P Bradding

Summary

Publications

  1. pmc Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, and Glenfield Hospital, Leicester, UK
    Eur J Immunol 37:1653-62. 2007
  2. pmc Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
    S Mark Duffy
    The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Eur J Immunol 38:2548-56. 2008
  3. pmc The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells
    Ian Ashmole
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, Leicestershire, United Kingdom
    PLoS ONE 8:e74895. 2013
  4. pmc The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis
    Katy Morgan Roach
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    PLoS ONE 8:e85244. 2013
  5. pmc Functional KCa3.1 K+ channels are required for human fibrocyte migration
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 128:1303-1309.e2. 2011
  6. pmc CRACM/Orai ion channel expression and function in human lung mast cells
    Ian Ashmole
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 129:1628-35.e2. 2012
  7. pmc IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
    Glenn Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester and Warwick Medical School, University of Leicester, University Road, Leicester, LE1 9HN, UK
    BMC Immunol 9:2. 2008
  8. pmc Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer
    Chandra M Ohri
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    BMC Cancer 10:172. 2010
  9. pmc Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer
    Chandra M Ohri
    Institute for Lung Health, Glenfield Hospital, Leicester, UK
    BMC Cancer 10:323. 2010
  10. pmc The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy
    Peter Bradding
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Br J Pharmacol 157:1330-9. 2009

Collaborators

Detail Information

Publications68

  1. pmc Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, and Glenfield Hospital, Leicester, UK
    Eur J Immunol 37:1653-62. 2007
    ..1, providing a clearly defined mechanism by which adenosine inhibits HLMC migration and degranulation. A2A receptor agonists with channel-modulating function may be useful for the treatment of mast cell-mediated disease...
  2. pmc Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
    S Mark Duffy
    The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Eur J Immunol 38:2548-56. 2008
    ..1 in HLMC and attenuates both chemokine- and PGE(2)-dependent HLMC migration. EP(2) receptor agonists with K(Ca)3.1 modulating function may be useful for the treatment of mast cell-mediated disease...
  3. pmc The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells
    Ian Ashmole
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, Leicestershire, United Kingdom
    PLoS ONE 8:e74895. 2013
    ..However the individual role of each of the three members of the Orai channel family in Ca(2+) influx and mediator release has not been defined in human mast cells...
  4. pmc The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis
    Katy Morgan Roach
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    PLoS ONE 8:e85244. 2013
    ..Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy. We hypothesised that K(Ca)3.1 K(+) channel-dependent cell processes contribute to IPF pathophysiology...
  5. pmc Functional KCa3.1 K+ channels are required for human fibrocyte migration
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 128:1303-1309.e2. 2011
    ..Targeting fibrocyte migration might therefore offer a new approach for the treatment of these diseases. Ion channels play key roles in cell function, but the ion-channel repertoire of human fibrocytes is unknown...
  6. pmc CRACM/Orai ion channel expression and function in human lung mast cells
    Ian Ashmole
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 129:1628-35.e2. 2012
    ..However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The recently discovered members of the CRACM/Orai ion channel family that carries the Ca(2+) release-activated Ca(2+) current are candidates...
  7. pmc IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
    Glenn Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester and Warwick Medical School, University of Leicester, University Road, Leicester, LE1 9HN, UK
    BMC Immunol 9:2. 2008
    ..In this study we have examined whether IgE alone enhances human lung mast cell (HLMC) survival...
  8. pmc Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer
    Chandra M Ohri
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    BMC Cancer 10:172. 2010
    ..This study investigated chemokine receptor expression in the tumour islets and stroma in NSCLC...
  9. pmc Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer
    Chandra M Ohri
    Institute for Lung Health, Glenfield Hospital, Leicester, UK
    BMC Cancer 10:323. 2010
    ..The role of TNFalpha in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function...
  10. pmc The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy
    Peter Bradding
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Br J Pharmacol 157:1330-9. 2009
    ..3 and K(Ca)3.1 in the treatment of asthma...
  11. doi request reprint Subclinical phenotypes of asthma
    Peter Bradding
    Institute for Lung Health and Department of Respiratory Medicine, Glenfield Hospital, UK
    Curr Opin Allergy Clin Immunol 10:54-9. 2010
    ..An accurate and comprehensive clinicopathological classification system therefore remains an important priority for asthma research. The present review discusses the important recent literature in this field...
  12. pmc Asthma: eosinophil disease, mast cell disease, or both?
    Peter Bradding
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Allergy Asthma Clin Immunol 4:84-90. 2008
    ..Targeting this mast cell-airway smooth muscle interaction in asthma offers exciting prospects for the treatment of this common disease...
  13. ncbi request reprint Mast cell ion channels
    Peter Bradding
    Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Glenfield Hospital, Leicester, UK
    Chem Immunol Allergy 87:163-78. 2005
    ..With current techniques it will be possible to identify the molecular origin of these channels and define precisely their role in mast cell function. Mast cell ion channels offer a novel target for the attenuation of allergic disease...
  14. ncbi request reprint The role of the mast cell in the pathophysiology of asthma
    Peter Bradding
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Allergy Clin Immunol 117:1277-84. 2006
    ..The development of potent and specific inhibitors of mast cell secretion, which remain active when administered long-term to asthmatic airways, should offer a novel approach to the treatment of asthma...
  15. ncbi request reprint Ion channel gene expression in human lung, skin, and cord blood-derived mast cells
    Peter Bradding
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester Medical School, United Kingdom
    J Leukoc Biol 73:614-20. 2003
    ....
  16. ncbi request reprint The role of the mast cell in asthma: a reassessment
    Peter Bradding
    Institute for Lung Health, University of Leicester Medical School, UK
    Curr Opin Allergy Clin Immunol 3:45-50. 2003
    ..This review will discuss current advances in this field...
  17. pmc Induced sputum and bronchial mucosal expression of interleukin-13 is not increased in chronic obstructive pulmonary disease
    S Saha
    Institute of Lung Health, Leicester, UK
    Allergy 63:1239-43. 2008
    ..We sought to examine IL-13 expression in COPD subjects in induced sputum and bronchus specimens. We hypothesized that inflammatory cells expressing IL-13 localize to the airway smooth muscle bundle and bronchial glands...
  18. pmc Airway smooth muscle chemokine receptor expression and function in asthma
    R Saunders
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 39:1684-92. 2009
    ..The expression profile of other chemokine receptors by ASM and their function needs to be further explored...
  19. pmc Airway smooth muscle proliferation and survival is not modulated by mast cells
    D Kaur
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:279-88. 2010
    ..The cause of this increased ASM mass is uncertain and whether it is a consequence of ASM-mast cell interactions is unknown...
  20. ncbi request reprint Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma
    C E Brightling
    Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 33:1711-6. 2003
    ..In asthma, Th2 cytokines have been implicated as playing a critical role in the development of airway inflammation and hyper-responsiveness. Whether inflammatory cells within the airway smooth muscle release these cytokines is unknown...
  21. ncbi request reprint Sputum eosinophilia in idiopathic pulmonary fibrosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom
    Inflamm Res 54:51-6. 2005
    ..We tested the hypothesis that the cough and increased cough reflex sensitivity seen in patients with idiopathic pulmonary fibrosis may be due to airway inflammation in a prospective, cross-sectional study...
  22. ncbi request reprint Resting and activation-dependent ion channels in human mast cells
    S M Duffy
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Immunol 167:4261-70. 2001
    ..Charybdotoxin did not consistently attenuate histamine or leukotriene C(4) release, indicating that the Ca(2+)-activated K(+) current may enhance, but is not essential for, the release of these mediators...
  23. ncbi request reprint Voltage-dependent and calcium-activated ion channels in the human mast cell line HMC-1
    S M Duffy
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Leukoc Biol 70:233-40. 2001
    ..We suggest that this current may contribute to the malignant phenotype while the Ca(2+)-activated K(+) and Cl(-) currents may be involved in cell activation...
  24. pmc Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics
    A Sutcliffe
    Institute for Lung Health, Department of Infection, University of Leicester, Leicester, UK
    Thorax 61:657-62. 2006
    ..Mast cell microlocalisation within the airway smooth muscle (ASM) bundle is an important determinant of the asthmatic phenotype. We hypothesised that mast cells migrate towards ASM in response to ASM derived chemokines...
  25. ncbi request reprint Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma
    C E Brightling
    Glenfield Hospital, Leicester, United Kingdom and Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 162:878-82. 2000
    ..64 ng/ml [0.36 to 0.90] and 11-fold [3.3 to 36]), respectively. In conclusion, eosinophilic bronchitis is associated with active airway inflammation with increased release of vasoactive and bronchoconstrictor mediators...
  26. ncbi request reprint Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression
    D Kaur
    Department of Infection, Institute for Lung Health, Inflammation and Immunity, University of Leicester, Leicester, UK
    Allergy 61:1047-53. 2006
    ..The IL-13 receptor, IL-13Ralpha1, is expressed on most leukocytes, except T-cells. Evidence to support IL-13Ralpha1 expression on mast cells is limited...
  27. ncbi request reprint Activation of human lung mast cells by monomeric immunoglobulin E
    G Cruse
    Institute for Lung Health, Dept of Infection, Immunity and Inflammation, University of Leicester, UK
    Eur Respir J 25:858-63. 2005
    ..These findings support the hypothesis that immunoglobulin E loading of mast cells within the asthmatic airway contributes to the disordered airway physiology of this disease...
  28. pmc Functional KCa3.1 K+ channels are required for human lung mast cell migration
    G Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Thorax 61:880-5. 2006
    ..A study was undertaken to test the hypothesis that blockade of K(Ca)3.1 would attenuate HLMC proliferation and migration...
  29. pmc The airway smooth muscle CCR3/CCL11 axis is inhibited by mast cells
    R Saunders
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Allergy 63:1148-55. 2008
    ..Mast cells are microlocalized to the airway smooth muscle bundle and whether mast cells influence CCR3-mediated migration is uncertain...
  30. pmc Comparison of airway immunopathology of eosinophilic bronchitis and asthma
    C E Brightling
    Institute for Lung Health, University of Leicester, Division of Respiratory Medicine, Leicester UK
    Thorax 58:528-32. 2003
    ....
  31. ncbi request reprint New insights into the role of the mast cell in asthma
    C E Brightling
    University of Leicester and Warwick Medical School, Leicester, UK
    Clin Exp Allergy 33:550-6. 2003
  32. ncbi request reprint Attenuation of human lung mast cell degranulation by bronchial epithelium
    W Yang
    Department of Infection, Immunity, and Inflammation, University of Leicester Medical School, Leicester, UK
    Allergy 61:569-75. 2006
    ..We investigated the consequences of this adhesive interaction on HLMC activation in response to Fc epsilon RI cross-linking...
  33. pmc Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1
    J Agbetile
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 42:782-91. 2012
    ..Fungal sensitization is common in severe asthma, but the clinical relevance of this and the relationship with airway colonization by fungi remain unclear. The range of fungi that may colonize the airways in asthma is unknown...
  34. pmc Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    C E Brightling
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    Thorax 60:193-8. 2005
    ..Whether the response to inhaled corticosteroids is related to the presence of eosinophilic inflammation is unclear...
  35. ncbi request reprint New insights into the relationship between airway inflammation and asthma
    A J Wardlaw
    Department of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School, Glenfield Hospital, Groby Road, Leicester LE3 9QP, U K
    Clin Sci (Lond) 103:201-11. 2002
    ....
  36. ncbi request reprint Human mast cell ion channels
    P Bradding
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester Medical School, Glenfield Hospital, Leicester, UK pbradding hotmail com
    Clin Exp Allergy 32:979-83. 2002
  37. pmc Chemokines and their receptors as potential targets for the treatment of asthma
    C Palmqvist
    Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Br J Pharmacol 151:725-36. 2007
    ..Specific blockade of the responses elicited by chemokines and chemokine receptors responsible for the pathological migration of airway cells could therefore be of great therapeutic interest for the treatment of asthma...
  38. ncbi request reprint The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma
    R J F Carter
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Clinical Sciences, Glenfield Hospital, UK
    Curr Pharm Des 17:685-98. 2011
    ..Novel targeting of mast cells and their mediators therefore should offer significant therapeutic potential in the treatment of asthma...
  39. ncbi request reprint Co-cultivation of mast cells and Fc epsilon RI alpha+ dendritic-like cells from human hip bone marrow
    D Kaur
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester and Warwick Medical School, University Hospitals of Leicester, Glenfield General Hospital, Leicester, UK
    Clin Exp Allergy 35:226-33. 2005
    ..Hip bone marrow could provide a more convenient less invasive source of mast cell progenitors...
  40. doi request reprint Ion channels regulating mast cell biology
    I Ashmole
    Department of Infection, Immunity and Inflammation, Institute for Lung Heath, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK
    Clin Exp Allergy 43:491-502. 2013
    ..In this review we provide an overview of our current knowledge of ion channel expression and function in mast cells with an emphasis on how channels interact to regulate Ca2+ signalling...
  41. ncbi request reprint Clinical significance of small airway obstruction markers in patients with asthma
    S Gonem
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 44:499-507. 2014
    ..The role of small airway obstruction in the clinical expression of asthma is incompletely understood...
  42. ncbi request reprint The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, UK
    J Allergy Clin Immunol 114:66-72. 2004
    ..This channel is predicted to enhance IgE-dependent mast cell responses...
  43. ncbi request reprint Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    ..We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle...
  44. pmc Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6
    Fay Hollins
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, United Kingdom
    J Immunol 181:2772-80. 2008
    ..Targeting these interactions in asthma might offer a new strategy for the treatment of this common disease...
  45. pmc Airway hyperresponsiveness is dissociated from airway wall structural remodeling
    Salman Siddiqui
    Institute of Lung Health, Leicester, United Kingdom
    J Allergy Clin Immunol 122:335-41, 341.e1-3. 2008
    ..However, it is not known whether other features of structural remodeling including increased airway smooth muscle (ASM) mass, matrix deposition, and glandular hyperplasia are also present in EB...
  46. ncbi request reprint Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation
    S Mark Duffy
    Division of Respiratory Medicine, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Allergy Clin Immunol 112:965-72. 2003
    ..A similar but distinct current has been implicated in the control of cell proliferation in astrocytes...
  47. ncbi request reprint Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival
    Rob C E Wykes
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Immunol 179:4045-52. 2007
    ..In summary, HLMC and human mast cell lines express the nonselective cation channel TRPM7 whose presence is essential for cell survival...
  48. ncbi request reprint Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma
    Davinder Kaur
    Institute for Lung Health, and Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 174:1179-88. 2006
    ..We hypothesized that this results from migration of ASM or progenitors in response to chemokines derived from ASM or mast cells within the ASM bundle...
  49. ncbi request reprint Mast cell infiltration of airway smooth muscle in asthma
    Peter Bradding
    Respir Med 101:1045; author reply 1046-7. 2007
  50. ncbi request reprint The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 171:1103-8. 2005
    ..These results suggest that inhibition of the CXCL10/CXCR3 axis offers a novel target for the treatment of asthma...
  51. ncbi request reprint Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    FASEB J 19:1006-8. 2005
    ..Furthermore, the degree of constitutive beta2-receptor "tone" may control the threshold for human mast cell activation through the regulation of iKCa1...
  52. pmc Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    Mike Berry
    Institute for Lung Health, Glenfield Hospital, Leicester LE3 9QP, UK
    Thorax 62:1043-9. 2007
    ..However, little is known about the underlying airway immunopathology and there are no data from placebo-controlled studies examining the effect of inhaled corticosteroids...
  53. pmc Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  54. ncbi request reprint The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis
    Christopher E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, University of Leicester and Warwick Medical School, University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP, UK
    Curr Allergy Asthma Rep 5:130-5. 2005
    ..This suggests that interactions between mast cells and airway smooth muscle cells are critical for the development of the disordered airway physiology in asthma...
  55. ncbi request reprint Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis
    Mike A Berry
    Institute for Lung Health, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    J Allergy Clin Immunol 114:1106-9. 2004
    ..In asthma, the T H 2-type cytokine IL-13 has been implicated in the development of airway inflammation and hyperresponsiveness. Whether the expression of IL-13 is different between these 2 conditions is unknown...
  56. ncbi request reprint Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1
    Weidong Yang
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Immunol 176:1238-43. 2006
    ..This supports the hypothesis that adhesion is important in the recruitment and retention of HLMC by the ASM in asthma, and for the functional interaction of these cells...
  57. ncbi request reprint Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, Leicester Warwick Medical School and University Hospitals of Leicester, Groby Road, Leicester, LE3 9QP, UK
    J Leukoc Biol 77:759-66. 2005
    ..As CXCR3 ligands are elevated in many pulmonary diseases, CXCR3 may be important for determining the anatomical microlocalization of mast cells within the human lung...
  58. ncbi request reprint Induced sputum inflammatory mediator concentrations in chronic cough
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 169:15-9. 2004
    ..Our findings support the view that there is release of inflammatory and tussive mediators in patients with chronic cough and suggest that there might be similarities in the mechanism of cough in a diverse range of conditions...
  59. ncbi request reprint C3a, mast cells, and asthma
    Peter Bradding
    FASEB J 19:1585. 2005
  60. ncbi request reprint Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer
    Tomas J Welsh
    Department of Infection, Immunity, and Inflammation, University of Leicester Medical School, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom
    J Clin Oncol 23:8959-67. 2005
    ..The role played by the innate immune system in determining survival from non-small-cell lung cancer (NSCLC) is unclear. The aim of this study was to investigate the prognostic significance of macrophage and mast-cell infiltration in NSCLC...
  61. ncbi request reprint Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
    ..The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma...
  62. ncbi request reprint The reclassification of asthma based on subphenotypes
    Ruth H Green
    Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester, UK
    Curr Opin Allergy Clin Immunol 7:43-50. 2007
    ..The present review discusses the important literature in this field, placing current work in its historical context...
  63. ncbi request reprint Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study
    Surinder S Birring
    Department of Respiratory Medicine, Radiology, and Respiratory Physiology, and Leicester Children s Asthma Centre, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 166:1078-83. 2002
    ..Further investigation of this group may disclose novel mechanisms of fixed airflow obstruction...
  64. ncbi request reprint TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 110:899-905. 2002
    ..Eosinophilic bronchitis has similar immunopathology to asthma but without disordered airway physiology. Whether eosinophilic bronchitis is associated with increased expression of T(H)2 cytokines is unknown...
  65. ncbi request reprint KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation
    Malcolm C Shepherd
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Am J Respir Cell Mol Biol 37:525-31. 2007
    ..1 channels in HASM cells. In addition, we have shown that K(Ca)3.1 channels are important in HASM cell proliferation, making these channels a potential therapeutic target in airway remodeling...
  66. ncbi request reprint Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 120:813-9. 2007
    ..Increased vascularity and expression of vascular endothelial growth factor (VEGF) are recognized features of the asthmatic airway. The association of vascular remodeling with airway hyperresponsiveness (AHR) is unclear...
  67. ncbi request reprint Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects
    Lucy Woodman
    Insitute for Lung Health, University of Leicester, Glenfield Hospital, UK
    Chest 130:371-8. 2006
    ..The mast cell chemotactic activity of airway secretions has not been assessed in patients with eosinophilic bronchitis...
  68. ncbi request reprint Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...