Michael W Brands

Summary

Publications

  1. doi Chronic blood pressure control
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    Compr Physiol 2:2481-94. 2012
  2. pmc Sodium-retaining effect of insulin in diabetes
    Michael W Brands
    Dept of Physiology, Medical College of Georgia, Georgia Health Sciences Univ, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 303:R1101-9. 2012
  3. ncbi Lack of blood pressure salt-sensitivity supports a preglomerular site of action of nitric oxide in Type I diabetic rats
    Michael W Brands
    Department of Physiology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Clin Exp Pharmacol Physiol 34:475-9. 2007
  4. pmc Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs
    Michael W Brands
    Department of Physiology, CA 3098, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 296:R265-71. 2009
  5. ncbi Blood pressure early in diabetes depends on a balance between glomerular filtration rate and the renin-angiotensin system
    Modesto Rojas
    Department of Physiology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Hypertens 19:1249-55. 2006
  6. pmc Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked
    Tracy D Bell
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Am J Physiol Renal Physiol 295:F1449-56. 2008
  7. pmc The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6
    Lashon C Sturgis
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1742-8. 2009
  8. pmc Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
    Marlina Manhiani
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Renal Physiol 297:F740-8. 2009
  9. pmc Chronic sodium-retaining action of insulin in diabetic dogs
    M Marlina Manhiani
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Renal Physiol 300:F957-65. 2011
  10. pmc Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 56:879-84. 2010

Collaborators

Detail Information

Publications30

  1. doi Chronic blood pressure control
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    Compr Physiol 2:2481-94. 2012
    ..In both instances, circulatory homeostasis is maintained because the sodium balance blood pressure set point is reached...
  2. pmc Sodium-retaining effect of insulin in diabetes
    Michael W Brands
    Dept of Physiology, Medical College of Georgia, Georgia Health Sciences Univ, Augusta, GA 30912, USA
    Am J Physiol Regul Integr Comp Physiol 303:R1101-9. 2012
    ..This new evidence that insulin has a sodium-retaining effect during hyperglycemia may have implications for maintaining sodium balance in uncontrolled Type II diabetes...
  3. ncbi Lack of blood pressure salt-sensitivity supports a preglomerular site of action of nitric oxide in Type I diabetic rats
    Michael W Brands
    Department of Physiology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Clin Exp Pharmacol Physiol 34:475-9. 2007
    ..The normal modulation of PRA by salt intake and the failure of GFR to increase are consistent with our hypothesis that nitric oxide may protect against hypertension early in diabetes by preventing preglomerular vasoconstriction by AngII...
  4. pmc Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs
    Michael W Brands
    Department of Physiology, CA 3098, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 296:R265-71. 2009
    ..However, the volume retention and peripheral edema suggest that systemic vasodilation offsets any potential renal actions to increase MAP in this experimental model in dogs...
  5. ncbi Blood pressure early in diabetes depends on a balance between glomerular filtration rate and the renin-angiotensin system
    Modesto Rojas
    Department of Physiology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Hypertens 19:1249-55. 2006
    ..These data support the hypothesis that normotension early in diabetes requires a balance between the increased AngII and GFR, and that BP will increase if AngII increases but GFR does not...
  6. pmc Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked
    Tracy D Bell
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Am J Physiol Renal Physiol 295:F1449-56. 2008
    ..These data strongly support a role for NO in causing renal vasodilation in diabetes and suggest that an effect of NO to blunt RBF autoregulation may play an important role...
  7. pmc The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6
    Lashon C Sturgis
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1742-8. 2009
    ..This suggests that aldosterone contributes to the increase in plasma IL-6 in the early stage of ANG II hypertension but that the blood pressure actions of IL-6 in that model are linked most likely to ANG II rather than aldosterone...
  8. pmc Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
    Marlina Manhiani
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Renal Physiol 297:F740-8. 2009
    ..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension...
  9. pmc Chronic sodium-retaining action of insulin in diabetic dogs
    M Marlina Manhiani
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Renal Physiol 300:F957-65. 2011
    ..These data may reveal an unrecognized physiologic function of insulin as a protector against hyperglycemia-induced salt wasting in diabetes...
  10. pmc Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 56:879-84. 2010
    ..These data suggest that IL-6-dependent activation of the renal janus kinase 2/signal transducer and activator of transcription 3 pathway plays a role in Ang II hypertension but not by mediating the effect of Ang II to decrease total RBF...
  11. ncbi Nitric oxide may prevent hypertension early in diabetes by counteracting renal actions of superoxide
    Michael W Brands
    Department of Physiology and the Vascular Biology Center, Medical College of Georgia, CL 3132, Augusta, GA 30912 3000, USA
    Hypertension 43:57-63. 2004
    ..Thus, the hypertension and decrease in GFR caused by onset of diabetes in rats without a functioning nitric oxide system was prevented by chronic administration of the superoxide dismutase mimetic tempol...
  12. ncbi Obesity-induced hypertension develops in young rats independently of the renin-angiotensin-aldosterone system
    Anita D Smith
    Department of Physiology, Medical College of Georgia, Augusta, 30912 3000, USA
    Exp Biol Med (Maywood) 231:282-7. 2006
    ..Surprisingly, this occurs without the increase in renin or aldosterone levels seen in the adult models of diet-induced obesity...
  13. ncbi Nitric oxide opposes glucose-induced hypertension by suppressing sympathetic activity
    Christie R Claxton
    Department of Physiology, University of Mississippi Medical Center, Jackson, USA
    Hypertension 41:274-8. 2003
    ....
  14. pmc Chronic intrarenal insulin replacement reverses diabetes mellitus-induced natriuresis and diuresis
    M Marlina Manhiani
    Department of Physiology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Hypertension 59:421-30. 2012
    ..Insulin plus glucose may work to prevent salt wasting in uncontrolled type 2 diabetes mellitus...
  15. ncbi Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice
    Dexter L Lee
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1394-8. 2004
    ....
  16. ncbi Angiotensin II hypertension is attenuated in interleukin-6 knockout mice
    Dexter L Lee
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Physiol Heart Circ Physiol 290:H935-40. 2006
    ..In addition, the early separation in MAP, the albumin excretion data, and the rapid, post-ANG II recovery of MAP suggest an IL-6-dependent mechanism that is independent of renal injury...
  17. pmc Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake
    Amy K L Banes-Berceli
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1169-76. 2011
    ....
  18. pmc Role of IL-6 in angiotensin II-induced retinal vascular inflammation
    Modesto Rojas
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:1709-18. 2010
    ..The present study was an investigation of the role of interleukin (IL)-6 in angiotensin II-induced retinopathy...
  19. pmc Early life stress sensitizes the renal and systemic sympathetic system in rats
    Analia S Loria
    Section of Experimental Medicine, CB 2200, 1459 Laney Walker Blvd, Dept of Medicine, Georgia Regents University, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 305:F390-5. 2013
    ..In conclusion, these data indicate that MS sensitizes the renal and systemic sympathetic system ultimately impairing blood pressure regulation...
  20. pmc Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure
    Kelly A Hyndman
    Section of Experimental Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA
    Hypertension 62:91-8. 2013
    ..These findings reveal that NOS1 in the CD is critical in the regulation of fluid-electrolyte balance, and this new genetic model of CD NOS1 gene deletion will be a valuable tool to study salt-dependent blood pressure mechanisms...
  21. ncbi Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats
    Hui Huang
    Dept of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 289:F1116-22. 2005
    ..These results demonstrate that the interaction between renal 20-HETE and NO is important in the regulation of renal function and blood pressure in pregnant rats...
  22. ncbi Mechanisms for renal blood flow control early in diabetes as revealed by chronic flow measurement and transfer function analysis
    Tracy D Bell
    Department of Physiology, Medical College of Georgia, Augusta State University, Augusta, GA 30912 3000, USA
    J Am Soc Nephrol 17:2184-92. 2006
    ..Together with previous reports of decreases in chronically measured cardiac output and hindquarter blood flow, this suggests that there may be differential effects of diabetes on RBF versus nonrenal BF control...
  23. ncbi Hypertensive response to acute stress is attenuated in interleukin-6 knockout mice
    Dexter L Lee
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 44:259-63. 2004
    ....
  24. pmc Role of glomerular filtration rate in controlling blood pressure early in diabetes
    Michael W Brands
    Department of Physiology, CA 3098, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 52:188-94. 2008
  25. ncbi Control of arterial pressure by angiotensin II and nitric oxide at the onset of diabetes
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Hypertens 16:600-3. 2003
    ....
  26. ncbi Blood pressure control early in diabetes: a balance between angiotensin II and nitric oxide
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Clin Exp Pharmacol Physiol 29:127-31. 2002
    ..A critical balance exists between these forces and NO plays a pivotal role by attenuating AngII- mediated renal vasoconstriction and facilitating the increase in glomerular filtration rate...
  27. ncbi Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet
    Yiqiang Zhou
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Hypertens 18:530-7. 2005
    ..The purpose of this study was to determine renal CYP-derived eicosanoid synthesis and its association with BP regulation in HF male and female rats...
  28. ncbi Hypertension in L-NAME-treated diabetic rats depends on an intact sympathetic nervous system
    Sharyn M Fitzgerald
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1070-6. 2002
    ..These results suggest that the sympathetic nervous system may be involved in the hypertensive response to onset of diabetes in L-NAME-treated rats, possibly through control of renin secretion...
  29. ncbi Decreased RhoA expression in myocardium of diabetic rats
    Jiping Tang
    Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Can J Physiol Pharmacol 83:775-83. 2005
    ..01 vs. control group), indicating that the activation of RhoA is markedly reduced in diabetic myocardium. Our data suggest that down-regulated RhoA may be involved in cardiomyopathy in diabetic rats...
  30. doi Active learning strategies to teach renal-cardiovascular integration with high student-to-teacher ratios
    Michael W Brands
    Department of Physiology, School of Medicine, Technological Nursing, School of Nursing, Medical College of Georgia, Augusta, Georgia 30912 3000, USA
    Adv Physiol Educ 33:282-5. 2009
    ..An integrated active learning approach can enhance student interest in integrating cardiovascular-renal physiology, particularly if faculty members are willing to revise the approach in response to student feedback...