Izabela Md Bastos
de Almeida H, Leroux V, Motta F, Grellier P, Maigret B, Santana J, et al
. Identification of novel Trypanosoma cruzi prolyl oligopeptidase inhibitors by structure-based virtual screening. J Comput Aided Mol Des. 2016;30:1165-1174 pubmed publisher
..This work paves the way for future development of innovative drugs against Chagas disease. ..
Andrade M, Azevedo C, Motta F, Santos M, Silva C, Santana J, et al
. Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition. BMC Complement Altern Med. 2016;16:444 pubmed
..amazonensis promastigotes forms and presented low cytotoxic activity against L6 cells. Thus, it represents a strong candidate for future studies aiming its molecular activity on these pathogenic parasites. ..
Bastos I, Motta F, Charneau S, Santana J, Dubost L, Augustyns K, et al
. Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice. Microbes Infect. 2010;12:457-66 pubmed publisher
..Furthermore, POP Tb is released into the bloodstream of T. brucei infected mice where it remains active. These data suggest that POP Tb might contribute to the pathogenesis of sleeping sickness. ..
Cadavid Restrepo G, Gastardelo T, Faudry E, de Almeida H, Bastos I, Negreiros R, et al
. The major leucyl aminopeptidase of Trypanosoma cruzi (LAPTc) assembles into a homohexamer and belongs to the M17 family of metallopeptidases. BMC Biochem. 2011;12:46 pubmed publisher
..cruzi forms and mediates the major parasite leucyl aminopeptidolytic activity. Since biosynthetic pathways for essential amino acids, including leucine, are lacking in T. cruzi, LAPTc could have a function in nutritional supply. ..