Richard L Bowen

Summary

Publications

  1. ncbi request reprint Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, N C, USA
    Gerontology 50:265-90. 2004
  2. ncbi request reprint Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    J Biol Chem 279:20539-45. 2004
  3. ncbi request reprint Antigonadotropins: a novel strategy to halt Alzheimer's disease progression
    Christopher W Gregory
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    Curr Pharm Des 12:685-90. 2006
  4. ncbi request reprint Sex hormones and ApoE4: beyond steroids
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    J Alzheimers Dis 6:229-30. 2004
  5. ncbi request reprint Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, North Carolina, USA
    J Neurosci Res 70:514-8. 2002
  6. ncbi request reprint Is the Abeta vaccine the answer?
    Richard L Bowen
    Voyager Pharmaceutical Corporation, 8540 Colonnade Center Drive, Suite 409, Raleigh, NC 27615, USA
    Neurobiol Aging 25:617-8. 2004
  7. ncbi request reprint The gonadotropin connection in Alzheimer's disease
    Sivan Vadakkadath Meethal
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, Veterans Administration Hospital, Madison, 53705, USA
    Endocrine 26:317-26. 2005
  8. ncbi request reprint Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence
    Craig S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, 53705, USA
    J Neuropathol Exp Neurol 64:93-103. 2005
  9. ncbi request reprint Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Drug Targets CNS Neurol Disord 3:281-5. 2004
  10. ncbi request reprint Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression
    Tianbing Liu
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurochem 100:1329-39. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, N C, USA
    Gerontology 50:265-90. 2004
    ....
  2. ncbi request reprint Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    J Biol Chem 279:20539-45. 2004
    ..Suppression of the age-related increase in serum gonadotropins using anti-gonadotropin agents may represent a novel therapeutic strategy for AD...
  3. ncbi request reprint Antigonadotropins: a novel strategy to halt Alzheimer's disease progression
    Christopher W Gregory
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    Curr Pharm Des 12:685-90. 2006
    ....
  4. ncbi request reprint Sex hormones and ApoE4: beyond steroids
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    J Alzheimers Dis 6:229-30. 2004
  5. ncbi request reprint Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, North Carolina, USA
    J Neurosci Res 70:514-8. 2002
    ..Elevated serum and cortical neuron levels of LH, coupled with the decline in sex steroid production, could play important roles in the pathogenesis of AD...
  6. ncbi request reprint Is the Abeta vaccine the answer?
    Richard L Bowen
    Voyager Pharmaceutical Corporation, 8540 Colonnade Center Drive, Suite 409, Raleigh, NC 27615, USA
    Neurobiol Aging 25:617-8. 2004
  7. ncbi request reprint The gonadotropin connection in Alzheimer's disease
    Sivan Vadakkadath Meethal
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, Veterans Administration Hospital, Madison, 53705, USA
    Endocrine 26:317-26. 2005
    ..Clinical trials are underway for the treatment of AD using GnRH analogs and should provide further insights into the gonadotropin connection in AD...
  8. ncbi request reprint Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence
    Craig S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, 53705, USA
    J Neuropathol Exp Neurol 64:93-103. 2005
    ..Ideally, supplementation with HPG hormones should mimic closely the serum concentrations of all HPG hormones in reproductive men and cycling women to prevent dyotic signaling and attempted neuron division...
  9. ncbi request reprint Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Drug Targets CNS Neurol Disord 3:281-5. 2004
    ..Therefore, the effects of agents that abolish LH, such as leuprolide acetate, which are currently being evaluated in Phase II clinical trials for the treatment of AD, are eagerly anticipated...
  10. ncbi request reprint Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression
    Tianbing Liu
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurochem 100:1329-39. 2007
    ....
  11. ncbi request reprint Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression
    Andrea C Wilson
    Department of Pathology and Laboratory Medicine, Veterans Administration Hospital, University of Wisconsin, 2500 Overlook Terrace, Madison, Wisconsin 53705, USA
    J Endocrinol 191:651-63. 2006
    ..Post-reproductive surges in GnRH I secretion may explain the accumulation of LH in pyramidal neurons of the aged human and rat...
  12. ncbi request reprint Evidence for the role of luteinizing hormone in Alzheimer disease
    Kate M Webber
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA
    Endocr Metab Immune Disord Drug Targets 7:300-3. 2007
    ..These promising findings support the importance of luteinizing hormone in Alzheimer disease and bring to the forefront an alternative, and much needed therapeutic avenue for the treatment of this insidious disease...
  13. ncbi request reprint Gonadotropins: a cohesive gender-based etiology of Alzheimer disease
    Kate M Webber
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Endocrinol 260:271-5. 2007
    ..In this review, we examine how the gonadotropins may play a central and determining role in modulating the susceptibility to, and progression of, Alzheimer disease...
  14. ncbi request reprint The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease
    Gemma Casadesus
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Drugs R D 7:187-93. 2006
    ....
  15. doi request reprint A multi-hit endocrine model of intrinsic adult-onset asthma
    Craig S Atwood
    Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Ageing Res Rev 7:114-25. 2008
    ..Future therapeutic strategies might therefore target the serotonergic, leptinergic and hypothalamic pathways in regulating cellular cAMP production and bronchoconstriction for the treatment of adult-onset asthma...
  16. ncbi request reprint Menopause, estrogen, and gonadotropins in Alzheimer's disease
    Gemma Casadesus
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Adv Clin Chem 45:139-53. 2008
    ..Moreover, targeting gonadotropins appears to have beneficial actions as a therapeutic regimen...
  17. ncbi request reprint Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
    ..Since both cognitive loss and amyloid-beta deposition are features of Alzheimer disease, leuprolide acetate treatment may prove to be a useful therapeutic strategy for this disease...
  18. ncbi request reprint The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 USA
    Curr Pharm Des 12:691-7. 2006
    ..Therapeutic interventions targeted at gonadotropins, if they are indeed the driving mitogenic force, could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted...
  19. ncbi request reprint Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 1052:201-9. 2005
    ..On this basis, we suggest that the results of the WHI Memory Study are not only predictable but also avoidable by therapeutically targeting the gonadotropins instead of the sex steroids...
  20. ncbi request reprint What is aging? What is its role in Alzheimer's disease? What can we do about it?
    J Wesson Ashford
    Stanford VA Alzheimer Center, Palo Alto, CA 94304 1207, USA
    J Alzheimers Dis 7:247-53; discussion 255-62. 2005
  21. ncbi request reprint Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis
    Craig S Atwood
    J Alzheimers Dis 7:1-2. 2005
  22. ncbi request reprint Dementia and testosterone levels in men
    Richard L Bowen
    JAMA 293:551; author reply 552. 2005
  23. ncbi request reprint Pennington scientific symposium on mechanisms and retardation of aging
    Craig S Atwood
    Section of Geriatrics and Gerontology, University of Wisconsin Medical School, Madison, WI, USA
    Exp Gerontol 38:1217-26. 2003
  24. ncbi request reprint Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply
    Craig S Atwood
    School of Medicine, University of Wisconsin and William S Middleton Memorial Veterans Administration, GRECC 11G, 2500 Overlook Terrace, Madison, WI 53705, USA
    Brain Res Brain Res Rev 43:164-78. 2003
    ..e. immunological responses to Abeta vaccination do not discriminate between physiologically purposive deposits of Abeta (vascular deposits) and pathological deposits of Abeta (senile plaques)...
  25. ncbi request reprint Estrogen replacement and risk of Alzheimer disease
    Mark A Smith
    JAMA 289:1100; author reply 1101-2. 2003
  26. pmc A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele
    Ryan J Haasl
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Med Genet 9:37. 2008
    ....