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Genomes and GenesSpecies | Sergio C OliveiraSummaryAffiliation: Belo Horizonte Country: Brazil Publications
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Recent advances in vaccine research against schistosomiasis in BrazilSergio C Oliveira
Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
Acta Trop 108:256-62. 2008..Lastly, we reviewed the S. mansoni genomic projects developed in the country and the recent advances in the identification of new molecules with potential as vaccine targets...
MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infectionLeonardo A de Almeida
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
PLoS ONE 6:e23135. 2011..This resistance phenotype is accompanied by increased IFN-γ and NO production by IFN-αβR KO spleen cells and reduced apoptosis...
Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 productionLucila G G Pacifico
Departamento de Bioquimica e Imunologia, Instituto de Investigação em Imunologia, Instituto Millennium, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
Mem Inst Oswaldo Cruz 101:365-8. 2006..In conclusion, we did not observe the adjuvant effect of aluminum hydroxide associated with rSm22.6 in protective immunity...- The Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces protection superior to that of vaccine strain 19 in immunocompromised and immunocompetent miceCyntia G M C Trant
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
Infect Immun 78:2283-91. 2010..Finally, the results shown here demonstrated that Brucella PGK is critical for full bacterial virulence and that a Delta pgk mutant may serve as a potential vaccine candidate in future studies... - Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infectionFernanda C Cardoso
Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
PLoS Negl Trop Dis 2:e308. 2008..In this study, we investigated murine cellular immune responses to recombinant (r) Sm29 and tested this protein as a vaccine candidate... - Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient miceAna Paula M S Brandão
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
Clin Dev Immunol 2012:589494. 2012..However, the lack of endogenous IFN-γ was found to be more important to control brucellosis than CD8+ T cells and IL-12-dependent IFN-γ deficiencies... - Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responsesNatalia B Carvalho
Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Infect Immun 79:1638-46. 2011..In summary, our data demonstrated that the involvement of TLR9 in the control of M. avium infection is not related to the induction of Th1 responses... - Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infectionFernanda S Oliveira
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Infect Immun 79:4688-95. 2011..In summary, the results shown in this study demonstrated that IRAK-4 is critical to trigger the initial immune response against B. abortus but not at later phases of infection... - Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in miceTeresa C M Garcia
Department of Biochemistry and Immunology and Institute for Investigation in Immunology Millenium Institute, Federal University of Minas Gerais, Avenue Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
Acta Trop 106:162-7. 2008..In contrast, paramyosin peptide vaccination did not engender protective immunity or liver pathology reduction and immunization was associated with a Th2 type of immune response... - The role of the vacB gene in the pathogenesis of Brucella abortusAnderson Miyoshi
Department of General Biology, Federal University of Minas Gerais, Minas Gerais, Pampulha, Belo Horizonte, MG, Brazil
Microbes Infect 9:375-81. 2007..In summary, this study reports that the vacB gene in B. abortus has no impact on bacterial pathogenesis... - Sm21.6 a novel EF-hand family protein member located on the surface of Schistosoma mansoni adult worm that failed to induce protection against challenge infection but reduced liver pathologyDebora O Lopes
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Pampulha, Belo Horizonte 31270 901, MG, Brazil
Vaccine 27:4127-35. 2009..In conclusion, Sm21.6 is a new tegument protein from S. mansoni that plays an important role in reducing pathology induced by parasite infection... - IL-12 and TNF-alpha production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and MyD88-dependentFernanda V Durães
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, A Belo Horizonte, Minas Gerais, Brazil
Immunol Lett 125:72-7. 2009..Finally, our findings lead us to conclude that TLR4 is a key receptor involved in Smteg induction of pro-inflammatory cytokines... - Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10Lucila G G Pacifico
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
Infect Immun 77:98-107. 2009..Neutralization of IL-10 receptor or depletion of CD25(+) T cells in vivo confirmed the critical role of CD4(+) CD25(+) Foxp3(+) regulatory T cells in experimental asthma modulation independent of IL-10... - Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in miceFernanda S Oliveira
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Clin Dev Immunol 2012:861426. 2012..Taken together, this study demonstrates that NOD1, NOD2 and Rip2 are dispensable for the control of B. abortus during in vivo infection... - Molecular characterization of the Schistosoma mansoni zinc finger protein SmZF1 as a transcription factorMarcela G Drummond
Laboratorio de Genetica Bioquimica, Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
PLoS Negl Trop Dis 3:e547. 2009..mansoni zinc finger (ZF) protein, specifically binds both DNA and RNA oligonucleotides. This suggests that this protein might act as a transcription factor in the parasite... - Update on the role of innate immune receptors during Brucella abortus infectionSergio C Oliveira
Department of Biochemistry and Immunology, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
Vet Immunol Immunopathol 148:129-35. 2012..Finally, this review discusses the mechanisms used by Brucella to escape detection by the host innate immune system... - Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strainsJeronimo C Ruiz
Research Center Rene Rachou, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil
PLoS ONE 6:e18551. 2011..Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity... - The role of innate immune signals in immunity to Brucella abortusMarco Túlio R Gomes
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais Belo Horizonte, MG, Brazil
Front Cell Infect Microbiol 2:130. 2012..Besides TLRs, herein we describe recent advances in NOD1, NOD2, and type I IFN receptors in innate immune pathways during B. abortus infection... - Human T cell and antibody-mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B, and ESAT-6 antigensGilson C Macedo
Laboratory of Immunology of Infectious Diseases, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
Clin Dev Immunol 2011:351573. 2011..In summary, these findings demonstrate the ability of Ag85A, Ag85B, and ESAT-6 to differentiate TB patients from controls by IgG1, IFN-γ and TNF-α production... - Oral administration of a live Aro attenuated Salmonella vaccine strain expressing 14-kDa Schistosoma mansoni fatty acid-binding protein induced partial protection against experimental schistosomiasisLuis G C Pacheco
Departamento de Biologia Geral, , Universidade Federal de Minas Gerais, , 6627-Pampulha, Belo Horizonte, MG 31270-901, Brazil
Acta Trop 95:132-42. 2005..Oogram studies showed diminished numbers of S. mansoni eggs in the intestinal wall of vaccinated mice, but individual female worm fecundity did not seem to be affected by our immunization protocol... - Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondiiSamantha R Béla
Centro de Pesquisas Rene Rachou, CPqRR Fundação Oswaldo Cruz, Belo Horizonte, Brazil
Infect Immun 80:4298-308. 2012..023 and P < 0.045, respectively). Thus, signaling via IRAK4 is essential for the activation of innate immune cells, development of parasite-specific acquired immunity, and host resistance to infection with T. gondii... - Putative ATP-binding cassette transporter is essential for Brucella ovis pathogenesis in miceTeane M A Silva
Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Infect Immun 79:1706-17. 2011..ovis WT strain was 100% lethal within 14 days postinfection. These results confirm that the predicted ABC transporter is required for the full virulence and survival of B. ovis in vivo... - IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathwayCristina T Fonseca
Department of Biochemistry and Immunology, Institute for Investigation in Immunology-Millenium Institute, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 30161970 Belo Horizonte, MG, Brazil
Vaccine 22:503-10. 2004..Although, rSm14 immunization induced partial protection, reduction of hepatic granuloma area was only observed when IL-12 was co-administered... - A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosisLuis G C Pacheco
Department of General Biology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av, Antonio Carlos, Belo Horizonte, 31, 270 901, Brazil
BMC Microbiol 11:12. 2011..Hence, we sought to implement a combined approach for characterizing the entire exoproteome of the pathogenic bacterium Corynebacterium pseudotuberculosis, the etiological agent of caseous lymphadenitis (CLA) in sheep and goats... - Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in miceMarco A Campos
Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil
Infect Immun 72:176-86. 2004..In conclusion, these results indicate that TLR4 plays a role in resistance to B. abortus infection and that S lipid A has potent adjuvant activity...