Heloisa Beraldo

Summary

Affiliation: Belo Horizonte
Country: Brazil

Publications

  1. doi request reprint Structural studies and investigation on the activity of imidazole-derived thiosemicarbazones and hydrazones against crop-related fungi
    Débora C Reis
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901, MG, Brazil
    Molecules 18:12645-62. 2013
  2. doi request reprint Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes
    Karina S O Ferraz
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 53:98-106. 2012
  3. doi request reprint Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement
    Claudia Rodrigues
    Departamento de Quimica, Universidade Federal de Sao Carlos, 13565 905 São Carlos SP, Brazil
    Eur J Med Chem 45:2847-53. 2010
  4. doi request reprint N⁴-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action
    Marcella A Soares
    Departamento de Fisiologia e Biofisica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Bioorg Med Chem 20:3396-409. 2012
  5. doi request reprint Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: cytotoxicity against human leukemia cell lines
    Débora C Reis
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 45:3904-10. 2010
  6. ncbi request reprint Ruthenium(II) complexes containing 2-pyridineformamide- and 2-benzoylpyridine-derived thiosemicarbazones and PPh3: NMR and electrochemical studies of cis-trans-isomerization
    Angelica E Graminha
    Departamento de Quimica, Universidade Federal de Sao Carlos, 1365 905 São Carlos, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 69:1277-82. 2008
  7. doi request reprint 2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells
    Angel A R Despaigne
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 50:163-72. 2012
  8. doi request reprint Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp
    Gabrieli L Parrilha
    Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 46:1473-82. 2011
  9. doi request reprint Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines
    Débora C Reis
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Biometals 24:595-601. 2011
  10. doi request reprint Spectroscopic and electrochemical characterization of gold(I) and gold(III) complexes with glyoxaldehyde bis(thiosemicarbazones): cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity
    Josane A Lessa
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Biometals 25:587-98. 2012

Collaborators

  • Mercedes Gonzalez
  • Tim Storr
  • Michael R Jones
  • Ingo Ott
  • Carlos L Zani
  • Adriano D Andricopulo
  • Isabel Garcia
  • Andreas Vogt
  • Leandro F S Bastos
  • Javier Ellena
  • Jeferson G da Silva
  • Josane A Lessa
  • Isolda C Mendes
  • Elaine M Souza-Fagundes
  • Gabrieli L Parrilha
  • Karina S O Ferraz
  • Débora C Reis
  • Raquel G Dos Santos
  • Nivaldo L Speziali
  • Angel A Recio Despaigne
  • Rafael P Vieira
  • Anayive Perez-Rebolledo
  • Willian R Rocha
  • Alzir A Batista
  • Letícia R Teixeira
  • Angelica E Graminha
  • Carla F D Romeiro
  • Luana F de Miranda
  • Marcella A Soares
  • Eduardo E Castellano
  • Mauro C X Pinto
  • Claudia Rodrigues
  • Luiza M F Gomes
  • Bernardo L Rodrigues
  • Pryscila R da Costa
  • Angelo M L Denadai
  • Nayane F Silva
  • Angel A R Despaigne
  • Oscar E Piro
  • Juliana C Guerra
  • Walfrido Bispo Júnior
  • Sonia R W Louro
  • Antonio S Mangrich
  • Eliezer J Barreiro
  • James L Wardell
  • Solange M S V Wardell
  • Karina O Ferraz
  • Hugo Cerecetto
  • Kely Navakoski de Oliveira
  • Jonas P Ramos
  • Christine Dyrager
  • Michael C P Wang
  • Izabela M P Daniel
  • Flávia M Costa
  • Cristiano C Bandeira
  • Bruno M Mendes
  • Ruben D Sinisterra
  • Leonardo Bertolini S Gomes
  • Pedro P G Guimarães
  • Jacqueline A Takahashi
  • Camila F Vilela
  • Edivaltrys I P de Rezende
  • Billy W Day
  • Mariany de Fátima A Carvalho
  • Paulo Jorge S Barbeira
  • Lívia B Salum
  • Sarah A Siqueira
  • Hikmat Daghestani
  • Wallace C Ferreira
  • Lucienir P Duarte
  • Márcio M Coelho
  • Jans B Izidoro
  • Grácia Divina F Silva
  • Jorge L Pesquero
  • Fernanda B Costa
  • Paula P Campos
  • Silvia P Andrade
  • Nayane F da Silva
  • Lúcia T Paradizzi
  • Cristiane M L Melo
  • Daniel A Santos
  • Lucas F Rocha
  • Ludmila F Gouveia
  • Valéria R A Pereira
  • Alan K Gasparoto
  • Lidia Moreira Lima
  • Marina A Alves
  • Roberta P Dias
  • Magna S Alexandre-Moreira
  • Nelilma C Romeiro

Detail Information

Publications31

  1. doi request reprint Structural studies and investigation on the activity of imidazole-derived thiosemicarbazones and hydrazones against crop-related fungi
    Débora C Reis
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901, MG, Brazil
    Molecules 18:12645-62. 2013
    ..4(5)ImpClPh and 4(5)ImpNO2Ph were very effective against C. cladosporioides. In many cases, activity was superior to that of the reference compound nystatin. ..
  2. doi request reprint Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes
    Karina S O Ferraz
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 53:98-106. 2012
    ..Upon coordination of the bis(benzoylhydrazones) to antimony(III) and bismuth(III) cytotoxicity significantly improved. Complex (5) presented high therapeutic indexes (TI = 11-508) against all cell lineages...
  3. doi request reprint Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement
    Claudia Rodrigues
    Departamento de Quimica, Universidade Federal de Sao Carlos, 13565 905 São Carlos SP, Brazil
    Eur J Med Chem 45:2847-53. 2010
    ..6-0.8 microM. In all cases the association of the thiosemicarbazone with ruthenium, dppb and bipyridine or phenanthroline in one same complex proved to be an excellent strategy for activity improvement...
  4. doi request reprint N⁴-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action
    Marcella A Soares
    Departamento de Fisiologia e Biofisica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Bioorg Med Chem 20:3396-409. 2012
    ..The compounds were able to induce programmed cell death. H2Ac4pClPh partially inhibited tubulin assembly at high concentrations and induced cellular microtubule disorganization...
  5. doi request reprint Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: cytotoxicity against human leukemia cell lines
    Débora C Reis
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 45:3904-10. 2010
    ..The cytotoxic activity of complexes 2 and 3 against HL-60 and Jurkat cells was significantly higher than that of the corresponding thiosemicarbazones, suggesting coordination to be an interesting strategy of cytotoxic dose reduction...
  6. ncbi request reprint Ruthenium(II) complexes containing 2-pyridineformamide- and 2-benzoylpyridine-derived thiosemicarbazones and PPh3: NMR and electrochemical studies of cis-trans-isomerization
    Angelica E Graminha
    Departamento de Quimica, Universidade Federal de Sao Carlos, 1365 905 São Carlos, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 69:1277-82. 2008
    ..Our results suggest that, although both factors may be operating simultaneously, in CH(2)Cl(2) solution the balance of these counterpoising effects favors the formation of the trans isomer...
  7. doi request reprint 2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells
    Angel A R Despaigne
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 50:163-72. 2012
    ..The therapeutic indexes (TI = IC(50MRC5)/IC(50glioma)) were 2-660 for T98 cells and 28-5000 for U87 cells, indicating that the studied hydrazones could be good antitumor drug candidates to treat brain tumors...
  8. doi request reprint Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp
    Gabrieli L Parrilha
    Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 46:1473-82. 2011
    ..albicans, C. parapsilosis and C. glabrata are similar to that of fluconazole. All studied compounds were more active than fluconazole against C. krusei...
  9. doi request reprint Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines
    Débora C Reis
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Biometals 24:595-601. 2011
    ..While SbCl(3) proved to be cytotoxic against HL-60 cells, it was not active against Jurkat cells. However, its coordination to the quinoline derivatives resulted in complexes with significant cytotoxicity against Jurkat cells...
  10. doi request reprint Spectroscopic and electrochemical characterization of gold(I) and gold(III) complexes with glyoxaldehyde bis(thiosemicarbazones): cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity
    Josane A Lessa
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Biometals 25:587-98. 2012
    ..Complex (2) was able to in vitro inhibit thioredoxin reductase (TrxR) activity, which suggests that inhibition of TrxR could be part of its mechanism of action...
  11. doi request reprint Gold(I) complexes with thiosemicarbazones: cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity
    Josane A Lessa
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    J Inorg Biochem 105:1729-39. 2011
    ..Complex (2) strongly inhibited the activity of thioredoxin reductase (TrxR), which suggests inhibition of TrxR to be part of its mechanism of action...
  12. doi request reprint 2-Benzoylpyridine-N(4)-tolyl thiosemicarbazones and their palladium(II) complexes: cytotoxicity against leukemia cells
    Karina S O Ferraz
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Brazil
    Bioorg Med Chem 17:7138-44. 2009
    ....
  13. doi request reprint Copper(II) complexes with 2-pyridineformamide-derived thiosemicarbazones: spectral studies and toxicity against Artemia salina
    Karina O Ferraz
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 73:140-5. 2009
    ..H2Am4Ph and complexes 2 and 3 revealed to be the most promising compounds as potential antineoplasic agents...
  14. doi request reprint Coordination of thiosemicarbazones and bis(thiosemicarbazones) to bismuth(III) as a strategy for the design of metal-based antibacterial agents
    Josane A Lessa
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Chem Biodivers 9:1955-66. 2012
    ..Coordination to Bi(III) proved to be an effective strategy to increase the antibacterial activity of the thiosemicarbazones and bis(thiosemicarbazones)...
  15. doi request reprint Cytotoxic activity, albumin and DNA binding of new copper(II) complexes with chalcone-derived thiosemicarbazones
    Jeferson G da Silva
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 65:415-26. 2013
    ..Unlike the free thiosemicarbazones, 1-4 induced DNA fragmentation in solid tumor cells indicating their pro-apoptotic potential...
  16. ncbi request reprint Organotin(IV) complexes of 2-pyridineformamide-derived thiosemicarbazones: antimicrobial and cytotoxic effects
    Isolda C Mendes
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Eur J Med Chem 43:1454-61. 2008
    ..Thiosemicarbazones and their tin(IV) complexes proved to be more potent as cytotoxic agents than cisplatin. All the compounds were able to induce apoptosis...
  17. doi request reprint Gallium(III) complexes of 2-pyridineformamide thiosemicarbazones: cytotoxic activity against malignant glioblastoma
    Isolda C Mendes
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 44:1870-7. 2009
    ..81-9.57 microM range against RT2 cells and in the 3.6-11.30 microM range against T98 cells, and were 20-fold more potent than cisplatin. All thiosemicarbazones and gallium complexes were able to induce cell death by apoptosis...
  18. ncbi request reprint 4-nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity
    Anayive Perez-Rebolledo
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 43:939-48. 2008
    ....
  19. doi request reprint Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone: cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase
    Gabrieli L Parrilha
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 84:537-44. 2014
    ..The selectivity of these complexes for TrxR suggests metal binding to a selenol residue in the active site of the enzyme. TrxR inhibition is likely a contributing factor to the mode of action of the gold and antimony derivatives. ..
  20. doi request reprint 2-Acetylpyridine thiosemicarbazones: cytotoxic activity in nanomolar doses against malignant gliomas
    Josane A Lessa
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 45:5671-7. 2010
    ....
  21. ncbi request reprint Ruthenium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones with cytotoxic activity against human tumor cell lines
    Angelica E Graminha
    Departamento de Quimica, Universidade Federal de Sao Carlos, 1365 905 São Carlos, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 69:1073-6. 2008
    ..H2BzDH, H2Bz4M, and [RuCl(dppb)(H2Bz4M)]Cl (2) show a selective cytocidal effect against the UACC-62 cell line which makes them the most promising compounds...
  22. doi request reprint Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes
    Walfrido Bispo Júnior
    LaFI Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceio, AL, Brazil
    Molecules 16:6902-15. 2011
    ..All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile...
  23. doi request reprint ROS-mediated cytotoxic effect of copper(II) hydrazone complexes against human glioma cells
    Angel A Recio Despaigne
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Brazil
    Molecules 19:17202-20. 2014
    ..The cytotoxic effect of 1 in U87 cells could be related to its ability to provoke the release of ROS, suggesting that the cytotoxicity of 1 might be somehow p53 dependent. ..
  24. doi request reprint Influence of susceptibility to hydrolysis and hydrophobicity of arylsemicarbazones on their anti-nociceptive and anti-inflammatory activities
    Rafael P Vieira
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Eur J Med Chem 50:140-8. 2012
    ..Inhibition of the first phase of formaldehyde response by BS could be attributed to its higher hydrophobicity and lower susceptibility to hydrolysis in comparison to 2-OHBS...
  25. doi request reprint Control of size in losartan/copper(II) coordination complex hydrophobic precipitate
    Angelo M L Denadai
    Departamento de Farmacia, Universidade Federal de Juiz de Fora UFJF, Campus Governador Valadares, Av Dr Raimundo Monteiro de Rezende, 330, Centro, 35010 177 Governador Valadares, MG, Brazil
    Mater Sci Eng C Mater Biol Appl 33:3916-22. 2013
    ..Zeta potential and DLS measurements showed that it is possible to control the size and charge of nanoprecipitates by adjusting the relative concentration of Los(-) and Cu(II). ..
  26. ncbi request reprint An effective anticonvulsant prepared following a host-guest strategy that uses hydroxypropyl-beta-cyclodextrin and benzaldehyde semicarbazone
    Heloisa Beraldo
    Departamento de Quimica, Universidade Federal de Minas Gerais, MG, Belo Horizonte, Brazil
    Biochem Biophys Res Commun 296:241-6. 2002
    ..In both tests the minimum dose of compound necessary to produce activity decreases from 100mg/kg for the free semicarbazone to 35 mg/kg for the inclusion compound, indicating a significant increase in the bio-availability of the drug...
  27. ncbi request reprint The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes
    Heloisa Beraldo
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil
    Mini Rev Med Chem 4:31-9. 2004
    ..Clinical or potential pharmacological applications of these versatile compounds are discussed...
  28. doi request reprint 8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation
    Luiza M F Gomes
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil Department of Chemistry, Simon Fraser University, V5A 1S6 Burnaby, BC, Canada
    J Inorg Biochem 139:106-16. 2014
    ..However, in the presence of ligands and Cu(II), the results match those for the peptide alone, suggesting that the ligands function by sequestering Cu(II) and limiting oligomer formation in this assay. ..
  29. doi request reprint N(4)-tolyl-2-acetylpyridine thiosemicarbazones and their platinum(II,IV) and gold(III) complexes: cytotoxicity against human glioma cells and studies on the mode of action
    Karina S O Ferraz
    Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270 901, Brazil
    Biometals 26:677-91. 2013
    ..Cells treated with the studied compounds presented morphological changes such as cell shrinkage and blebs formation, which indicate cell death by apoptosis induction. ..
  30. doi request reprint Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities
    Gabrieli L Parrilha
    Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270 901, Brazil
    Biometals 25:55-62. 2012
    ..However, coordination to bismuth(III) could be an interesting strategy for improvement of lapachol's therapeutic properties...
  31. ncbi request reprint Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes
    Anayive Perez-Rebolledo
    Departamento de Quimica, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Eur J Med Chem 40:467-72. 2005
    ..Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells...