Genomes and Genes


Emmanuel Bourinet



  1. Candelas M, Reynders A, Arango Lievano M, Neumayer C, Fruquière A, Demes E, et al. Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons. Sci Rep. 2019;9:3112 pubmed publisher
    ..Overall, in addition to their previously established roles in the superficial spinal cord and in primary afferent neurons, Cav3.2 channel appear to be necessary for specific, significant and multiple controls of LII neuron excitability. ..
  2. Reynders A, Mantilleri A, Malapert P, Rialle S, Nidelet S, Laffray S, et al. Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs. Cell Rep. 2015;10:1007-1019 pubmed publisher
    ..Our study greatly expands the molecular characterization of C-LTMRs and suggests that this particular population of neurons shares some molecular features with Aβ and Aδ low-threshold mechanoreceptors. ..
  3. Francois A, Schüetter N, Laffray S, Sanguesa J, Pizzoccaro A, Dubel S, et al. The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. Cell Rep. 2015;10:370-382 pubmed publisher
    ..Collectively, our findings support a fundamental role for Cav3.2 in touch/pain pathophysiology, validating their critic pharmacological relevance to relieve mechanical and cold allodynia. ..
  4. Song O, Kim H, Jouny S, Ricard I, Vandeputte A, Deboosere N, et al. A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. Toxins (Basel). 2017;9: pubmed publisher
    ..This result points towards novel ATâ‚‚R-dependent signaling pathways in DRG neurons underlying the analgesic effect of mycolactone, with the perspective for the development of new types of nature-inspired analgesics. ..