation of MAPKs and NF-κB in DCs. In summary, TLR6 is required for full resistance to M. avium and for the activation of DCs to produce proinflammatory cytokines. ..
  21. pmc Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in mice
    Fernanda S Oliveira
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Clin Dev Immunol 2012:861426. 2012
    ..Taken together, this study demonstrates that NOD1, NOD2 and Rip2 are dispensable for the control of B. abortus during in vivo infection...
  22. pmc Molecular characterization of the Schistosoma mansoni zinc finger protein SmZF1 as a transcription factor
    Marcela G Drummond
    Laboratorio de Genetica Bioquimica, Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 3:e547. 2009
    ..mansoni zinc finger (ZF) protein, specifically binds both DNA and RNA oligonucleotides. This suggests that this protein might act as a transcription factor in the parasite...
  23. doi Update on the role of innate immune receptors during Brucella abortus infection
    Sergio C Oliveira
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
    Vet Immunol Immunopathol 148:129-35. 2012
    ..Finally, this review discusses the mechanisms used by Brucella to escape detection by the host innate immune system...
  24. pmc Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii
    Samantha R Béla
    Centro de Pesquisas Rene Rachou, CPqRR Fundação Oswaldo Cruz, Belo Horizonte, Brazil
    Infect Immun 80:4298-308. 2012
    ..023 and P < 0.045, respectively). Thus, signaling via IRAK4 is essential for the activation of innate immune cells, development of parasite-specific acquired immunity, and host resistance to infection with T. gondii...
  25. pmc Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains
    Jeronimo C Ruiz
    Research Center Rene Rachou, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 6:e18551. 2011
    ..Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity...
  26. pmc The role of innate immune signals in immunity to Brucella abortus
    Marco Túlio R Gomes
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais Belo Horizonte, MG, Brazil
    Front Cell Infect Microbiol 2:130. 2012
    ..Besides TLRs, herein we describe recent advances in NOD1, NOD2, and type I IFN receptors in innate immune pathways during B. abortus infection...
  27. pmc Human T cell and antibody-mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B, and ESAT-6 antigens
    Gilson C Macedo
    Laboratory of Immunology of Infectious Diseases, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Clin Dev Immunol 2011:351573. 2011
    ..In summary, these findings demonstrate the ability of Ag85A, Ag85B, and ESAT-6 to differentiate TB patients from controls by IgG1, IFN-γ and TNF-α production...
  28. ncbi Oral administration of a live Aro attenuated Salmonella vaccine strain expressing 14-kDa Schistosoma mansoni fatty acid-binding protein induced partial protection against experimental schistosomiasis
    Luis G C Pacheco
    Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627 Pampulha, Belo Horizonte, MG 31270 901, Brazil
    Acta Trop 95:132-42. 2005
    ..Oogram studies showed diminished numbers of S. mansoni eggs in the intestinal wall of vaccinated mice, but individual female worm fecundity did not seem to be affected by our immunization protocol...
  29. pmc Putative ATP-binding cassette transporter is essential for Brucella ovis pathogenesis in mice
    Teane M A Silva
    Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Infect Immun 79:1706-17. 2011
    ..ovis WT strain was 100% lethal within 14 days postinfection. These results confirm that the predicted ABC transporter is required for the full virulence and survival of B. ovis in vivo...
  30. ncbi IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway
    Cristina T Fonseca
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millenium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, 30161970 Belo Horizonte, MG, Brazil
    Vaccine 22:503-10. 2004
    ..Although, rSm14 immunization induced partial protection, reduction of hepatic granuloma area was only observed when IL-12 was co-administered...
  31. pmc A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis
    Luis G C Pacheco
    Department of General Biology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av, Antonio Carlos, Belo Horizonte, 31, 270 901, Brazil
    BMC Microbiol 11:12. 2011
    ..Hence, we sought to implement a combined approach for characterizing the entire exoproteome of the pathogenic bacterium Corynebacterium pseudotuberculosis, the etiological agent of caseous lymphadenitis (CLA) in sheep and goats...
  32. pmc Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice
    Marco A Campos
    Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Infect Immun 72:176-86. 2004
    ..In conclusion, these results indicate that TLR4 plays a role in resistance to B. abortus infection and that S lipid A has potent adjuvant activity...