John H Boyd

Summary

Publications

  1. ncbi request reprint Toll-like receptors and opportunities for new sepsis therapeutics
    John H Boyd
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Curr Infect Dis Rep 14:455-61. 2012
  2. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
  3. ncbi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
  4. doi request reprint Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:1641-8. 2011
  5. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012
  6. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
  7. ncbi request reprint A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
  8. doi request reprint Normal-range blood lactate concentration in septic shock is prognostic and predictive
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Shock 38:4-10. 2012
  9. doi request reprint A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    Simone A Thair
    University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Immunol 186:2321-8. 2011
  10. doi request reprint beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
    Taka aki Nakada
    Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Respir Crit Care Med 181:143-9. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Toll-like receptors and opportunities for new sepsis therapeutics
    John H Boyd
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Curr Infect Dis Rep 14:455-61. 2012
    ..Furthermore, accurately characterizing the stage of sepsis will be essential to directing appropriate therapeutic choices...
  2. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  3. ncbi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
    ..This study examines whether a prolonged QTc interval is associated with adverse outcomes in patients with preoperative LVEF greater than 40% undergoing cardiac surgery...
  4. doi request reprint Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:1641-8. 2011
    ..The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock...
  5. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012
    ..We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients...
  6. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
    ..Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock...
  7. ncbi request reprint A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
    ..Investigators advocate that interventional trials in septic shock require effective outcome risk stratification. We derived and tested a multibiomarker-based approach to estimate mortality risk in adults with septic shock...
  8. doi request reprint Normal-range blood lactate concentration in septic shock is prognostic and predictive
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Shock 38:4-10. 2012
    ..05). Lactate concentrations within the "normal" range can be a useful prognostic indicator in septic shock. Furthermore, patients whose lactate level is less than or equal to 1.4 mmol/L may benefit from vasopressin infusion...
  9. doi request reprint A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    Simone A Thair
    University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Immunol 186:2321-8. 2011
    ..017). This suggests that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-κB pathway genes, including CXCL10...
  10. doi request reprint beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
    Taka aki Nakada
    Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Respir Crit Care Med 181:143-9. 2010
    ..Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown...
  11. pmc IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 15:R254. 2011
    ..Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis...
  12. doi request reprint A common polymorphism in the 5' region of the human protein c gene binds USF1
    Katherine R Thain
    Critical Care Research Laboratories, Institute for Heart Lung Health at St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Thromb Res 130:451-7. 2012
    ..We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding...
  13. ncbi request reprint Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2
    Sumeet Mathur
    Critical Care Research Laboratories, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Canada
    Circ J 75:2445-52. 2011
    ..Whether endogenous molecules produced by tissue injury (damage associated molecular patterns, DAMPs) can induce cardiomyocyte inflammation via TLR signalling pathways and/or reduce cardiomyocyte contractility is unknown...
  14. doi request reprint The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunction
    Sumeet Mathur
    Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Shock 36:478-83. 2011
    ..These may play a role in attenuation of cardiac inflammation. The TLR9 ligand CpG-C attenuates the acute inflammatory cardiac dysfunction induced by both LPS and ischemia-reperfusion of the left anterior descending artery...
  15. doi request reprint Inflammation in myocardial diseases
    David J Marchant
    James Hogg Research Centre and Institute for Heart Lung Health, Department of Pathology and Laboratory Medicine, University of British Columbia, Providence Health Care, Vancouver, Canada
    Circ Res 110:126-44. 2012
    ....
  16. ncbi request reprint The meta-genome of sepsis: host genetics, pathogens and the acute immune response
    John H Boyd
    Division of Critical Care Medicine, St Paul s Hospital, Vancouver, B C, Canada
    J Innate Immun 6:272-83. 2014
    ..Finally, we discuss the host clinical and immune responses and present new data to suggest that the immune response is the key to understanding sepsis and improving a death rate of nearly 30%...
  17. pmc Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice
    Toonchai Indrambarya
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Crit Care 13:R98. 2009
    ..However, the direct effect of arginine vasopressin on the function of the ischemia/reperfusion injured heart has not been clearly elucidated...