Ralf P Brandes

Summary

Publications

  1. ncbi Role of NADPH oxidases in the control of vascular gene expression
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Antioxid Redox Signal 5:803-11. 2003
  2. pmc Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice
    Marc Revermann
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 30:909-14. 2010
  3. doi Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt, Germany
    Circ Res 110:1217-25. 2012
  4. doi Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta
    Adrian Sturza
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt, Germany
    Hypertension 62:140-6. 2013
  5. ncbi NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J W Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Stroke 38:3000-6. 2007
  6. pmc Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease
    Oliver Jung
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Frankfurt am Main, Germany
    PLoS ONE 5:e11979. 2010
  7. doi Role of Nox4 in murine models of kidney disease
    Andrea Babelova
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat Frankfurt am Main, Germany
    Free Radic Biol Med 53:842-53. 2012
  8. doi Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progenitor cells by activating Nox2
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt am Main, Germany
    Antioxid Redox Signal 15:915-23. 2011
  9. doi Nox4 acts as a switch between differentiation and proliferation in preadipocytes
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 29:239-45. 2009
  10. ncbi Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    Sabine Heumüller
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 51:211-7. 2008

Detail Information

Publications74

  1. ncbi Role of NADPH oxidases in the control of vascular gene expression
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Antioxid Redox Signal 5:803-11. 2003
    ..Thus, the vascular NADPH oxidases play an important role in mediating the signal transduction cascade of pro-arteriosclerotic stimuli...
  2. pmc Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice
    Marc Revermann
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 30:909-14. 2010
    ..The soluble epoxide hydrolase (sEH) metabolizes EETs to their less active diols. We hypothesized that knockout and inhibition of sEH prevents neointima formation in hyperlipidemic ApoE(-/-) mice...
  3. doi Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt, Germany
    Circ Res 110:1217-25. 2012
    ..The function of Nox4, a source of vascular H(2)O(2), is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction...
  4. doi Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta
    Adrian Sturza
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt, Germany
    Hypertension 62:140-6. 2013
    ..Thus, MAO-A and MAO-B are both expressed in the mouse aorta, induced by in vivo lipopolysaccharide and angiotensin II treatment and contribute via the generation of H(2)O(2) to endothelial dysfunction in vascular disease models...
  5. ncbi NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J W Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Stroke 38:3000-6. 2007
    ..We hypothesized that NADPH oxidases mediate blood-brain barrier (BBB) disruption and contribute to tissue damage in ischemia/reperfusion...
  6. pmc Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease
    Oliver Jung
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Frankfurt am Main, Germany
    PLoS ONE 5:e11979. 2010
    ..Thus, sEH-inhibition failed to elicit protective effects in the 5/6-Nx model and showed a tendency to aggravate the disease. These effects might be consequence of a shift of arachidonic acid metabolism into the lipoxygenase pathway...
  7. doi Role of Nox4 in murine models of kidney disease
    Andrea Babelova
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat Frankfurt am Main, Germany
    Free Radic Biol Med 53:842-53. 2012
    ..Collectively, the first in vivo data of the kidney do not support the view that Nox4 is a main driver of renal disease. It rather appears that under specific conditions Nox4 may even slightly limit injury and disease progression...
  8. doi Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progenitor cells by activating Nox2
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt am Main, Germany
    Antioxid Redox Signal 15:915-23. 2011
    ..Ex vivo, SP600125 blocked HGF-induced migration and tube formation. We conclude that HGF-induced mobilization of EPCs and the proangiogenic effects of the growth factor require a Nox2-dependent ROS-mediated activation of Jak2 and Jnk...
  9. doi Nox4 acts as a switch between differentiation and proliferation in preadipocytes
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 29:239-45. 2009
    ..We determined in human and mouse preadipocytes whether Nox proteins contribute to ROS formation and differentiation in response to insulin...
  10. ncbi Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    Sabine Heumüller
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 51:211-7. 2008
    ..These observations indicate that apocynin predominantly acts as an antioxidant in endothelial cells and vascular smooth muscle cells and should not be used as an NADPH oxidase inhibitor in vascular systems...
  11. ncbi Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice
    Oliver Jung
    Institut für Kardiovaskuläre Physiologie, Funktionsbereich Nephrologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 93:622-9. 2003
    ..controlling blood pressure and vascular function in angiotensin II-dependent models of hypertension. ecSOD is expressed in such an abundance that even in situations of high oxidative stress no relative lack of enzyme activity occurs...
  12. ncbi Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Free Radic Biol Med 41:1353-60. 2006
    ..Therefore, tungsten, potentially via the inhibition of XO, prevents the development of endothelial dysfunction and atherosclerosis in ApoE(-/-) mice on WD...
  13. doi Identification of structural elements in Nox1 and Nox4 controlling localization and activity
    Ina Helmcke
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt am Main, Germany
    Antioxid Redox Signal 11:1279-87. 2009
    ..Thus, the very N-terminal part of Nox proteins determines subcellular localization and the ROS type released, whereas the cytosolic tail regulates activity...
  14. doi L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects
    Anja Mieth
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Hypertension 62:1098-104. 2013
    ..7 cells independent of the intracellular calcium concentration. Thus, diltiazem limits aortic aneurysm formation in mice by a blood pressure-independent anti-inflammatory effect on monocytic cells. ..
  15. ncbi Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension
    Oliver Jung
    Institut für Kardiovaskuläre Physiologie and ZAFES, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Hypertension 45:759-65. 2005
    ..Direct vasodilatation of resistance arteries in skeletal muscles does not appear to contribute to the antihypertensive effects of sEH inhibition in mice...
  16. pmc The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4
    Ina Takac
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, 60596 Frankfurt am Main, Germany
    J Biol Chem 286:13304-13. 2011
    ..Thus, H(2)O(2) formation is an intrinsic property of Nox4 that involves its E-loop. The structure of the E-loop may hinder O(2)(·-) egress and/or provide a source for protons, allowing dismutation to form H(2)O(2)...
  17. ncbi Noxa1 is a central component of the smooth muscle NADPH oxidase in mice
    Rashmi K Ambasta
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Free Radic Biol Med 41:193-201. 2006
    ..In conclusion, these data indicate that Noxa1 replaces p67phox in VSMC and plays a central role in the activation of the NADPH oxidase in the vascular wall...
  18. ncbi Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension
    Oliver Jung
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 27:470-7. 2007
    ..We studied the function of ecSOD in high-volume hypertension induced by the 1-kidney-1-clip model in wild-type, ecSOD-/- mice, and endothelial nitric oxide synthase (eNOS)-/- mice...
  19. doi NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Circ Res 105:537-44. 2009
    ..The role of hypoxia and reactive oxygen species (ROS) in mobilization and function of these cells is incompletely understood...
  20. ncbi Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species
    Alexandra Keller
    Institut für Kardiovaskuläre Physiologie, Klinikum der JW Goethe Universität, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Free Radic Res 38:1257-67. 2004
    ..These observations indicate that H2-DCF is an indicator for intracellular ROS, whereas the oxidation of H2-calcein most likely occurs as a consequence of direct electron transfer to mitochondrial complex I...
  21. pmc Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Frankfurt am Main, Germany
    Antioxid Redox Signal 18:1400-17. 2013
    ..We will illustrate that the current data provide evidence for Nox2 as the most important NADPH oxidase mediating cerebral injury...
  22. doi Leptin potentiates endothelium-dependent relaxation by inducing endothelial expression of neuronal NO synthase
    Sebastian Benkhoff
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 32:1605-12. 2012
    ..Obesity is associated with hyperleptinemia but it is not clear whether leptin protects vascular function or promotes dysfunction. We therefore studied the consequences of hyperleptinemia in lean mice...
  23. ncbi Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cardiovasc Res 65:897-906. 2005
    ..We assessed whether the uncoupling of eNOS was associated with alterations in eNOS phosphorylation and/or the assembly of the eNOS signaling complex...
  24. ncbi Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells
    Katrin Schröder
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 27:1736-43. 2007
    ..Basic fibroblast growth factor (bFGF) stimulates vascular smooth muscle cell (SMC) migration. We determined whether bFGF increases SMC reactive oxygen-species (ROS) and studied the role of ROS for SMC migration...
  25. ncbi Endothelial aging
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Cardiovasc Res 66:286-94. 2005
    ..Aging is also associated with a reduction in the regenerative capacity of the endothelium and endothelial senescence, which is characterized by an increased rate of endothelial cell apoptosis...
  26. doi NADPH oxidases as therapeutic targets in ischemic stroke
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Frankfurt, Germany
    Cell Mol Life Sci 69:2345-63. 2012
    ....
  27. doi The Nox family of NADPH oxidases: friend or foe of the vascular system?
    Ina Takac
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Curr Hypertens Rep 14:70-8. 2012
    ..This review focuses on the specific role of different NADPH oxidase isoforms in vascular physiology and their potential contributions to vascular diseases...
  28. ncbi Direct detection of reactive oxygen species ex vivo
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, J W Goethe Universitat, Frankfurt, Germany
    Kidney Int 67:1662-4. 2005
    ..Emphasis will be put on most recent technical innovations and the shortcomings associated with current techniques...
  29. doi The polarity protein Scrib is essential for directed endothelial cell migration
    U Ruth Michaelis
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Circ Res 112:924-34. 2013
    ..Polarity proteins are involved in the apico-basal orientation of epithelial cells, but relatively little is known regarding their function in mesenchymal cells...
  30. pmc Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats
    Marc Revermann
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Frankfurt am Main, Germany
    J Hypertens 27:322-31. 2009
    ..Because EETs have antiinflammatory properties, we determined whether or not inhibition of sEH attenuates disease development in the monocrotaline model of pulmonary hypertension in rats...
  31. ncbi Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells
    Karin Kohlstedt
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 94:60-7. 2004
    ..Thus, ACE is involved in outside-in signaling in endothelial cells and "ACE signaling" may be an important cellular mechanism contributing to the beneficial effects of ACE inhibitors...
  32. doi Differential vascular functions of Nox family NADPH oxidases
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Curr Opin Lipidol 19:513-8. 2008
    ..Recently, significant progress has been made in the understanding of differences among the Nox proteins...
  33. ncbi Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice
    Carmine Vecchione
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circ Res 91:173-9. 2002
    ..The underlying mechanism involves activation of a gp91phox-containing NADPH oxidase by Rac-1 and the subsequent scavenging of endothelium-derived NO by superoxide anions generated from this enzyme...
  34. doi NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury
    Wiebke Kallenborn-Gerhardt
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 32:10136-45. 2012
    ..Our results suggest that Nox4 essentially contributes to nociceptive processing in neuropathic pain states. Accordingly, inhibition of Nox4 may provide a novel therapeutic modality for the treatment of neuropathic pain...
  35. doi Composition and functions of vascular nicotinamide adenine dinucleotide phosphate oxidases
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, D 60596 Frankfurt am Main, Germany
    Trends Cardiovasc Med 18:15-9. 2008
    ..Consequently, selective pharmacologic inhibition of Nox proteins has a potential to interfere with cardiovascular disease initiation and progression...
  36. ncbi Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells
    Miriam Pleskova
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    FASEB J 20:139-41. 2006
    ..Obviously, there exists a fine-tuned crosstalk between NO and ROS generating systems in the course of inflammatory diseases...
  37. ncbi NADPH oxidases in cardiovascular disease
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe Universität, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Free Radic Biol Med 49:687-706. 2010
    ..Finally, the contribution of NADPH oxidases to the predominant cardiovascular diseases will be discussed...
  38. ncbi Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
    Rashmi K Ambasta
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, D 60596 Frankfurt am Main, Germany
    J Biol Chem 279:45935-41. 2004
    ....
  39. ncbi Vascular NADPH oxidases: molecular mechanisms of activation
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Universitat Frankfurt, Frankfurt, Germany
    Cardiovasc Res 65:16-27. 2005
    ..This article reviews the components of the NADPH oxidases in leukocytes and vascular tissue. Emphasis is put on the activation of the oxidases, including upstream signalling events and molecular modes of interaction between the subunits...
  40. pmc Nox family NADPH oxidases in mechano-transduction: mechanisms and consequences
    Ralf P Brandes
    1 Institut für Kardiovaskuläre Physiologie, Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    Antioxid Redox Signal 20:887-98. 2014
    ..Mechano-transduction links these events to appropriate reactions of the cells involving stimulation of signaling cascades, reorganization of the cytoskeleton and alteration of gene expression...
  41. pmc Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease
    Andrea Babelova
    Physiology I, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 8:e80328. 2013
    ..This suggests that Rac-1 and RhoA are mediators of podocyte dysfunction in CKD. Inhibition of Rho-GTPases may be a novel approach for the treatment of CKD. ..
  42. ncbi Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery
    Eckhart Büssemaker
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 42:562-8. 2003
    ....
  43. pmc Phenotypic Characterization of miR-92a-/- Mice Reveals an Important Function of miR-92a in Skeletal Development
    Daniela Penzkofer
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, J W Goethe University Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 9:e101153. 2014
    ..Bone density was not affected. These findings demonstrate that deletion of miR-92a is sufficient to induce a developmental skeletal defect. ..
  44. doi Anti-atherosclerotic mechanisms of statin therapy
    Andrea Babelova
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt, Germany
    Curr Opin Pharmacol 13:260-4. 2013
    ..These are in part consequence of lipid lowering but also result from pleiotropic actions of the drugs. In this article, the anti-atherosclerotic actions of statins will be reviewed. ..
  45. ncbi The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression
    Ralf P Brandes
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Free Radic Biol Med 32:1116-22. 2002
    ..We conclude that p47phox is important for vascular ROS production and redox-modulated signaling and gene expression in VSMC...
  46. ncbi NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cells
    Olaf Herkert
    Institut für Kardiovaskuläre Physiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Circulation 105:2030-6. 2002
    ..Because ROS exert signaling functions, we investigated whether the NADPH oxidase, an important source of ROS in VSMCs, contributes to upregulation of TF by thrombin...
  47. ncbi Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid
    Rüdiger Popp
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W G Universität, Frankfurt am Main, Germany
    Circ Res 90:800-6. 2002
    ....
  48. ncbi Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling
    Rania Harfouche
    Critical Care and Respiratory Divisions, Royal Victoria Hospital and Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    FASEB J 19:1728-30. 2005
    ....
  49. ncbi Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells
    Mariano Janiszewski
    Vascular Biology Laboratory, Heart Institute Instituto do Coração, School of Medicine, University of Sao Paulo, Av Eneas Carvalho Aguiar, 44 subsolo, Sao Paulo, CEP 05403 000 Brazil
    J Biol Chem 280:40813-9. 2005
    ..These results suggest that PDI closely associates with NAD(P)H oxidase and acts as a novel redox-sensitive regulatory protein of such enzyme complex, potentially affecting subunit traffic/assembling...
  50. pmc Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis
    Manuela Schaper
    Institute for Infectious Diseases, University of Berne, 3010 Berne, Switzerland
    Infect Immun 71:4087-92. 2003
    ..Therefore, these results indicate that ROS generated by a gp91-independent NADPH oxidase(s) are important for establishing an adequate inflammatory response to pneumococcal CSF infection...
  51. doi CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization
    Aurelie S Leroyer
    Institut National de la Sante et de la Recherche Medicale, Cardiovascular Research Center INSERM Lariboisière, Paris
    J Am Coll Cardiol 52:1302-11. 2008
    ..Our goal was to demonstrate that microparticles (MPs) are the endogenous signal leading to neovessel formation through CD40 ligation in human atherosclerotic plaques...
  52. doi First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction
    Philip Wenzel
    2nd Medical Clinic, Department of Cardiology, Johannes Gutenberg University, Mainz, Germany
    Antioxid Redox Signal 10:1435-47. 2008
    ..This suggests a crosstalk between mitochondrial and Nox-derived ROS with distinct mechanistic effects and sites for pharmacological intervention...
  53. ncbi Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties
    Elisabeth Teissier
    UR 545 INSERM Institut Pasteur de Lille and Faculté de Pharmacie, Universite de Lille II, Lille, France
    Circ Res 95:1174-82. 2004
    ..These data identify a novel mechanism of autogeneration of endogenous PPAR-alpha ligands via stimulation of NADPH oxidase activity...
  54. ncbi Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases
    Rudolf Locher
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Hypertension 39:645-50. 2002
    ....
  55. ncbi And what about the endothelium? On the predominance of cerebral superoxide formation for angiotensin II-induced systemic hypertension
    Ralf P Brandes
    Circ Res 95:122-4. 2004
  56. ncbi Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress
    Elisabeth Dernbach
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Blood 104:3591-7. 2004
    ..Taken together, EPCs reveal a higher expression of antioxidative enzymes and, thus, are exquisitely equipped to be protected against oxidative stress consistent with their progenitor cell character...
  57. ncbi Out of balance: a role of impaired superoxide dismutase activity for vascular constrictive remodeling after angioplasty
    Ralf P Brandes
    Arterioscler Thromb Vasc Biol 23:2121-2. 2003
  58. ncbi Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells
    Christiane Viedt
    Innere Medizin III, Universitat Heidelberg, Bergheimer Strasse 58, 69115 Heidelberg, Germany
    J Mol Med (Berl) 82:31-8. 2004
    ..This highlights the crucial role of the p22phox-containing NAD(P)H oxidase in the ANG II and PDGF AA induced signal transduction pathway...
  59. ncbi A radical adventure: the quest for specific functions and inhibitors of vascular NAPDH oxidases
    Ralf P Brandes
    Circ Res 92:583-5. 2003
  60. ncbi AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase
    Ralf Dechend
    HELIOS Klinikum Berlin, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    Circulation 107:1632-9. 2003
    ..To elucidate their role further, we studied the effects of AT1-AA on reactive oxygen species (ROS), NADPH oxidase expression, and nuclear factor-kappaB (NF-kappaB) activation...
  61. ncbi Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor
    Karim Sabrane
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, D 48149 Munster, Germany
    J Biol Chem 278:17963-8. 2003
    ..Increased vasodilating responsiveness to endothelial NO contributes to compensate for the missing vasodilating effect of ANP in SMC GC-A KO mice...
  62. ncbi Triggering mitochondrial radical release: a new function for NADPH oxidases
    Ralf P Brandes
    Hypertension 45:847-8. 2005
  63. ncbi Statin-mediated inhibition of Rho: only to get more NO?
    Ralf P Brandes
    Circ Res 96:927-9. 2005
  64. ncbi p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling
    Yves Castier
    INSERM Centre de Recherche Cardiovasculaire Lariboisiere, Paris, France
    Circ Res 97:533-40. 2005
    ..Generated ROS interact with NO to produce peroxynitrite, which in turn activates MMPs, facilitating vessel remodeling. Our study provides the first evidence that ROS play a fundamental role in flow-induced vascular enlargement...
  65. ncbi Regulation of proliferation of skeletal muscle precursor cells by NADPH oxidase
    Mahroo Mofarrahi
    Critical Care Division, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Antioxid Redox Signal 10:559-74. 2008
    ..We conclude that NADPH oxidase is expressed in skeletal muscle precursor cells and that its activity plays an important role in promoting proliferation of these cells...
  66. ncbi Avoiding vicious circles: mineralocorticoid receptor antagonism prevents vascular oxidative stress early after myocardial infarction
    Ralf P Brandes
    Hypertension 50:842-3. 2007
  67. ncbi Evidence against a role for NADPH oxidase modulating hepatic vascular tone in cirrhosis
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Ciberehd and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain
    Gastroenterology 133:959-66. 2007
    ..Thus, our aims were to study the molecular and biochemical state of NADPH-oxidase in cirrhotic livers and to investigate its possible role in modulating hepatic vascular tone in cirrhosis...
  68. ncbi Roads to dysfunction: argininase II contributes to oxidized low-density lipoprotein-induced attenuation of endothelial NO production
    Ralf P Brandes
    Circ Res 99:918-20. 2006
  69. pmc Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy
    Ken ichiro Sasaki
    Department of Internal Medicine III, J W Goethe University, 60590 Frankfurt, Germany
    Proc Natl Acad Sci U S A 103:14537-41. 2006
    ..Here, we show that pharmacological enhancement of eNOS expression with AVE at least partially reverses the impaired functional activity of BMC from ICMP patients, highlighting the critical role of NO for progenitor cell function...
  70. ncbi Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats
    Matthias Oelze
    Johannes Gutenberg University Hospital, Division of Cardiology, Mainz, Germany
    Hypertension 48:677-84. 2006
    ..Thus, inhibitory effects of this beta-blocker on vascular NADPH oxidase may explain, at least in part, its beneficial effect on endothelial function in angiotensin II-induced hypertension...
  71. ncbi Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation
    Karsten Grote
    Department of Cardiology and Angiology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Cardiovasc Res 71:596-605. 2006
    ..Here, we investigated the role of p47phox in blood pressure control, endothelium-dependent relaxation, cardiac hypertrophy, RAS activation, and renal oxidative stress under resting conditions...
  72. pmc Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia
    Fleur Fresquet
    Universite Victor Segalen Bordeaux 2, INSERM E356, 146 rue Leo Saignat, F 33076 Bordeaux, Cedex, France
    Br J Pharmacol 148:714-23. 2006
    ..In intrapulmonary arteries, endothelial dysfunction depends on gp91phox, the latter being rather the trigger than the mediator of impaired endothelial NO-dependent relaxation..
  73. ncbi Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX
    Stefan Frantz
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 101:127-32. 2006
    ..Since NADPH oxidases are a major source of reactive oxygen species in the heart, we studied left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91(phox)...
  74. ncbi Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes
    Cornel Badorff
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circulation 107:1024-32. 2003
    ..Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial progenitor cells (EPCs) is unknown...