WinSAAM: a windows-based compartmental modeling systemDarko Stefanovski
School of Veterinary Medicine, University of Pennsylvania, PA 19348, USA
Metabolism 52:1153-66. 2003
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- AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology
Raymond C Boston
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
Diabetes Technol Ther 7:298-307. 2005
..The Bergman Minimal Model enables estimation of two key indices of glucose/ insulin dynamics: glucose effectiveness and insulin sensitivity...
Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United StatesMaria Soledad Cepeda
Johnson and Johnson Pharmaceutical Research and Development, Titusville, NJ, USA
BMC Palliat Care 9:14. 2010
..Little data exist on how opioid doses vary with the length of exposure among chronic opioid users...
A numerical deconvolution method to estimate C-peptide secretion in humans after an intravenous glucose tolerance testRay C Boston
School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, PA 19348, USA
Metabolism 58:891-900. 2009
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- NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test
Ray C Boston
School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 382 W St Road, Kennett Square, PA 19348, USA
Am J Physiol Regul Integr Comp Physiol 295:R395-403. 2008
..Modeling plasma NEFA concentrations over 24 h has helped to identify and quantify the extent that periprandial NEFA peaks and nocturnal elevation in plasma NEFA can be accounted for by our model...
- Modeling circadian rhythms of food intake by means of parametric deconvolution: results from studies of the night eating syndrome
Raymond C Boston
New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
Am J Clin Nutr 87:1672-7. 2008
..Disordered temporal eating patterns are a feature of a number of eating disorders. There is currently no standard mathematical model to quantify temporal eating patterns...
- A novel minimal model to describe NEFA kinetics following an intravenous glucose challenge
Ray C Boston
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
Am J Physiol Regul Integr Comp Physiol 294:R1140-7. 2008
..l(-1).min(-1). All model parameters were well identified and had coefficients of variation < 15% of their estimated values. It is concluded that this model is suitable to describe NEFA kinetics in human subjects...
- A novel minimal model to describe non-esterified fatty acid kinetics in Holstein dairy cows
Raymond C Boston
University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
J Dairy Res 75:13-8. 2008
..812+/-0.276 [mmol/l]. It is concluded that the model is suitable to describe NEFA kinetics in lactating dairy cows and it may have application in other species...
- AKA-TPG: a program for kinetic and epidemiological analysis of data from labeled glucose investigations using the two-pool model and database technology
Raymond C Boston
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
Diabetes Technol Ther 9:99-108. 2007
..Until now, there has been no program available dedicated to the TPG model, and a number of technical reasons have deterred researchers from performing TPG analysis...
- STATA: a statistical analysis system for examining biomedical data
Ray C Boston
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
Adv Exp Med Biol 537:353-69. 2003
- Evaluation of a compartmental model to describe non-esterified fatty acid kinetics in Holstein dairy cows
Peter J Moate
University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
J Dairy Res 74:430-7. 2007
..It is concluded that the Thomaseth model is not suitable for describing NEFA kinetics in lactating dairy cows...
- MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test
Ray C Boston
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
Diabetes Technol Ther 5:1003-15. 2003
..In contrast to earlier versions of MINMOD and some other minimal model programs, Millennium provides identified estimates of insulin sensitivity and glucose effectiveness for almost every subject...
- Pharmacokinetics of methylprednisolone acetate after intra-articular administration and its effect on endogenous hydrocortisone and cortisone secretion in horses
Lawrence R Soma
New Bolton Center Campus, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
Am J Vet Res 67:654-62. 2006
..A single intra-articular administration of MPA profoundly affected the secretion of HYD and COR in horses; secretion of endogenous corticosteroids remained suppressed for as long as 240 hours after injection...
- BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
R Daniel Rudic
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
PLoS Biol 2:e377. 2004
..Furthermore, asynchronous dietary cues may modify glucose homeostasis via their interactions with peripheral molecular clocks...
- A modified logistic model to describe gadolinium kinetics in breast tumors
Peter J Moate
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA
Magn Reson Imaging 22:467-73. 2004
..The advantages of this heuristic model compared to commonly used compartmental modeling approaches are discussed...
- Evaluation of plasma ACTH, alpha-melanocyte-stimulating hormone, and insulin concentrations during various photoperiods in clinically normal horses and ponies and those with pituitary pars intermedia dysfunction
Jill Beech
Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA
J Am Vet Med Assoc 235:715-22. 2009
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- The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse
Lawrence R Soma
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center Campus, 382 West Street Rd, Kennett Square, PA 19348, USA
Anesth Analg 100:1570-5. 2005
..Mammalian species dispose of Hb using similar mechanisms, and there is no unique metabolic process in the horse that would not allow a logical extension of the general interpretation of this study...
- Cardiac output determination by use of lithium dilution during exercise in horses
Mary M Durando
Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
Am J Vet Res 69:1054-60. 2008
..To compare cardiac output (CO) obtained by the lithium dilution method (LiDCO) with CO calculated from the Fick principle (FickCO), in horses maximally exercising on a high-speed treadmill...
- Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis
Simon R Bailey
Department of Veterinary Basic Sciences, Royal Veterinary College, London, NW1 0TU, England
J Am Vet Med Assoc 231:1365-73. 2007
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- Dietary energy source affects glucose kinetics in trained Arabian geldings at rest and during endurance exercise
Kibby H Treiber
Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
J Nutr 138:964-70. 2008
..Fat supplementation in horses may therefore promote greater flexibility in the selection of substrate to meet energy demands for optimal health and performance...
- The rate of de novo galactose synthesis in patients with galactose-1-phosphate uridyltransferase deficiency
Gerard T Berry
Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Mol Genet Metab 81:22-30. 2004
..The GAR in patients suggests the source of galactose for the continued elevation of galactose metabolites as well as the basis for the long-term complications in galactosemia despite restricted dietary galactose intake...
- WinSAAM: application and explanation of use
Janet A Novotny
USDA, BHNRC, DHPL, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
Adv Exp Med Biol 537:343-51. 2003
- Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in horses
Ferenc Toth
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
Am J Vet Res 69:82-8. 2008
..To evaluate the effects of endotoxin administered IV on glucose and insulin dynamics in horses...
- Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses
Nicholas Frank
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
Am J Vet Res 69:76-81. 2008
..To determine the effects of long-term oral administration of levothyroxine sodium (L-T(4)) on glucose dynamics in adult euthyroid horses...
- High frame-rate simultaneous bilateral breast DCE-MRI
Lawrence Dougherty
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 57:220-5. 2007
..In 11 of these cases there was a significant finding in the contralateral breast. DCE images of both breasts can be acquired simultaneously, resulting in high-resolution images as well as rapid sampling of the contrast kinetics...
- Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans
Anne E Sumner
Clincial Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Arch Intern Med 165:1395-400. 2005
..Our goal was to determine whether TG levels or TG-HDL-C ratio predicted insulin resistance in African Americans with a BMI of 25 kg/m(2) or more...
- Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP
Dara L Kraitchman
Johns Hopkins University, School of Medicine, Department of Radiology, MD 21287 0845, USA
Circulation 107:2025-30. 2003
..In this study, we investigate the use of fast harmonic phase (FastHARP) MRI for the quantitative, operator-independent detection of the onset of ischemia during acute coronary occlusion...
