Sieto Bosgra

Summary

Publications

  1. doi request reprint An integrated probabilistic framework for cumulative risk assessment of common mechanism chemicals in food: an example with organophosphorus pesticides
    Sieto Bosgra
    Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80 177, NL 3508 TD Utrecht, The Netherlands
    Regul Toxicol Pharmacol 54:124-33. 2009
  2. doi request reprint Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood
    Sieto Bosgra
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80 177, NL 3508 TD Utrecht, The Netherlands
    Toxicol Appl Pharmacol 236:9-15. 2009
  3. doi request reprint Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro
    Sieto Bosgra
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80 177, NL 3508 TD Utrecht, The Netherlands
    Toxicol Appl Pharmacol 236:1-8. 2009
  4. doi request reprint Dose addition and the isobole method as approaches for predicting the cumulative effect of non-interacting chemicals: a critical evaluation
    Sieto Bosgra
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Crit Rev Toxicol 39:418-26. 2009
  5. doi request reprint An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry
    Sieto Bosgra
    Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80 178, NL 3508, Utrecht, The Netherlands
    Crit Rev Toxicol 42:751-67. 2012

Detail Information

Publications5

  1. doi request reprint An integrated probabilistic framework for cumulative risk assessment of common mechanism chemicals in food: an example with organophosphorus pesticides
    Sieto Bosgra
    Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80 177, NL 3508 TD Utrecht, The Netherlands
    Regul Toxicol Pharmacol 54:124-33. 2009
    ..This demonstration may help to familiarize risk assessors and risk managers with the somewhat more complex output of probabilistic risk assessment...
  2. doi request reprint Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood
    Sieto Bosgra
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80 177, NL 3508 TD Utrecht, The Netherlands
    Toxicol Appl Pharmacol 236:9-15. 2009
    ..Other possibilities of validating dose-addition using toxicodynamic modeling are briefly discussed...
  3. doi request reprint Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro
    Sieto Bosgra
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80 177, NL 3508 TD Utrecht, The Netherlands
    Toxicol Appl Pharmacol 236:1-8. 2009
    ..Despite the differences in dynamics between methamidophos and methomyl, their dose-response curves were close to parallel, and dose addition gave a reasonably accurate prediction of the combined effects...
  4. doi request reprint Dose addition and the isobole method as approaches for predicting the cumulative effect of non-interacting chemicals: a critical evaluation
    Sieto Bosgra
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Crit Rev Toxicol 39:418-26. 2009
    ..We discuss the implications for research focusing on detecting or defining interactions, and for the prediction of effects from combined exposures assuming zero interaction...
  5. doi request reprint An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry
    Sieto Bosgra
    Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80 178, NL 3508, Utrecht, The Netherlands
    Crit Rev Toxicol 42:751-67. 2012
    ..The conceptual differences among the three models are discussed and they are quantitatively compared by running all three models for various specific combinations of anthropometric properties...