Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic dietKristopher J Bough
Department of Pharmacology, Emory University, Atlanta, GA, USA
Ann Neurol 60:223-35. 2006
..The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect...
- Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
Kristopher J Bough
Department of Pharmacology, Emory University, Atlanta, GA, USA
Epilepsy Res 74:232-6. 2007
..These multiple studies suggest that the anticonvulsant nature of the KD does not stem from enhanced glutamate re-uptake...
Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrusJames J Doherty
Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA
J Physiol 561:395-401. 2004
..These findings indicate that group II mGluRs modulate excitatory drive to interneurones in a developmentally regulated manner and thereby modulate feedback inhibition in the dentate gyrus...
- Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo
Kristopher J Bough
Emory University School of Medicine, Department of Pharmacology, Rollins Research Center, Atlanta, GA 30322, USA
Epilepsia 44:752-60. 2003
..The ketogenic diet (KD) is an effective treatment for intractable epilepsy. However, little is known about its underlying mechanisms...
- Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus
Kristopher J Bough
School of Medicine, Dept of Pharmacology, Emory University, Rollins Research Center, Rm 5002, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
J Neurophysiol 92:1549-57. 2004
..These data suggest that reduced presynaptic inhibition mediated by mGluR7, but not mGluR2/3 or mGluR8, may play a role during the latent period in generating hyperexcitability in the dentate and thereby contribute to epileptogenesis...
- Anticonvulsant mechanisms of the ketogenic diet
Kristopher J Bough
Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20855, USA
Epilepsia 48:43-58. 2007
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- An anticonvulsant profile of the ketogenic diet in the rat
Kristopher J Bough
Department of Biology, Georgetown University, Washington, DC 20057-1229, USA
Epilepsy Res 50:313-25. 2002
..Uniquely, the KD is the only treatment described that protects against both convulsive and non-convulsive (absence) seizures in rats...
- The ketogenic diet for the treatment of epilepsy: a challenge for nutritional neuroscientists
Carl E Stafstrom
Department of Neurology and the Neuroscience Training Program, University of Wisconsin, Madison, WI 53792, USA
Nutr Neurosci 6:67-79. 2003
..We encourage scientists with a primary interest in nutritional neuroscience to join with those of us in the epilepsy research community to address these urgent questions, for the benefit of children ravaged by intractable seizures...
