H L Bradlow

Summary

Publications

  1. ncbi request reprint Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol
    D W Sepkovic
    Institute for Biomedical Research, Hackensack University Medical Center, Hackensack, NJ 07601, USA
    Nutr Cancer 41:57-63. 2001
  2. ncbi request reprint Steroids as procarcinogenic agents
    H Leon Bradlow
    The David and Alice Jurist Institute for Biomedical Research, HUMC, 30 Prospect Ave, Hackensack, NJ 07601, USA
    Ann N Y Acad Sci 1028:216-32. 2004
  3. ncbi request reprint Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments
    H L Bradlow
    David and Alice Jurist Institute for Medical Research, HUMC Hackensack, NJ 07601, USA
    In Vivo 24:387-91. 2010
  4. ncbi request reprint Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer
    H Leon Bradlow
    David and Alice Jurist Institute for Medical Research, Hackensack University Medical Center Hackensack, NJ 07601, USA
    In Vivo 22:441-5. 2008
  5. ncbi request reprint The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer
    Marilie D Gammon
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Breast Cancer Res Treat 74:235-54. 2002
  6. ncbi request reprint Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre- versus post-treatment collection
    Jay H Fowke
    Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Steroids 68:65-72. 2003
  7. ncbi request reprint Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer
    Kathie M Dalessandri
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    Nutr Cancer 50:161-7. 2004
  8. ncbi request reprint Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood
    Marilie D Gammon
    Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 11:686-97. 2002
  9. ncbi request reprint Urinary estrogen metabolites and their ratio among Asian American women
    Roni T Falk
    Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7234, Suite 7070, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:221-6. 2005
  10. ncbi request reprint Estrogen metabolism and breast cancer
    Geoffrey C Kabat
    Department of Preventive Medicine, School of Medicine, Stony Brook University, New York, USA
    Epidemiology 17:80-8. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol
    D W Sepkovic
    Institute for Biomedical Research, Hackensack University Medical Center, Hackensack, NJ 07601, USA
    Nutr Cancer 41:57-63. 2001
    ..The assay provides an objective marker of consumption using a noninvasive biological fluid and illustrates that diindolylmethane may be used as a marker of compliance in I3C dietary intervention studies...
  2. ncbi request reprint Steroids as procarcinogenic agents
    H Leon Bradlow
    The David and Alice Jurist Institute for Biomedical Research, HUMC, 30 Prospect Ave, Hackensack, NJ 07601, USA
    Ann N Y Acad Sci 1028:216-32. 2004
    ..Of the various hormones produced in the body, only aldosterone does not cause any cancers, although excess aldosterone can cause Conn's syndrome, which may be detected by the resultant hypertension...
  3. ncbi request reprint Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments
    H L Bradlow
    David and Alice Jurist Institute for Medical Research, HUMC Hackensack, NJ 07601, USA
    In Vivo 24:387-91. 2010
    ..This suggests that DIM is the predominant active agent and that I3C is a precursor, 'pro-drug' in vivo. However, in cell culture studies carried out in neutral solutions, I3C has been considered fully active...
  4. ncbi request reprint Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer
    H Leon Bradlow
    David and Alice Jurist Institute for Medical Research, Hackensack University Medical Center Hackensack, NJ 07601, USA
    In Vivo 22:441-5. 2008
    ..Because DIM provides a predictable, safer response than the mélange of compounds derived from I3C DIM should be regarded as the chemoprotective compound of choice...
  5. ncbi request reprint The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer
    Marilie D Gammon
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Breast Cancer Res Treat 74:235-54. 2002
    ....
  6. ncbi request reprint Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre- versus post-treatment collection
    Jay H Fowke
    Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Steroids 68:65-72. 2003
    ..We investigated the association between the relative concentrations of these metabolites in urine (2-OHE/16-OHE) and breast cancer in a case-control study of Chinese women living in Shanghai...
  7. ncbi request reprint Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer
    Kathie M Dalessandri
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3200, USA
    Nutr Cancer 50:161-7. 2004
    ..020), DIM (P =0. 045), and cortisol (P = 0.039), and a nonsignificant increase of 47% in the 2-OHE1/16alpha-OHE1 ratio from 1.46 to 2.14 (P=0.059). In this pilot study, DIM increased the 2-hydroxylation of estrogen urinary metabolites...
  8. ncbi request reprint Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood
    Marilie D Gammon
    Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 11:686-97. 2002
    ..These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women...
  9. ncbi request reprint Urinary estrogen metabolites and their ratio among Asian American women
    Roni T Falk
    Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7234, Suite 7070, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:221-6. 2005
    ..Our study suggests that the ratio of 2-OHE(1):16alpha-OHE(1) may be a marker for lifestyle influences on estrogen metabolism associated with westernization...
  10. ncbi request reprint Estrogen metabolism and breast cancer
    Geoffrey C Kabat
    Department of Preventive Medicine, School of Medicine, Stony Brook University, New York, USA
    Epidemiology 17:80-8. 2006
    ....
  11. ncbi request reprint Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
    Heather Greenlee
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
    Breast Cancer Res Treat 102:111-7. 2007
    ....
  12. ncbi request reprint Diet and breast cancer
    H Leon Bradlow
    David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA
    Ann N Y Acad Sci 963:247-67. 2002
    ..These effects are not merely theoretical actions in cell culture and tissue explants; they have been demonstrated in human patients as a range of studies have demonstrated...