José E Belizário
- New routes for transgenesis of the mouseJosé E Belizário
Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Lineu Prestes, 1524, CEP 05508 900, Sao Paulo, SP, Brazil
J Appl Genet 53:295-315. 2012....
- Induction of apoptosis in cancer cells by tumor necrosis factor and butyrolactone, an inhibitor of cyclin-dependent kinasesJ E Belizario
Laboratorio de Genetica, Instituto Butantan, Sao Paulo, Brasil
Braz J Med Biol Res 32:473-82. 1999..These findings link the decrease of cyclin-dependent kinase activities to the increase of protease activities within the growth arrest and apoptosis pathways induced by TNF...
- A mechanistic view of mitochondrial death decision poresJ E Belizario
Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
Braz J Med Biol Res 40:1011-24. 2007....
- Coupling caspase cleavage and proteasomal degradation of proteins carrying PEST motifJosé E Belizário
From Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
Curr Protein Pept Sci 9:210-20. 2008..This could explain the inherent susceptibility to proteolysis among proteins containing PEST motif...
- Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexiaJ E Belizario
Department of Pharmacology of Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, 05508 900, Brazil
Br J Cancer 84:1135-40. 2001..This data supports a role for caspases in the catabolic events in muscle involved in the cancer cachexia syndrome...
- CaSPredictor: a new computer-based tool for caspase substrate predictionH M Garay-Malpartida
Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo Sao Paulo, Brazil
Bioinformatics 21:i169-76. 2005..However, there is little information about the substrate recognition patterns in vivo. The prediction and characterization of proteolytic cleavage sites in natural substrates could be useful for uncovering these structural relationships...