Matheus D Baldissera

Summary

Country: Brazil

Publications

  1. Souza C, Baldissera M, Descovi S, Diniz S, Henn A, Flores E, et al. Diphenyl diselenide dietary supplementation protects against methylmercury-chloride-induced immunotoxicity in the head kidney and spleen of grass carp (Ctenopharyngodon idella) via regulation of purinergic signaling and the NLRP3 inflammasome. Comp Biochem Physiol C Toxicol Pharmacol. 2019;: pubmed publisher
  2. de Freitas Souza C, Baldissera M, Verdi C, Santos R, da Rocha M, DA Veiga M, et al. Oxidative stress and antioxidant responses in Nile tilapia Oreochromis niloticus experimentally infected by Providencia rettgeri. Microb Pathog. 2019;131:164-169 pubmed publisher
  3. Baldissera M, Souza C, Descovi S, Petrolli T, Da Silva A, Baldisserotto B. A caffeine-supplemented diet modulates oxidative stress markers and prevents oxidative damage in the livers of Nile tilapia (Oreochromis niloticus) exposed to hypoxia. Fish Physiol Biochem. 2019;: pubmed publisher
  4. Baldissera M, Souza C, Descovi S, Petrolli T, Da Silva A, Baldisserotto B. Caffeine modulates brain purinergic signaling in Nile tilapia (Oreochromis niloticus) under hypoxia conditions: improvement of immune and inflammatory responses. Fish Physiol Biochem. 2018;: pubmed publisher
  5. Baldissera M, Souza C, Descovi S, Zanella R, Prestes O, de Matos A, et al. Disturbance of energetic homeostasis and oxidative damage provoked by trichlorfon as relevant toxicological mechanisms using silver catfish as experimental model. Chem Biol Interact. 2019;299:94-100 pubmed publisher
    ..Moreover, alterations on CK and PK activities provoke an impairment on Na+, K+-ATPase activity, which can be mediated by lipid oxidative damage and reduction of NPSH content. ..
  6. Jaguezeski A, Baldissera M, Rhoden L, Gomes T, Mendes R, Bottari N, et al. Listeria monocytogenes impairs enzymes of the phosphotransfer network and alters antioxidant/oxidant status in cattle brain structures. Microb Pathog. 2018;124:284-290 pubmed publisher
    ..In summary, these alterations contribute to disease pathogenesis linked to CNS during cattle listeriosis. ..
  7. Baldissera M, Rech V, Da Silva A, Nishihira V, Ianiski F, Gressler L, et al. Relationship between behavioral alterations and activities of adenylate kinase and creatine kinase in brain of rats infected by Trypanosoma evansi. Exp Parasitol. 2015;151-152:96-102 pubmed publisher
    ..evansi. ..
  8. Souza C, Baldissera M, Zeppenfeld C, Descovi S, Stefani L, Baldisserotto B, et al. Oxidative stress mediated the inhibition of cerebral creatine kinase activity in silver catfish fed with aflatoxin B1-contaminated diet. Fish Physiol Biochem. 2019;45:63-70 pubmed publisher
    ..Moreover, the inhibition of brain CK activity appears to be mediated by the oxidation of lipids, proteins, and thiol group, as well as by a reduction in the antioxidant capacity. ..
  9. Do Carmo G, Baldissera M, Vaucher R, Rech V, Oliveira C, Sagrillo M, et al. Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi. Exp Parasitol. 2015;149:39-46 pubmed publisher
    ..evansi. In summary, the nanoencapsulated form showed better activity on the trypanosome; it did not cause liver toxicity and prevented renal damage. ..

More Information

Publications40

  1. Baldissera M, Souza C, Baldisserotto B. Purinergic signaling modulates the splenic inflammatory response in silver catfish naturally infected with Ichthyophthirius multifiliis. Parasitol Res. 2018;117:1169-1173 pubmed publisher
    ..In summary, modulation of the splenic purinergic cascade has an anti-inflammatory role in reducing or preventing inflammatory damage. ..
  2. Baldissera M, Souza C, De Matos A, Baldisserotto B, Stefani L, Da Silva A. Purinergic system as a potential target for inflammation and toxicity induced by thymol in immune cells and tissues. Mol Cell Biochem. 2019;452:105-110 pubmed publisher
    ..In summary, all tested thymol concentrations induced inflammation and toxicity in tissues and immune cells of treated mice. ..
  3. Baldissera M, Souza C, Grando T, Da Silva A, Monteiro S. Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation. Microb Pathog. 2016;99:191-195 pubmed publisher
    ..evansi decrease the activities of AChE, BChE and ADA in order to reduce the oxidative damage increasing the levels of ACh, BCh and adenosine. These alterations in the kidney may be contribute on pathophysiology of T. evansi infection. ..
  4. Baldissera M, Souza C, Doleski P, Júnior G, de Vargas A, Baldisserotto B. Involvement of cholinergic and purinergic systems during the inflammatory response caused by Aeromonas hydrophila in Rhamdia quelen. Microb Pathog. 2016;99:78-82 pubmed publisher
    ..hydrophila with an anti-inflammatory effect. In summary, AChE and ADA activities reduced probably in order to protect against tissue inflammatory damage caused by infection. ..
  5. Baldissera M, Rech V, Grings M, Kolling J, Da Silva A, Gressler L, et al. Relationship between pathological findings and enzymes of the energy metabolism in liver of rats infected by Trypanosoma evansi. Parasitol Int. 2015;64:547-52 pubmed publisher
    ..evansi infected rats. Therefore, these alterations are directly related to disease pathogenesis. ..
  6. Baldissera M, Sagrillo M, de Sá M, Grando T, Souza C, de Brum G, et al. Relationship between DNA damage in liver, heart, spleen and total blood cells and disease pathogenesis of infected rats by Trypanosoma evansi. Exp Parasitol. 2016;161:12-9 pubmed publisher
    ..001). Our data show that T. evansi infection causes genotoxicity due to the production of NO, causing not only the death of the protozoan, but also inducing DNA damage in the host. ..
  7. Baldissera M, Grando T, Souza C, Gressler L, Stefani L, Da Silva A, et al. In vitro and in vivo action of terpinen-4-ol, γ-terpinene, and α-terpinene against Trypanosoma evansi. Exp Parasitol. 2016;162:43-8 pubmed publisher
    ..evansi infection. The compound α-terpinene from M. alternifolia essential oil is the one responsible for the trypanocidal effect, a fact confirmed by in vitro results and the increased longevity observed on treated mice. ..
  8. Baldissera M, Gonçalves R, Sagrillo M, Grando T, Ritter C, Grotto F, et al. Effects of treatment with the anti-parasitic drug diminazene aceturate on antioxidant enzymes in rat liver and kidney. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:429-38 pubmed publisher
    ..Histopathology revealed vacuolar degeneration in liver and kidney samples on day 21 PT. Our findings indicate that DA could cause oxidative damage to liver and kidney of rats. ..
  9. Baldissera M, Grando T, Souza C, Cossetin L, Sagrillo M, Nascimento K, et al. Nerolidol nanospheres increases its trypanocidal efficacy against Trypanosoma evansi: New approach against diminazene aceturate resistance and toxicity. Exp Parasitol. 2016;166:144-9 pubmed publisher
    ..Therefore, nanoencapsulation increased the therapeutic efficacy of nerolidol against T. evansi, and can be used as an alternative treatment for T. evansi infection. ..
  10. Baldissera M, Grando T, de Souza C, Cossetin L, da Silva A, Giongo J, et al. A nanotechnology based new approach for Trypanosoma evansi chemotherapy: In vitro and vivo trypanocidal effect of (-)-?-bisabolol. Exp Parasitol. 2016;170:156-160 pubmed publisher
    ..A., and for treatment of infected animals with T. evansi. Also, the nanotechnology associated with natural products arises an important alternative for the improve the trypanocidal action. ..
  11. Baldissera M, Souza C, Zeppenfeld C, Descovi S, Da Silva A, Baldisserotto B. Changes in the cerebral phosphotransfer network impair energetic homeostasis in an aflatoxin B1-contaminated diet. Fish Physiol Biochem. 2018;44:1051-1059 pubmed publisher
    ..Moreover, the absence of a reciprocal compensatory mechanism between these enzymes contributes to cerebral energetic imbalance, which may contribute to disease pathophysiology. ..
  12. Baldissera M, Souza C, Golombieski J, Seben D, Sippert L, Salbego J, et al. Purinergic signaling as potential target of thiamethoxam-induced neurotoxicity using silver catfish (Rhamdia quelen) as experimental model. Mol Cell Biochem. 2018;449:39-45 pubmed publisher
    ..In summary, the brain purinergic signaling may be considered a potential target for thiamethoxam-induced neurotoxicity in silver catfish. ..
  13. Souza C, Verdi C, Baldissera M, Doleski P, Vizzotto B, Santos R, et al. Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae. Microb Pathog. 2017;113:25-28 pubmed publisher
    ..In summary, upregulation of XO activity may be considered a pathway involved in ROS and NOx production. ..
  14. Baldissera M, Souza C, Santos R, Baldisserotto B. Purinergic system displays an anti-inflammatory profile in serum of silver catfish experimentally infected with Streptococcus agalactiae: An attempt to ameliorate the inflammatory response. Microb Pathog. 2018;114:193-196 pubmed publisher
    ..In summary, the purinergic system is capable of modulating the immune and inflammatory responses during fish streptococcosis. ..
  15. Baldissera M, Souza C, Grando T, Sagrillo M, Da Silva A, Stefani L, et al. The use of tucumã oil (Astrocaryum vulgare) in alloxan-induced diabetic mice: effects on behavior, oxidant/antioxidant status, and enzymes involved in brain neurotransmission. Mol Cell Biochem. 2017;436:159-166 pubmed publisher
    ..In conclusion, the present data showed that treatment with tucumã oil is beneficial to diabetic mice, demonstrating that this oil can modulate cholinergic neurotransmission and consequently improve or avoid memory deficits. ..
  16. Baldissera M, Souza C, Grando T, Stefani L, Monteiro S. ?-caryophyllene reduces atherogenic index and coronary risk index in hypercholesterolemic rats: The involvement of cardiac oxidative damage. Chem Biol Interact. 2017;270:9-14 pubmed publisher
    ..Thus, this compound can be used as an attempt to prevent or reduce atherosclerosis in hypercholesterolemic rats. ..
  17. Souza C, Baldissera M, Cossetin L, Dalla Lana D, Monteiro S. Achyrocline satureioides essential oil loaded in nanocapsules ameliorate the antioxidant/oxidant status in heart of rats infected with Trypanosoma evansi. Microb Pathog. 2017;105:30-36 pubmed publisher
    ..evansi, which might be due to its antioxidant properties. AS-NC might be considered a promising therapeutic agent against oxidative stress, when associated with nanotechnology. ..
  18. Baldissera M, Souza C, Doleski P, Grando T, Sagrillo M, Da Silva A, et al. Treatment with tucumã oil (Astrocaryum vulgare) for diabetic mice prevents changes in seric enzymes of the purinergic system: Improvement of immune system. Biomed Pharmacother. 2017;94:374-379 pubmed publisher
    ..Thus, the tucumã oil is a promising natural compound with protective action against diabetes and its side effects, such as changes in the purinergic system, improving the immune system. ..
  19. Souza C, Baldissera M, Moreira K, da Rocha M, DA Veiga M, Santos R, et al. Involvement of xanthine oxidase activity with oxidative and inflammatory renal damage in silver catfish experimentally infected with Streptococcus agalactiae: Interplay with reactive oxygen species and nitric oxide. Microb Pathog. 2017;111:1-5 pubmed publisher
    ..In summary, the upregulation on XO activity may be considered a pathway involved in the renal injury during S. agalactiae infection. ..
  20. Baldissera M, Souza C, Grando T, Doleski P, Boligon A, Stefani L, et al. Hypolipidemic effect of ?-caryophyllene to treat hyperlipidemic rats. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:215-223 pubmed publisher
  21. Baldissera M, Souza C, Baldisserotto B. Ichthyophthirius multifiliis impairs splenic enzymes of the phosphoryl transfer network in naturally infected Rhamdia quelen: effects on energetic homeostasis. Parasitol Res. 2018;117:413-418 pubmed publisher
    ..In summary, these alterations contribute to disease pathogenesis linked to spleen tissue in animals infected with white spot disease. ..
  22. Baldissera M, Souza C, Doleski P, de Vargas A, Duarte M, Duarte T, et al. Melaleuca alternifolia essential oil prevents alterations to purinergic enzymes and ameliorates the innate immune response in silver catfish infected with Aeromonas hydrophila. Microb Pathog. 2017;109:61-66 pubmed publisher
    ..hydrophila infection. In summary, prophylactic therapy with TTO can be considered an important approach to improve the immune response and consequently avoid the inflammatory process in fish infected with A. hydrophila. ..
  23. Baldissera M, Souza C, Grando T, Cossetin L, Sagrillo M, Nascimento K, et al. Antihyperglycemic, antioxidant activities of tucumã oil (Astrocaryum vulgare) in alloxan-induced diabetic mice, and identification of fatty acid profile by gas chromatograph: New natural source to treat hyperglycemia. Chem Biol Interact. 2017;270:51-58 pubmed publisher
  24. Baldissera M, Souza C, Júnior G, de Vargas A, Boligon A, de Campos M, et al. Melaleuca alternifolia essential oil enhances the non-specific immune system and prevents oxidative damage in Rhamdia quelen experimentally infected by Aeromonas hydrophila: Effects on cholinergic and purinergic systems in liver tissue. Fish Shellfish Immunol. 2017;61:1-8 pubmed publisher
    ..In addition, TTO prophylactic treatment might be considered an important approach to prevent the hepatic damage caused by A. hydrophila. ..
  25. Baldissera M, Souza C, Santos R, Stefani L, Moreira K, DA Veiga M, et al. Pseudomonas aeruginosa strain PA01 impairs enzymes of the phosphotransfer network in the gills of Rhamdia quelen. Vet Microbiol. 2017;201:121-125 pubmed publisher
    ..aeruginosa inhibits key enzymes linked to the production and utilization of metabolic energy in silver catfish, and consequently, impairs cellular energy homeostasis, which may contribute to disease pathogenesis. ..
  26. Ritter C, Baldissera M, Grando T, Souza C, Sagrillo M, da Silva A, et al. Achyrocline satureioides essential oil-loaded in nanocapsules reduces cytotoxic damage in liver of rats infected by Trypanosoma evansi. Microb Pathog. 2017;103:149-154 pubmed publisher
    ..In summary, the treatment with AS-NC was able to protect the liver tissue against the cytotoxic effect caused by the parasite by avoiding exacerbated production of ROS. ..
  27. Baldissera M, Souza C, Doleski P, Leal D, Stefani L, Boligon A, et al. Enzymes that hydrolyze adenine nucleotides in a model of hypercholesterolemia induced by Triton WR-1339: protective effects of ?-caryophyllene. Mol Cell Biochem. 2017;434:127-134 pubmed publisher
    ..These results indicated that ?-caryophyllene treatment could improve the immune response during hypercholesterolemia through purinergic pathway. ..
  28. Baldissera M, Souza C, Grando T, Moreira K, Schafer A, Cossetin L, et al. Nerolidol-loaded nanospheres prevent behavioral impairment via ameliorating Na+, K+-ATPase and AChE activities as well as reducing oxidative stress in the brain of Trypanosoma evansi-infected mice. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:139-148 pubmed publisher
    ..These results suggest that N-NS treatment may be a useful strategy to treat memory dysfunction and oxidative stress caused by T. evansi infection. ..
  29. Baldissera M, Souza C, Grings M, Parmeggiani B, Leipnitz G, Moreira K, et al. Inhibition of the mitochondrial respiratory chain in gills of Rhamdia quelen experimentally infected by Pseudomonas aeruginosa: Interplay with reactive oxygen species. Microb Pathog. 2017;107:349-353 pubmed publisher
    ..Moreover, the inhibition on mitochondrial complexes I-III and IV are linked to the ROS production, contributing to disease pathogenesis. ..
  30. Souza C, Baldissera M, Bottari N, Moreira K, da Rocha M, DA Veiga M, et al. Purinergic signaling modulates the cerebral inflammatory response in experimentally infected fish with Streptococcus agalactiae: an attempt to improve the immune response. Mol Cell Biochem. 2018;443:131-138 pubmed publisher
    ..In summary, the modulation of the cerebral purinergic cascade exerts an anti-inflammatory profile in an attempt to reduce inflammatory damage. ..
  31. Baldissera M, Souza C, Júnior G, Verdi C, Moreira K, da Rocha M, et al. Aeromonas caviae alters the cytosolic and mitochondrial creatine kinase activities in experimentally infected silver catfish: Impairment on renal bioenergetics. Microb Pathog. 2017;110:439-443 pubmed publisher
    ..In summary, A. caviae infection causes a severe energetic imbalance in infected silver catfish, which may contribute to disease pathogenesis. ..