John H Boyd

Summary

Publications

  1. ncbi request reprint Toll-like receptors and opportunities for new sepsis therapeutics
    John H Boyd
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Curr Infect Dis Rep 14:455-61. 2012
  2. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
  3. doi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
  4. doi request reprint Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:1641-8. 2011
  5. doi request reprint VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock
    Taka aki Nakada
    Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
    J Innate Immun 7:545-53. 2015
  6. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012
  7. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
  8. pmc A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
  9. doi request reprint Normal-range blood lactate concentration in septic shock is prognostic and predictive
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Shock 38:4-10. 2012
  10. doi request reprint A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    Simone A Thair
    University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Immunol 186:2321-8. 2011

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Toll-like receptors and opportunities for new sepsis therapeutics
    John H Boyd
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Curr Infect Dis Rep 14:455-61. 2012
    ..Furthermore, accurately characterizing the stage of sepsis will be essential to directing appropriate therapeutic choices...
  2. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  3. doi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
    ..This study examines whether a prolonged QTc interval is associated with adverse outcomes in patients with preoperative LVEF greater than 40% undergoing cardiac surgery...
  4. doi request reprint Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:1641-8. 2011
    ..The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock...
  5. doi request reprint VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock
    Taka aki Nakada
    Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
    J Innate Immun 7:545-53. 2015
    ..Genetic variations contribute to septic shock mortality. To discover a novel locus, we performed in vitro genome-wide association studies (GWAS) and further tested the result in a cohort of septic shock patients...
  6. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012
    ..We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients...
  7. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
    ..Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock...
  8. pmc A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
    ..Investigators advocate that interventional trials in septic shock require effective outcome risk stratification. We derived and tested a multibiomarker-based approach to estimate mortality risk in adults with septic shock...
  9. doi request reprint Normal-range blood lactate concentration in septic shock is prognostic and predictive
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Shock 38:4-10. 2012
    ..05). Lactate concentrations within the "normal" range can be a useful prognostic indicator in septic shock. Furthermore, patients whose lactate level is less than or equal to 1.4 mmol/L may benefit from vasopressin infusion...
  10. doi request reprint A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    Simone A Thair
    University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Immunol 186:2321-8. 2011
    ..017). This suggests that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-κB pathway genes, including CXCL10...
  11. doi request reprint beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
    Taka aki Nakada
    Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Respir Crit Care Med 181:143-9. 2010
    ..Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown...
  12. pmc PCSK9 is a critical regulator of the innate immune response and septic shock outcome
    Keith R Walley
    Centre for Heart Lung Innovation, University of British Columbia, Vancouver V6Z 1Y6, Canada
    Sci Transl Med 6:258ra143. 2014
    ..Together, our results show that reduced PCSK9 function is associated with increased pathogen lipid clearance via the LDLR, a decreased inflammatory response, and improved septic shock outcome. ..
  13. pmc IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 15:R254. 2011
    ..Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis...
  14. doi request reprint Identification of a nonsynonymous polymorphism in the SVEP1 gene associated with altered clinical outcomes in septic shock
    Taka aki Nakada
    1Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada 2Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
    Crit Care Med 43:101-8. 2015
    ..We then test the hypothesis that these nonsynonymous single-nucleotide polymorphisms across the genome alter clinical outcome of septic shock...
  15. doi request reprint A common polymorphism in the 5' region of the human protein c gene binds USF1
    Katherine R Thain
    Critical Care Research Laboratories, Institute for Heart Lung Health at St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Thromb Res 130:451-7. 2012
    ..We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding...
  16. doi request reprint Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis
    John H Boyd
    Centre for Heart Lung Innovation, University of British Columbia, Vancouver, B C, Canada
    J Innate Immun 8:211-20. 2016
    ..Our objective was to determine the relationship between plasma PCSK9 levels and the rate of endotoxin clearance, and then correlate PCSK9 levels with the development of acute organ failures in a cohort of patients with sepsis...
  17. doi request reprint Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock
    Nattachai Anantasit
    1Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 2Division of Critical Care Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Crit Care Med 42:1812-20. 2014
    ..The objectives of this study were to determine frequency, risk factors (including candidate gene polymorphisms), and outcomes of serious adverse events in septic shock patients...
  18. ncbi request reprint Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2
    Sumeet Mathur
    Critical Care Research Laboratories, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Canada
    Circ J 75:2445-52. 2011
    ..Whether endogenous molecules produced by tissue injury (damage associated molecular patterns, DAMPs) can induce cardiomyocyte inflammation via TLR signalling pathways and/or reduce cardiomyocyte contractility is unknown...
  19. doi request reprint The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunction
    Sumeet Mathur
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Shock 36:478-83. 2011
    ..These may play a role in attenuation of cardiac inflammation. The TLR9 ligand CpG-C attenuates the acute inflammatory cardiac dysfunction induced by both LPS and ischemia-reperfusion of the left anterior descending artery...
  20. doi request reprint The Central Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Septic Pathogen Lipid Transport and Clearance
    Keith R Walley
    1 Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 192:1275-86. 2015
    ..Increased pathogen lipid clearance, which can be achieved by inhibiting proprotein convertase subtilisin/kexin type 9, may decrease the systemic inflammatory response to sepsis and improve clinical outcomes. ..
  21. pmc Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department
    Adam Linder
    1Department of Clinical Sciences, Division of Infection Medicine, Klinikgatan 1, Skane University Hospital, Lund University, Lund, Sweden 2Value Institute and Department of Emergency Medicine, Christiana Care Health System, Newark, DE 3Centre for Heart Lung Innovation, Division of Critical Care Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada 4Department of Infectious Diseases, Orebro University Hospital, Orebro, Sweden 5Department of Translational Medicine, Lund University, Lund, Sweden 6Department of Emergency Medicine, Linkoping University Hospital, Linkoping, Sweden 7Axis Shield Diagnostics, Dundee, GB, United Kingdom
    Crit Care Med 43:2378-86. 2015
    ..We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting...
  22. doi request reprint Long-term (10-year) mortality of younger previously healthy patients with severe sepsis/septic shock is worse than that of patients with nonseptic critical illness and of the general population
    Adam Linder
    1Centre for Heart Lung Innovation, Division of Critical Care Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada 2Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden 3Centre for Health Evaluation and Outcome Sciences, University of British Columbia, Vancouver, BC, Canada 4School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    Crit Care Med 42:2211-8. 2014
    ..We aimed to determine the 1- to 10-year mortality rates of previously healthy patients with severe sepsis and compare these to mortality rates of patients with nonseptic critical illness and the general population...
  23. doi request reprint Inflammation in myocardial diseases
    David J Marchant
    James Hogg Research Centre and Institute for Heart Lung Health, Department of Pathology and Laboratory Medicine, University of British Columbia, Providence Health Care, Vancouver, Canada
    Circ Res 110:126-44. 2012
    ....
  24. doi request reprint The meta-genome of sepsis: host genetics, pathogens and the acute immune response
    John H Boyd
    Division of Critical Care Medicine, St Paul s Hospital, Vancouver, B C, Canada
    J Innate Immun 6:272-83. 2014
    ..Finally, we discuss the host clinical and immune responses and present new data to suggest that the immune response is the key to understanding sepsis and improving a death rate of nearly 30%...
  25. pmc Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice
    Toonchai Indrambarya
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Crit Care 13:R98. 2009
    ..However, the direct effect of arginine vasopressin on the function of the ischemia/reperfusion injured heart has not been clearly elucidated...