Saeid Bouzari

Summary

Publications

  1. request reprint
    Bouzari S, Jafari A, Zarepoor M. Distribution of genes encoding toxins and antibiotic resistance patterns in diarrhoeagenic Escherichia coli isolates in Tehran. East Mediterr Health J. 2007;13:287-93 pubmed
    ..9%). Furthermore, 40 strains (70.0%) carried resistance. We conclude that toxigenicity and antibiotic resistance are the main contributing factors leading to the virulence potential of these E. coil isolates. ..
  2. Habibi M, Asadi Karam M, Shokrgozar M, Oloomi M, Jafari A, Bouzari S. Intranasal immunization with fusion protein MrpH·FimH and MPL adjuvant confers protection against urinary tract infections caused by uropathogenic Escherichia coli and Proteus mirabilis. Mol Immunol. 2015;64:285-94 pubmed publisher
    ..mirabilis. These data altogether are promising and these formulations are good candidates for elimination of UPEC and P. mirabilis. ..
  3. Habibi M, Asadi Karam M, Bouzari S. Evaluation of the effect of MPL and delivery route on immunogenicity and protectivity of different formulations of FimH and MrpH from uropathogenic Escherichia coli and Proteus mirabilis in a UTI mouse model. Int Immunopharmacol. 2015;28:70-8 pubmed publisher
    ..mirabilis in a UTI mouse model. Therefore considering these results MrpH.FimH fusion with MPL administered subcutaneously or intranasally could be a promising vaccine candidate for elimination of UTIs caused by UPEC and P. mirabilis. ..
  4. Shahbazi S, Asadi Karam M, Habibi M, Talebi A, Bouzari S. Distribution of extended-spectrum ?-lactam, quinolone and carbapenem resistance genes, and genetic diversity among uropathogenic Escherichia coli isolates in Tehran, Iran. J Glob Antimicrob Resist. 2018;14:118-125 pubmed publisher
    ..These results indicate that the high antimicrobial resistance among UPEC isolates is alarming and requires urgent attention. ..
  5. Golshani M, Rafati S, Siadat S, Nejati Moheimani M, Shahcheraghi F, Arsang A, et al. Improved immunogenicity and protective efficacy of a divalent DNA vaccine encoding Brucella L7/L12-truncated Omp31 fusion protein by a DNA priming and protein boosting regimen. Mol Immunol. 2015;66:384-91 pubmed publisher
    ..The pcDNA-L7/L12-TOmp31 priming followed by rL7/L12-TOmp31 boosting led to improved protection against B. abortus or B. melitensis infection. ..
  6. Asadi Karam M, Habibi M, Bouzari S. Use of flagellin and cholera toxin as adjuvants in intranasal vaccination of mice to enhance protective immune responses against uropathogenic Escherichia coli antigens. Biologicals. 2016;44:378-86 pubmed publisher
    ..These data indicated that intranasal administration of a FliC and CT adjuvant-based vaccine has the potential to provide protective responses against UPEC strains. ..
  7. Savar N, Sardari S, Jahanian Najafabadi A, Bouzari S. In Silico and In Vitro Studies of Truncated Forms of Flagellin (FliC) of Enteroaggregative Escherichia coli (EAEC). Mol Inform. 2013;32:707-16 pubmed publisher
    ..Our in silico and in vitro results indicated that two truncated forms of FliC- EAEC (amino acids 79-117 and 477-508) effectively interact with TLR-5, thus could be capable of inducing in vivo immune responses. ..
  8. Habibi M, Asadi Karam M, Bouzari S. Construction and evaluation of the immune protection of a recombinant divalent protein composed of the MrpA from MR/P fimbriae and flagellin of Proteus mirabilis strain against urinary tract infection. Microb Pathog. 2018;117:348-355 pubmed publisher
    ..Our results suggest the recombinant flagellin of P. mirabilis could be used as an intranasal adjuvant in combination with other potential antigens against UTIs. ..
  9. Roudkenar M, Bouzari S, Kuwahara Y, Roushandeh A, Oloomi M, Fukumoto M. Recombinant hybrid protein, Shiga toxin and granulocyte macrophage colony stimulating factor effectively induce apoptosis of colon cancer cells. World J Gastroenterol. 2006;12:2341-4 pubmed
    ..Selective cytotoxic effect of the hybrid protein on the colon cancer cell line expressing GM-CSF receptors (GM-CSFRs) receptor and apoptosis can be observed in this cell line. The hybrid protein can be considered as a therapeutic agent. ..

More Information

Publications14

  1. Golshani M, Rafati S, Nejati Moheimani M, Pourabdi S, Arsang A, Bouzari S. Protein/Protein, DNA/DNA and DNA/Protein based vaccination strategies using truncated Omp2b against Brucella infection in BALB/c Mice. Int J Med Microbiol. 2017;307:249-256 pubmed publisher
    ..melitensis and B. abortus infection. Therefore, TOmp2b could be introduced as a new subunit vaccine candidate against Brucella infection. ..
  2. Golshani M, Rafati S, Nejati Moheimani M, Ghasemian M, Bouzari S. Comparison of potential protection conferred by three immunization strategies (protein/protein, DNA/DNA, and DNA/protein) against Brucella infection using Omp2b in BALB/c Mice. Vet Microbiol. 2016;197:47-52 pubmed publisher
    ..melitensis and B. abortus infection. Therefore, it could be introduced as a new potential candidate for the development of a subunit vaccine against Brucella infection. ..
  3. Valiyari S, Salami M, Mahdian R, Shokrgozar M, Oloomi M, Mohammadi Farsani A, et al. sIL-24 peptide, a human interleukin-24 isoform, induces mitochondrial-mediated apoptosis in human cancer cells. Cancer Chemother Pharmacol. 2017;80:451-459 pubmed publisher
    ..Notably, among the tested cells, induction of apoptosis was more significant in PC-3 cells. Our results suggest that the sIL-24 peptide is a promising candidate for potential treatment of human cancers. ..
  4. Habibi M, Asadi Karam M, Bouzari S. Evaluation of prevalence, immunogenicity and efficacy of FyuA iron receptor in uropathogenic Escherichia coli isolates as a vaccine target against urinary tract infection. Microb Pathog. 2017;110:477-483 pubmed publisher
    ..Since, FyuA induced significant IgG1 (Th2) and IgG2a (Th1) responses and protected the mice against experimental UTI, it could be a promising target against UPEC infections. ..
  5. Bameri Z, Asadi Karam M, Habibi M, Ehsani P, Bouzari S. Determination immunogenic property of truncated MrpH.FliC as a vaccine candidate against urinary tract infections caused by Proteus mirabilis. Microb Pathog. 2018;114:99-106 pubmed publisher
    ..Thus, fusion protein tMrpH.FliC can be considered as promising vaccine against P. mirabilis. ..