Cross-species models of OCD spectrum disordersVasileios Boulougouris
Department of Experimental Psychology and the Behavioural and Clinical Neuroscience Institute BCNI, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
Psychiatry Res 170:15-21. 2009
..We then survey animal models of OC spectrum conditions within this framework, focusing on (i) ethological models; (ii) genetic and pharmacological models; and (iii) behavioral models. Key future research directions are highlighted...
Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specificVasileios Boulougouris
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 30:930-8. 2010
..These data also bear on the issue of whether 5-HT(2C) receptor antagonism within the OFC might help elucidate the biological substrate of obsessive-compulsive disorder, offering the potential for therapeutic application...
Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in ratsVasileios Boulougouris
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 33:2007-19. 2008
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Pre-surgical training ameliorates orbitofrontal-mediated impairments in spatial reversal learningVasileios Boulougouris
Behavioural and Clinical Neuroscience Institute and the Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
Behav Brain Res 197:469-75. 2009
..These data, together with the previously reported reversal deficit following OFC lesions, suggest that OFC is not needed when task experience has been gained but it is necessary when task demands are relatively high...
Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behaviorVasileios Boulougouris
Department of Experimental Psychology, Behavioral and Clinical Neuroscience Institute BCNI, University of Cambridge, Downing Street, CB23EB Cambridge, UK
Psychopharmacology (Berl) 202:611-20. 2009
..Dopamine is strongly implicated in the ability to shift behavior in response to changing stimulus-reward contingencies...
Trichotillomania: neurobiology and treatmentSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Neurosci Biobehav Rev 33:831-42. 2009
..Finally, we highlight important areas for future neurobiological and treatment research...
Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the ratVasileios Boulougouris
Behavioural and Clinical Neuroscience Institute BCNI and the Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Behav Brain Res 179:219-28. 2007
..This study examines the behavioural effects of selective lesions centred on orbitofrontal, infralimbic and prelimbic cortex on serial spatial reversal learning in the rat...