Donald W Bowden

Summary

Publications

  1. doi request reprint Genetic risk score associations with cardiovascular disease and mortality in the diabetes heart study
    Amanda J Cox
    Corresponding author Donald W Bowden
    Diabetes Care 37:1157-64. 2014
  2. pmc Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study
    Laura M Raffield
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:95. 2013
  3. pmc Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study
    Amanda J Cox
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 229:155-60. 2013
  4. pmc Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:68. 2013
  5. pmc Coronary calcium score predicts cardiovascular mortality in diabetes: diabetes heart study
    Subhashish Agarwal
    Department of Cardiology, Oakwood Hospital and Medical Center, Dearborn, Michigan, USA
    Diabetes Care 36:972-7. 2013
  6. pmc Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study
    Jeremy N Adams
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Cardiovasc Diabetol 12:31. 2013
  7. pmc Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 123:333-41. 2008
  8. doi request reprint Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
  9. pmc Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:63-71. 2008
  10. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008

Detail Information

Publications74

  1. doi request reprint Genetic risk score associations with cardiovascular disease and mortality in the diabetes heart study
    Amanda J Cox
    Corresponding author Donald W Bowden
    Diabetes Care 37:1157-64. 2014
    ..28 [1.05-1.56]; P = 0.01), and CVD mortality (HR 1.46 [1.08-1.96]; P = 0.01). CONCLUSIONS These findings support the utility of two simple GRSs in examining genetic associations for adverse outcomes in EAs with type 2 diabetes. ..
  2. pmc Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study
    Laura M Raffield
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:95. 2013
    ..This study examined the utility of HDL-associated single nucleotide polymorphisms (SNPs) for CVD risk prediction in European Americans with T2D enrolled in the Diabetes Heart Study (DHS)...
  3. pmc Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study
    Amanda J Cox
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 229:155-60. 2013
    ..This study replicated the genetic association for TBili in the Diabetes Heart Study (DHS), and examined the relationships of TBili-associated SNPs with measures of subclinical CVD and mortality...
  4. pmc Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Cardiovasc Diabetol 12:68. 2013
    ....
  5. pmc Coronary calcium score predicts cardiovascular mortality in diabetes: diabetes heart study
    Subhashish Agarwal
    Department of Cardiology, Oakwood Hospital and Medical Center, Dearborn, Michigan, USA
    Diabetes Care 36:972-7. 2013
    ..In type 2 diabetes mellitus (T2DM), it remains unclear whether coronary artery calcium (CAC) provides additional information about cardiovascular disease (CVD) mortality beyond the Framingham Risk Score (FRS) factors...
  6. pmc Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study
    Jeremy N Adams
    Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Cardiovasc Diabetol 12:31. 2013
    ..HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individuals with type 2 diabetes (T2DM)...
  7. pmc Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 123:333-41. 2008
    ..We have identified a novel region of the ESR1 gene that may contain important functional polymorphisms in relation to susceptibility to T2DM and/or diabetic nephropathy...
  8. doi request reprint Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  9. pmc Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:63-71. 2008
    ..This study confirms known diabetic nephropathy loci and identifies potentially novel susceptibility variants located within 6q24-27 in AA...
  10. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  11. pmc Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
    Jasmin Divers
    Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:5382-9. 2010
    ..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
  12. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
    ..After adjustment, two APOL1 risk variants weakly predict mild forms of kidney disease. Second hits appear necessary for the initiation of APOL1-associated nephropathy...
  13. doi request reprint Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:1057-62. 2008
    ..Our objective was to comprehensively evaluate variants in ENPP1 for association with type 2 diabetic end-stage renal disease (ESRD)...
  14. ncbi request reprint Association analysis of the plasminogen activator inhibitor-1 4G/5G polymorphism in Hispanics and African Americans: the IRAS family study
    Jeannette T Bensen
    Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Hered 57:128-37. 2004
    ..In addition, we explore whether transforming growth factor (TGF-beta1), a key regulator of PAI-1 expression, modifies the influence of the PAI-1 4G/5G polymorphism on these traits...
  15. pmc Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes
    Yongmei Liu
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, UAS
    Am J Kidney Dis 52:242-50. 2008
    ..These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy...
  16. ncbi request reprint A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  17. pmc Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study
    Matthew E Talbert
    Program in Molecular Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Hum Genet 125:153-62. 2009
    ..Multi-SNP haplotype testing using the quantitative pedigree disequilibrium test was broadly consistent with the single-SNP associations. In conclusion, these results support a role for SOCS3 genetic variants in human obesity...
  18. doi request reprint Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diab Vasc Dis Res 5:128-34. 2008
    ..057 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small...
  19. pmc Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease
    Keith L Keene
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 124:147-54. 2008
    ..This study presents exploratory analyses of the impact of admixture on studies of AA with T2DM-ESRD and supports the use of ancestral proportions as a means of reducing confounding effects due to admixture...
  20. pmc Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann Noninvasive Electrocardiol 14:72-9. 2009
    ..It is unclear whether these genetic variants remain relevant in subjects with underlying conditions such as diabetes that are associated with prolonged QT interval...
  21. pmc Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    BMC Med Genet 11:22. 2010
    ..Ordered subset linkage analysis (OSA) revealed a linkage peak on chromosome 7p in the subset of families with earlier age of T2D diagnosis...
  22. ncbi request reprint Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study
    Donald W Bowden
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:1985-94. 2006
    ....
  23. pmc Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:1916-22. 2013
    ..Adipokines vary in relation to changes in body composition and may play roles in regulation of BMD and risk of cardiovascular disease...
  24. ncbi request reprint Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy
    Michele M Sale
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 56:2638-42. 2007
    ..Our objective was to investigate the importance of TCF7L2 in a larger African-American case-control population...
  25. pmc Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 27:1505-11. 2012
    ..We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM-ESRD in European Americans; additionally, three APOL1 gene variants were evaluated...
  26. pmc Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes Res Clin Pract 87:69-76. 2010
    ..Evaluate discs large homolog 2 (DLG2) as a positional candidate gene for disposition index (DI) in the Insulin Resistance Atherosclerosis Family Study (IRAS-FS) African-American sample...
  27. pmc Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans
    Pamela J Hicks
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA 27157 1053
    Kidney Int 80:1339-43. 2011
    ..05) in dominant models. In addition, no evidence of APOL1 or MYH9 interactions with sickle cell trait was detected. Hence, sickle cell trait is not associated with diabetic or non-diabetic ESRD in a large sample of African Americans...
  28. pmc Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:2220-5. 2008
    ..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
  29. ncbi request reprint Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: the Insulin Resistance Atherosclerosis Family Study
    Carla J Gallagher
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 56:2135-41. 2007
    ....
  30. pmc Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
    Maria R Wing
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 125:615-26. 2009
    ..038 and 0.058). These results confirm that FTO variants are associated with adiposity measures, predisposing individuals to obesity by increasing overall fat mass in Hispanic Americans and to a lesser degree in African Americans...
  31. pmc Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mediators Inflamm 2010:170153. 2010
    ..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds...
  32. pmc Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 19:4112-20. 2010
    ..This approach is applicable to a wide range of family studies and has potential to be a discovery tool for identification of novel genes influencing complex traits...
  33. ncbi request reprint Association of protein tyrosine phosphatase-N1 polymorphisms with coronary calcified plaque in the Diabetes Heart Study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:651-8. 2006
    ..53 +/- 0.1 to 0.57 +/- 0.1 (P = 8.1 x 10(-10)), suggesting a modest but detectable effect of this gene on the phenotype of CorCP in type 2 diabetic patients...
  34. ncbi request reprint Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 92:345-52. 2007
    ....
  35. pmc Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 24:1719-27. 2009
    ..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans...
  36. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    ..These analyses reveal a role for FRMD3 in AA T2DN susceptibility and accounting for c22 nephropathy risk variants can assist in detecting DN susceptibility genes...
  37. pmc Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
    Tennille S Leak
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Mol Genet Metab 92:145-50. 2007
    ..028), rs4814597 (Pa=0.039) and rs2269023 (Pa=0.043). None of the PCSK2 SNPs were associated with age at T2DM diagnosis. A variant in the PCKS2 gene, rs2021785, appears to play a role in susceptibility to T2DM in this AA population...
  38. ncbi request reprint A genome scan for ESRD in black families enriched for nondiabetic nephropathy
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 15:2719-27. 2004
    ..1 and 13q33.3 as contributing to early-onset ESRD and ESRD in the presence of increased BMI, respectively. These regions should receive priority in the search for loci that contribute susceptibility to nondiabetic nephropathy...
  39. pmc Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study
    S Sandy An
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Mol Genet Metab 107:721-8. 2012
    ..Adiponectin is an adipocytokine associated with a variety of metabolic traits. These associations in human studies, in conjunction with functional studies in model systems, have implicated adiponectin in multiple metabolic processes...
  40. ncbi request reprint Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 53:3013-9. 2004
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein...
  41. pmc Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 35:287-92. 2012
    ..These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans...
  42. pmc Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study
    Megan E Rudock
    From the Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 203:459-65. 2009
    ..We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population...
  43. ncbi request reprint Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations
    Carla J Gallagher
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Diabetes 56:675-84. 2007
    ..033) were associated with type 2 diabetes and/or ESRD. Results suggest that intron 1 and intron 2 of the ESR1 gene may contain functionally important regions related to type 2 diabetes or ESRD risk...
  44. pmc Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:4979-83. 2008
    ..2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addressed the physiological impact of variants in Hispanic-Americans and African-Americans carefully phenotyped for components of glucose homeostasis...
  45. pmc Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD
    Barry I Freedman
    1Internal Medicine Nephrology, 2Biochemistry, 3Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 24:3366-71. 2009
    ....
  46. pmc Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study
    Ryan L McKimmie
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Gastroenterol 103:3029-35. 2008
    ....
  47. pmc INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study
    Matthew E Talbert
    Program in Molecular Medicine and Translational Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 17:1554-62. 2009
    ..Trending association after multiple comparisons adjustment remains suggestive of a role for genetic variation of INSIG2 in obesity, but these results require validation...
  48. ncbi request reprint Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study
    Leslie A Lange
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 70:717-25. 2006
    ..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
  49. pmc Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
    Jennifer L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    BMC Med Genet 6:42. 2005
    ..GLUT10 (gene symbol SLC2A10) is a facilitative glucose transporter within the type 2 diabetes (T2DM)-linked region on chromosome 20q12-13.1. Therefore, we evaluated GLUT10 as a positional candidate gene for T2DM in Caucasian Americans...
  50. ncbi request reprint A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans
    Barry I Freedman
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    Nephrol Dial Transplant 22:1131-5. 2007
    ..A trinucleotide repeat sequence in exon 2 of the carnosinase gene (CNDP1) residing on 18q22.3 was subsequently associated with DN in European Caucasians and Arabs...
  51. pmc The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Exp Mol Pathol 82:280-3. 2007
    ..Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis...
  52. pmc Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 96:211-9. 2010
    ..0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans...
  53. doi request reprint Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 57:1108-14. 2008
    ..We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry...
  54. pmc Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease
    Pamela J Hicks
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 28:914-20. 2008
    ..Interactions between the ephrin-B2 receptor and ephrin-B2 ligand play essential roles in renal angiogenesis, blood vessel maturation, and kidney disease...
  55. pmc Genome-wide association of BMI in African Americans
    Maggie C Y Ng
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 20:622-7. 2012
    ..Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations...
  56. pmc Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Liver Int 31:412-6. 2011
    ..Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, particularly among Hispanic Americans. A genetic variant in PNPLA3 (rs738409) has been identified as a strong predictor of hepatic fat content...
  57. pmc Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study
    Mariana Murea
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1053, USA
    BMC Nephrol 13:148. 2012
    ..Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D)...
  58. pmc Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease
    Meredith A Bostrom
    David H Murdoch Research Institute, Kannapolis, NC, USA
    Am J Nephrol 36:252-60. 2012
    ..Rare mutations in ACTN4 (α-actinin-4), an actin-binding protein expressed in podocytes, cause familial focal segmental glomerulosclerosis...
  59. ncbi request reprint The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ....
  60. pmc Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hum Genet 128:195-204. 2010
    ..This is the first GWAS for non-DM ESRD in African Americans using pooled DNA. We demonstrate strong association between non-DM ESRD in African Americans with MYH9, and have identified additional candidate loci...
  61. ncbi request reprint T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study
    Yongmei Liu
    Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Soc Nephrol 16:1085-90. 2005
    ..The -786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members...
  62. ncbi request reprint P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study
    Yongmei Liu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 68:741-6. 2005
    ..We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS)...
  63. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
    ..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
  64. pmc Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:499-504. 2009
    ..Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations...
  65. pmc Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes 60:662-8. 2011
    ..The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans...
  66. ncbi request reprint A genome scan for diabetic nephropathy in African Americans
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Kidney Int 66:1517-26. 2004
    ..There is substantial evidence for a genetic contribution to diabetic nephropathy susceptibility in the African American population, but little is known about location or identity of susceptibility genes...
  67. pmc Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 58:1457-62. 2009
    ..CONCLUSIONS We observed evidence for association of SSTR2 polymorphisms with measures of glucose homeostasis. Thus, variants in SSTR2 may influence pathways of S(I)to modulate glucose homeostasis...
  68. pmc The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans
    Caitrin W McDonough
    Center for Diabetes Research, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Hum Genet 126:265-75. 2009
    ..Protection from diabetic nephropathy afforded by 5L-5L homozygosity in CNDP1 may be masked by the effects of additional risk haplotypes in CNDP1 and CNDP2...
  69. ncbi request reprint A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 166:340-7. 2007
    ..0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another...
  70. doi request reprint Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes
    Jasmin Divers
    Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 26:1554-60. 2011
    ..This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes...
  71. pmc A genome-wide association search for type 2 diabetes genes in African Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e29202. 2012
    ..These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations...
  72. pmc Genetic mapping of vascular calcified plaque loci on chromosome 16p in European Americans from the diabetes heart study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 75:222-35. 2011
    ..The causal variants remain to be identified, but results are consistent with a linkage peak that is due to multiple common variants, though rare variants cannot be excluded...
  73. pmc Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants
    Isai Gopalakrishnan
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hum Pathol 42:291-4. 2011
    ....
  74. doi request reprint Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study
    Matthew R Nelson
    Department of Medicine Cardiology Section, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pacing Clin Electrophysiol 31:314-21. 2008
    ..We examined the relationship between coronary artery disease, measured by coronary artery calcified plaque (CAC), and the duration of QRS, JT, and QT intervals, among predominantly type two diabetic participants...