Philippe Bouillet

Summary

Publications

  1. ncbi request reprint BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
  2. ncbi request reprint Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases
    Peter Hughes
    Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Curr Dir Autoimmun 9:74-94. 2006
  3. ncbi request reprint Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Science 315:856-9. 2007
  4. ncbi request reprint BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Cell Sci 115:1567-74. 2002
  5. pmc Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
    Toru Okamoto
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia
    Proc Natl Acad Sci U S A 111:261-6. 2014
  6. pmc Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
    Mark D McKenzie
    St Vincent s Institute, Melbourne, Australia
    Diabetes 59:644-52. 2010
  7. pmc The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens
    Daniel H D Gray
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Immunity 37:451-62. 2012
  8. pmc Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
    Delphine Merino
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 119:5807-16. 2012
  9. pmc Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
    Andreas Villunger
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:7052-7. 2004
  10. pmc Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    EMBO J 24:3963-73. 2005

Collaborators

Detail Information

Publications50

  1. ncbi request reprint BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection...
  2. ncbi request reprint Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases
    Peter Hughes
    Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Curr Dir Autoimmun 9:74-94. 2006
    ..This chapter focuses on the role of Bim in the development and function of the immune system and its potential role in autoimmunity. Degenerative disorders due to increased apoptosis mediated by Bim are also discussed...
  3. ncbi request reprint Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Science 315:856-9. 2007
    ..Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak...
  4. ncbi request reprint BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Cell Sci 115:1567-74. 2002
    ..In response, they unleash the apoptotic cascade by inactivating the protective function of the pro-survival members of the Bcl-2 family and by activating the Bax/Bax-like pro-apoptotic family members...
  5. pmc Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
    Toru Okamoto
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia
    Proc Natl Acad Sci U S A 111:261-6. 2014
    ....
  6. pmc Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
    Mark D McKenzie
    St Vincent s Institute, Melbourne, Australia
    Diabetes 59:644-52. 2010
    ..We investigated the apoptotic pathway induced in mouse pancreatic islet cells after exposure to high concentrations of the reducing sugars ribose and glucose as a model of beta-cell death due to long-term metabolic stress...
  7. pmc The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens
    Daniel H D Gray
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Immunity 37:451-62. 2012
    ..Our data show that Puma cooperates with Bim to impose a thymic-deletion checkpoint to peripheral self-antigens and cement the notion that defects in apoptosis alone are sufficient to cause autoimmune disease...
  8. pmc Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
    Delphine Merino
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 119:5807-16. 2012
    ..These results have profound implications for how BH3-mimetics induce apoptosis and how the use of these compounds can be optimized for treating lymphoid malignancies...
  9. pmc Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
    Andreas Villunger
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:7052-7. 2004
    ..These results reveal the mechanisms of apoptosis in negative selection of semimature thymocytes and have implications for immunological tolerance and autoimmunity...
  10. pmc Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    EMBO J 24:3963-73. 2005
    ..Thus, Bik and Bim share, upstream of Bax, the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development...
  11. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..These results identify critical overlapping roles for Fas and Bim in T cell death in immune response shutdown and prevention of immunopathology and thereby resolve a long-standing controversy...
  12. pmc The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins
    Delphine Merino
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Cell Biol 186:355-62. 2009
    ..Thus, initiation of apoptosis in vivo appears to require features of both models...
  13. pmc Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1
    Ben A Croker
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 108:13135-40. 2011
    ..These data demonstrate that the intrinsic apoptosis pathway directly controls the kinetics of Fas-triggered apoptosis in neutrophils...
  14. pmc Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells
    Edwina Naik
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Exp Med 208:1351-8. 2011
    ..They also indicate that drugs mimicking BH3-only proteins may be exploited to kill tumor cells not only directly but also indirectly by ablating the tumor vasculature...
  15. pmc Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
    Anselm Enders
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 198:1119-26. 2003
    ..Mechanistically, we determined that BCR ligation promoted interaction of Bim with Bcl-2, inhibiting its survival function. These findings demonstrate that Bim is a critical player in BCR-mediated apoptosis and in B lymphocyte deletion...
  16. pmc Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..These observations identify caspase-8 and the BH3-only proteins Bid and Bim as potential therapeutic targets for treatment of inflammatory liver diseases...
  17. ncbi request reprint What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Immunol Cell Biol 86:57-66. 2008
    ..Finally, we speculate on the processes that may lead to the activation of Bim when antigen receptors are activated on autoreactive T or B cells...
  18. pmc Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 200:1189-95. 2004
    ..This indicates that pharmacological inhibition of Bim function might be useful for boosting immune responses in immunodeficient patients...
  19. ncbi request reprint Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 101:2393-400. 2003
    ....
  20. pmc Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
    Lorraine A O' Reilly
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 461:659-63. 2009
    ....
  21. pmc Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
    Silke F Fischer
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 110:3978-84. 2007
    ..We have identified for the first time the physiologic mechanisms for killing low-affinity antibody-expressing B cells in an immune response and have shown this to be dependent on the BH3-only protein Bim...
  22. pmc A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
    Erinna F Lee
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Cell Biol 180:341-55. 2008
    ..Our data have important implications for the discovery of compounds that might kill cells whose survival depends on Mcl-1...
  23. pmc Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Sci 120:2044-52. 2007
    ..These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells...
  24. pmc Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
    Marc Pellegrini
    Division of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Proc Natl Acad Sci U S A 100:14175-80. 2003
    ..These findings have implications for the therapeutic manipulation of immune responses to infections and immunization...
  25. pmc XIAP discriminates between type I and type II FAS-induced apoptosis
    Philipp J Jost
    The Walter and Eliza Hall Institute of Medical Research, Melbourne University, Parkville, Victoria 3050, Australia
    Nature 460:1035-9. 2009
    ..These results show that XIAP is the critical discriminator between type I and type II apoptosis signalling and suggest that IAP inhibitors should be used with caution in cancer patients with underlying liver conditions...
  26. pmc Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:1570-81. 2004
    ..These results indicate that any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only proteins...
  27. pmc Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
    J Exp Med 196:947-55. 2002
    ..Bim-deficient T cells were not deleted in response to cross-presented self-antigen, strongly implicating Bim as the pro-apoptotic mediator of cross-tolerance...
  28. pmc Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein
    Marco J Herold
    1 The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 2 Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia
    EMBO Rep 14:992-8. 2013
    ..These results indicate that regulation of Bim by Foxo transcription factors is not critical for the killing of hematopoietic cells. ..
  29. ncbi request reprint ER stress triggers apoptosis by activating BH3-only protein Bim
    Hamsa Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell 129:1337-49. 2007
    ..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases...
  30. pmc Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
    Stefan P Glaser
    The Walter and Eliza Hall Institute, Parkville, Melbourne, Victoria 3052, Australia
    Genes Dev 26:120-5. 2012
    ..Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML...
  31. pmc Bim is a suppressor of Myc-induced mouse B cell leukemia
    Alexander Egle
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:6164-9. 2004
    ..Whereas the p19Arf/p53 pathway is frequently mutated in tumors arising in Bim(+/+) Emicro-Myc mice, it was unaffected in most Bim-deficient tumors, indicating that Bim reduction is an effective alternative to loss of p53 function...
  32. ncbi request reprint Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration
    Philippe Bouillet
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Neurosci Res 74:777-81. 2003
    ..Our studies show that Bim deficiency does not modify the Lurcher phenotype, ruling out an indispensable role for Bim in this neurodegenerative disease...
  33. pmc Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
    Junya Kuroda
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:14907-12. 2006
    ..These results demonstrate that Bim and Bad account for most, perhaps all, imatinib-induced killing of Bcr/Abl+ leukemic cells and suggest previously undescribed drug combination strategies for cancer therapy...
  34. ncbi request reprint CD95, BIM and T cell homeostasis
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Rev Immunol 9:514-9. 2009
    ....
  35. ncbi request reprint Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  36. ncbi request reprint The control of apoptosis in lymphocyte selection
    Andreas Strasser
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Immunol Rev 193:82-92. 2003
    ....
  37. doi request reprint The Bcl-2 family in autoimmune and degenerative disorders
    Delphine Merino
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, Melbourne, Vic, Australia
    Apoptosis 14:570-83. 2009
    ..The present review highlights the role of Bcl-2 family members in autoimmune and degenerative disorders, with a particular focus on the mouse models that have been used to study their function...
  38. ncbi request reprint Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, 35487, USA
    Brain Res 1099:150-9. 2006
    ..These results indicate that Bad and Bim are selectively involved in neuron death following neonatal HI and may be targets for therapeutic intervention...
  39. ncbi request reprint Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim
    David A Hildeman
    Howard Hughes Medical Institute and Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunity 16:759-67. 2002
    ..Thus, the death of superantigen-stimulated T cells in vivo is mediated by Bim and may be modulated by a decrease in Bcl-2...
  40. ncbi request reprint Bax and Bak: back-bone of T cell death
    Philippe Bouillet
    Nat Immunol 3:893-4. 2002
  41. pmc BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms
    Arnaud A Mailleux
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 12:221-34. 2007
    ..These data provide important mechanistic information on the processes involved in sculpting the mammary gland and demonstrate that BIM is a critical regulator of apoptosis in vivo...
  42. pmc Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
    Jack Hutcheson
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Exp Med 201:1949-60. 2005
    ..These data suggest an essential overlapping role for Bak or Bax and Bim in the intrinsic apoptotic pathway...
  43. ncbi request reprint Bim expression indicates the pathway to retinal cell death in development and degeneration
    Francesca Doonan
    Tumour Biology Laboratory, Biochemistry Department, Bioscience Research Institute, University College Cork, Cork, Republic of Ireland
    J Neurosci 27:10887-94. 2007
    ..However, the absence of BimEL expression correlates with caspase-independent death in the rd model...
  44. pmc Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death
    Lauren E Holz
    Centenary Institute, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and Faculty of Medicine, University of Sydney, Camperdown, New South Wales, Australia
    Gastroenterology 135:989-97. 2008
    ..However, the molecular mechanism by which intrahepatically activated T cells become tolerant is unknown. Here, we investigated the phenotype and fate of naïve CD8 T cells activated by hepatocytes in vivo...
  45. ncbi request reprint Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Cancer Cell 7:227-38. 2005
    ....
  46. pmc NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge
    Adam P Uldrich
    Department Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 175:3092-101. 2005
    ..In summary, this study significantly enhances our understanding of how NKT cells respond to primary and secondary antigenic challenge in vivo...
  47. doi request reprint MicroRNAs and lymphocyte homeostasis: dangerous eggs in a single basket
    Delphine Merino
    Molecular Genetics of Cancer Division, The Water and Eliza Hall Institute, Parkville, Victorial, Australia
    Immunol Cell Biol 86:387-8. 2008
  48. ncbi request reprint Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77
    Ildiko Kiss
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen
    Eur J Immunol 36:1559-71. 2006
    ..Collectively our data demonstrate that adenosine-induced cell death involves signaling pathways originally found in negative selection of thymocytes and suggest a determining role of Bim and a regulatory role for Nur77...
  49. pmc The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis
    Takashi Yano
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Cell Biol 26:4474-88. 2006
    ..These results demonstrate that RUNX3 is responsible for transcriptional up-regulation of Bim in TGF-beta-induced apoptosis...
  50. pmc Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease
    Celine Perier
    Research Institute University Hospital Vall d Hebron, 08035 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:8161-6. 2007
    ..These results provide further insight into the pathogenesis of PD neurodegeneration and identify molecular targets of potential therapeutic significance for this disabling neurological illness...