Ray C Boston

Summary

Publications

  1. ncbi request reprint WinSAAM: a windows-based compartmental modeling system
    Darko Stefanovski
    School of Veterinary Medicine, University of Pennsylvania, PA 19348, USA
    Metabolism 52:1153-66. 2003
  2. ncbi request reprint AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology
    Raymond C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 7:298-307. 2005
  3. pmc Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States
    Maria Soledad Cepeda
    Johnson and Johnson Pharmaceutical Research and Development, Titusville, NJ, USA
    BMC Palliat Care 9:14. 2010
  4. ncbi request reprint AKA-TPG: a program for kinetic and epidemiological analysis of data from labeled glucose investigations using the two-pool model and database technology
    Raymond C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 9:99-108. 2007
  5. ncbi request reprint A novel minimal model to describe non-esterified fatty acid kinetics in Holstein dairy cows
    Raymond C Boston
    University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
    J Dairy Res 75:13-8. 2008
  6. doi request reprint A novel minimal model to describe NEFA kinetics following an intravenous glucose challenge
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1140-7. 2008
  7. doi request reprint A numerical deconvolution method to estimate C-peptide secretion in humans after an intravenous glucose tolerance test
    Ray C Boston
    School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, PA 19348, USA
    Metabolism 58:891-900. 2009
  8. pmc NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 382 W St Road, Kennett Square, PA 19348, USA
    Am J Physiol Regul Integr Comp Physiol 295:R395-403. 2008
  9. ncbi request reprint Modeling circadian rhythms of food intake by means of parametric deconvolution: results from studies of the night eating syndrome
    Raymond C Boston
    New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Clin Nutr 87:1672-7. 2008
  10. ncbi request reprint STATA: a statistical analysis system for examining biomedical data
    Ray C Boston
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
    Adv Exp Med Biol 537:353-69. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint WinSAAM: a windows-based compartmental modeling system
    Darko Stefanovski
    School of Veterinary Medicine, University of Pennsylvania, PA 19348, USA
    Metabolism 52:1153-66. 2003
    ....
  2. ncbi request reprint AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology
    Raymond C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 7:298-307. 2005
    ..The Bergman Minimal Model enables estimation of two key indices of glucose/ insulin dynamics: glucose effectiveness and insulin sensitivity...
  3. pmc Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States
    Maria Soledad Cepeda
    Johnson and Johnson Pharmaceutical Research and Development, Titusville, NJ, USA
    BMC Palliat Care 9:14. 2010
    ..Little data exist on how opioid doses vary with the length of exposure among chronic opioid users...
  4. ncbi request reprint AKA-TPG: a program for kinetic and epidemiological analysis of data from labeled glucose investigations using the two-pool model and database technology
    Raymond C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 9:99-108. 2007
    ..Until now, there has been no program available dedicated to the TPG model, and a number of technical reasons have deterred researchers from performing TPG analysis...
  5. ncbi request reprint A novel minimal model to describe non-esterified fatty acid kinetics in Holstein dairy cows
    Raymond C Boston
    University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
    J Dairy Res 75:13-8. 2008
    ..812+/-0.276 [mmol/l]. It is concluded that the model is suitable to describe NEFA kinetics in lactating dairy cows and it may have application in other species...
  6. doi request reprint A novel minimal model to describe NEFA kinetics following an intravenous glucose challenge
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1140-7. 2008
    ..l(-1).min(-1). All model parameters were well identified and had coefficients of variation < 15% of their estimated values. It is concluded that this model is suitable to describe NEFA kinetics in human subjects...
  7. doi request reprint A numerical deconvolution method to estimate C-peptide secretion in humans after an intravenous glucose tolerance test
    Ray C Boston
    School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, PA 19348, USA
    Metabolism 58:891-900. 2009
    ....
  8. pmc NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 382 W St Road, Kennett Square, PA 19348, USA
    Am J Physiol Regul Integr Comp Physiol 295:R395-403. 2008
    ..Modeling plasma NEFA concentrations over 24 h has helped to identify and quantify the extent that periprandial NEFA peaks and nocturnal elevation in plasma NEFA can be accounted for by our model...
  9. ncbi request reprint Modeling circadian rhythms of food intake by means of parametric deconvolution: results from studies of the night eating syndrome
    Raymond C Boston
    New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Clin Nutr 87:1672-7. 2008
    ..Disordered temporal eating patterns are a feature of a number of eating disorders. There is currently no standard mathematical model to quantify temporal eating patterns...
  10. ncbi request reprint STATA: a statistical analysis system for examining biomedical data
    Ray C Boston
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
    Adv Exp Med Biol 537:353-69. 2003
  11. ncbi request reprint Evaluation of a compartmental model to describe non-esterified fatty acid kinetics in Holstein dairy cows
    Peter J Moate
    University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
    J Dairy Res 74:430-7. 2007
    ..It is concluded that the Thomaseth model is not suitable for describing NEFA kinetics in lactating dairy cows...
  12. ncbi request reprint MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 5:1003-15. 2003
    ..In contrast to earlier versions of MINMOD and some other minimal model programs, Millennium provides identified estimates of insulin sensitivity and glucose effectiveness for almost every subject...
  13. ncbi request reprint Pharmacokinetics of methylprednisolone acetate after intra-articular administration and its effect on endogenous hydrocortisone and cortisone secretion in horses
    Lawrence R Soma
    New Bolton Center Campus, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 67:654-62. 2006
    ....
  14. pmc BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
    R Daniel Rudic
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Biol 2:e377. 2004
    ..Furthermore, asynchronous dietary cues may modify glucose homeostasis via their interactions with peripheral molecular clocks...
  15. doi request reprint Optimization of an in vitro assay to detect Streptococcus equi subsp. equi
    Ashley G Boyle
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Rd, Kennett Square, PA 19348, USA
    Vet Microbiol 159:406-10. 2012
    ..At higher cell densities (>100 cfu/ml) flocked swab culture was not statistically better than rayon swab culture, but it was superior to all other methods tested...
  16. ncbi request reprint The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse
    Lawrence R Soma
    Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center Campus, 382 West Street Rd, Kennett Square, PA 19348, USA
    Anesth Analg 100:1570-5. 2005
    ..Mammalian species dispose of Hb using similar mechanisms, and there is no unique metabolic process in the horse that would not allow a logical extension of the general interpretation of this study...
  17. doi request reprint Evaluation of plasma ACTH, alpha-melanocyte-stimulating hormone, and insulin concentrations during various photoperiods in clinically normal horses and ponies and those with pituitary pars intermedia dysfunction
    Jill Beech
    Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA
    J Am Vet Med Assoc 235:715-22. 2009
    ....
  18. doi request reprint Cardiac output determination by use of lithium dilution during exercise in horses
    Mary M Durando
    Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    Am J Vet Res 69:1054-60. 2008
    ..To compare cardiac output (CO) obtained by the lithium dilution method (LiDCO) with CO calculated from the Fick principle (FickCO), in horses maximally exercising on a high-speed treadmill...
  19. ncbi request reprint A modified logistic model to describe gadolinium kinetics in breast tumors
    Peter J Moate
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA
    Magn Reson Imaging 22:467-73. 2004
    ..The advantages of this heuristic model compared to commonly used compartmental modeling approaches are discussed...
  20. ncbi request reprint Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis
    Simon R Bailey
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, NW1 0TU, England
    J Am Vet Med Assoc 231:1365-73. 2007
    ....
  21. ncbi request reprint Dietary energy source affects glucose kinetics in trained Arabian geldings at rest and during endurance exercise
    Kibby H Treiber
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 138:964-70. 2008
    ..Fat supplementation in horses may therefore promote greater flexibility in the selection of substrate to meet energy demands for optimal health and performance...
  22. ncbi request reprint The rate of de novo galactose synthesis in patients with galactose-1-phosphate uridyltransferase deficiency
    Gerard T Berry
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Genet Metab 81:22-30. 2004
    ..The GAR in patients suggests the source of galactose for the continued elevation of galactose metabolites as well as the basis for the long-term complications in galactosemia despite restricted dietary galactose intake...
  23. ncbi request reprint WinSAAM: application and explanation of use
    Janet A Novotny
    USDA, BHNRC, DHPL, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    Adv Exp Med Biol 537:343-51. 2003
  24. ncbi request reprint High frame-rate simultaneous bilateral breast DCE-MRI
    Lawrence Dougherty
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 57:220-5. 2007
    ..In 11 of these cases there was a significant finding in the contralateral breast. DCE images of both breasts can be acquired simultaneously, resulting in high-resolution images as well as rapid sampling of the contrast kinetics...
  25. ncbi request reprint Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans
    Anne E Sumner
    Clincial Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 165:1395-400. 2005
    ..Our goal was to determine whether TG levels or TG-HDL-C ratio predicted insulin resistance in African Americans with a BMI of 25 kg/m(2) or more...
  26. doi request reprint Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in horses
    Ferenc Toth
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Am J Vet Res 69:82-8. 2008
    ..To evaluate the effects of endotoxin administered IV on glucose and insulin dynamics in horses...
  27. doi request reprint Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses
    Nicholas Frank
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Am J Vet Res 69:76-81. 2008
    ..To determine the effects of long-term oral administration of levothyroxine sodium (L-T(4)) on glucose dynamics in adult euthyroid horses...
  28. ncbi request reprint Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP
    Dara L Kraitchman
    Johns Hopkins University, School of Medicine, Department of Radiology, MD 21287 0845, USA
    Circulation 107:2025-30. 2003
    ..In this study, we investigate the use of fast harmonic phase (FastHARP) MRI for the quantitative, operator-independent detection of the onset of ischemia during acute coronary occlusion...