Kristopher J Bough

Summary

Publications

  1. ncbi request reprint Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Ann Neurol 60:223-35. 2006
  2. ncbi request reprint Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Epilepsy Res 74:232-6. 2007
  3. pmc Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus
    James J Doherty
    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA
    J Physiol 561:395-401. 2004
  4. ncbi request reprint Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo
    Kristopher J Bough
    Emory University School of Medicine, Department of Pharmacology, Rollins Research Center, Atlanta, GA 30322, USA
    Epilepsia 44:752-60. 2003
  5. ncbi request reprint Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus
    Kristopher J Bough
    School of Medicine, Dept of Pharmacology, Emory University, Rollins Research Center, Rm 5002, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    J Neurophysiol 92:1549-57. 2004
  6. ncbi request reprint Anticonvulsant mechanisms of the ketogenic diet
    Kristopher J Bough
    Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20855, USA
    Epilepsia 48:43-58. 2007
  7. ncbi request reprint An anticonvulsant profile of the ketogenic diet in the rat
    Kristopher J Bough
    Department of Biology, Georgetown University, Washington, DC 20057 1229, USA
    Epilepsy Res 50:313-25. 2002
  8. ncbi request reprint The ketogenic diet for the treatment of epilepsy: a challenge for nutritional neuroscientists
    Carl E Stafstrom
    Department of Neurology and the Neuroscience Training Program, University of Wisconsin, Madison, WI 53792, USA
    Nutr Neurosci 6:67-79. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Ann Neurol 60:223-35. 2006
    ..The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect...
  2. ncbi request reprint Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Epilepsy Res 74:232-6. 2007
    ..These multiple studies suggest that the anticonvulsant nature of the KD does not stem from enhanced glutamate re-uptake...
  3. pmc Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus
    James J Doherty
    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA
    J Physiol 561:395-401. 2004
    ..These findings indicate that group II mGluRs modulate excitatory drive to interneurones in a developmentally regulated manner and thereby modulate feedback inhibition in the dentate gyrus...
  4. ncbi request reprint Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo
    Kristopher J Bough
    Emory University School of Medicine, Department of Pharmacology, Rollins Research Center, Atlanta, GA 30322, USA
    Epilepsia 44:752-60. 2003
    ..The ketogenic diet (KD) is an effective treatment for intractable epilepsy. However, little is known about its underlying mechanisms...
  5. ncbi request reprint Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus
    Kristopher J Bough
    School of Medicine, Dept of Pharmacology, Emory University, Rollins Research Center, Rm 5002, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    J Neurophysiol 92:1549-57. 2004
    ..These data suggest that reduced presynaptic inhibition mediated by mGluR7, but not mGluR2/3 or mGluR8, may play a role during the latent period in generating hyperexcitability in the dentate and thereby contribute to epileptogenesis...
  6. ncbi request reprint Anticonvulsant mechanisms of the ketogenic diet
    Kristopher J Bough
    Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20855, USA
    Epilepsia 48:43-58. 2007
    ....
  7. ncbi request reprint An anticonvulsant profile of the ketogenic diet in the rat
    Kristopher J Bough
    Department of Biology, Georgetown University, Washington, DC 20057 1229, USA
    Epilepsy Res 50:313-25. 2002
    ..Uniquely, the KD is the only treatment described that protects against both convulsive and non-convulsive (absence) seizures in rats...
  8. ncbi request reprint The ketogenic diet for the treatment of epilepsy: a challenge for nutritional neuroscientists
    Carl E Stafstrom
    Department of Neurology and the Neuroscience Training Program, University of Wisconsin, Madison, WI 53792, USA
    Nutr Neurosci 6:67-79. 2003
    ..We encourage scientists with a primary interest in nutritional neuroscience to join with those of us in the epilepsy research community to address these urgent questions, for the benefit of children ravaged by intractable seizures...